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| 1 | Onco-miR-24 regulates cell growth and apoptosis by targeting BCL2L11 in gastric cancer显示文摘胃的癌症是世界范围的最普通的恶意之一;然而,在 tumorigenesis 的分子的机制仍然需要探索。BCL2L11 属于 BCL-2 家庭,并且充当内在的 apoptotic 串联的一个中央管理者并且调停房间 apoptosis。尽管 miRNAs 被报导了涉及癌症开发的每个阶段,在 GC 的 miR-24 的角色还没被报导。在现在的学习,当 BCL2L11 的表示在 GC 的肿瘤纸巾被禁止时, miR-24 被发现起来调整。研究从在 vitro 并且在显示出的 vivo,那 miR-24 调整 BCL2L11 表示由与 mRNA 的 3UTR 直接有约束力,因此支持房间生长,移植当禁止房间 apoptosis 时。因此, miR-24 是能是为未来的潜在的药目标的新奇 onco-miRNA 临床的使用。 | Haiyang Zhang Jingjing Duan Yanjun Qu Ting Deng Rui Liu Le Zhang Ming Bai Jialu Li Tao Ning Shaohua Ge Xia Wang ZhenzhenWang~ Qian Fan Hongli Li Guoguang Ying Dingzhi Huang Yi Ba | 2016 | Protein & Cell2016，7，2： | 11 |
| 2 | A widely adaptable approach to generate integration-free iPSCs from non-invasively acquired human somatic cells显示文摘 | Zhichao Ding Lina Sui Ruotong Ren Yanjun Liu Xiuling Xu Lina Fu Ruijun Bai Tingting Yuan Ying Hao Weiqi Zhang Huize Pan Wensu Liu Han Yu Concepcion Rodriguez Esteban Xiaobing Yu Ze Yang Jian Li Xiaomin Wang Juan Carlos Izpisua Belmonte Guang-Hui Liu Fei Yi Jing Qu | 2015 | Protein & Cell2015，6，5： | 5 |
| 3 | Mechanism of combination membrane and electro-winning process on treatment and remediation of Cu^(2+) polluted water body显示文摘Mechanism of treatment and remediation of synthetic Cu2+ polluted water body by membrane and electro-winning combination process was investigated.The influences of electrolysis voltage,pH,and electrolysis time on the metal recovery effciencies were studied.Relationship between trans-membrane pressure drop(△P),additions ratio,initial Cu2+ concentration on operating effciency,stability of membrane and the possibility of water reuse were also investigated.The morphology of membrane and electrodes were observed using scanning electron microscopy(SEM),the composition of surface deposits was ascertained using combined energy dispersive X-ray spectroscopy(EDX) and atomic absorption spectrophotometer.The results showed that using low pressure reverse osmosis(LPRO),Cu2+ concentration could increase from 20 to 100 mg/L or even higher in concentrated solutions and permeate water conductivity could be less than 20 μS/cm.The addition of sodium dodecy/sulfate sodium dodecyl sulfate improved Cu2+ removal effciency,while EDTA had little side influence.In electro-reduction process,using plante electrode cell,Cu2+ concentration could be further reduced to 5 mg/L,and the average current effciency ranged from 9% to 40%.Using 3D electrolysis treatment,Cu2+ concentration could be reduced to 0.5 mg/L with a current effciency range 60%-70%. | ZHANG Linnan WU Yanjun QU Xiaoyan LI Zhenshan NI Jinren | 2009 | Journal of Environmental Sciences2009，21，6： | 3 |
| 4 | Coordinated development of land multi-function space: An analytical framework for matching the supply of resources and environment with the use of land space for ecological protection, agricultural production and urban construction显示文摘Based on the carrying capacity of the resources and the environment,this article defines the connotation of the land multifunctional space(LMFS)from three aspects,ecological protection,agricultural production and urban construction,in the new era of land space planning system.Moreover,a framework is constructed for the coordinated development of the multi-functional oriented space to match the use of land space(ULS)with the supply of resources and environment(SRE).Based on this,the technology and methods of comprehensive evaluation,dominance recognition,and matching relationship division functions of the use of land space(FULS)and functions of the supply of resources and environment(FSRE)are discussed.The advantageous functions of the use of land space(AFULS)and advantageous functions of the supply of resources and environment(AFSRE)are also identified in the study area.A LMFS coordinated development system integrating“function position-comprehensive partition-regulation strategy”is proposed.Through the empirical study of Shandong province,we found that,first,the FULS of ecological protection space in the province is mainly found in high value areas,and the FSRE is mainly in low value areas,which has certain complementarity in the space.The FULS of agricultural production space is mainly observed in high value areas,the FSRE is mainly in middle value areas,and the spatial distribution is balanced and staggered.The FULS of the urban construction space and the FSRE are mainly in middle values areas,and the spatial distribution is basically similar.Second,the FULS in the study area is dominated by the single advantage of agricultural production and urban construction,while the FSRE has a relatively balanced distribution of the advantages of ecological protection,single agricultural production and compound advantages of agricultural production and urban construction,and urban construction and ecological protection.The matching between the two is mainly at high and middle levels.Specifically,70%of the province’s land space still has a certain development and utilization potential,and 30%of ULS intensity is close to or exceeds the resource and environment carrying capacity.Third,considering the comprehensive impact of resource endowment,social and economic development and policy and institutional environment on different matching relationships,this paper constructs the land spatial development strategic pattern of“two screens-seven regions-multicore”positioning and“four regions-eight categories”hierarchical area of Shandong at the macro level,and puts forward a differentiated land space development strategy. | QU Yanbo ZHANG Yanjun WANG Shilei SHANG Ran ZONG Haining ZHAN Lingyun | 2023 | Journal of Geographical Sciences2023，33，2： | 1 |
| 5 | Research on the Seismotectonic Zones and Seismicity State in the Southern Xinjiang Region显示文摘Based on the studies of earthquake activity, tectonic movement, crustal shortening rate, fault activity, local stress field and historical characteristics of strong earthquake activities in Xinjiang, we divide the south part of Xinjiang into 4 seismotectonic zones, namely, the eastern segment of south Tianshan seismic belt, the Kalpin block, the Kashi-Wuqia junction zone, and the west Kunlun Mountains seismic belt. Using earthquake catalogues from Xinjiang since 1900, and on the basis of integrity analysis of earthquake records in different magnitude ranges, the seismicity state of different seismotectonic zones is analyzed quantificationally by calculating the mean value of annual strain energy release, annual rate of earthquakes with different lower limits of magnitude, b-value, and the parameter m of accelerating strain release model. The characteristic indexes of seismicity state for each of the seismic tectonic zones are then determined, which provide a quantitative basis for earthquake tendency analysis and judgment. | Qu Yanjun Wang Qiong Nie Xiaohong | 2012 | Earthquake Research in China2012，26，2： | 0 |
| 6 | Relocation of the M_S≥2.0 Earthquakes in the Northern Tianshan Region, Xinjiang, Using the Double-Difference Earthquake Relocation Algorithm显示文摘We applied the double-difference earthquake relocation algorithm to 1348 earthquakes with M_S≥2.0 that occurred in the northern Tianshan region, Xinjiang, from April 1988 to June 2003, using a total of 28701 P- and S-wave arrival times recorded by 32 seismic stations in Xinjiang. Aiming to obtain most of these M_S≥2.0 earthquakes relocations, and considering the requirements of the DD method and the condition of data, we added the travel time data of another 437 earthquakes with 1.5≤M_S<2.0. Finally, we obtained the relocation results for 1253 earthquakes with M_S≥2.0, which account for 93% of all the 1348 earthquakes with M_S≥2.0 and includes all the M_S≥3.0 earthquakes. The reason for not relocating the 95 earthquakes with 2.0≤M_S<3.0 is analyzed in the paper. After relocation, the RMS residual decreased from 0.83s to 0.14s, the average error is 0.993 km in E-W direction, 1.10 km in N-S direction, and 1.33 km in vertical direction. The hypocenter depths are more convergent than before and distributed from 5 km to 35 km, with 94% being from 5km to 35 km, 68.2% from 10 km to 25 km. The average hypocenter depth is 19 km. | Wang Haitao Li Zhihai Zhao Cuiping Qu Yanjun | 2007 | Earthquake Research in China2007，21，4： | 0 |
| 7 | State-of-the-art advances in vacancy defect engineering of graphitic carbon nitride for solar water splitting显示文摘Developing low-cost,efficient,and stable photocatalysts is one of the most promising methods for large-scale solar water splitting.As a metal-free semiconductor material with suitable band gap,graphitic carbon nitride(g-C_(3)N_(4))has attracted attention in the field of photocatalysis,which is mainly attributed to its fascinating physicochemical and photoelectronic properties.However,several inherent limitations and shortcomings—involving high recombination rate of photocarriers,insufficient reaction kinetics,and optical absorption—impede the practical applicability of g-C_(3)N_(4).As an effective strategy,vacancy defect engineering has been widely used for breaking through the current limitations,considering its ability to optimize the electronic structure and surface morphology of g-C_(3)N_(4) to obtain the desired photocatalytic activity.This review summarizes the recent progress of vacancy defect engineered g-C_(3)N_(4) for solar water splitting.The fundamentals of solar water splitting with g-C_(3)N_(4) are discussed first.We then focus on the fabrication strategies and effect of vacancy generated in g-C_(3)N_(4).The advances of vacancy-modified g-C_(3)N_(4) photocatalysts toward solar water splitting are discussed next.Finally,the current challenges and future opportunities of vacancy-modified g-C_(3)N_(4) are summarized.This review aims to provide a theoretical basis and guidance for future research on the design and development of highly efficient defective g-C_(3)N_(4). | Jie Li Kaige Huang Yanbin Huang Yumin Ye Marcin Ziółek Zhijie Wang Shizhong Yue Mengmeng Ma Jun Liu Kong Liu Shengchun Qu Zhi Zhao Yanjun Zhang Zhanguo Wang | 2023 | Journal of Semiconductors2023，44，8： | 0 |
| 8 | Photothermal scaffolds/surfaces for regulation of cell behaviors显示文摘Regulation of cell behaviors and even cell fates is of great significance in diverse biomedical applications such as cancer treatment,cell-based therapy,and tissue engineering.During the past decades,diverse methods have been developed to regulate cell behaviors such as applying external stimuli,delivering exogenous molecules into cell interior and changing the physicochemical properties of the substrates where cells adhere.Photothermal scaffolds/surfaces refer to a kind of materials embedded or coated with photothermal agents that can absorb light with proper wavelength(usually in near infrared region)and convert light energy to heat;the generated heat shows great potential for regulation of cell behaviors in different ways.In the current review,we summarize the recent research progress,especially over the past decade,of using photothermal scaffolds/surfaces to regulate cell behaviors,which could be further categorized into three types:(i)killing the tumor cells via hyperthermia or thermal ablation,(ii)engineering cells by intracellular delivery of exogenous molecules via photothermal poration of cell membranes,and(iii)releasing a single cell or an intact cell sheet via modulation of surface physicochemical properties in response to heat.In the end,challenges and perspectives in these areas are commented. | Yangcui Qu Kunyan Lu Yanjun Zheng Chaobo Huang Guannan Wang Yanxia Zhang Qian Yu | 2022 | Bioactive Materials2022，7，2： | 0 |
| 9 | Charge-reversible crosslinked nanoparticle for pro-apoptotic peptide delivery and synergistic photodynamic cancer therapy显示文摘Although anti-cancer nanotherapeutics have made breakthroughs,many remain clinically unsatisfactory due to limited delivery efficiency and complicated biological barriers.Here,we prepared charge-reversible crosslinked nanoparticles(PDC NPs)by supramolecular self-assembly of pro-apoptotic peptides and photosensitizers,followed by crosslinking the self-assemblies with polyethylene glycol to impart tumor microenvironment responsiveness and charge-reversibility.The resultant PDC NPs have a high drug loading of 68.3%,substantially exceeding that of 10%–15%in conventional drug delivery systems.PDC NPs can overcome the delivery hurdles to significantly improve the tumor accumulation and endocytosis of payloads by surface charge reversal and responsive crosslinking strategy.Pro-apoptotic peptides target the mitochondrial membranes and block the respiratory effect to reduce local oxygen consumption,which extensively augments oxygen-dependent photodynamic therapy(PDT).The photosensitizers around mitochondria increased along with the peptides,allowing PDT to work with pro-apoptotic peptides synergistically to induce tumor cell death by mitochondria-dependent apoptotic pathways.Our strategy would provide a valuable reference for improving the delivery efficiency of hydrophilic peptides and developing mitochondrial-targeting cancer therapies. | Haijing Qu Han Chen Wei Cheng Yuqing Pan Zhiran Duan Yanjun Wang Xing-Jie Liang Xiangdong Xue | 2023 | Nano Research2023，16，12： | 0 |
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