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| 1 | Quality of life, work productivity impairment and healthcare resources in inflammatory bowel diseases in Brazil显示文摘BACKGROUND Inflammatory bowel diseases(IBD)have been associated with a low quality of life(QoL)and a negative impact on work productivity compared to the general population.Information about disease control,patient-reported outcomes(PROs),treatment patterns and use of healthcare resources is relevant to optimizing IBD management.AIM To describe QoL and work productivity and activity impairment(WPAI),treatment patterns and use of healthcare resources among IBD patients in Brazil.METHODS A multicenter cross-sectional study included adult outpatients who were previously diagnosed with moderate to severe Crohn’s disease(CD)or ulcerative colitis(UC).At enrolment,active CD and UC were defined as having a Harvey Bradshaw Index≥8 or a CD Activity Index≥220 or calprotectin>200μg/g or previous colonoscopy results suggestive of inadequate control(per investigator criteria)and a 9-point partial Mayo score≥5,respectively.The PRO assessment included the QoL questionnaires SF-36 and EQ-5D-5L,the Inflammatory Bowel Disease Questionnaire(IBDQ),and the WPAI questionnaire.Information about healthcare resources and treatment during the previous 3 years was collected from medical records.Chi-square,Fisher’s exact and Student’s t-/Mann-Whitney U tests were used to compare PROs,treatment patterns and the use of healthcare resources by disease activity(α=0.05).RESULTS Of the 407 patients in this study(CD/UC:64.9%/35.1%,mean age 42.9/45.9 years,54.2%/56.6%female,38.3%/37.1%employed),44.7%/25.2%presented moderate-to-severe CD/UC activity,respectively,at baseline.Expressed in median values for CD/UC,respectively,the SF-36 physical component was 46.6/44.7 and the mental component was 45.2/44.2,the EQ-visual analog scale score was 80.0/70.0,and the IBDQ overall score was 164.0/165.0.Moderate to severe activity,female gender,being unemployed,a lower educational level and lower income were associated with lower QoL(P<0.05).Median work productivity impairment was 20%and 5%for CD and UC patients,respectively,and activity impairment was 30%,the latter being higher among patients with moderate to severe disease activity compared to patients with mild or no disease activity(75.0%vs 10.0%,P<0.001).For CD/UC patients,respectively,25.4%/2.8%had at least one surgery,38.3%/19.6%were hospitalized,and 70.7%/77.6%changed IBD treatment at least once during the last 3 years.The most common treatments at baseline were biologics(75.3%)and immunosuppressants(70.9%)for CD patients and 5-ASA compounds(77.5%)for UC patients.CONCLUSION Moderate to severe IBD activity,especially among CD patients,is associated with a substantial impact on QoL,work productivity impairment and an increased number of IBD surgeries and hospitalizations in Brazil. | Rogerio Serafim Parra Julio MF Chebli Heda MBS Amarante Cristina Flores Jose ML Parente Odery Ramos Milene Fernandes Jose JR Rocha Marley R Feitosa Omar Feres Antonio S Scotton Rodrigo B Nones Murilo M Lima Cyrla Zaltman Carolina D Goncalves Isabella M Guimaraes Genoile O Santana Ligia Y Sassaki Rogerio S Hossne Mauro Bafutto Roberto LK Junior Mikaell AG Faria Sender J Miszputen Tarcia NF Gomes Wilson R Catapani Anderson A Faria Stella CS Souza Rosana F Caratin Juliana T Senra Maria LA Ferrari | 2019 | World Journal of Gastroenterology2019，25，38： | 2 |
| 2 | A study on the characteristics of various conductive contaminants accumulated on high voltage insulators显示文摘 | Ramos N G Campillo R M T Naito K | 1993 | IEEE Trans on Power Delivery1993，8，4： | 1 |
| 3 | A study on the char- acteristics of various conductive contaminants accumulated on high voltage insulators显示文摘 | Ramos N G Campillo R M T Naito K | 1993 | IEEE Transactions on Power Deliv- ery1993，8，18： | 1 |
| 4 | Role of cortical cell type and morphology in sub- and su- prathreshold uniform electric field stimulation in vitro 显示文摘 | Radman T Ramos R L Brumberg J C | 2009 | Brain Stimulation2009，2，4： | 1 |
| 5 | A study On the characteristics of various conductive contaminants accumulated on high voltage in- sulators显示文摘 | Ramos N G Campillo R M T Naito K | 1993 | IEEE Transactions on Power Delivery1993，8，4： | 1 |
| 6 | A study on the characteristics of various conductive contaminants accumulated on high voltage insulators显示文摘 | Ramos N G CampiUo R M T Naito K | 1993 | IEEE Transactions on Power Delivery1993，8，4： | 1 |
| 7 | A study on the characteristics of various conductive contaminants accumulated on high voltage insulators显示文摘 | Ramos G N Campillo M T R Naito K | 1993 | IEEE Transactions on PowerDelivery1993，8，4： | 1 |
| 8 | Fast heterodyne optical phase-lock loop using double quantum well laser diodes 显示文摘 | RAMOS R T SEEDS A J | 1992 | Electronics Letters(S0013-5194)1992，28，1： | 1 |
| 9 | A study on the char- acteristics of various conductive contaminants accumulated on high voltage insulators显示文摘 | Ramos N G Campillo R M T Naito K | 1993 | IEEE Transactions on Power Deliv- ery1993，8，4： | 1 |
| 10 | Role of cortical cell type and morphology in sub- and su-prathreshold uniform electric field stimulation显示文摘 | Radman T Ramos R L Brumberg J C | | 0，，04： | 1 |
| 11 | Control of irreversible fouling by application of dynamic membranes 显示文摘 | Pessoa de Amorim M T Ramos I R A | 2006 | Desalination2006，192，13： | 1 |
| 12 | Paleogeography and Andean structural geometry, northwest Argentina 显示文摘 | Allmendinger R Ramos V A Jordan T | 1983 | Tec tonics1983，2，1： | 1 |
| 13 | Tip dieback of mango (Mangifera indica) caused by Botryosphaeria ribis显示文摘 | Ramos L J Lara S P McMillan R T Jr | 1991 | Plant disease1991，75，： | 1 |
| 14 | A study on the characteristics of various conductive contaminants accumulated on high voltage insulators显示文摘 | Ramos N G Campillo R M T Naito K | 1993 | IEEE Transactions on Power Delivery1993，8，4： | 1 |
| 15 | Health Monitoring of Com- posite Structures by Embedded FBG and Interferometric Fabry-Perot Sensors 显示文摘 | de Oliveira R Ramos C A Marques A T | 2007 | Computers and Structures2007，86，3： | 1 |
| 16 | Adsorption of fluoride from aqueous solution on aluminum-impregnated carbon显示文摘 | Ramos R L J Ovalle T Sanchez M A C | 1997 | Carbon1997，37，： | 1 |
| 17 | Dyslipidemia and cardiovascular risk in type 2 diabetes mellitus patients with associated diabetic nephropathy显示文摘 | Martinez C A Ramo R Gonzalez M T | 2002 | Nefrologia2002，，： | 1 |
| 18 | Technological variables and absorptive capacity influence on performance through corporate entrepreneurship 显示文摘 | GARCIA - MORALES V J BOLIVAR - RAMOS M T MARTIN - ROJAS R | 2014 | Journal of Business Research2014，67，7： | 1 |
| 19 | A study on the characteristics of various conductive contaminants accumulated on high voltage insulators显示文摘 | Ramos N G Campillo R M T Naito K | 1993 | IEEE Trans on Power Delivery1993，8，4： | 1 |
| 20 | Tip dieback of mango (Mangifera indica) caused byBotryosphaeria ribis显示文摘 | Ramos L J Lara S P McMillan R T Jr | 1991 | Plant Disease1991，75，3： | 1 |
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