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| 1 | 心肌梗死多维度评估量表的信效度研究显示文摘目的翻译“心肌梗死多维度评估量表”(Myocardial Infarction Dimensional Assessment Scale,MIDAS),评价其效度、信度及文化相关性,提供一种有效评估心肌梗死患者生活质量的中史版问卷。方法应用专家小组评定法进行问卷文化相关性、语言一致性及内容效度的评价。对88例心肌梗死患者应用问卷对其内部一致性、效标关联效度及结构效度进行评价,对其中30例心梗患者在2周内重新应用问卷收集资料,进行重测信度的评价。结果问卷中所有务目均具有较好的文化相关性,其中2个条目被重新修订。中文版“心肌梗死多维度评估量表”具有较好的表面和内容效度,内容效度指数(CVI)为0.94,其内部一致性及重测信度均可接受。问卷7个亚量表的Cronbach'sa为0.73~0.91,重测信度系数为0.74~0.94,总体Cronbach's α为0.93,重测信度系数为0.85。中史版MIDAS中的各亚量表与中文版“36条目简明量表”(ShortForm 36,SF-36)中的相关亚量表具有显著相关性(P〈0.05)。因子分析结果提示中文版MIDAS具有与原英文量表一致的结构效度。结论中文版“心肌梗死多维度评估量表”是一种具有较高效度和信度的疾病专用量表,可为医护人员量化评估心肌梗死患者生活质量提供可靠的依据。 | 王文茹 Violeta Lopez David R Thompson 李小妹 李小霞 刘美丽 高春燕 | 2006 | 中华护理杂志2006，41，1： | 38 |
| 2 | Platelet thromboxane(11-dehydro-Thromboxane B_2) and aspirin response in patients with diabetes and coronary artery disease显示文摘Aspirin(ASA) irreversibly inhibits platelet cyclooxygenase-1(COX-1) leading to decreased thromboxane-mediated platelet activation. The effect of ASA ingestion on thromboxane generation was evaluated in patients with diabetes(DM) and cardiovascular disease. Thromboxane inhibition was assessed by measuring the urinary excretion of 11-dehydro-thromboxane B2(11dhTxB2), a stable metabolite of thromboxane A2. The mean baseline urinary 11dhTxB2 of DM was 69.6% higher than healthy controls(P = 0.024): female subjects(DM and controls) had 50.9% higher baseline 11dhTxB2 than males(P = 0.0004), while age or disease duration had no influence. Daily ASA ingestion inhibited urinary 11dhTxB2 in both DM(71.7%) and controls(75.1%, P < 0.0001). Using a pre-established cut-off of 1500 pg/mg of urinary 11dhTxB2, there were twice as many ASA poor responders(ASA 'resistant') in DM than in controls(14.8% and 8.4%, respectively). The rate of ASA poor responders in two populations of acute coronary syndrome(ACS) patients was 28.6 and 28.7%, in spite of a significant(81.6%) inhibition of urinary 11dhTxB2(P < 0.0001). Both baseline 11dhTxB2 levels and rate of poor ASA responders were significantly higher in DM and ACS compared to controls. Underlying systemic oxidative inflammation may maintain platelet function in atherosclerotic cardiovascular disease irrespective of COX-1 pathway inhibition and/or increase systemic generation of thromboxane from non-platelet sources. | Luis R Lopez Kirk E Guyer Ignacio Garcia De La Torre Kelly R Pitts Eiji Matsuura Paul RJ Ames | 2014 | World Journal of Diabetes2014，5，2： | 13 |
| 3 | Efficacy of peroral endoscopic myotomy vs other achalasia treatments in improving esophageal function显示文摘AIM: To assess and compare the esophageal function after peroral endoscopic myotomy(POEM) vs other conventional treatments in achalasia.METHODS: Chart review of all achalasia patients who underwent POEM, laparoscopic Heller myotomy(LHM) or pneumatic dilation(PD) at our institution between January 2012 and March 2015 was performed. Patient demographics, type of achalasia, prior treatments, pre- and post-treatment timed barium swallow(TBE) and high-resolution esophageal manometry(HREM) findings were compared between the three treatment groups. Patients who had both pre- and 2 mo posttreatment TBE or HREM were included in the final analysis. TBE parameters compared were barium column height, width and volume of barium remaining at 1 and 5 min. HREM parameters compared were basal lower esophageal sphincter(LES) pressures and LES-integrated relaxation pressures(IRP). Data are presented as mean ± SD, median [25th, 75 th percentiles] or frequency(percent). Analysis of variance, KruskalWallis test, Pearsons χ~2 test and Fishers Exact tests were used for analysis.RESULTS: A total of 200 achalasia patients were included of which 36 underwent POEM, 22 underwent PD and 142 underwent LHM. POEM patients were older(55.4 ± 16.8 years vs 46.5 ± 15.7 years, P = 0.013) and had higher BMI than LHM(29.1 ± 5.9 kg/m^2 vs 26 ± 5.1 kg/m^2, P = 0.012). More number of patients in POEM and PD groups had undergone prior treatments compared to LHM group(72.2% vs 68.2% vs 44.3% respectively, P = 0.003). At 2 mo post-treatment, all TBE parameters including barium column height, width and volume remaining at 1 and 5 min improved significantly in all three treatment groups(P = 0.01 to P < 0.001) except the column height at 1 min in PD group(P = 0.11). At 2 mo post-treatment, there was significant improvement in basal LES pressure and LES-IRP in both LHM(40.5 mm Hg vs 14.5 mm Hg and 24 mm Hg vs 7.1 mm Hg respectively, P < 0.001) and POEM groups(38.7 mm Hg vs 11.4 mm Hg and 23.6 mm Hg vs 6.6 mm Hg respectively, P < 0.001). However, when the efficacy of three treatments were compared to each other in terms of improvement in TBE or HREM parameters at 2 mo, there was no significant difference(P > 0.05).CONCLUSION: POEM, PD and LHM were all effective in improving esophageal function in achalasia at shortterm. There was no difference in efficacy between the three treatments. | Madhusudhan R Sanaka Umar Hayat Prashanthi N Thota Ramprasad Jegadeesan Monica Ray Scott L Gabbard Neha Wadhwa Rocio Lopez Mark E Baker Sudish Murthy Siva Raja | 2016 | World Journal of Gastroenterology2016，22，20： | 7 |
| 4 | 非诺贝特治疗与2型糖尿病患者长期心血管病风险的关系显示文摘2型糖尿病患者心血管病风险高,部分原因在于高三酰甘油和低高密度脂蛋白胆固醇血症。而在他汀类药物治疗基础上,加强降低三酰甘油治疗,能否降低这种风险尚不清楚。该研究的目的是在使用他汀类药物治疗的2型糖尿病患者中,确定非诺贝特能否降低心血管病风险。 | 刘莉 叶鹏 Elam MB Ginsberg HN Lovato LC Corson M Largay J Leiter LA Lopez C O'Connor PJ Sweeney ME Weiss D Friedewald WT Buse JB Gerstein HC Probstfield J Grimm R Ismail-Beigi F Goff DC Jr Fleg JL Rosenberg Y Byington RP ACCORDION study investigators | 2017 | 中华高血压杂志2017，25，6： | 7 |
| 5 | 中阿40m射电望远镜选址与电磁环境监测显示文摘优良站址的选择是射电望远镜完成既定科学目标并实现高效运行的重要保障。影响射电望远镜选址的主要因素包括电磁环境、水文、气象、地质条件、隔离性与可及性等。对于射电天文观测而言,来自宇宙天体的射电信号往往极其微弱,对望远镜系统及设备的灵敏度要求极高。然而,随着人类活动的不断加强,人们日常工作和生活中使用的电子通讯设备越来越多,无线电干扰源呈爆炸式涌现。在射电望远镜选址工作中,进行电磁环境监测,选择一个电磁环境良好的站址,对于射电望远镜实现常规观测运行、获取有效数据资料至关重要。同时,电磁环境监测结果也是射电望远镜接收机系统研制、站址电磁环境及无线电宁静区立法保护的重要依据。中阿天文学者和技术人员历时1年半完成了16个候选站址的初步勘察,并对优选出的3个主要候选站址进行了深入细致的电磁环境监测工作,获得了大量可靠数据。中阿双方依据电磁环境监测结果并结合各主要候选站址的水文、气象、地质及道路等条件,最终将位于Talacasto戈壁的3号候选站址确定为中阿CART射电望远镜的建设站点。 | 赵卫普 李建斌 李金增 孙建民 齐力 罗滔 马晓耘 莫铠玮 李鹏程 夏跃兵 MALLAMACI C C PODESTA R C PACHECO A M ACTIS E CASTRO J I ALVIS R H LOPEZ C E FRANCILE C PODESTA F PEREZ J | 2014 | 天文学进展2014，32，3： | 4 |
| 6 | 胰岛素抵抗者的葡萄糖刺激胰岛素分泌的增强作用受损显示文摘T2DM根据IR和胰岛p细胞功能障碍进行分类,后者可能是胰岛B细胞胰岛素信号缺陷引起的。为评估IR人群较之胰岛素敏感人群在胰岛素调节葡萄糖刺激的胰岛素分泌(GSIS)方面的作用,美国研究者对10例IGT患者. | Halperin F Lopez X Manning R | 2014 | 中国糖尿病杂志2014，22，1： | 4 |
| 7 | 稳定性冠状动脉疾病患者的尿11-脱氢血栓素B_2与死亡率的关系显示文摘已有研究证明,应用阿司匹林抗血小板治疗可减少冠状动脉疾病(coronary artery disease,CAD)患者的不良预后。阿司匹林不可逆地抑制血小板环加氧酶1(cyclooxygenase-1,COX-1)并减弱血栓烷A2(thromboxane A2,TXA2)介导的血小板聚集, | 刘莉 叶鹏 McCullough PA Vasudevan A Sathyamoorthy M Schussler JM Velasco CE Lopez LR Swift C Peterson M Bennett-Firmin J Schiffmann R Bottiglieri T | 2017 | 中华高血压杂志2017，25，1： | 3 |
| 8 | Healthcare utilization and costs associated with gastroparesis显示文摘AIM To use a national database of United States hospitals to evaluate the incidence and costs of hospital admissions associated with gastroparesis.METHODS We analyzed the National Inpatient Sample Database(NIS)for all patients in whom gastroparesis(ICD-9 code:536.3)was the principal discharge diagnosis during the period,1997-2013.The NIS is the largest publicly available all-payer inpatient care database in the United States.It contains data from approximately eight million hospital stays each year.The statistical significance of the difference in the number of hospital discharges,length of stay and hospital costs over the study period was determined by regression analysis.RESULTS In 1997,there were 3978 admissions with a principal discharge diagnosis of gastroparesis as compared to16460 in 2013(P<0.01).The mean length of stay for gastroparesis decreased by 20%between 1997 and 2013from 6.4 d to 5.1 d(P<0.001).However,during this period the mean hospital charges increased significantly by 159%from$13350(after inflation adjustment)per patient in 1997 to$34585 per patient in 2013(P<0.001).The aggregate charges(i.e.,'national bill') for gastroparesis increased exponentially by 1026%from$50456642±4662620 in 1997 to$568417666±22374060 in 2013(P<0.001).The percentage of national bill for gastroparesis discharges(national bill for gastroparesis/total national bill)has also increased over the last 16 years(0.0013%in 1997 vs 0.004%in2013).During the study period,women had a higher frequency of gastroparesis discharges when compared to men(1.39/10000 vs 0.9/10000 in 1997 and 5.8/10000vs 3/10000 in 2013).There was a 6-fold increase in the discharge diagnosis of gastroparesis amongst type 1 DM and 3.7-fold increase amongst type 2 DM patients over the study period(P<0.001).CONCLUSION The number of inpatient admissions for gastroparesis and associated costs have increased significantly over the last 16 years.Inpatient costs associated with gastroparesis contribute significantly to the national healthcare bill.Further research on cost-effective evaluation and management of gastroparesis is required. | Vaibhav Wadhwa Dhruv Mehta Yash Jobanputra Rocio Lopez Prashanthi N Thota Madhusudhan R Sanaka | 2017 | World Journal of Gastroenterology2017，23，24： | 3 |
| 9 | 高血压患者肾素血管紧张素系统阻断的血浆分子标志:肾损害与初发蛋白尿的新预测指标显示文摘蛋白尿是一个与心血管病密切相关的危险因素,也是一般人群的首位死亡原因。虽然已经明确肾素血管紧张素系统(renin-angiotensin system,RAS)阻断剂能延缓高血压患者初发蛋白尿进展、减少蛋白尿排出,但仍不能忽视高血压患者发生初发蛋白尿的比例。 | Baldan-Martin M Mourino-Alvarez L Gonzalez-Calero L Moreno-Luna R Sastre-Oliva T Ruiz-Hurtado G Segura J Lopez JA Vazquez J Vivanco F Alvarez-Llamas G Ruilope LM de la Cuesta F Barderas MG 赵狄 练桂丽 | 2016 | 中华高血压杂志2016，24，6： | 2 |
| 10 | Hepatitis C Virus Infects the Endothelial Cells of the Blood-Brain Barrier显示文摘 | Nicola F. Fletcher Garrick K. Wilson Jacinta Murray Ke Hu Andrew Lewis Gary M. Reynolds Zania Stamataki Luke W. Meredith Ian A. Rowe Guangxiang Luo Miguel A. Lopez–Ramirez Thomas F. Baumert Babette Weksler Pierre–Olivier Couraud Kwang Sik Kim Ignacio A. R | 2012 | Gastroenterology2012，，3： | 2 |
| 11 | Polymerization of vinyl acetate in ternary microemulsions stabilized with hexadecyhrimethylammonium bromide显示文摘 | LOPEZ R G TREVINO M E SALAZAR L V | 1997 | Polymer Bulletin1997，38，4： | 1 |
| 12 | Govern- ment Ownership of Banks 显示文摘 | La Porta R Lopez - de - Silanes F Shleifer A | 2002 | Journal of Finance2002，57，1： | 1 |
| 13 | Deliberative on-line localpathplanning for autonomous mobile robots显示文摘 | DIEGUEZ A R SANZ R LOPEZ J | 2003 | Journal of Intelligent and Robotic System2003，37，1： | 1 |
| 14 | Nitrate removal using natural clays modified by acid thermoactivation显示文摘 | Mena-Duran C J Sun Kou M R Lopez T | 2007 | Applied Surface Science2007，253，： | 1 |
| 15 | Recombinant vaccinia virus coexpressing the F protein of respiratory syncytial virus (RSV) and interleukin-4 does not inhibit the development of RSV-specific memory cytotoxic T lymphocytes, whereas priming is diminished in the presence of high levels of IL-2 or gamma interferon 显示文摘 | Bembridge G Lopez J Cook R | 1998 | Virology1998，72，： | 1 |
| 16 | Numt, a recent transfer and tandem amplification of mitochondrial DNA to the nuclear genome of the domestic cat 显示文摘 | Lopez J V Yuhki N Masuda R | 1994 | J Mol Evol1994，39，： | 1 |
| 17 | Two-dimensional current percolation in nanocrystalline vana- dium dioxide films 显示文摘 | Rozen John Lopez Rene Haglund R F | 2006 | Applied Physics Letters2006，88，08： | 1 |
| 18 | Corporate Ownership Around the Wurld 显示文摘 | La Port R Lopez - De - Silanes F Shleifer A | 1999 | the Journal of Finance1999，，54： | 1 |
| 19 | Investor Protection and Corporate Governance 显示文摘 | La Porta R Lopez - de - Silanes F Shleifer A Vishny R | 2000 | Journal of Financial Economics2000，58，： | 1 |
| 20 | Transplantation of retinal cells显示文摘 | Gouras P Lopez R Du J | 1990 | Neuro Ophthalmol1990，10，： | 1 |
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