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| 1 | Quality of life, work productivity impairment and healthcare resources in inflammatory bowel diseases in Brazil显示文摘BACKGROUND Inflammatory bowel diseases(IBD)have been associated with a low quality of life(QoL)and a negative impact on work productivity compared to the general population.Information about disease control,patient-reported outcomes(PROs),treatment patterns and use of healthcare resources is relevant to optimizing IBD management.AIM To describe QoL and work productivity and activity impairment(WPAI),treatment patterns and use of healthcare resources among IBD patients in Brazil.METHODS A multicenter cross-sectional study included adult outpatients who were previously diagnosed with moderate to severe Crohn’s disease(CD)or ulcerative colitis(UC).At enrolment,active CD and UC were defined as having a Harvey Bradshaw Index≥8 or a CD Activity Index≥220 or calprotectin>200μg/g or previous colonoscopy results suggestive of inadequate control(per investigator criteria)and a 9-point partial Mayo score≥5,respectively.The PRO assessment included the QoL questionnaires SF-36 and EQ-5D-5L,the Inflammatory Bowel Disease Questionnaire(IBDQ),and the WPAI questionnaire.Information about healthcare resources and treatment during the previous 3 years was collected from medical records.Chi-square,Fisher’s exact and Student’s t-/Mann-Whitney U tests were used to compare PROs,treatment patterns and the use of healthcare resources by disease activity(α=0.05).RESULTS Of the 407 patients in this study(CD/UC:64.9%/35.1%,mean age 42.9/45.9 years,54.2%/56.6%female,38.3%/37.1%employed),44.7%/25.2%presented moderate-to-severe CD/UC activity,respectively,at baseline.Expressed in median values for CD/UC,respectively,the SF-36 physical component was 46.6/44.7 and the mental component was 45.2/44.2,the EQ-visual analog scale score was 80.0/70.0,and the IBDQ overall score was 164.0/165.0.Moderate to severe activity,female gender,being unemployed,a lower educational level and lower income were associated with lower QoL(P<0.05).Median work productivity impairment was 20%and 5%for CD and UC patients,respectively,and activity impairment was 30%,the latter being higher among patients with moderate to severe disease activity compared to patients with mild or no disease activity(75.0%vs 10.0%,P<0.001).For CD/UC patients,respectively,25.4%/2.8%had at least one surgery,38.3%/19.6%were hospitalized,and 70.7%/77.6%changed IBD treatment at least once during the last 3 years.The most common treatments at baseline were biologics(75.3%)and immunosuppressants(70.9%)for CD patients and 5-ASA compounds(77.5%)for UC patients.CONCLUSION Moderate to severe IBD activity,especially among CD patients,is associated with a substantial impact on QoL,work productivity impairment and an increased number of IBD surgeries and hospitalizations in Brazil. | Rogerio Serafim Parra Julio MF Chebli Heda MBS Amarante Cristina Flores Jose ML Parente Odery Ramos Milene Fernandes Jose JR Rocha Marley R Feitosa Omar Feres Antonio S Scotton Rodrigo B Nones Murilo M Lima Cyrla Zaltman Carolina D Goncalves Isabella M Guimaraes Genoile O Santana Ligia Y Sassaki Rogerio S Hossne Mauro Bafutto Roberto LK Junior Mikaell AG Faria Sender J Miszputen Tarcia NF Gomes Wilson R Catapani Anderson A Faria Stella CS Souza Rosana F Caratin Juliana T Senra Maria LA Ferrari | 2019 | World Journal of Gastroenterology2019，25，38： | 2 |
| 2 | Assessing heavy metal contamination in Sado Estuary sediment:an index analysis approach 显示文摘 | Caeiro S Costa M H Ramos T B et cd | 2005 | Ecological Indicators2005，，5： | 1 |
| 3 | Mutual in fluence of Cu and a cationic herbicide on their adsorption desorp tion processes on two selected soils显示文摘 | Undabeytia T Morillo E Ramos A B Maqueda C | 2002 | Water Air and Soil Pollution2002，137，14： | 1 |
| 4 | Assessing heavy metal contamination in Sado Estuary sediment: An index analysis approach 显示文摘 | Caeiro S Costa M tt Ramos T B | 2005 | Ecol Indic2005，5，2： | 1 |
| 5 | 3-D AVO analysis and modeling appliedc to fracture detection in coalbed methane reservoirs显示文摘 | Ramos A C B Davis T L | 1997 | Geophysics1997，62，6： | 1 |
| 6 | 3-D AVO analysis and modeling applied to fracture detection in coalbed methane reservoirs显示文摘 | Ramos A C B Davis T L | 1997 | Geophysics1997，62，6： | 1 |
| 7 | 3D AVO analysis and modeling applied to fracture detection in coalbed methane reservoirs显示文摘 | Ramos A C B Davis T L | 1997 | Geophysics1997，62，6： | 1 |
| 8 | Influence of silver on the structure and mechanical properties of TiAl based intermetallics显示文摘 | TRINDADE B RAMOS A S | 1999 | Thin solid films1999，34，4： | 1 |
| 9 | Assessing heavymetal contamination in Sado Estuary sediment an index analysisapproach显示文摘 | CAEIRO S COSTA M H RAMOS T B | 2005 | Ecological Indicators2005，5，： | 1 |
| 10 | Assessing heavy metal contamination in Sado Estuary sediment: an index analysis approach 显示文摘 | Caeiro S Costa M H Ramos T B | 2005 | Ecological Indicators2005，5，15： | 1 |
| 11 | Assessing heavy metal contamination in Sado Estuary sediment: an index analysis approach 显示文摘 | Caeiro S Costa M H Ramos T B | 2005 | Ecological Indicators2005，5，2： | 1 |
| 12 | Tumor necrosis factor alpha and interleukin 10 promoter region polymorphisms and risk of late-onset Alzheimer disease显示文摘 | Ramos E M Lin M T Larson E B | 2006 | Arch Neurol2006，63，8： | 1 |
| 13 | Assessing heavy metal contamination in Sado Estuary sediment - An index a- nalysis approach显示文摘 | Caeiro S Costa M H Ramos T B | | 0，，05： | 1 |
| 14 | Superparasitism and host size effects in Oomyzus sokolowskii, a parasitoid of diamondback moth 显示文摘 | SILVA-TORRES C S A RAMOS FILHO I T TORRES J B | 2009 | Entomologia Experimentalis et Applicata2009，133，1： | 1 |
| 15 | Extreme event dynamics in methane ebullition fluxes from tropical reservoirs显示文摘 | RAMOS F M LIMA I B T ROSA R R | 2006 | Geophysical Research Letters2006，33，： | 1 |
| 16 | Screening for PGPR to improve growth of Cistus ladanifer seedlings for reforestation of degraded mediterra- nean ecosystems 显示文摘 | Ramos Solano B Pereyra de la Iglesia M T Probanza A | 2006 | PlantS ell2006，287，： | 1 |
| 17 | Assessing heavy metal contamination in Sado Estuary sediment-An index analysis approach显示文摘 | Caeiro S Costa M H Ramos T B | 2005 | Ecological Indicators2005，，5： | 1 |
| 18 | Assessing heavy metal contamination in Sado Estuary sediment : an index analysis ap- proach 显示文摘 | Caeiro S Costa M H Ramos T B | 2005 | Ecological Indicators2005，5，： | 1 |
| 19 | The state of envi- ronmental performance evaluation in the public sector: The case of the Portuguese defenee sector显示文摘 | RAMOS T B ALVES I SUBTIL R | 2009 | Journal of Cleaner Production2009，17，1： | 1 |
| 20 | Estimation of the surface tension of a solid: Application to a liquid crystalline polymer显示文摘 | CORREIA N T MOURA RAMOS J J SARAMAGO B J V | 1997 | J Colloid Interface Sci1997，189，： | 1 |
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