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| 1 | Comparative analysis of ERCP,IDUS,EUS and CT in predicting malignant bile duct strictures显示文摘AIM:To compare endoscopic retrograde cholangio-pancreatography(ERCP),intraductal ultrasound(IDUS),endosonography(EUS),endoscopic transpapillary forceps biopsies(ETP)and computed tomography(CT)with respect to diagnosing malignant bile duct strictures.METHODS:A patient cohort with bile duct strictures of unknown etiology was examined by ERCP and IDUS,ETP,EUS,and CT.The sensitivity,specificity,and accuracy rates of the diagnostic procedures were calculated based on the definite diagnoses proved by histopathology or long-term follow-up in those patients who did not undergo surgery.For each of the diagnostic measures,the sensitivity,specificity,and accuracy rates were calculated.In all cases,the gold standard was the histopathologic staging of specimens or long-term follow-up of at least 12 mo.A comparison of the accuracy rates between the localization of strictures was performed by using the Mann-Whitney U-test and theχ2test as appropriate.A comparison of the accuracy rates between the diagnostic procedures was performed by using the McNemar’s test.Differences were considered statistically significant if P<0.05.RESULTS:A total of 234 patients(127 males,107 females,median age 64,range 20-90 years)with indeterminate bile duct strictures were included.A total of 161patients underwent operative exploration;thus,a surgical histopathological correlation was available for those patients.A total of 113 patients had malignant disease proven by surgery;in 48 patients,benign disease was surgically found.In these patients,the decision for surgical exploration was made due to the suspicion of malignant disease in multimodal diagnostics(ERCP,CT,or EUS).Fifty patients had a benign diagnosis and were followed by a surveillance protocol with a followup of at least 12 mo;the median follow-up was 34 mo.Twenty-three patients had extended malignant disease,and thus were considered palliative.A comparison of the different diagnostic tools for detecting bile duct malignancy resulted in accuracy rates of 91%(ERCP/IDUS),59%(ETP),92%(IDUS+ETP),74%(EUS),and 73%(CT),respectively.In the subgroup analysis,the accuracy rates(%,ERCP+IDUS/ETP/IDUS+ETP;EUS;CT)for each tumor entity were as follows:cholangiocellular carcinoma:92%/74%/92%/70%/79%;pancreatic carcinoma:90%/68%/90%/81%/76%;and ampullary carcinoma:88%/90%/90%/76%/76%.The detection rate of malignancy by ERCP/IDUS was superior to ETP(91%vs 59%,P<0.0001),EUS(91%vs74%,P<0.0001)and CT(91%vs 73%,P<0.0001);EUS was comparable to CT(74%vs 73%,P=0.649).When analyzing accuracy rates with regard to localization of the bile duct stenosis,the accuracy rate of EUS for proximal vs distal stenosis was significantly higher for distal stenosis(79%vs 57%,P<0.0001).CONCLUSION:ERCP/IDUS is superior to EUS and CT in providing accurate diagnoses of bile duct strictures of uncertain etiology.Multimodal diagnostics is recommended. | Hauke S Heinzow Sara Kammerer Carina Rammes Johannes Wessling Dirk Domagk Tobias Meister | 2014 | World Journal of Gastroenterology2014，20，30： | 14 |
| 2 | Role of iron in hepatic fibrosis: One piece in the puzzle显示文摘铁是涉及各种各样的生物小径的一个必要元素。什么时候在房间以内在过量介绍,铁能由于它 catalyse 的能力是有毒的损坏激进分子的形成,它支持细胞的损害和细胞死亡。在肝以内,铁联系了氧化应力能导致纤维变性并且最终到肝硬化。这里,我们在与肝的各种各样的慢性病联系的病理考察过多的铁的角色。我们也描述铁由贡献肝的纤维变性的发展的分子的机制。 | Marie A Philippe Richard G Ruddell Grant A Ramm | 2007 | World Journal of Gastroenterology2007，13，35： | 11 |
| 3 | Paediatric cholestatic liver disease:Diagnosis,assessment of disease progression and mechanisms of fibrogenesis显示文摘Cholestatic liver disease causes significant morbidity and mortality in children.The diagnosis and management of these diseases can be complicated by an inability to detect early stages of fibrosis and a lack of adequate interventional therapy.There is no single gold standard test that accurately reflects the presence of liver disease,or that can be used to monitor fibrosis progression,particularly in conditions such as cystic fibrosis.This has lead to controversy over how suspected liver disease in children is detected and diagnosed.This review discusses the challenges in using commonly available methods to diagnose hepatic fibrosis and monitor disease progression in children with cholestatic liver disease.In addition,the review examines the mechanisms hypothesised to be involved in the development of hepatic fibrogenesis in paediatric cholestatic liver injury which may ultimately aid in identifying new modalities to assist in both disease detection and therapeutic intervention. | Tamara N Pereira Meagan J Walsh Peter J Lewindon Grant A Ramm | 2010 | World Journal of Gastrointestinal Pathophysiology2010，1，2： | 7 |
| 4 | Activation of Pancreatic Stellate Cells in Human and Experimental Pancreatic Fibrosis显示文摘 | Paul S. Haber Gregory W. Keogh Minoti V. Apte Corey S. Moran Nancy L. Stewart Darrell H.G. Crawford Romano C. Pirola Geoffrey W. McCaughan Grant A. Ramm Jeremy S. Wilson | 1999 | The American Journal of Pathology1999，，4： | 2 |
| 5 | Three-dimensional extension of non-linear shell formulation based on the enhanced assumed strain concept显示文摘 | Bücher N Ramm E Roehl D | 1994 | Inter J Numer Methods Engrg1994，37，： | 2 |
| 6 | A contributory role for activated hepatic stellate cells in the dynamics of Schistosoma japonicum egg-induced fibrosis显示文摘 | Bartley PB Ramm GA Jones MK | 2006 | Int J Parasitol2006，36，9： | 1 |
| 7 | A general finite element approach to the form-finding of tensile structures by the updated reference strategy 显示文摘 | BLETZINGER K U RAMM E | 1999 | Interuational J Space Structures1999，14，2： | 1 |
| 8 | A scheme for stable numerical differentiation显示文摘 | Ahn S Choi U J Ramm A G | | 0，，02： | 1 |
| 9 | Phosphorus balance of a polytrophic shallow lake with consideration of phosphorus release显示文摘 | RAMM K SCHEPS V | 1997 | Hydrobiologia1997，34，： | 1 |
| 10 | Phosphorus balance of a polytrophic shallow lake with consideration of phosphorus release显示文摘 | Ramm K Scheps V 1997 | 1997 | Hydrobiologia1997，34，： | 1 |
| 11 | Sandstone diagenesis and porosity modification during basin evolution显示文摘 | BjΦrlykke K Ramm M Saigal G | | 0，，01： | 1 |
| 12 | Brennessel-extract beirheuma-tischen Beschwerden 显示文摘 | Ramm S Hansen C | 1995 | Dtsch Apoth Ztg1995，，： | 1 |
| 13 | Limb Salvage and outcome of osteosarcoma:The university of Muenster experience显示文摘 | Lindner NJ Ramm O Hillmann A | 1999 | Clin Orthop1999，358，： | 1 |
| 14 | Modeling of SiC-matrix composite formation by isothermal chemical vapor infiltration显示文摘 | Kulik V I Kulik A V Ramm M S | 2004 | J Cryst Growth2004，266，： | 1 |
| 15 | Some salient features of the time-averaged ground vehicle wake 显示文摘 | S R Ahmed R Ramm G Falfin | 1984 | SAE technical Paper Series 8403001984，，： | 1 |
| 16 | Elevated serum type Ⅳ collagen:a sensitive indicator of the presence of cirrhosis in haemochromatosis显示文摘 | George DK Ramm GA Walker NI | 1999 | J Hepatol1999，31，1： | 1 |
| 17 | High speed ultrasound volumetric imaging system-Part I:Transducer design and beam steering显示文摘 | Smith S W Pavy Jr H G von Ramm O T | 1991 | IEEE Trans Ultrason Ferroelec Freq Contr1991，38，2： | 1 |
| 18 | Digital rights management and watermarking of multimedia content for m- commerce applications 显示文摘 | HARTUNG F RAMME F | 2000 | Communications Magazine IEEE2000，38，11： | 1 |
| 19 | A unified approach for shear-locking-free triangular and rectangular shell finite elements 显示文摘 | BLETZINGER K U BISCHOFF M RAMM E | 2000 | Computers & Structures2000，75，3： | 1 |
| 20 | Modeling of SiC-matrix composite formation by isothermal chemical vapor infiltration 显示文摘 | KULIK V I KULIK A V RAMM M S | 2004 | Journal of Crystal Growth2004，266，13： | 1 |
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