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| 1 | Homologous recombination in DNA repair and DNA damage tolerance显示文摘相应再结合(HR ) 包括在脱氧核糖核酸双 stranded 裂缝(DSB ) 的修理工作的一系列互连的小径并且内部海滨交叉连接(ICL ) 。另外,再结合在阻止或碎的复制叉的恢复为 DNA 提供批评支持,贡献脱氧核糖核酸损坏的忍耐。蛋白质的一个中央核心,最非常 RecA 相当或相同的事物 Rad51,催化代表 HR 的关键反应:相同搜索和脱氧核糖核酸海滨侵略。再结合的多样的功能在对与核心蛋白质一起执行补加的功能的上下文特定的因素的需要被反映。适当地修理复杂脱氧核糖核酸损坏并且解决 DNA 应力的无能导致 genomic 不稳定性并且贡献癌症病原学。在 BRCA2 重组基因的变化引起倾向到胸和卵巢的癌症以及 Fanconi 贫血症,癌症倾向症候群在脱氧核糖核酸的修理由一个缺点描绘了内部海滨交叉连接。再结合的细胞的功能对癌症的基于 DNA 的治疗形式也适切,它指向由是为再结合小径的底层的脱氧核糖核酸损害的直接或间接的正式就职复制房间。这评论集中于关于 DSB 和 ICL 修理以及复制叉支持的 HR 的机械学的方面。 | Xuan Li Wolf-Dietrich Heyer | 2008 | Cell Research2008，18，1： | 26 |
| 2 | Advanced gastric cancer:what we know and what we stillhave to learn显示文摘Gastric cancer is a common neoplastic disease and, more precisely, is the third leading cause of cancer death in the world, with differences amongst geographic areas. The definition of advanced gastric cancer is still debated. Different stadiating systems lead to slightly different stadiation of the disease, thus leading to variations between the single countries in the treatment and outcomes. In the present review all the possibilities of treatment for advanced gastric cancer have been analyzed. Surgery, the cornerstone of treatment for advanced gastric cancer, is analyzed first, followed by an investigation of the different forms and drugs of chemotherapy and radiotherapy. New frontiers in treatment suggest the growing consideration for intraperitoneal administration of chemotherapeutics and combination of traditional drugs with new ones. Moreover, the necessity to prevent the relapse of the disease leads to the consideration of administering intraperitoneal chemotherapy earlier in the therapeutical algorithm. | Federico Coccolini Giulia Montori Marco Ceresoli Simona Cima Maria Carla Valli Gabriela E Nita Arianna Heyer Fausto Catena Luca Ansaloni | 2016 | World Journal of Gastroenterology2016，22，3： | 25 |
| 3 | Acute appendicitis: Epidemiology, treatment and outcomesanalysis of 16544 consecutive cases显示文摘AIM To investigate the epidemiology,treatment and outcomes of acute appendicitis(AA) in a large population study.METHODS This is a retrospective cohort study derived from the administrative dataset of the Bergamo district healthcare system(more than 1 million inhabitants) from 1997 to 2013.Data about treatment,surgery,length of stay were collected.Moreover for each patients were registered data about relapse of appendicitis and hospital admission due to intestinal obstruction.RESULTS From 1997 to 2013 in the Bergamo district we collected 16544 cases of AA,with a crude incidence rate of 89/100000 inhabitants per year; mean age was 24.51 ± 16.17,54.7% were male and the mean Charlson's comorbidity index was 0.32 ± 0.92.Mortality was < 0.0001%.Appendectomy was performed in 94.7% of the patients and the mean length of stay was 5.08 ± 2.88 d; the cumulative hospital stay was 5.19 ± 3.36 d and 1.2% of patients had at least one further hospitalization due intestinal occlusion.Laparoscopic appendectomy was performed in 48% of cases.Percent of 5.34 the patients were treated conservatively with a mean length of stay of 3.98 ± 3.96 d; the relapse rate was 23.1% and the cumulative hospital stay during the study period was 5.46 ± 6.05 d.CONCLUSION The treatment of acute appendicitis in Northern Italy is slowly changing,with the large diffusion of laparoscopic approach; conservative treatment of non-complicated appendicitis is still a neglected option,but rich of promising results. | Marco Ceresoli Alberto Zucchi Niccolò Allievi Asaf Harbi Michele Pisano Giulia Montori Arianna Heyer Gabriela E Nita Luca Ansaloni Federico Coccolini | 2016 | World Journal of Gastrointestinal Surgery2016，8，10： | 14 |
| 4 | Mutation of the Arabidopsis Calmodulin-Like Protein CML37 Deregulates the Jasmonate Pathway and Enhances Susceptibility to Herbivory显示文摘在整个他们的生活,植物被各种各样的不能生活、关於生命的压力因素质问。在那些之中是从食草的昆虫的攻击。位于草食动物和随后的信号 transduction 的察觉下面的分子的机制很好没被理解。作为第二个送信人,在细胞内部的 Ca 2+ 层次的流动在调停起一个关键作用压力反应小径。Ca 2+ 信号被象象 calmodulin 一样蛋白质(电流型逻辑) 那样的 Ca 2+ 传感器蛋白质译码。这里,我们证明 recombinant CML37 在 vitro 象一个 Ca 2+ 传感器一样表现并且在 Arabidopsis, AtCML37 被机械伤害以及由群袭与通晓各方面知识经验丰富的人的幼虫导致鳞翅类的草食动物 Spodoptera littoralis。CML37 的功能的损失导致了建议 CML37 是一个积极防卫管理者的幼虫的更好的喂表演。尽管在 jasmonates 的累积的重要减小被观察,在象 glucosinolates 或 flavonoids 那样的第二等的代谢物的导致 herbivory 的变化都没在 cml37 植物被检测,由于 JAR1 mRNA 和细胞的酶活动的减少的表示。因而, jasmonate 应答的基因的表示也被减少。总结,我们的结果建议 Ca 2+ 传感器蛋白质, CML37,在在 herbivory,连接 Ca 2+ 并且 jasmonate 发信号期间发信号的 Ca 2+ 作为一个积极管理者工作。 | Sandra S. Scholz Jyothilakshmi Vadassery Monika Heyer Michael Reichelt Kyle W. Bender Wayne A. Snedden Wilhelm Boland Axel Mithofer | 2014 | Molecular Plant2014，7，12： | 11 |
| 5 | 先进的锂离子电池系统充电管理和保护显示文摘许多便携式设备选择锂离子(Li-Ion)化学电池作为其电池技术已经变得十分普遍。在要求的充电算法方面,这种化学电池已为人们所熟知,市场上有许多充电管理集成电路(IC),而其顿具竞争力的低成本又推动它在更多应用中使用。 | Patrick Heyer | 2011 | 中国电子商情2011，，8： | 4 |
| 6 | Comparison of Two Dose-response Relationship of Noise Exposure Evaluation Results with High Frequency Hearing Loss显示文摘Background: Complex noise and its relation to hearing loss are difficult to measure and evaluate. In complex noise measurement, individual exposure results may not accurately represent lifetime noise exposure. Thus, the mean LAcq.8h values of individuals in the same workgroup were also used to represent LAcq.8h in our study. Our study aimed to explore whether the mean exposure levels of workers in the same workgroup represented real noise exposure better than individual exposure levels did. Methods: A cross-sectional study was conducted to establish a model for cumulative noise exposure (CNE) and hearing loss in 205 occupational noise-exposed workers who were recruited from two large automobile manufacturers in China. We used a personal noise dosimeter and a questionnaire to determine the workers' occupational noise exposure levels and exposure times, respectively. A qualified audiologist used standardized audiometric procedures to assess hearing acuity after at least 16 h of noise avoidance. Results: We observed that 88.3% of workers were exposed to more than 85 dB(A) of occupational noise (mean: 89.3 ± 4.2 dB(A)). The personal CNE (CNEp) and workgroup CNE (CNEg) were 100.5 ± 4.7 dB(A) and 100.5 ± 2.9 dB(A), respectively. In the binary logistic regression analysis, we established a regression model with high-frequency hearing loss as the dependent variable and CNE as the independent variable. The Wald value was 5.014 with CNEp as the independent variable and 8.653 with CNEg as the independent variable. Furthermore, we found that the figure for CNEg was more similar to the stationary noise reference than CNEp was. The CNEg model was better than the CNEp model. In this circumstance, we can measure some subjects instead of the whole workgroup and save manpower. Conclusions: In a complex noise environment, the measurements of average noise exposure level of the workgroup can improve the accuracy and save manpower. | Hua Zhang Nan Li Qiu-Ling Yang Wei Qiu Liang-Liang Zhu Li-Yuan Tao Robert I Davis Nicholas Heyer Yi-Ming Zhao | 2015 | Chinese Medical Journal2015，，6： | 3 |
| 7 | Neurocognitive Performance in Hypertensive Patients after Spine Surgery显示文摘 | Gene T. Yocum John G. Gaudet Lauren A. Teverbaugh Donald O. Quest Paul C. McCormick E Sander Connolly Eric J. Heyer | 2009 | Anesthesiology2009，，2： | 2 |
| 8 | 便携式电池供电应用中的DC/DC功率转换显示文摘 | Patrick Heyer | 2004 | 电子设计应用2004，，5： | 2 |
| 9 | Anesthesia for intraoperative neurophysiologic monitoring ofthe spinal cord显示文摘 | Sloan TB Heyer EJ | 2002 | J Clin Neurophysiol2002，19，5： | 1 |
| 10 | Targeting axons to specific fiber tracts in vivo by altering cadherin expression显示文摘 | Treubert-Zimmermann U Heyers D Redies C | 2002 | J Neurosci2002，22，： | 1 |
| 11 | Anesthesia for intraoperative neurophysiologic monitoring of the spinal cord显示文摘 | Sloan T B Heyer E J | | J Clinical Neurophysiol0，19，5： | 1 |
| 12 | detection of atherosclerotic plaque with gadofluorine-enhanced magnetic resonance imaging显示文摘 | Barkhausen J Ebert W Heyer C | 2003 | Circulation2003，108，： | 1 |
| 13 | Image quality and radiation exposure at pulmonary CT angiography with 100 or 120kVp proto- col : prospective randomized study 显示文摘 | Heyer CM Mohr PS Lemburg SP | 2007 | Raiology2007，245，2： | 1 |
| 14 | Recent advances in estrogen receptor modulators显示文摘 | Henke BR Heyer D | 2005 | Curr Opin Drug Discov Devel2005，8，4： | 1 |
| 15 | Severe pain confounds neuropsychologieal test performance 显示文摘 | Heyer EJ Sharma R Winfree CJ | 2000 | J Clin Exp Neuropsychol2000，22，7： | 1 |
| 16 | Intraoperative data acquisition for the study os cerebral dysfunction folling cardiopulmonary bypass显示文摘 | Heyer EJ Wald A Mencke A | 1995 | J Clin Monit1995，，5： | 1 |
| 17 | Diagnostic value of ductoscopy in the diagnosis of nipple discharge and intraductal proliferations in comparison to standard methods显示文摘 | GRUNWALD S HEYER H PAEPKE S | 2007 | Onkologie2007，30，5： | 1 |
| 18 | Estimating Y chromosome specific microsatellite mutation frequencies using deep rooting pedigrees显示文摘 | | 1997 | Hum Mol Genet1997，6，： | 1 |
| 19 | Development of a green fluores-cent protein reporter for a yeast genotoxicity biosensor显示文摘 | Billinton N Barker MG Michel CE Knight AW Heyer WD Goddard NJ | 1998 | Biosens Bioelectron1998，13，78： | 1 |
| 20 | Tracheobronchial anom alies and stenoses: detection with low dose multi-detector CT with virtual tracheobronchoscopy comparison with flexible tracheobronchoscopy显示文摘 | Heyer CM Nuesslein TG Jung D | 2007 | Radiology2007，242，2： | 1 |
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