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| 1 | Quality of life, work productivity impairment and healthcare resources in inflammatory bowel diseases in Brazil显示文摘BACKGROUND Inflammatory bowel diseases(IBD)have been associated with a low quality of life(QoL)and a negative impact on work productivity compared to the general population.Information about disease control,patient-reported outcomes(PROs),treatment patterns and use of healthcare resources is relevant to optimizing IBD management.AIM To describe QoL and work productivity and activity impairment(WPAI),treatment patterns and use of healthcare resources among IBD patients in Brazil.METHODS A multicenter cross-sectional study included adult outpatients who were previously diagnosed with moderate to severe Crohn’s disease(CD)or ulcerative colitis(UC).At enrolment,active CD and UC were defined as having a Harvey Bradshaw Index≥8 or a CD Activity Index≥220 or calprotectin>200μg/g or previous colonoscopy results suggestive of inadequate control(per investigator criteria)and a 9-point partial Mayo score≥5,respectively.The PRO assessment included the QoL questionnaires SF-36 and EQ-5D-5L,the Inflammatory Bowel Disease Questionnaire(IBDQ),and the WPAI questionnaire.Information about healthcare resources and treatment during the previous 3 years was collected from medical records.Chi-square,Fisher’s exact and Student’s t-/Mann-Whitney U tests were used to compare PROs,treatment patterns and the use of healthcare resources by disease activity(α=0.05).RESULTS Of the 407 patients in this study(CD/UC:64.9%/35.1%,mean age 42.9/45.9 years,54.2%/56.6%female,38.3%/37.1%employed),44.7%/25.2%presented moderate-to-severe CD/UC activity,respectively,at baseline.Expressed in median values for CD/UC,respectively,the SF-36 physical component was 46.6/44.7 and the mental component was 45.2/44.2,the EQ-visual analog scale score was 80.0/70.0,and the IBDQ overall score was 164.0/165.0.Moderate to severe activity,female gender,being unemployed,a lower educational level and lower income were associated with lower QoL(P<0.05).Median work productivity impairment was 20%and 5%for CD and UC patients,respectively,and activity impairment was 30%,the latter being higher among patients with moderate to severe disease activity compared to patients with mild or no disease activity(75.0%vs 10.0%,P<0.001).For CD/UC patients,respectively,25.4%/2.8%had at least one surgery,38.3%/19.6%were hospitalized,and 70.7%/77.6%changed IBD treatment at least once during the last 3 years.The most common treatments at baseline were biologics(75.3%)and immunosuppressants(70.9%)for CD patients and 5-ASA compounds(77.5%)for UC patients.CONCLUSION Moderate to severe IBD activity,especially among CD patients,is associated with a substantial impact on QoL,work productivity impairment and an increased number of IBD surgeries and hospitalizations in Brazil. | Rogerio Serafim Parra Julio MF Chebli Heda MBS Amarante Cristina Flores Jose ML Parente Odery Ramos Milene Fernandes Jose JR Rocha Marley R Feitosa Omar Feres Antonio S Scotton Rodrigo B Nones Murilo M Lima Cyrla Zaltman Carolina D Goncalves Isabella M Guimaraes Genoile O Santana Ligia Y Sassaki Rogerio S Hossne Mauro Bafutto Roberto LK Junior Mikaell AG Faria Sender J Miszputen Tarcia NF Gomes Wilson R Catapani Anderson A Faria Stella CS Souza Rosana F Caratin Juliana T Senra Maria LA Ferrari | 2019 | World Journal of Gastroenterology2019，25，38： | 2 |
| 2 | Frequency transfer function of dispersive and nonlinear single-mode optical fibers in microwave optical systems显示文摘 | Ramos F Marti J | 2000 | IEEE Photon Technol Lett2000，12，5： | 2 |
| 3 | Adult bone marrow stromal cells differentiate into neural cells in vitro显示文摘 | Sanchez Ramos J Song S Cardozo Pelaez F | | 0，，： | 2 |
| 4 | Determination of the furaltadone metabolite 5-methylmorpholino-3-amino -9 oxazolidinone (AMOZ) using liquid chromatography coupled to electrospray tandem mass spectrometry during the nitrofuran crisis in Portugal显示文摘 | Barbosa J Ferreira M L Ramos F | 2007 | Accred Qual Assur2007，12，： | 1 |
| 5 | Optimization of millimeter-wave signal generation through FM-IM conversion in chirped fiber gratings 显示文摘 | Marti J Fuster J M Ramos F | 2000 | Microwave and Optical Technology Letters2000，27，6： | 1 |
| 6 | Adult bone marrow stromal cells differentiate into neural cells in vivo显示文摘 | Sanchez - Ramos J Song S Cardozo - Pelaez F | 2000 | Exp Neurol2000，164，： | 1 |
| 7 | Wave-Based Slewing and Vibration Control of a Flexible Arm显示文摘 | Yang Tangwen O'Connor W J Ramos F | | 0，，02： | 1 |
| 8 | Chases in volatiles with the application of progressive freeze-concentration to Andes berry(Rubus glaucus Benth)显示文摘 | RAMOS F A DELGADO J L BAUTISTAE MORALES A L DUQUEC | 2005 | Journal of Food Engineering2005，，69： | 1 |
| 9 | Reduced- dimension blind space - time 2 - D Rank receivers for DS - CDMA communication systems 显示文摘 | CHEN Y F ZOLTOWSKI M D RAMOS J | 2000 | IEEE Trans on Signal Process2000，48，： | 1 |
| 10 | Mitigation of chromatic dispersion effects employing electro absorption modula- tor-based transmitters显示文摘 | Polo V Mart'l J Ramos F | 1999 | IEEE Photonics Technology Letters1999，11，7： | 1 |
| 11 | Probabilistic midterm transmission planning in a liberalized market 显示文摘 | Sanchez-Martin P Ramos A Alonso J F | 2005 | IEEE Transactions on Power Systems2005，20，4： | 1 |
| 12 | Adult bone marrow stromal cell differentiate into neural cells in vitro显示文摘 | Sanchez Ramos J Song S CARDOZO pelac F | 2000 | ExpNeuro 12000，164，： | 1 |
| 13 | Adult bone marrow stromal cells differentiate into neural cells in vitro显示文摘 | Sanchez - Ramos J Song S Cardozo - Plaez F | 2000 | Exp Neurol2000，164，2： | 1 |
| 14 | Site effects in Mexico City: constraints from surface wave inversion of shallow refraction data显示文摘 | RAMOS Martinez J CHAVEZ Garcia F J ROMEROJimenez E | 1997 | Journal of Applied Geophysics1997，36，4： | 1 |
| 15 | State-of-the-art, challenges, and future trends in security constrained optimal power flow显示文摘 | CAPITANESCU F MARTINEZ RAMOS J L PANCIATICI P | 2011 | Electric Power System Research2011，81，： | 1 |
| 16 | Adult bone marrow stromal cells differentiate into neural cells in vitro显示文摘 | Sanchez -Ramos J Song S Cardozo-Pelaez F | 2000 | Exp Neural2000，164，2： | 1 |
| 17 | Intercalation of benzamide into kaolinite显示文摘 | RAMOS L P WYPYCH F | 2000 | Colloid Interface Sci2000，221，： | 1 |
| 18 | Worsening of hepatic dysfunction as a consequence of repeated hydroxyethylstarch infusions显示文摘 | Mal F Ramos J | 2001 | J Hepatol2001，35，6： | 1 |
| 19 | Adult bone marrow stromal cells differentiate into neural cells in vitro显示文摘 | Sanchez- Ramos J Song S Cardozo- Pelaez F | 2000 | Exp Neurol2000，164，2： | 1 |
| 20 | Computational analysis of ligand recognition sites of homo-and heteropentameric5-HT3 receptors显示文摘 | Moura Barbosa A J De Rienzo F Ramos M J | 2010 | Eur J Med Chem2010，45，11： | 1 |
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