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| 1 | Understanding plant drought resistance in a Mediterranean coastal sand dune ecosystem:differences between native and exotic invasive species显示文摘Aims Mediterranean coastal dunes are habitats of great conservation interest,with a distinctive and rich flora.In the last century,Acacia spp.,native from Australia,have been introduced in Portugal,with the objective of stabilizing sand dunes,and since have become dominant in numerous sand dune habitats.This invasion process led to the reduction of native plant species richness,changed soil characteristics and modified habitat’s microclimatic char-acteristics.The aim of this research was to typify and compare,in Mediterranean sand dune ecosystems,the ecophysiological responses to drought of Helichrysum italicum and Corema album,two native species,and Acacia longifolia,an exotic invasive spe-cies.We addressed the following specific objectives:(i)to com-pare water relations and water use efficiencies,(ii)to evaluate water stress,(iii)to assess water use strategies and water sources used by plants and(iv)to evaluate the morphological adaptations at leaf and phyllode level.Methods In order to obtain an integrative view of ecophysiological patterns,water relations and performance measuring methods have been applied:predawn(ψPD)and midday(ψMD)water potential,chloro-phyll a fluorescence,oxygen isotopic composition of xylem,rain and groundwater(δ18O)and leaf carbon isotopic discrimination(Δ13C).The leaf characteristics of the three species,as well as the histochemistry of non-glandular trichome cell walls,were also studied to identify morpho-traits related to drought resistance.Important Findings The results support our initial hypothesis:although A.longifolia clearly possesses a degree of resistance to water stress,such ability is provided by a different water strategy,when compared to native species.Natives relied on morphological adaptations to restrict water loss,whereas the invasive species adjusted the water uptake as a way to balance their limited ability of restricting water loss.We corroborate that woody native species(i)have a conservative water-saving strategy and minor seasonal variations relative to invasive species,(ii)use enriched water sources during drought periods,indicating different water sources and root systems com-paring with invasive species and(iii)present drought leaf morpho-functional adaptations related with limiting water loss.Comparing the physiological performance of invasive and native species can offer causal explanations for the relative success of alien plant invasions on sand dunes ecosystems. | Cristina Antunes Ana Júlia Pereira Patrícia Fernandes Margarida Ramos Lia Ascensão Otília Correia Cristina Máguas | 2018 | Journal of Plant Ecology2018，11，1： | 4 |
| 2 | Biliary cystadenoma显示文摘The diagnosis of cystadenoma is rare, even more so when located in the extrahepatic bile duct.Unspeciflc clinical signs may lead this pathology to be misdiagnosed.The need for pathological anatomy in order to distinguish cystadenomas from simple biliary cysts is crucial.The most usual treatment nowadays is resection of the bile duct, together with cholecystectomy and Roux-en-Y reconstruction. | Miguel A Hernandez Bartolome Sagrario Fuerte Ruiz Israel Manzanedo Romero Beatriz Ramos Lojo Ignacio Rodriguez Prieto Luis Gimenez Alvira Rosario Granados Carreo Manuel Limones Esteban | 2009 | World Journal of Gastroenterology2009，15，28： | 4 |
| 3 | Quality of life, work productivity impairment and healthcare resources in inflammatory bowel diseases in Brazil显示文摘BACKGROUND Inflammatory bowel diseases(IBD)have been associated with a low quality of life(QoL)and a negative impact on work productivity compared to the general population.Information about disease control,patient-reported outcomes(PROs),treatment patterns and use of healthcare resources is relevant to optimizing IBD management.AIM To describe QoL and work productivity and activity impairment(WPAI),treatment patterns and use of healthcare resources among IBD patients in Brazil.METHODS A multicenter cross-sectional study included adult outpatients who were previously diagnosed with moderate to severe Crohn’s disease(CD)or ulcerative colitis(UC).At enrolment,active CD and UC were defined as having a Harvey Bradshaw Index≥8 or a CD Activity Index≥220 or calprotectin>200μg/g or previous colonoscopy results suggestive of inadequate control(per investigator criteria)and a 9-point partial Mayo score≥5,respectively.The PRO assessment included the QoL questionnaires SF-36 and EQ-5D-5L,the Inflammatory Bowel Disease Questionnaire(IBDQ),and the WPAI questionnaire.Information about healthcare resources and treatment during the previous 3 years was collected from medical records.Chi-square,Fisher’s exact and Student’s t-/Mann-Whitney U tests were used to compare PROs,treatment patterns and the use of healthcare resources by disease activity(α=0.05).RESULTS Of the 407 patients in this study(CD/UC:64.9%/35.1%,mean age 42.9/45.9 years,54.2%/56.6%female,38.3%/37.1%employed),44.7%/25.2%presented moderate-to-severe CD/UC activity,respectively,at baseline.Expressed in median values for CD/UC,respectively,the SF-36 physical component was 46.6/44.7 and the mental component was 45.2/44.2,the EQ-visual analog scale score was 80.0/70.0,and the IBDQ overall score was 164.0/165.0.Moderate to severe activity,female gender,being unemployed,a lower educational level and lower income were associated with lower QoL(P<0.05).Median work productivity impairment was 20%and 5%for CD and UC patients,respectively,and activity impairment was 30%,the latter being higher among patients with moderate to severe disease activity compared to patients with mild or no disease activity(75.0%vs 10.0%,P<0.001).For CD/UC patients,respectively,25.4%/2.8%had at least one surgery,38.3%/19.6%were hospitalized,and 70.7%/77.6%changed IBD treatment at least once during the last 3 years.The most common treatments at baseline were biologics(75.3%)and immunosuppressants(70.9%)for CD patients and 5-ASA compounds(77.5%)for UC patients.CONCLUSION Moderate to severe IBD activity,especially among CD patients,is associated with a substantial impact on QoL,work productivity impairment and an increased number of IBD surgeries and hospitalizations in Brazil. | Rogerio Serafim Parra Julio MF Chebli Heda MBS Amarante Cristina Flores Jose ML Parente Odery Ramos Milene Fernandes Jose JR Rocha Marley R Feitosa Omar Feres Antonio S Scotton Rodrigo B Nones Murilo M Lima Cyrla Zaltman Carolina D Goncalves Isabella M Guimaraes Genoile O Santana Ligia Y Sassaki Rogerio S Hossne Mauro Bafutto Roberto LK Junior Mikaell AG Faria Sender J Miszputen Tarcia NF Gomes Wilson R Catapani Anderson A Faria Stella CS Souza Rosana F Caratin Juliana T Senra Maria LA Ferrari | 2019 | World Journal of Gastroenterology2019，25，38： | 2 |
| 4 | Clinical hematological and biochemical parameters in Swiss,BALB/c,C57BL/6 and B6D2F1 Mus musculus显示文摘Background:Animal models are widely used in scientific research in order to obtain information from a whole organism under a specific set of experimental conditions.Various lineages of mice have been used to investigate diseases and new therapeutic strategies,and,consequently,hematological and biochemical tests in these laboratory animals are essential to validate scientific studies.Our study seeks to establish reference values for hematological and biochemical parameters of four lineages of mice.Methods:We evaluated the hematological and biochemical profiles of 20 males and 20 females from the lineages Swiss(heterogeneous),BALB/c and C57BL/6(isogenic),and B6D2F1(hybrid),totaling 160 mice.Analysis were standardized using the systems pocH-100iV Diff™for 19 hematological parameters and VITROS®350 for 12 biochemical parameters.Results:Results are shown as means and standard deviation,grouped by lineage and genre.Comparing the values obtained in this study with the values from previous studies,some variations were detected,which could be explained by differences in methodologies or individual variability.Conclusion:Thus our study shows that knowledge and disclosure of the values of physiological parameters of laboratory animals is necessary,and emphasises the importance of considering variations influenced by gender,lineage and genotype in the choice of the best experimental model. | Giorgio Silva-Santana Juliet Cunha Bax Débora Cristina Silva Fernandes Daniela Tendler Leibel Bacellar Cleber Hooper Alexandre Alves Souza Oliveira Dias Cristina Barbosa Silva Aline Moreira de Souza Simone Ramos Ricardo Alexandre Santos Thainara Ramos Pinto Mariana Antunes Ramão Ana Luíza Mattos-Guaraldi | 2020 | Animal Models and Experimental Medicine2020，3，4： | 2 |
| 5 | Small bowel bacterial overgrowth in patients with alcoholic cirrhosis显示文摘 | Dr. F. Casafont Morencos MD G. Heras Casta?o MD L. Martín Ramos MD Maria J. López Arias MD F. Ledesma MD F. Pons Romero MD | 1996 | Digestive Diseases and Sciences1996，，3： | 2 |
| 6 | Wave-Based Slewing and Vibration Control of a Flexible Arm显示文摘 | Yang Tangwen O'Connor W J Ramos F | | 0，，02： | 1 |
| 7 | Phenotypical and molecular characterization of the Tomato mottle Taino virus-Nicotiana megalosiphon interaction显示文摘 | COLLAZO C RAMOS P L CHAC(O)N O | | 0，，： | 1 |
| 8 | Effects of Cd vacancies on the electrical properties of polycrystalline CdTe sputtered films显示文摘 | Becerril M Zelaya--Angel O Ramo Arez--Bon R | 2001 | Journal of Physics and Chemistry of Solids2001，62，： | 1 |
| 9 | Tactile sen-sors for robotic applications显示文摘 | Girao P S Ramos P M P Postolache O | | 0，，3： | 1 |
| 10 | Transparent thin film transistors based on indium oxide semiconductor显示文摘 | Lavareda G de Carvalho.C.N Fortunato E Ramos A.R Alves E Conde O and Amaral A | | 0，，23： | 1 |
| 11 | Collagen binding is a key factor for the hemorrhagic activity of snake venom metallo- proteinases 显示文摘 | Mourada-Silva A M Ramos O H Baldo C | 2008 | Biochimie2008，90，3： | 1 |
| 12 | Impact of alternative fuels on performance and pollutant emissions of a light duty engine tested under the new European driving cycle 显示文摘 | ARMAS O GARCIA-CONTRERAS R RAMOS 2: | 2013 | Applied Energy2013，107，： | 1 |
| 13 | Cannabidiol reduced the striatal atrophy caused 3-nitropropionic acid in vivo by mechanisms independent of the activation of cannabinoid,vanilloid TRPV1 and adenosine A2A receptors显示文摘 | Sagredo O Ramos J A Decio A | | 0，，4： | 1 |
| 14 | 显示文摘 | Ramos O | 1995 | Environ Health Perspect1995，103，1： | 1 |
| 15 | Isolation and characterization of cells with neurogenic potential from adult skeletal muscle 显示文摘 | Vourc'h P Romero- Ramos M Chivatakam O etal | 2004 | Biochem Biophvs Res Commun2004，317，3： | 1 |
| 16 | Progress in the development of animal models of acute kidney injury and its impact on drug discovery显示文摘 | Ana B Sanz Marí a Dolores Sanchez-Ni? o Catalina Martí n-Cleary Alberto Ortiz Adriá n M Ramos | 2013 | Expert Opinion on Drug Discovery2013，，7： | 1 |
| 17 | Thermal stability of plasminogen activators and plasminogen activation in heated milk显示文摘 | PRADO B M ISMAIL B RAMOS O | 2007 | International Dairy Journal2007，17，9： | 1 |
| 18 | Clinical, etiological and progression factors of hearing in sudden deafness显示文摘 | Penido Nde O Ramos HV Barros FA | 2005 | Braz J Otorhinolaryngol2005，71，5： | 1 |
| 19 | Clinical, etiological and progression factors of hearing in sudden deafness 显示文摘 | Penido Nde O Ramos HV Barros FA | 2005 | Braz J Otorhinolaryngol2005，71，5： | 1 |
| 20 | Thermal properties of hybrid lignocellulosic fabric-reinforced polyester matrix composites显示文摘 | Alsina O L S L H de Carvalho Ramos Filho F G | 2005 | Polymer Testing2005，24，： | 1 |
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