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| 1 | Helicobacter pylori in human health and disease:Mechanisms for local gastric and systemic effects显示文摘Helicobacter pylori(H. pylori) is present in roughly 50% of the human population worldwide and infection levels reach over 70% in developing countries. The infection has classically been associated with different gastro-intestinal diseases, but also with extra gastric diseases. Despite such associations, the bacterium frequently persists in the human host without inducing disease, and it has been suggested that H. pylori may also play a beneficial role in health. To understand how H. pylori can produce such diverse effects in the human host, several studies have focused on understanding the local and systemic effects triggered by this bacterium. One of the main mechanisms by which H. pylori is thought to damage the host is by inducing local and systemic inflammation. However, more recently, studies are beginning to focus on the effects of H. pylori and its metabolism on the gastric and intestinal microbiome. The objective of this review is to discuss how H. pylori has co-evolved with humans, how H. pylori presence is associated with positive and negative effects in human health and how inflammation and/or changes in the microbiome are associated with the observed outcomes. | Denisse Bravo Anilei Hoare Cristopher Soto Manuel A Valenzuela Andrew FG Quest | 2018 | World Journal of Gastroenterology2018，24，28： | 32 |
| 2 | Helicobacter pylori-induced inflammation and epigenetic changes during gastric carcinogenesis显示文摘The sequence of events associated with the development of gastric cancer has been described as 'the gastric precancerous cascade'. This cascade is a dynamic process that includes lesions, such as atrophic gastritis, intestinal metaplasia and dysplasia. According to this model, Helicobacter pylori(H. pylori) infection targets the normal gastric mucosa causing non-atrophic gastritis, an initiating lesion that can be cured by clearing H. pylori with antibiotics or that may then linger in the case of chronic infection and progress to atrophic gastritis. The presence of virulence factors in the infecting H. pylori drives the carcinogenesis process. Independent epidemiological and animal studies have confirmed the sequential progression of these precancerous lesions. Particularly long-term follow-up studies estimated a risk of 0.1% for atrophic gastritis/intestinal metaplasia and 6% in case of dysplasia for the long-term development of gastric cancer. With this in mind, a better understanding of the genetic and epigenetic changes associated with progression of the cascade is critical in determining the risk of gastric cancer associated with H. pylori infection. In this review, we will summarize some of the mostrelevant mechanisms and focus predominantly but not exclusively on the discussion of gene promoter methylation and mi RNAs in this context. | Manuel A Valenzuela Jimena Canales Alejandro H Corvalán Andrew FG Quest | 2015 | World Journal of Gastroenterology2015，21，45： | 33 |
| 3 | Neurocognitive Performance in Hypertensive Patients after Spine Surgery显示文摘 | Gene T. Yocum John G. Gaudet Lauren A. Teverbaugh Donald O. Quest Paul C. McCormick E Sander Connolly Eric J. Heyer | 2009 | Anesthesiology2009，，2： | 2 |
| 4 | Caveolin-1:an ambiguous partner in cell signaling and cancer显示文摘 | Quest AF Gutierrez-Pajares JL Torres VA | 2008 | J Cell Mol Med2008，12，4： | 1 |
| 5 | Des-acyl ghrelin fragments evoke endothelium-dependent vasodilatation of rat mesenteric vascular bed via activation of potassium channels显示文摘 | Moazed B Quest D Gopalakrishnan V | 2009 | Eur J Pharmacol2009，604，13： | 1 |
| 6 | Des-acyl ghrelin fragments evoke endothelium-dependent vasodilatation of rat mesenteric vascular bed via activation of potassium channels显示文摘 | Banafsheh Moazed Dale Quest Venkat Gopalakrishnan | 2008 | European Journal of Pharmacology2008，，1： | 1 |
| 7 | Prognostic value of computerized EEG analysis during carotid endarterectomy显示文摘 | Rampil IJ Holzer JA Quest DO | 1983 | Anesth Analg1983，62，： | 1 |
| 8 | A short history of the European transonic wind tunnel ETW显示文摘 | GREEN J QUEST J | 2011 | Progress in Aerospace Sciences2011，47，7： | 1 |
| 9 | Grain refinement of A1 alloys: Mechanisms determining as-cast grain size in directional solidification 显示文摘 | QUESTED T E GREER A L | 2005 | Acta Materialia2005，53，： | 1 |
| 10 | More than a soremouth:patients'experience of oral mucositis显示文摘 | Borhasi S Cameron K Quested B | 2002 | Oncol Nurs Forum2002，29，7： | 1 |
| 11 | Changes in brain morphology associated with obstructive sleep apnea 显示文摘 | Morre11 MJ McRobbie DW Quest RA | 2003 | Sleep Med2003，4，： | 1 |
| 12 | Is there a role for free breathing non-contrast steady-state free precession renal MRA imaging for assessing live donors? A preliminary study显示文摘 | Laurence I Ariff B Quest RA | 2012 | Br J Radiol2012，85，1016： | 1 |
| 13 | Effect of small amount of nitrogen and silicon on mierostructure and properties of MAR-M002 nickel-base superalloy显示文摘 | DURBER G L R OSGERBY S QUESTED P N | 1984 | Metals Technology1984，11，4： | 1 |
| 14 | Central nervous system site of action for the respiratory depressant effect of diacetylmorphine (heroin) in the cat显示文摘 | Taveira da Silva AM Souza JD Quest | 1983 | J Clin Invest1983，72，4： | 1 |
| 15 | Assessment of guilt and shame in patients with non - small - cell lung cancer compared with patients with breast and prostate cancer 显示文摘 | LoConte NK Else- Quest NM Eickhoff J | 2008 | Clin Lung Cancer2008，9，3： | 1 |
| 16 | Decomposi- tion of sub-arctic plants with differing nitrogen economies : a func- tional role for hemiparasites 显示文摘 | Quested H M Cornelissen J H C Press M C | 2003 | Ecology2003，84，： | 1 |
| 17 | Perceived stig- ma, self - blame, and adjustment among lung, breast and prostate cancer patients 显示文摘 | Else - Quest NM LoConte NK Schiller JH | 2009 | PSychol Health2009，24，8： | 1 |
| 18 | Caveolins, caveolae, and lipid rafts in cellular transport, signaling, and disease 显示文摘 | Quest AF Leyton L Parraga M | 2004 | Biochem Cell Biol2004，82，1： | 1 |
| 19 | Caveolin-1-mediated posttranscriptional regulation of inducible nitric oxide synthase in human colon carcinoma cells 显示文摘 | Felley-Bosco E Bender F Quest A F | 2002 | Biol Res2002，35，2： | 1 |
| 20 | The effect of the size distri bution of inoeulant particles on as-cast grain size in alumin ium alloys 显示文摘 | Quested T E Greer A L | 2004 | Acta Mater2004，52，： | 1 |
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