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| 1 | 非血缘供者骨髓移植治疗骨髓增生异常综合征及继发性急性髓细胞白血病:一项欧洲骨髓移植调查显示文摘骨髓增生异常综合征(MDS)是造血干细胞获得性克隆性异常疾病,以无效造血及外周血细胞进行性减少为特征,粒细胞缺乏致感染及血小板减少致出血是最常见的死亡原因,10%~40%患者可能发展为急性髓细胞白血病(AML)。 | R.Arnold T.de Witle A.Van Biezen J.Hermans N.Jacobsen V.Runde A.Gratwohl JF.Apperley 曾慧兰 | 2000 | 德国医学2000，17，1： | 5 |
| 2 | Transcriptional and epigenetic regulation of immune tolerance:roles of the NF-κB family members显示文摘Immune tolerance is a highly regulated state and involves diverse mechanisms.Central to the induction of tolerance is the targeted modulation of T-cell activities(both effector and regulatory),in which transcription factors play a significant role.The nuclear factor kappa-B(NF-κB)family is a family of transcription factors that not only are critically involved in diverse T-cell responses but also are regulated by many mechanisms to maintain tolerance and T-cell homeostasis.NF-κB,as a transcription factor,has been extensively studied in recent decades,and the molecular mechanisms that regulate NF-κB activities have been well documented.However,recent studies have revealed exciting new roles for NF-κB;in addition to its transcriptional activity,NF-κB can also activate diverse epigenetic mechanisms that mediate extensive chromatin remodeling of target genes to regulate T-cell activities.In this review article,we highlight recent discoveries and emerging opportunities in targeting NF-κB family members as well as their associated chromatin modifiers in the induction of immune tolerance and in the clinical treatment of immune diseases. | Lei Zhang Xiang Xiao Preston R.Arnold Xian C.Li | 2019 | Cellular & Molecular Immunology2019，16，4： | 5 |
| 3 | Intestinal phase of human antro‐pyloro‐duodenal motility: cholinergic and CCK‐mediated regulation显示文摘 | M.KATSCHINSKI J.SCHIRRA C.BEGLINGER S.LANGBEIN U.WANK M.D’AMATO R.ARNOLD | 2003 | European Journal of Clinical Investigation2003，，7： | 1 |
| 4 | The transcription factor RelB restrains group 2 innate lymphoid cells and type 2 immune pathology in vivo显示文摘The exact relationships between group 2 innate lymphoid cells(ILC2s)and Th2 cells in type 2 pathology,as well as the mechanisms that restrain the responses of these cells,remain poorly defined.Here we examined the roles of ILC2s and Th2 cells in type 2 lung pathology in vivo using germline and conditional fie/b-deficient mice.We found that mice with germline deletion of Relb^(-/-)spontaneously developed prominent type 2 pathology in the lung,which contrasted sharply with mice with T-cell-specific Relb deletion(Relb^(f/f)Cd4-Cre),which were healthy with no observed autoimmune pathology.We also found that in contrast to wild-type B6 mice,Rel6-defident mice showed markedly expanded ILC2s but not ILC1s or ILC3s.Moreover,adoptive transfer of naive CD4^(+)T cells into Rag1^(-/-)Relb^(-/-)hosts induced prominent type 2 lung pathology,which was inhibited by depletion of ILC2s.Mechanistically,we showed that Relb deletion led to enhanced expression of Bcl11b,a key transcription factor for ILC2s.We concluded that RelB plays a critical role in restraining ILC2s,primarily by suppressing Bcl11b activity,and consequently inhibits type 2 lung pathology in vivo. | Lei Zhang Yuanlin Ying Shuqiu Chen Preston R.Arnold Fafa Tian Laurie J.Minze Xiang Xiao Xian C.Li | 2021 | Cellular & Molecular Immunology2021，18，1： | 1 |
| 5 | Monocytic TNFα secretion patterns in IDDM patients with periodontal diseases*显示文摘 | Giovanni E.Salvi John G.Collins BehnazYalda Roland R.Arnold Niklaus P.Lang StevenOffenbacher | 2005 | Journal of Clinical Periodontology2005，，1： | 1 |
| 6 | 肝门胆管完全阻塞应用自动扩张金属支架的姑息疗法显示文摘胆总管处狭窄引起的恶性阻塞性黄疸,可应用塑料和金属支架获得较好的姑息性治疗,而肝门胆管阻塞治疗非常困难。肝管分又处的阻塞,可由各种原发性肿瘤(胆管细胞癌、胆囊癌、肝细胞癌)和其它恶性肿瘤的继发性转移(肝十二指肠韧带的淋巴结转移、肝转移)引起,根据 Bismuth 等的观点可分为4期:①无肝管分又处参与的近端胆总管狭窄; | H.-J.Wagner J.Werhand W.-B.Schwerk M.Rothmund R.Arnold K.-J.Klose 胡俊波 | 1994 | 德国医学1994，11，3： | 0 |
| 7 | 跑道式循环水臭氧处理实验显示文摘在230升的跑道式循环海水中,用于养殖温水性海水鱼——红拟石首鱼(Sciaenopsocellatus)鱼苗和方氏对虾(Penaeus vannamei)稚虾,辅助臭氧处理作用,分别在3小时、6小时和24小时观测鱼、虾对水中残留臭氧的忍耐力。实验证明,虾能够忍受残留臭氧浓度超过2.5mg/L达3小时,浓度为1.0mg/L时。达24小时;鱼种可以忍受臭氧浓度高于0. | Bartreid Connie R.Arnold 孙彦铭 | 1998 | 北京水产1998，，4： | 0 |
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