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80篇 您的检索式：作者名="Quarles L"

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	题名	作者	年代	出处	被引量
1	The hypoxia-inducible factor-1α activates ectopic production of fibroblast growth factor 23 in tumor-induced osteomalacia显示文摘Tumor-induced osteomalacia(TIO) is a rare paraneoplastic syndrome in which ectopic production of fibroblast growth factor 23(FGF23) by non-malignant mesenchymal tumors causes phosphate wasting and bone fractures. Recent studies have implicated the hypoxia-inducible factor-1α(HIF-1α) in other phosphate wasting disorders caused by elevated FGF23, including X-linked hypophosphatemic rickets and autosomal dominant hypophosphatemia. Here we provide evidence that HIF-1α mediates aberrant FGF23 in TIO by transcriptionally activating its promoter. Immunohistochemical studies in phosphaturic mesenchymal tumors resected from patients with documented TIO showed that HIF-1α and FGF23 were co-localized in spindleshaped cells adjacent to blood vessels. Cultured tumor tissue produced high levels of intact FGF23 and demonstrated increased expression of HIF-1α protein. Transfection of MC3T3-E1 and Saos-2 cells with a HIF-1α expression construct induced the activity of a FGF23 reporter construct. Prior treatment of tumor organ cultures with HIF-1α inhibitors decreased HIF-1α and FGF23 protein accumulation and inhibited HIF-1α-induced luciferase reporter activity in transfected cells. Chromatin immunoprecipitation assays confirmed binding to a HIF-1α consensus sequence within the proximal FGF23 promoter, which was eliminated by treatment with a HIF-1α inhibitor. These results show for the first time that HIF-1α is a direct transcriptional activator of FGF23 and suggest that upregulation of HIF-1α activity in TIO contributes to the aberrant FGF23 production in these patients.	Qian Zhang Michele Doucet Ryan E Tomlinson Xiaobin Han L Darryl Quarles Michael T Collins Thomas L Clemens	2016	Bone Research2016，4，2：	6
2	Endocrine functions of bone in mineral metabolism regulation显示文摘	Quarles L Darryl	2008	Journal of Clinical Investigation2008，，12：	2
3	The calcimimetic AMG 073 as a potential treatment for secondary hyperparathyroidism of end-stage renal disease 显示文摘	Quarles L D Sherrard D J Adler S	2003	Am J Soc Nephrol2003，14，3：	1
4	Eval-uation of yucca saponin on broiler performance andammonia suppression显示文摘	Johnston N L Quarles C L Fagerberg D J	1981	Poultry Science1981，60，10：	1
5	Selective deficiency of the 'bone-related' runx2-II unexpectedly preserves osteoblast-mediated skeletogenesis显示文摘	Xiao Z S Hjelmeland A B Quarles L D	2004	Biol Chem2004，279，20：	1
6	Calcyclin mediates serum response element(SRE) activation by an osteoblastic extracellular cation-sensing mechanism 显示文摘	Tu Q Pi M Quarles L D	2003	Journal of Bone and Mineral Research2003，18，：	1
7	The role of fibroblast growth factor-23 in eardiorenal syndrome显示文摘	KOVESDY C P QUARLES L D	2013	Nephron Clin Pratt2013，123，34：	1
8	Emerging role of fibroblast growth factor 23 in a bone-kidney axis regulating systemic phosphate homeostasis and extracellular matrix mineralization显示文摘	Liu S Gupta A Quarles L	2007	Curr Opin Nephrol Hypertens2007，16，4：	1
9	Examples of nonisothermal moisture movement in wood 显示文摘	QUARLES S L ERICKSON R W	1990	Wood and Fiber Science1990，22，3：	1
10	Novel bone endocrine networksintegrating mineral and energy metabolism 显示文摘	Min Pi Darryl L Quarles	2013	Current Osteoporosis Reports2013，11，4：	1
11	Role of the polycytin-primary cilia complex in bone development and mechanosensing显示文摘	Xiao Z Quarles L	2010	Annals of the New York Acade- my of Sciences2010，1192，1：	1
12	The calcimimetic AMG 073 as a potential treatment for secondary hyperparathyroid- ism of end stage renal disease显示文摘	Quarles L D Sherrard D J Adler S	2003	J Am Soc Nephrol2003，14，3：	1
13	Evaluation of ammonia and infectious bronchitis vaccination stress on broiler performance and carcass quality 显示文摘	QUARLES C L KLING H F	1974	Poult Sci1974，53，：	1
14	The effect of atmosphericammonia stress on broiler performance and carcass quality 显示文摘	CAVENY D D QUARLES C L	1978	Poult Sci1978，57，：	1
15	Acoustic emission associated with oak dur ingdrying显示文摘	QUARLES S L	1992	Wood Fiber Scicnce1992，24，1：	1
16	Atmospheric ammonia and broiler cockerel performance 显示文摘	CAVENY D D QUARLES C L GREATHOUSE G A	1981	Poult Sci1981，60，：	1
17	Resveratrol enhances prolife- ration and osteoblastic differentiation in human mesenchymal stem cells via ER -dependent ERK1/2 activation显示文摘	DAI Z LI Y QUARLES L D	2007	Phytomedicine2007，14，12：	1
18	Evaluation of zeolites fed to male broiler chicken显示文摘	Willis W L Quarles C L Fagerber D J	1982	Poultry Science1982，61，：	1
19	Effect of air contaminants on performance and quality of broilers显示文摘	Quarles C L Caveny D D	1979	Poult Sci1979，58，：	1
20	Genistein stimulates the osteoblastic differentiation via NO/cGMP in bone marrow culture显示文摘	Pan W Quarles L D Song L H	2005	J Cell Biochem2005，94，2：	1

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