|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | 高产奶量的母猪有更高的采食量和体动员显示文摘选择能哺育更大窝产仔数的超高产母猪以提高产仔数,但是综合考虑这些现代母猪产奶量、采食量和体动员相互之间联系的研究还很有限。试验旨在研究什么样的母猪产奶量高、窝产仔数多,不同胎次有何影响,以及哺乳期生产性能对下一胎繁殖性能有何影响。选择565头1~4胎母猪,试验期从产前7 d至断奶。产后第2天每窝仔猪统一调整为14头。产前7 d、产后第2天和断奶时测定母猪体重和背膘厚度。产后第2天和断奶时称取仔猪窝重。计算变量之间的皮尔森相关系数,建立回归模型。母猪的平均日采食量(6.1±1.1)kg,仔猪每天窝增重(2.92±0.53)kg,每头母猪的平均断奶仔猪数(13.0±1.1)头。总的来讲,与2~4胎母猪相比,1胎母猪平均日采食量和产奶量更低,下一胎总产仔数也下降,这可能是因为初产母猪相比经产母猪会动用更多体储。仔猪每窝平均日增重与母猪的采食量、窝产仔数和体重损失呈正相关。1~4胎母猪整个哺乳期日采食量每提高1 kg,仔猪窝日增重提高220~440 g,母猪哺乳期体重下降6.6~13.9 kg。但是每天平均产奶量提高1 kg,第4胎母猪哺乳期体重损失减少4.3~21.0 kg。下一胎总产仔数与上一胎产仔数呈正相关。总之,高采食量和高体动员是高产奶量的先决条件。母猪可能已经非常接近他们身体饲料摄取的生理极限,因此,未来的研究应着眼于优化哺乳期超高产母猪的饲粮能量和营养浓度以及初产母猪和经产母猪之间的区别。 | Strathe A V Bruun T S Hansen C F 李元凤 | 2017 | 养猪2017，，4： | 8 |
| 2 | INT-767 improves histopathological features in a dietinduced ob/ob mouse model of biopsy-confirmed nonalcoholic steatohepatitis显示文摘AIM To characterize the efficacy of the dual FXR/TGR5 receptor agonist INT-767 upon histological endpoints in a rodent model of diet-induced and biopsy-confirmed non-alcoholic steatohepatitis(NASH).METHODS The effects of INT-767 on histological features of NASH were assessed in two studies using Lep^(ob/ob)(ob/ob) NASH mice fed the AMLN diet(high fat with transfat, cholesterol and fructose). In a proof-of-conceptstudy, Lep^(ob/ob)(ob/ob) NASH mice were first dosed with INT-767(3 or 10 mg/kg for 8 wk). A second ob/ob NASH study compared INT-767(3 and 10 mg/kg) to obeticholic acid(OCA)(10 or 30 mg/kg; 16 wk). Primary histological endpoints included qualitative and quantitative assessments of NASH. Other metabolic and plasma endpoints were also assessed. A comparative assessment of INT-767 and OCA effects on drug distribution and hepatic gene expression was performed in C57 Bl/6 mice on standard chow. C57 Bl/6 mice were orally dosed with INT-767 or OCA(1-30 mg/kg) for 2 wk, and expression levels of candidate genes were assessed by RNA sequencing and tissue drug levels were measured by liquid chromatography tandem-mass spectrometry.RESULTS INT-767 dose-dependently(3 and 10 mg/kg, PO, QD, 8 wk) improved qualitative morphometric scores on steatohepatitis severity, inflammatory infiltrates and fibrosis stage. Quantitative morphometric analyses revealed that INT-767 reduced parenchymal collagen area, collagen fiber density, inflammation(assessed by Galectin-3 immunohistochemistry) and hepatocyte lipid droplet area following INT-767 treatment. In a comparative study(16 wk), the FXR agonists OCA(10 and 30 mg/kg) and INT-767(3 and 10 mg/kg) both improved NASH histopathology, with INT-767 exerting greater therapeutic potency and efficacy than OCA. Mechanistic studies suggest that both drugs accumulate similarly within the liver and ileum, however, the effects of INT-767 may be driven by enhanced hepatic, but not ileal, FXR function. CONCLUSION These findings confirm the potential utility of FXR and dual FXR/TGR5 activation as disease intervention strategies in NASH. | Jonathan D Roth Michael Feigh Sanne S Veidal Louise KD Fensholdt Kristoffer T Rigbolt Henrik H Hansen Li C Chen Mathieu Petitjean Weslyn Friley Niels Vrang Jacob Jelsing Mark Young | 2018 | World Journal of Gastroenterology2018，24，2： | 7 |
| 3 | An in vitro prototype of a porcine biomimetic testis-like cell culture system: a novel tool for the study of reassembled Sertoli and Leydig cells显示文摘目前,有在 vitro 不可靠像睾丸的 biomimetic 机关文化系统设计了在 Sertoli 和 Leydig 房间上估计人的 gonadotropins 的功能的效果的装配 prepubertal。精子发生被调整由内分泌, paracrine,和 juxtacrine 因素(阴囊的串音) ,主要由象 luteinizing 荷尔蒙(LH ) 和由分别地刺激 Leydig 和 Sertoli 房间起一个枢轴的作用的刺激滤泡的荷尔蒙(FSH ) 那样的 gonadotropins 安排了。我们的学习的目的是建立一在里面 vitro prepubertal 是的猪的 bioengineered 构造为重新集合的 Sertoli 和 Leydig 房间上的试验性的研究的一个新模型。我们评估了从 15- 获得到 20-day-old 的 Sertoli 和 Leydig 房间新生的猪睾丸以纯净和功能。随后,净化了 Sertoli 并且充实 Leydig 房间受到 coincubation 获得一在里面 vitro prepubertal 猪的像睾丸的文化系统。我们为 anti-M 执行了连接酶的 immunosorbent 试金(ELISA ) | Iva Arato Giovanni Luca Francesca Mancuso Catia Bellucci Cinzia Lilli Mario Calvitti Barbara C Hansen Domenico Milardi Giuseppe Grande Riccardo Calafiore | 2018 | Asian Journal of Andrology2018，20，2： | 4 |
| 4 | 含有菊粉但不含羽扇豆的饲粮有助预防实验诱导的猪痢疾显示文摘猪痢疾是一种传染性黏膜出血的腹泻疾病,由定植于肠道的猪痢疾短螺旋体引起,能够诱发盲肠和结肠发炎。据报道饲料中添加菊苣根和甜羽扇豆可预防猪痢疾。本试验旨在验证是菊苣根中的菊粉而不是羽扇豆中的半乳糖起到保护作用的假设。 | Hansen C F Phillips N D La T.(等) 闫轶洁(译) 无 | 2010 | 养猪2010，，6： | 2 |
| 5 | Multifunctionality of the linker histones: an emerging role for protein-protein interactions显示文摘连接器 histones,例如, H1,最好为他们绑在 nucleosomes 并且稳定的能力被知道 nucleosome 结构和压缩高顺序的染色质结构。然而,多年以来,许多调查者报导了在涉及重要细胞的进程的连接器 histones 和蛋白质之间的特定的相互作用。这评论的目的为 H1 正在显示行动的一个重要其他的模式到热点证据,也就是蛋白质蛋白质相互作用。我们首先考察连接器 histone 行动的传统的看法的关键方面,包括 H1 C 终端领域的重要性。我们然后讨论和另外的蛋白质的连接器 histone 相互作用的知识的当前的状态,并且,在哪儿可能,加亮连接器的机制调停 histone 的蛋白质蛋白质相互作用。一起拿,数据为连接器 histones 建议一个组合角色,作为主要染色质两个都工作建筑上的蛋白质并且同时,作为招募,蛋白质的中心在存取并且修改染色质纤维包含了。 | Steven J McBryant Xu Lu Jeffrey C Hansen | 2010 | Cell Research2010，20，5： | 2 |
| 6 | Crisis in corporate America:The role of strategy 显示文摘 | HANSEN F D SMITH M C | 2003 | Business Horizons2003，15，1： | 1 |
| 7 | Two-dimensionalgel electrophoretie analysis of vectorially labeled surface proteins of human spermatozoa 显示文摘 | Naaby Hansen S Flickinger C J Herr J C | 1997 | Biol Reprod1997，56，3： | 1 |
| 8 | A robust and scalable microfluidic metering method that allows protein crystal growth by free interface diffusion显示文摘 | Hansen C L Skordalakes E Berger J M | 2002 | Proc Natl Acad Sci USA2002，99，16： | 1 |
| 9 | Thalassiolins A-C: new marine-derived inhibitors of HIV eDNA integrase显示文摘 | Rowley D C Hansen M S T Rhodes D | 2002 | Bioorg Med Chen2002，10，： | 1 |
| 10 | Removal of heavy metals from mine waters by natural zeolite 显示文摘 | Wingenfelder U Hansen C Furrer G | 2005 | Environment Science and Technology2005，39，12： | 1 |
| 11 | Clinical management of metabolic syndrome: report of the Ameri- can Heart Association/National Heart, Lung, and Blood Institute/American Diabetes Association conference on scientific issues related to management显示文摘 | Grundy S M Hansen B Smith S C Jr | 2004 | Circulation2004，109，4： | 1 |
| 12 | The design of systems to control actively periodic sound transmission into enclosed spaces, Part II: Mechanisms and trends显示文摘 | Snyder S D Hansen C H | 1994 | J Sound and Vibration1994，170，4： | 1 |
| 13 | Selenium and fertility in animals and man -a review显示文摘 | HANSEN J C DEGUCHI Y | 1996 | Acta Vet Scand1996，37，： | 1 |
| 14 | Analysis of orbital T cells in thyroid-asssociated ophthalmopathy显示文摘 | Forster G Otto E Hansen C | 1998 | Clin Exp Imunol1998，11，2： | 1 |
| 15 | Cyclic AMP induced neuronal differentiation via activation of p38 mitogen-activated protein kinase显示文摘 | Hansen T O Rehfeld J F Nielsen F C | 2000 | J Neurochem2000，75，5： | 1 |
| 16 | Regularization Tools: A Matlab Package for Analysis and Solution of Discrete Ill-posed Problems 显示文摘 | Hansen P C | 1994 | Numerical Algorithms1994，6，： | 1 |
| 17 | Finding functional sequence elements by multiple local alignments 显示文摘 | FRITH M C HANSEN U SPOUGE J L | 2004 | Nucleic Acids Res2004，32，： | 1 |
| 18 | Effect of Deletion of Chitin Synthase Genes on Mycelial Morphology and Culture Viscosity in Aspergillus oryzae显示文摘 | M tiller C Hansen K Szabo P | 2003 | Biotechnology and Bioengineering2003，81，5： | 1 |
| 19 | Pharmacokinetics of mycophenolatemofetil for autoimmune disease in children显示文摘 | FILLER G HANSEN M LEBLANC C | 2003 | Pediatr Nephrol2003，18，5： | 1 |
| 20 | Sodic soil reclamation using cottage cheese(acid)whey显示文摘 | Jones S B Robbins C W Hansen C L | 1993 | Arid Soil Research and Rehabilitation1993，7，1： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员