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| 1 | 近50a来青藏高原东部高海拔洞穴现代石笋氧同位素组成及其含义显示文摘基于210Pb和230Th两种定年方法,并结合黄龙洞石笋δ18O测试数据建立了青藏高原东部近半个世纪以来平均分辨率达到年际的亚洲季风变化序列.通过对黄龙洞石笋氧同位素体系的研究,表明现代洞穴滴水与洞穴周围大气降水的氧同位素具有一致性,石笋方解石与洞穴滴水是在同位素平衡分馏状态下沉积的.与器测数据对比分析发现,黄龙洞石笋δ18O的轻重变化主要受西南季风(印度季风)带来的降水量效应所控制,受温度的影响比较弱.石笋δ18O在短时间尺度上的轻重变化主要反映了季风降水δ18O的信息,指示了西南季风的年际变化.最近50a来,四川黄龙洞石笋的氧同位素组成具有逐渐变重的趋势,即逐渐变得相对富集18O,与亚洲季风区其他石笋δ18O具有相同的变化趋势,而且也与东亚、南亚季风指数所指示的季风减弱趋势相一致,与全球季风指数密切相关.这种亚洲季风的减弱趋势主要受太阳辐射变化的影响,并紧密地匹配于高空平流层的温度变化. | 杨勋林 张平中 陈发虎 扈治安 李红春 程海 Kathleen R.Johnson 刘敬华 安春雷 | 2007 | 科学通报2007，52，6： | 17 |
| 2 | 冬小麦丰抗13抗条锈病基因的分析显示文摘 | 辛志勇 R.Johnson C.N.Law A.J.Worland | 1984 | 作物学报1984，10，4： | 5 |
| 3 | Benefits and organization of cooperation research for fisheries management显示文摘 | Teresa R.Johnson Wim L.T.van Densen | | 0，，04： | 1 |
| 4 | Reflections on the Bundle of Rights显示文摘 | Denise R.Johnson | | 0，，： | 1 |
| 5 | Novel Three - Axis Beam Waveguide Feed for Space - Based Millimeter - Wave Applications显示文摘 | Brent Toland Alon S. Barlevy William M. Hughes Dan R.Johnson | | 0，，06： | 1 |
| 6 | What is biomedical informatics显示文摘 | E V Bernstam J W Smith T R.Johnson | | 0，，01： | 1 |
| 7 | The G‐protein‐coupled receptor, GPR84, is important for eye development in Xenopus laevis显示文摘 | Kimberly J.Perry Verity R.Johnson Erica L.Malloch LisaFukui JasonWever Alvin G.Thomas Paul W.Hamilton Jonathan J.Henry | 2010 | Dev Dyn2010，，11： | 1 |
| 8 | Immunohistochemical surrogate markers of breast cancer molecular classes predicts response to neoadjuvant chemotherapy显示文摘 | RohitBhargava SushilBeriwal David J.Dabbs UmutOzbek AtillaSoran Ronald R.Johnson Adam M.Brufsky Barry C.Lembersky Gretchen M.Ahrendt | 2010 | Cancer2010，，6： | 1 |
| 9 | Demand Spillovers and the Collapse of Trade in the Global Recession显示文摘 | R.Bems R.Johnson K.M.Yi | | 0，，02： | 1 |
| 10 | Role of the transcription factor Sox‐2 in the expression of the FGF‐4 gene in embryonal carcinoma cells显示文摘 | Lance R.Johnson Kimberly A.Lamb QingshengGao Tamara K.Nowling AngieRizzino | 1998 | Mol. Reprod. Dev1998，，4： | 1 |
| 11 | Guidelines for using human event‐related potentials to study cognition: Recording standards and publication criteria显示文摘 | T.W.Picton S.Bentin P.Berg E.Donchin S.A.Hillyard R.Johnson G.A.Miller W.Ritter D.S.Ruchkin M.D.Rugg M.J.Taylor | 2003 | Psychophysiology2003，，2： | 1 |
| 12 | 饲用酸化剂、酶制剂在保持仔猪健康和生产性能中的作用(综述)显示文摘养猪业利润的高低,很大程度上取决于断奶仔猪从母奶过渡到人工日粮过程中,对疾病爆发与生长停滞的控制成功与否。猪生长最大潜力是从断奶开始,但因对干饲料的适应能力差与消化系统不健全等因素采食能力受到限制,在商品生产条件下往往不能获得应有的潜势。 科学研究表明。 | 蔡益辉 R.Johnson | 1994 | 国外畜牧学(饲料)1994，，4： | 0 |
| 13 | A call to action: Multi-disciplinary care and treatment of obesity in pediatrics显示文摘Pediatric obesity is the most prevalent chronic disease affecting 1 in 5 US children and is correlated with an increase in young patients diagnosed with obesity-related diseases.Early identification and treatment of childhood obesity is pivotal to slow or prevent progression of obesity and obesity-related diseases into adulthood.Current practice guidelines support a staged treatment approach to manage pediatric obesity with emphasis on multidisciplinary care in stages 3 and 4.^(1) | Veronica R.Johnson Kanika A.Bowen-Jallow Fatima Cody Stanford | 2021 | Pediatric Investigation2021，5，1： | 0 |
| 14 | 一个变化的职业中的律师渎职行为:合同法原则的作用显示文摘本文作者指出,今天的美国律师业,是一个具有高度统一性及垄断性的职业,律师职业道德的两个支柱是职业纪律以及以过失原则和信托义务为基础的渎职诉讼。经过近50年的发展,美国建立了比较完善的现代律师职业道德制度。但是,面对技术进步和全球化产生的挑战,美国律师职业和法律教育已经隐现变化,高度统一的律师职业可能转变为各式法律服务提供者的集合体,包括非律师和没有完全执照的律师。对于非律师和没有完全执照的律师,当前的律师职业道德制度难以有效适用。为回应这一变化,有知名学者提出应当用合同法原则和违约诉讼代替当前的职业纪律和渎职诉讼。本文回应这一提议,指出了合同法原则和违约诉讼在实现律师职业道德目标上的局限性和缺陷,提出这一挑战尚未得到解决,需要法律界以热忱共同应对。对于我国而言,本文除了提供对美国律师职业道德的知识性了解,更重要的在于它对我国律师职业道德领域的启示。与美国相较,我国律师职业道德制度在保护委托人方面无疑比较落后,受损害的委托人一般只能基于合同法获得赔偿。对于美国这样一个律师职业纪律、合同法及侵权法都比我国更完善的国家,合同法尚无法对委托人提供比较周全的保护,我们更应反思我国这一现状。本文是对美国律师职业道德领域的前瞻性思考,对于律师职业道德制度尚不完善的我国而言,我们更应该思考,是否可以考虑建立完善的渎职责任规则,以侵权诉讼取代违约诉讼作为保护委托人利益的重要模式。 | Vincent R.Johnson 王永霞(译) | 2017 | 山东大学法律评论2017，，1： | 0 |
| 15 | A Review of Three-Dimensional Medical Image Visualization显示文摘Importance. Medical images are essential for modern medicine and an important research subject in visualization. However,medical experts are often not aware of the many advanced three-dimensional (3D) medical image visualization techniques thatcould increase their capabilities in data analysis and assist the decision-making process for specific medical problems. Ourpaper provides a review of 3D visualization techniques for medical images, intending to bridge the gap between medicalexperts and visualization researchers. Highlights. Fundamental visualization techniques are revisited for various medicalimaging modalities, from computational tomography to diffusion tensor imaging, featuring techniques that enhance spatialperception, which is critical for medical practices. The state-of-the-art of medical visualization is reviewed based on aprocedure-oriented classification of medical problems for studies of individuals and populations. This paper summarizes freesoftware tools for different modalities of medical images designed for various purposes, including visualization, analysis, andsegmentation, and it provides respective Internet links. Conclusions. Visualization techniques are a useful tool for medicalexperts to tackle specific medical problems in their daily work. Our review provides a quick reference to such techniques giventhe medical problem and modalities of associated medical images. We summarize fundamental techniques and readily availablevisualization tools to help medical experts to better understand and utilize medical imaging data. This paper could contributeto the joint effort of the medical and visualization communities to advance precision medicine. | Liang Zhou Mengjie Fan Charles Hansen Chris R.Johnson Daniel Weiskopf | 2022 | Health Data Science2022，，1： | 0 |
| 16 | Genomic stability at the coding regions of the multidrug transporter gene ABCB1: insights into the development of alternative drug resistance mechanisms in human leukemia cells显示文摘Aim:Despite considerable efforts to reverse clinical multidrug resistance(MDR),targeting the predominant multidrug transporter ABCB1/P-glycoprotein(P-gp)using small molecule inhibitors has been unsuccessful,possibly due to the emergence of alternative drug resistance mechanisms.However,the non-specific P-gp inhibitor cyclosporine(CsA)showed significant clinical benefits in patients with acute myeloid leukemia(AML),which likely represents the only proof-of-principle clinical trial using several generations of MDR inhibitors.Nevertheless,the mutational mechanisms that may underlie unsuccessful MDR modulation by CsA are not elucidated because of the absence of CsA-relevant cellular models.In this study,our aims were to establish CsA-resistant leukemia models and to examine the presence or absence of ABCB1 exonic mutations in these models as well as in diverse types of human cancer samples including AMLs.Methods:Drug-resistant lines were established by stepwise drug co-selection and characterized by drug sensitivity assay,rhodamine-123 accumulation,[3H]-labeled drug export,ABCB1 cDNA sequencing,and RNase protection assay.The genomic stability of the ABCB1 coding regions was evaluated by exome sequencing analysis of variant allele frequencies in human populations.Moreover,the mutational spectrum of ABCB1 was further assessed in diverse types of cancer samples including AMLs in the Cancer Genome Atlas(TCGA)at the National Cancer Institute.Results:We report the development of two erythroleukemia variants,RVC and RDC,which were derived by stepwise co-selection of K562/R7 drug-resistant leukemia cells with the etoposide-CsA and doxorubicin-CsA drug combinations,respectively.Interestingly,both RVC and RDC cell lines,which retained P-gp expression,showed altered multidrug-resistant phenotypes that were resistant to CsA modulation.Strikingly,no mutations were found in the ABCB1 coding regions in these variant cells even under long-term stringent drug selection.Genomically,ABCB1 displayed relatively low variant allele frequencies in human populations when compared with several ABC superfamily members.Moreover,ABCB1 also exhibited a very low mutational frequency in AMLs compared with all types of human cancer.In addition,we found that CsA played a role in undermining the selection of highly drug-resistant cells via induction of low-level and unstable drug resistance.Conclusion:Our data indicate that ABCB1 coding regions are genomically stable and relatively resistant to drug-induced mutations.Non-ABCB1 mutational mechanisms are responsible for the drug-resistant phenotypes in both RVC and RDC cell lines,which are also prevalent in clinical AML patients.Accordingly,we propose several relevant models that account for the development of alternative drug resistance mechanisms in the absence of ABCB1 mutations. | Kevin G.Chen George E.Duran Mark J.Mogul Yan C.Wang Kevin L.Ross Jean-Pierre Jaffrézou Lyn M.Huff Kory R.Johnson Tito Fojo Norman J.Lacayo Branimir I.Sikic | 2020 | Cancer Drug Resistance2020，3，4： | 0 |
| 17 | Full noncontact laser ultrasound:first human data显示文摘Full noncontact laser ultrasound(LUS)imaging has several distinct advantages over current medical ultrasound(US)technologies:elimination of the coupling mediums(gel/water),operator-independent image quality,improved repeatability,and volumetric imaging.Current light-based ultrasound utilizing tissue-penetrating photoacoustics(PA)generally uses traditional piezoelectric transducers in contact with the imaged tissue or carries an optical fiber detector close to the imaging site.Unlike PA,the LUS design presented here minimizes the optical penetration and specifically restricts optical-to-acoustic energy transduction at the tissue surface,maximizing the generated acoustic source amplitude.With an appropriate optical design and interferometry,any exposed tissue surfaces can become viable acoustic sources and detectors.LUS operates analogously to conventional ultrasound but uses light instead of piezoelectric elements.Here,we present full noncontact LUS results,imaging targets at~5 cm depths and at a meterscale standoff from the target surface.Experimental results demonstrating volumetric imaging and the first LUS images on humans are presented,all at eye-and skin-safe optical exposure levels.The progression of LUS imaging from tissue-mimicking phantoms,to excised animal tissue,to humans in vivo is shown,with validation from conventional ultrasound images.The LUS system design insights and results presented here inspire further LUS development and are a significant step toward the clinical implementation of LUS. | Xiang Zhang Jonathan R.Fincke Charles M.Wynn Matt R.Johnson Robert W.Haupt Brian W.Anthony | 2019 | Light(Science & Applications)2019，8，1： | 0 |
| 18 | 航空轮胎的准静态粘弹性负荷试验显示文摘为了观察轮胎的准静态粘弹性响应,对航空轮胎进行了梯级负荷、周期负荷和长期松弛试验。试验数据显示,即使由于轮胎变形而变软后,轮胎也会继续产生粘弹性响应。从以15 000磅负荷进行梯级试验获得的负荷松弛数据与单调递减普朗尼级数对应。 | 李汉堂 Angela J.Mason John A.Tanner Arthur R.Johnson | 2015 | 现代橡胶技术2015，41，6： | 0 |
| 19 | Determination of Effectiveness of Energy Management System in Buildings显示文摘Building Energy Management Systems(BEMS)are computer-based systems that aid in managing,controlling,and monitoring the building technical services and energy consumption by equipment used in the building.The effectiveness of BEMS is dependent upon numerous factors,among which the operational characteristics of the building and the BEMS control parameters also play an essential role.This research develops a user-driven simulation tool where users can input the building parameters and BEMS controls to determine the effectiveness of their BEMS.The simulation tool gives the user the flexibility to understand the potential energy savings by employing specific BEMS control and help in making intelligent decisions.The simulation is developed using Visual Basic Application(VBA)in Microsoft Excel,based on discrete-event Monte Carlo Simulation(MCS).The simulation works by initially calculating the energy required for space cooling and heating based on current building parameters input by the user in the model.Further,during the second simulation,the user selects all the BEMS controls and improved building envelope to determine the energy required for space cooling and heating during that case.The model compares the energy consumption from the first simulation and the second simulation.Then the simulation model will provide the rating of the effectiveness of BEMS on a continuous scale of 1 to 5(1 being poor effectiveness and 5 being excellent effectiveness of BEMS).This work is intended to facilitate building owner/energy managers to analyze the building energy performance concerning the efficacy of their energy management system. | Vivash Karki Roseline Mostafa Bhaskaran Gopalakrishnan Derek R.Johnson | 2023 | Energy Engineering2023，120，2： | 0 |
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