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| 1 | 一种房颤风险评分系统的建立(Framingham心脏研究):基于社区的队列研究显示文摘背景房颤导致了发病率和病死率的显著上升。本研究旨在建立一种预测个体罹患房颤绝对风险的风险评分系统,并提供研究人员评价新危险因素的流程。方法作者评估了Framingham心脏研究中于1968年6月至1987年9月间进行了8044次检测的4764例参与者(55%为女性,年龄45~95岁)。此后,参与者被随访至房颤首发,随访期最长达10年。多变量Coxi回归确认出1(1年内罹患房颤的临床危险因素。次级分析纳入了常规超声心动图检测指标(5152例4参与者,7156次检测)对房颤风险进行再分层评估,并评价超声检测指标能否提高风险预测能力。结果4764例参与者中的457例4(10%)罹患房颤。年龄、性别、体重指数、收缩压、降压治疗、PR间期、有临床意义的心脏杂音及心力衰竭与房颤相关,并被纳入了风险评分模型(除体重指数P=0.08外,其余均为P〈0.05),模型的C统计量为0.78(95%CI0.76~0.80)。10年房颤风险随年龄变化:年龄〈65岁的人群中53例(1%)风险高于15%,而〉65岁的人群中为783例(27%)。为提高预测能力而纳入超声检测指标仅使模型C统计量略微增高,由0.78(95%C10.75~0.80)增至0.79(95%CI0.77~0.82:P=0.005)。超声心动图检测指标并不能改善风险再分层评估(P=0.18)。结论基于社区医疗中易得的临床因素建立的风险评分系统,有助于确认社区个体罹患房颤的风险,评估技术或标志物能否改善风险预测,以及针对高危个体采取预防措施。 | Renate B Schnabel Lisa M Sullivan Daniel Levy Michael J Pencina Joseph M Massaro Ralph B D'Agostino Sr Christopher Newton-Cheh Jennifer F Yamamoto Jared W Magnani Thomas M Tadros William B Kannel Thomas J Wang Patrick T Ellinor Philip A Wolf Ramachanclran S Vasan Emelia J Benjamin 黄刚(译) | 2009 | 世界临床医学2009，，9： | 2 |
| 2 | Non-alcoholic steatohepatitis and iron: increased prevalence of mutations of the HFE gene in non-alcoholic steatohepatitis显示文摘 | Herbert L Bonkovsky Qaiser Jawaid Kristina Tortorelli Paula LeClair Joseph Cobb Richard W Lambrecht Barbara F Banner | 1999 | Journal of Hepatology1999，，3： | 2 |
| 3 | Effect of dietary fat and cholesterol on the in vitro incorporation of acetate-14C into hen liver and ovarian lipids 显示文摘 | JOSEPH F W EDWARD C N RALPH M J | 1967 | The Journal of Nutrition1967，93，： | 1 |
| 4 | Consumer brand confusion: A conceptual framework 显示文摘 | Ellen R F Phil W B Joseph A C | 1992 | Psychology and Marketing1992，9，2： | 1 |
| 5 | Human capital heterogeneity,collaborative relationships,and publication patterns in a multidisciplinary scientific alliance:a comparative case study of two scientific teams显示文摘 | JOSEPH F P JAMES B W HARALD M F | 2004 | Research Policy2004，，33： | 1 |
| 6 | Recent advance in techniques for hyperspectral image processing显示文摘 | Antonio P Jon A B Joseph W B Jason B Lorenzo B Gustavo C V Jocelyn C Mathieu F Paolo G Anthony G Mattia M James C T Giovanna T | 2009 | Remote Sensing of Environment2009，113，： | 1 |
| 7 | Chlorinated dioxins and furans from kelp and copper sulfate:initial investigations of dioxin formation in mineral feed supplements显示文摘 | Christian B Dwain W | 2003 | Organohalogen Compounds2003，65，： | 1 |
| 8 | Comparison of airborne hyperspectral data and EO-1 hyperion for mineral mapping 显示文摘 | Fred A Kruse Joseph W Boardman Jonathan F Huntington | 2003 | IEEE2003，41，6： | 1 |
| 9 | Improved transi- ent response modeling in ICs显示文摘 | JOSEPH R F ROBERT W J | 1984 | IEEE Trans Nucl Sci1984，31，6： | 1 |
| 10 | Factor structure and psychometric properties of the Connor--Davidson resilience scale among Chinese adolescents显示文摘 | YU X N JOSEPH T F LAU WINNIE W S MAK | 2011 | Comprehensive Psychiatry2011，52，2： | 1 |
| 11 | Tissue engineering of the anterior cruciate ligament using a braid-twist scaffold design显示文摘 | JOSEPH W F MIA D W CATO T L | 2007 | Journal of Biomechanics2007，40，： | 1 |
| 12 | Enantioselective Synthesis of α-hydroxy Carboxylic Acids:Direct Conversion of α-oxocarboxylic Acids to Enantiomerically Enriched α-hydroxy Carboxylic Acids Via Neighboring Group Control显示文摘 | Zhe W Brittany L Joseph M F | 1998 | Tctrahedron Lett1998，39，： | 1 |
| 13 | Delection of duck hepatits B virus DNA on filter paper by PCR and SYBR green dye Ⅰ based quantitative PCR显示文摘 | ChiYoung J W ang Joseph J Giambrone Bruce F Smith | 2002 | Journal of Clinical Microbiology2002，7，2： | 1 |
| 14 | Comparison of Airborne Hyperspectral Data and EO-1Hyperion for Mineral Mapping显示文摘 | Kruse F A Joseph W Boardman Jonathan F Huntington | 2003 | IEEE Transactions onGeoscience and Remote Sensing2003，41，6： | 1 |
| 15 | Pseudomonas putida Septicemia in a Special Care Nursery Due to Contaminated Flush Solutions Prepared in a Hospital Pharmacy显示文摘 | Perz Joseph F Craig Allen S Stratton Charles W | 2005 | Journal of Clinical Microbiology2005，43，10： | 1 |
| 16 | 查看详情显示文摘 | Mendel F Joseph S W | | 0，，： | 1 |
| 17 | Predictors of congestive heart failure in the elderly: the cardiovascular health study显示文摘 | John S Gottdiener Alice M Arnold Gerard P Aurigemma Joseph F Polak Russell P Tracy Dalane W Kitzman Julius M Gardin John E Rutledge Robin C Boineau | 2000 | Journal of the American College of Cardiology2000，，6： | 1 |
| 18 | Ocular myasthenia gravis:predictive value of single fiber electromyography显示文摘 | David H W Joseph F | 1999 | Muscle Nerve1999，，： | 1 |
| 19 | Natural frequencies and modes of suspension bridges显示文摘 | HARRY H W JOSEPH E S LOUIS F G | 1984 | ASCE Journal of Structural Engineering1984，110，10： | 1 |
| 20 | Contemporary utilization and outcomes of intra-aortic balloon counterpulsation in acute myocardial infarction显示文摘 | Gregg W Stone E.Magnus Ohman Michael F Miller Debra L Joseph Jan T Christenson Marc Cohen Philip M Urban Ramachandra C Reddy Robert J Freedman Karen L Staman James J Ferguson | 2003 | Journal of the American College of Cardiology2003，，11： | 1 |
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