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| 1 | 一种房颤风险评分系统的建立(Framingham心脏研究):基于社区的队列研究显示文摘背景房颤导致了发病率和病死率的显著上升。本研究旨在建立一种预测个体罹患房颤绝对风险的风险评分系统,并提供研究人员评价新危险因素的流程。方法作者评估了Framingham心脏研究中于1968年6月至1987年9月间进行了8044次检测的4764例参与者(55%为女性,年龄45~95岁)。此后,参与者被随访至房颤首发,随访期最长达10年。多变量Coxi回归确认出1(1年内罹患房颤的临床危险因素。次级分析纳入了常规超声心动图检测指标(5152例4参与者,7156次检测)对房颤风险进行再分层评估,并评价超声检测指标能否提高风险预测能力。结果4764例参与者中的457例4(10%)罹患房颤。年龄、性别、体重指数、收缩压、降压治疗、PR间期、有临床意义的心脏杂音及心力衰竭与房颤相关,并被纳入了风险评分模型(除体重指数P=0.08外,其余均为P〈0.05),模型的C统计量为0.78(95%CI0.76~0.80)。10年房颤风险随年龄变化:年龄〈65岁的人群中53例(1%)风险高于15%,而〉65岁的人群中为783例(27%)。为提高预测能力而纳入超声检测指标仅使模型C统计量略微增高,由0.78(95%C10.75~0.80)增至0.79(95%CI0.77~0.82:P=0.005)。超声心动图检测指标并不能改善风险再分层评估(P=0.18)。结论基于社区医疗中易得的临床因素建立的风险评分系统,有助于确认社区个体罹患房颤的风险,评估技术或标志物能否改善风险预测,以及针对高危个体采取预防措施。 | Renate B Schnabel Lisa M Sullivan Daniel Levy Michael J Pencina Joseph M Massaro Ralph B D'Agostino Sr Christopher Newton-Cheh Jennifer F Yamamoto Jared W Magnani Thomas M Tadros William B Kannel Thomas J Wang Patrick T Ellinor Philip A Wolf Ramachanclran S Vasan Emelia J Benjamin 黄刚(译) | 2009 | 世界临床医学2009，，9： | 2 |
| 2 | Estimation of tropical forest structural characteristics using large-footprint lidar显示文摘 | Jason B Drake Ralph O Dubayah David B Clark Robert G Knox J.Bryan Blair Michelle A Hofton Robin L Chazdon John F Weishampel Steve Prince | 2001 | Remote Sensing of Environment2001，，2： | 1 |
| 3 | Summary of Findings of the School Health Edueation Evaluation: Health Promotion Effectiveness, Implementation, and Costs 显示文摘 | David B Ralph R Elaine F | 1985 | Journal of School Health1985，55，8： | 1 |
| 4 | Prepulse inhibition deficits and perseverative motor patterns in dopamine transporter knock-out mice:differential effects of D1 and D2 receptor antagonists显示文摘 | Paulus MP Fumagalli F | 2001 | J Neurosci2001，21，1： | 1 |
| 5 | Comparison of the binding stoichiometries of positively charged DNA-binding drugs using positive and negative ion electrospray ionization mass spectrometry显示文摘 | Gupta R Beck J L Ralph S F | 2004 | J Am Soc Mass Spectrom2004，15，10： | 1 |
| 6 | New high-speed scanning technique for Computed Radiography显示文摘 | Ralph S Robert F Peter K | 2002 | SPIE2002，4682，： | 1 |
| 7 | Transport of metal ions across an electrically switchable cation exchange membrane based on polypyrrole doped with a sulfonated calyx arene 显示文摘 | Akich M N Ralph S F Bobacka J | 2010 | J Membrane Sci2010，354，： | 1 |
| 8 | Effect of dietary fat and cholesterol on the in vitro incorporation of acetate-14C into hen liver and ovarian lipids 显示文摘 | JOSEPH F W EDWARD C N RALPH M J | 1967 | The Journal of Nutrition1967，93，： | 1 |
| 9 | Transplanted suprachiasmatic nucleus determines circadian period显示文摘 | Ralph M R Foster R G Davis F C | 1990 | Science1990，247，4945： | 1 |
| 10 | Precipitation identification from radar wind profiler spectral moment data: Vertical velocity histograms, velocity variance, and signal power-vertical velocity correlations显示文摘 | Ralph F M Neiman P J Uffieux D | 1995 | J Atmos Oceanic Technol1995，13，： | 1 |
| 11 | Modeling and simulation of the degradation of perfluorinated ion-exchange membranes in PEM fuel Cells显示文摘 | Shah A A Ralph T R Walsh F C | 2009 | J Electrochem Soc2009，156，13： | 1 |
| 12 | 1001 unanswered research questions in GSS显示文摘 | BRIGGS R O NUNAMAKER J F RALPH J R | 1998 | Journal of Management Information Systems1998，14，3： | 1 |
| 13 | Cytokines, insulin-like growth factor 1, sarcopenia, and mortality in very old community-dwelling men and women: the Framingham Heart Study显示文摘 | Ronenn Roubenoff Helen Parise Hélène A Payette Leslie W Abad Ralph D’Agostino Paul F Jacques Peter W.F Wilson Charles A Dinarello Tamara B Harris | 2003 | The American Journal of Medicine2003，，6： | 1 |
| 14 | Phthalates and di-(2-ethylhexyl)adipate(DEHA)intake by German infants based on the results of a duplicate diet study and biomonitoring data(INES 2)显示文摘 | HERMANN F LUDWIG G RALPH S | 2013 | Food Chem Toxicol2013，53，： | 1 |
| 15 | Antiviral activities of biflavonoids显示文摘 | LI Y M Michael T F Ralph S | 1999 | Planta Med1999，65，： | 1 |
| 16 | Lentiviral-mediated delivery of Bcl-2 or GDNF protects against excitotoxlcity in the rat hipp pus 显示文摘 | Wong L F Ralph S G Walmsley E L | 2005 | Mol Ther2005，11，1： | 1 |
| 17 | Use of information by National Weather Service forecasters and emergency managers during CALJET and PACJET-2001显示文摘 | Morss R E Ralph F M | | 0，，3： | 1 |
| 18 | Riluzole for the treatment of acute traumatic spinal cord injury:rationale for and design of the NACTN Phase I clinical trial显示文摘 | Michael G Fehlings Jefferson R Wilson Ralph F Frankowski | | 0，，： | 1 |
| 19 | Toward a precise definition of interstitial cystitis: further evidence of differences in classic and nonulcer disease显示文摘 | Ralph P Magnus F | 2002 | JUrol2002，167，6： | 1 |
| 20 | 3D charac- terization of hot metallic shells during industrial forging 显示文摘 | Youssef Bokhahrine Ralph Seulin Lew F C | 2012 | Ma- chine Vision and Applications2012，23，3： | 1 |
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