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| 1 | Role of Helicobacter pylori infection in pathogenesis of atherosclerosis显示文摘Though a century old hypothesis, infection as a cause for atherosclerosis is still a debatable issue. Epidemiological and clinical studies had shown a possible association but inhomogeneity in the study population and study methods along with potential confounders have yielded conflicting results. Infection triggers a chronic inflammatory state which along with other mechanisms such as dyslipidemia, hyper-homocysteinemia, hypercoagulability, impaired glucose metabolism and endothelial dysfunction, contribute in pathogenesis of atherosclerosis. Studies have shown a positive relations between Cytotoxic associated gene-A positive strains of Helicobacter pylori and vascular diseases such as coronary artery disease and stroke. Infection mediated genetic modulation is a new emerging theory in this regard. Further large scale studies on infection and atherosclerosis focusing on multiple pathogenetic mechanisms may help in refining our knowledge in this aspect. | Rajesh Vijayvergiya Ramalingam Vadivelu | 2015 | World Journal of Cardiology2015，7，3： | 37 |
| 2 | 25例子宫内膜神经内分泌癌的临床病理分析显示文摘子宫内膜神经内分泌癌(NECa)是一种罕见的肿瘤。作者分析了25例该肿瘤的临床病理特点。患者年龄范围37~87岁(中位年龄57岁),最常见的临床症状表现为阴道出血。10例为单纯性NECa,15例混合有其它组织学类型,最常见混合的是子宫内膜样腺癌。 | Pocrnich C E Ramalingam P Euscher E D 魏建国 许春伟 | 2016 | 临床与实验病理学杂志2016，32，12： | 10 |
| 3 | Laparoscopic adenomectomy in BPH--Does it have a role today?显示文摘Symptomatic benign prostatic hyperplasia(BPH)is managed medically worldwide,but transurethral resection of prostate(TURP)is the gold standard in refractory cases.Holmium laser enucleation of prostate(HoLEP),laser vaporization are other options which are widely practiced.However in larger glands which are more than 80 g,open adenomectomy is still practiced.Laparoscopic adenomectomy is a minimally invasive option in such circumstances.This article explains about different techniques in minimally invasive adenomectomy and the role for this procedure today.Laparoscopic simple prostatectomy(LSP)has a place in symptomatic,larger prostatic adenoma in the hands of experienced laparoscopic surgeons when open simple prostatectomy is needed. | Ramalingam Manickam Sivasankaran Nachimuthu Senthil Kallappan Mizar GPai | 2018 | Asian Journal of Urology2018，5，1： | 5 |
| 4 | Anti-chikungunya activity of luteolin and apigenin rich fraction from Cynodon dactylon显示文摘Objective:To obtain Iuteolin and apigenin rich fraction from the ethanolic extract of Cynodon dactylon(L.)(C.dactylon) Pers and evaluate the fraction's cytotoxicity and anti-Chikungunya potential using Vero cells.Methods:The ethanolic extract of C.dactylon was subjected to silica gel column chromatography to obtain anti-chikungunya virus(CHIKV) fraction.Reverse phase-HPLC and GC-MS studies were carried out to identily the major phytochemicals in the fraction using phylochemical standards.Cytotoxicity and the potential of the fraction against CHIKV were evaluated in vitro using Vero cells.Reduction in viral replication was assessed by reverse transcriptase-polymerase chain reaction(RT-PCR) after treating the viral infected Vero cells with the fraction.Results:Reverse Phase-HPLC and GC-MS studies confirmed the presence of flavonoids,luteolin and apigenin as major phytochemicals in the anti-CHIKV ethanolic fraction of C.dactylon- The fraction was found to exhibit potent viral inhibitory activity(about 98%) at the concentration of 50 μg/mL as observed by reduction in cytopathic effect,and the cytotoxic concentration of the fraction was found to be 250 μg/mL.RT-PCR analyses indicated that the reduction in viral mRNA synthesis in fraction treated infected cells was much higher than the viral infected control cells.Conclusions:Luteolin and apigenin rich ethanolic fraction from C.dactylon can be utilized as a potential therapeutic agent against CHIKV infection as the fraction does not show cytotoxicity while inhibiting the virus. | Krishnan Saravana Murali Srinivasan Sivasubramanian Savariar Vincent Shanmugaraj Bala Murugan Bupesh Giridaran Sundaram Dinesh Palani Gunasekaran Kaveri Krishnasamy Ramalingam Sathishkumar | 2015 | Asian Pacific Journal of Tropical Medicine2015，8，5： | 5 |
| 5 | Chikungunya infection:A potential re-emerging global threat显示文摘Infectious diseases are indeed a lifelong threat to everyone irrespective of age, sex, lifestyle and socio-economic status. The infectious diseases have persisted among the prominent causes of death globally. Recently, re-emergence of Chikungunya viral infection harmed many in Asian and African countries. Chikungunya was considered as a major threat in developing and underdeveloped countries; the recent epidemiological outbreak of Chikungunya in La Reunion urges the global researchers to develop effective vaccine against this viral disease. In this review, Chikungunya, pathogenesis and epidemiology were briefly described. | Shanmugaraj Bala Murugan Ramalingam Sathishkumar | 2016 | Asian Pacific Journal of Tropical Medicine2016，9，10： | 5 |
| 6 | Intrinsic apoptosis and NF-κB signaling are potential molecular targets for chemoprevention by black tea polyphenols in HepG2 cells in vitro and in a rat hepatocarcinogenesis model in vivo显示文摘 | R. Senthil Murugan R. Vidya Priyadarsini K. Ramalingam Y. Hara D. Karunagaran S. Nagini | 2010 | Food and Chemical Toxicology2010，，11： | 2 |
| 7 | Protective Effects of d ‐Limonene on Lipid Peroxidation and Antioxidant Enzymes in Streptozotocin‐Induced Diabetic Rats显示文摘 | Ramakrishnan Murali Arumugam Karthikeyan Ramalingam Saravanan | 2012 | Basic Clin Pharmacol Toxicol2012，，3： | 2 |
| 8 | DNA Barcode ITS Effectively Distinguishes the Medicinal Plant Boerhavia diffusa from Its Adulterants显示文摘Boerhavia diffusa (B. diffusa), also known as Punarnava, is an indigenous plant in India and an important component in traditional Indian medicine. The accurate identification and collection of this medicinal herb is vital to enhance the drug's efficacy and biosafety. In this study, a DNA barcoding technique has been applied to identify and distinguish B. diffusa from its closely-related species. The phylogenetic analysis was carried out for the four species of Boerhavia using barcode candidates including nuclear ribosomal DNA regions ITS, ITS1, ITS2 and the chloroplast plastid gene psbA-trnH. Sequence alignment revealed 26% polymorphic sites in ITS, 30% in ITS1, 16% in ITS2 and 6% in psbA-trnH, respectively. Additionally, a phylogenetic tree was constructed for 15 species using ITS sequences which clearly distinguished B. diffusa from the other species. The ITS1 demonstrates a higher transition/transversion ratio, percentage of variation and pairwise distance which differentiate B. diffusa from other species of Boerhavia. Our study revealed that ITS and ITS1 could be used as potential candidate regions for identifying B. diffusa and for authenticating its herbal products. | Dhivya Selvaraj Dhivya Shanmughanandhan Rajeev Kumar Sarma Jijo C. Joseph Ramachandran V. Srinivasan Sathishkumar Ramalingam | 2012 | Genomics, Proteomics & Bioinformatics2012，10，6： | 2 |
| 9 | Real-time-guided bone regeneration around standardized critical size calvarial defects using bone marrow-derived mesenchymal stem cells and collagen membrane with and without using tricalcium phosphate: an in vivo microcomputed tomographic and histologic e显示文摘The aim of the present real time in vivo micro-computed tomography(m CT)and histologic experiment was to assess the efficacy of guided bone regeneration(GBR)around standardized calvarial critical size defects(CSD)using bone marrow-derived mesenchymal stem cells(BMSCs),and collagen membrane(CM)with and without tricalcium phosphate(TCP)graft material.In the calvaria of nine female Sprague-Dawley rats,full-thickness CSD(diameter 4.6 mm)were created under general anesthesia.Treatment-wise,rats were divided into three groups.In group 1,CSD was covered with a resorbable CM;in group 2,BMSCs were filled in CSD and covered with CM;and in group 3,TCP soaked in BMSCs was placed in CSD and covered with CM.All defects were closed using resorbable sutures.Bone volume and bone mineral density of newly formed bone(NFB)and remaining TCP particles and rate of new bone formation was determined at baseline,2,4,6,and 10 weeks using in vivo m CT.At the 10th week,the rats were killed and calvarial segments were assessed histologically.The results showed that the hardness of NFB was similar to that of the native bone in groups 1 and 2 as compared to the NFB in group 3.Likewise,values for the modulus of elasticity were also significantly higher in group 3 compared to groups 1 and 2.This suggests that TCP when used in combination with BMSCs and without CM was unable to form bone of significant strength that could possibly provide mechanical'lock'between the natural bone and NFB.The use of BMSCs as adjuncts to conventional GBR initiated new bone formation as early as 2 weeks of treatment compared to when GBR is attempted without adjunct BMSC therapy. | Khalid Al-Hezaimi Sundar Ramalingam Mansour Al-Askar Aws S ArRejaie Nasser Nooh Fawad Jawad Abdullah Aldahmash Muhammad Atteya Cun-Yu Wang | 2016 | International Journal of Oral Science2016，8，1： | 2 |
| 10 | Colitis and Intestinal Inflammation in IL10 ?/? Mice Results From IL-13Rα2–Mediated Attenuation of IL-13 Activity显示文摘 | Mark S. Wilson Thirumalai R. Ramalingam Aymeric Rivollier Kevin Shenderov Margaret M. Mentink–Kane Satish K. Madala Allen W. Cheever David Artis Brian L. Kelsall Thomas A. Wynn | 2011 | Gastroenterology2011，，1： | 2 |
| 11 | CD91 is a common receptor for heat shock proteins gp96, hspgO, hsp70, and calreticulin 显示文摘 | Basu S Binder R J Ramalingam T Srivastava PK | 2001 | Immunity2001，14，3： | 1 |
| 12 | CD91 is a common receptor for heat shock proteins gp96,hsp90,hsp70,and calreticulin显示文摘 | Basu S Binder RJ Ramalingam T | 2001 | Immunity2001，14，3： | 1 |
| 13 | Molecular epidemiology of HIV 显示文摘 | Kandathil A J Ramalingam S Kannangai R | 2005 | Indian J Med Res2005，12，1： | 1 |
| 14 | Vitamin d deficiency and insulin resistance in normal and type 2 diabetes subjects显示文摘 | Bachali S Dasu K Ramalingam K | 2013 | Indian J Clin Biochem2013，28，1： | 1 |
| 15 | Maintenance therapy for advanced non-small cell lung cancer: current status, controversies, and emerging consensus显示文摘 | Owonikoko TK Ramalingam SS Belani CP | 2010 | Clin Cancer Res2010，16，9： | 1 |
| 16 | Hazardous dichloromethane recovery in combined temperature and vacuum pressure swing adsorption process显示文摘 | RAMALINGAM S G SAUSSAC J PRIEE P | 2011 | Journal of Hazardous Materials2011，198，： | 1 |
| 17 | AZD9291, a mutant- selective EGFR inhibitor, as first-line treatment for EGFR mutation-positive advanced non-small cell lung cancer (NSCLC) :Results from a phase 1 expansion cohort显示文摘 | Ramalingam SS Yang JC Lee CK | 2015 | J Clin Oncol2015，33，15： | 1 |
| 18 | The next generation of epidermal growth factor receptor tyrosine kinase inhibitors in the treatment of lung cancer 显示文摘 | Steuer CE Khuri FR Ramalingam SS | 2015 | Carmer2015，121，8： | 1 |
| 19 | Meaningful survival in lung cancerpatients显示文摘 | Belani C | 2002 | Senlin Oncol2002，29，4： | 1 |
| 20 | Application of response surface methodology to optimize the process variables for reactive red and acid brown dye removal using a novel adsorbent显示文摘 | RAVIKUMAR K RAMALINGAM S KRISHNAN S | 2006 | Dyes and Pigmcnts2006，70，1： | 1 |
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