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| 1 | Liver cancer incidence and mortality in China: Temporal trends and projections to 2030显示文摘Objective: Liver cancer is one of the most common cancers and major cause of cancer deaths in China,which accounts for over 50% of new cases and deaths worldwide.The systematic liver cancer statistics including of projection through 2030 could provide valuable information for prevention and control strategies in China,and experience for other countries.Methods: The burden of liver cancer in China in 2014 was estimated using 339 cancer registries' data selected from Chinese National Cancer Center(NCC).Incident cases of 22 cancer registries were applied for temporal trends from 2000 to 2014.The burden of liver cancer through 2030 was projected using age-period-cohort model.Results: About 364,800 new cases of liver cancer(268,900 males and 95,900 females) occurred in China,and about 318,800 liver cancer deaths(233,500 males and 85,300 females) in 2014.Western regions of China had the highest incidence and mortality rates.Incidence and mortality rates decreased by about 2.3% and 2.6% per year during the period of 2000-2014,respectively,and would decrease by more than 44% between 2014 and 2030 in China.The young generation,particularly for those aged under 40 years,showed a faster down trend.Conclusions: Based on the analysis,incidence and mortality rates of liver cancer are expected to decrease through 2030,but the burden of liver cancer is still serious in China,especially in rural and western areas.Most cases of liver cancer in China can be prevented through vaccination and more prevention efforts should be focused on high risk groups. | Rongshou Zheng Chunfeng Qu Siwei Zhang Hongmei Zeng Kexin Sun Xiuying Gu Changfa Xia Zhixun Yang He Li Wenqiang Wei Wanqing Chen Jie He | 2018 | Chinese Journal of Cancer Research2018，30，6： | 132 |
| 2 | The Chinese Society of Clinical Oncology(CSCO):Clinical guidelines for the diagnosis and treatment of gastric cancer,2021显示文摘There exist differences in the epidemiological characteristics,clinicopathological features,tumor biological characteristics,treatment patterns,and drug selections between gastric cancer patients from the Eastern and Western countries.The Chinese Society of Clinical Oncology(CSCO)has organized a panel of senior experts specializing in all sub-specialties of gastric cancer to compile a clinical guideline for the diagnosis and treatment of gastric cancer since 2016 and renews it annually.Taking into account regional differences,giving full consideration to the accessibility of diagnosis and treatment resources,these experts have conducted expert consensus judgment on relevant evidence and made various grades of recommendations for the clinical diagnosis and treatment of gastric cancer to reflect the value of cancer treatment and meeting health economic indexes in China.The 2021 CSCO Clinical Practice Guidelines for Gastric Cancer covers the diagnosis,treatment,follow-up,and screening of gastric cancer.Based on the 2020 version of the CSCO Chinese Gastric Cancer guidelines,this updated guideline integrates the results ofmajor clinical studies from China and overseas for the past year,focused on the inclusion of research data from the Chinese population for more personalized and clinically relevant recommendations.For the comprehensive treatment of non-metastatic gastric cancer,attentions were paid to neoadjuvant treatment.The value of perioperative chemotherapy is gradually becoming clearer and its recommendation level has been updated.For the comprehensive treatment of metastatic gastric cancer,recommendations for immunotherapy were included,and immune checkpoint inhibitors fromthird-line to the first-line of treatment for different patient groups with detailed notes are provided. | Feng-Hua Wang Xiao-Tian Zhang Yuan-Fang Li Lei Tang Xiu-Juan Qu Jie-Er Ying Jun Zhang Ling-Yu Sun Rong-Bo Lin Hong Qiu Chang Wang Miao-Zhen Qiu Mu-Yan Cai QiWu Hao Liu Wen-Long Guan Ai-Ping Zhou Yu-Jing Zhang Tian-Shu Liu Feng Bi Xiang-Lin Yuan Sheng-Xiang Rao Yan Xin Wei-Qi Sheng Hui-Mian Xu Guo-Xin Li Jia-Fu Ji Zhi-Wei Zhou Han Liang Yan-Qiao Zhang Jing Jin Lin Shen Jin Li Rui-Hua Xu | 2021 | Cancer Communications2021，41，8： | 97 |
| 3 | H7N9 virulent mutants detected in chickens in China pose an increased threat to humans显示文摘 | Jianzhong Shi Guohua Deng Huihui Kong Chunyang Gu Shujie Ma Xin Yin Xianying Zeng Pengfei Cui Yan Chen Huanliang Yang Xiaopeng Wan Xiurong Wang Liling Liu Pucheng Chen Yongping Jiang Jinxiong Liu Yuntao Guan Yasuo Suzuki Mei Li Zhiyuan Qu Lizheng Guan Jinkai Zang Wenli Gu Shuyu Han Yangming Song Yuzhen Hu Zeng Wang Linlin Gu Wenyu Yang Libin Liang Hongmei Bao Guobin Tian Yanbing Li Chuanling Qiao Li Jiang Chengjun Li Zhigao Bu Hualan Chen | 2017 | Cell Research2017，27，12： | 70 |
| 4 | Diagnostic value of glypican-3 in serum and liver for primary hepatocellular carcinoma显示文摘AIM:To evaluate the diagnostic value of glypican-3(GPC3) in serum and liver for primary hepatocellular carcinoma(HCC).METHODS:Serum levels of GPC3 and α-fetoprotein(AFP) were measured in 75 patients with primary HCC and 32 patients with liver cirrhosis.Expression of GPC3 and AFP in 58 HCC and 12 cirrhotic specimens was detected with immunohistochemical staining.RESULTS:When the cut-off value of serum GPC3 was set at 300 ng/L,its sensitivity and specificity for HCC were 47.0% and 93.5%,respectively.Among the 14 patients with HCC at stage according to the Barcelona Clinic Liver Cancer staging system,the serum GPC3 level was higher than 300 ng/L in 50%(7/14) patients,the serum AFP level was not ≥ 400 μg/L in any patient.Combined serum AFP and GPC3 significantly increased the sensitivity to the diagnosis of HCC.The GPC3 expression was detected in cytoplasm of HCC cells but not in hepatocytes and bile ducts of benign tumors.Among the 58 HCC patients,the GPC3 was expressed in 100%(28/28) patients with their serum AFP level ≥ 400 μg/L,and in 90%(27/30) patients with their AFP level < 400 μg/L,respectively.The GPC3 was weakly or negatively expressed in all paracarcinomatous and cirrhotic tissue samples.AFP positive HCC cells were only found in 1 out of the 58 HCC patients.CONCLUSION:GPC3 protein is a sensitive and specific serum marker for diagnosis of early HCC.Its expression in liver tissues can be used to discriminate tumor cells from benign hepatic cells. | Hui Liu Li-Jie Zhang Peng Li Yun Zhai Yu-Fen Tan Ning Li Hui-Guo Ding Chun-Feng Qu | 2010 | World Journal of Gastroenterology2010，16，35： | 57 |
| 5 | Orbit determination and time synchronization for a GEO/IGSO satellite navigation constellation with regional tracking network显示文摘Aiming at regional services,the space segment of COMPASS (Phase I) satellite navigation system is a constellation of Geostationary Earth Orbit (GEO),Inclined Geostationary Earth Orbit (IGSO) and Medium Earth Orbit (MEO) satellites.Precise orbit determination (POD) for the satellites is limited by the geographic distribution of regional tracking stations.Independent time synchronization (TS) system is developed to supplement the regional tracking network,and satellite clock errors and orbit data may be obtained by simultaneously processing both tracking data and TS data.Consequently,inconsistency between tracking system and TS system caused by remaining instrumental errors not calibrated may decrease navigation accuracy.On the other hand,POD for the mixed constellation of GEO/IGSO/MEO with the regional tracking network leads to parameter estimations that are highly correlated.Notorious example of correlation is found between GEO's orbital elements and its clock errors.We estimate orbital elements and clock errors for a 3GEO+2IGSO constellation in this study using a multi-satellite precise orbit determination (MPOD) strategy,with which clock error elimination algorithm is applied to separate orbital and clock estimates to improve numerical efficiency.Satellite Laser Ranging (SLR) data are used to evaluate User Ranging Error (URE),which is the orbital error projected on a receiver's line-of-sight direction.Two-way radio-wave time transfer measurements are used to evaluate clock errors.Experimenting with data from the regional tracking network,we conclude that the fitting of code data is better than 1 m in terms of Root-Mean-Square (RMS),and fitting of carrier phase is better than 1 cm.For orbital evaluation,difference between computed receiver-satellite ranging based on estimated orbits and SLR measurements is better than 1 m (RMS).For clock estimates evaluation,2-hour linear-fitting shows that the satellite clock rates are about 1.E-10 s/s,while receiver clock rates are about 1×10 13-1×10 12 s/s.For the 72-hour POD experiment,the average differences between POD satellite clock rates estimates and clock measurements based on TS system are about 1×10 13 s/s,and for receiver clock rates,the differences are about 1×10 15 s/s. | ZHOU ShanShi HU XiaoGong WU Bin LIU Li QU WeiJing GUO Rui HE Feng CAO YueLing Wu XiaoLi ZHU LingFeng SHI Xin TAN HongLi | 2011 | Science China(Physics,Mechanics & Astronomy)2011，54，6： | 44 |
| 6 | The efficacy and safety of endovascular recanalization of occluded large cerebral arteries during the subacute phase of cerebral infarction:a case series report显示文摘background Intravenous tissue plasminogen activator with or without mechanical thrombectomy during the acute phase are approved therapies for ischaemic stroke.Due to the short treatment time window(<6 hours)and often treatment failure,these patients would still have an intracranial arterial occlusion(IAO).It is unclear whether these patients can benefit from subsequent interventional recanalizationof their occluded artery in the subacute phase.In this retrospective study,we have examined the efficacy and safety in patients who have received either percutaneous transluminal angioplasty(PTA)or percutaneous transluminal angioplasty and stenting(PTAS)for IAO in the subacute phase of their stroke.Methods Patients with subacute symptomatic ischaemic stroke caused by IAO were assessed to identify the responsible artery and low perfusion areas by CT angiography,MR angiography or digital subtraction angiography.In eligible patients,a PTA or PTAS was performed to reopen the occluded artery.Regular antithrombotic therapy,use of statins,control of risk factors and rehabilitation therapy were prescribed after the procedure.All patients had regular follow-up up to 12 months.results PTA or PTAS was performed in 16 patients with cerebral infarction caused by IAO in the subacute phase.After the procedure,12 cases were recanalized,two were partially recanalized and two failed to open.One patient with left C6 segment occlusion of the carotid artery had a central retinal artery embolism after PTAS.The perioperative adverse events were 6.25%.At 3 months,the distribution of modified Rankin scale scores was 0(seven cases),1(three cases),2(five cases)and 3(one case).conclusion Selective PTA or PTAS could be performed in ischaemic stroke patients with a small infarct size and large area of hypoperfusion from an occluded large cerebral artery after the acute phase.It may improve neurological dysfunction and reduce the incidence of disability. | Kangning Chen Xianhua Hou Zhenhua Zhou Guangjian Li Qu Liu Li Gui Jun Hu Shugui Shi | 2017 | Stroke & Vascular Neurology2017，2，3： | 41 |
| 7 | Expression and functional analysis of the rice plasma-membrane intrinsic protein gene family显示文摘血浆膜内在的蛋白质(果仁) 是 aquaporins 的一个亚科越过膜启用水的快、控制的 translocation。在这研究,我们系统地从米饭识别了并且克隆十果仁基因。基于他们编码了的氨基酸序列的类似,这些米饭果仁基因被分类进二个组并且指定了为 OsPIP1-1 到 OsPIP1-3 和 OsPIP2-1 到在玉米跟随果仁基因的名称的 OsPIP2-7。量的 RT-PCR 分析识别了三根特定并且一叶特定的 OsPIP 基因。而且,响应盐,干旱和骆驼毛的织物处理的每 OsPIP 基因的表示侧面详细被检验。OsPIP1 (OsPIP1-1 ) 或在野类型的 Arabidopsis,腌,然而并非腌更高的集中(NaCl 的 150 公里) 的处理的显示出的提高的忍耐(NaCl 的 100 公里) 和干旱(甘露糖醇的 200 公里) 的 OsPIP2 (OsPIP2-2 ) 过去表示的转基因的植物上的分析。总起来说,这些数据响应不同压力建议每 OsPIP 基因的一个不同角色,并且应该把新层加到米饭果仁基因的生理的功能的理解。 | Lei Guo Zi Yi Wang Hong Lin Wei Er Cui Jun Chen Meihua Liu Zhang Liang Chen Li Jia Qu Hongya Gu | 2006 | Cell Research2006，16，3： | 35 |
| 8 | Pachytene piRNAs instruct massive mRNA elimination during late spermiogenesis显示文摘在哺乳动物的精子发生被 piRNA 表示的二个波浪描绘:一个人对应于负责的经典 piRNAs 因为 silencing retrotransponsons 和第二个波浪主要在 pachytene spermatocytes 从 nontransposon intergenic 区域被导出,但是这些 pachytene piRNAs 的功能大部分是未知的。这里,我们在在老鼠伸长指示巨大的 mRNA 消除报导 pachytene piRNAs 的参与 spermatids (ES ) 。我们证明包含鼠科的 PIWI (MIWI ) 和 deadenylase CAF1 的导致 piRNA 的 silencing 建筑群(pi-RISC ) 有选择地在 ES 被装配,它负责经由在体的房间类似于 miRNAs 的行动的机制导致 mRNA deadenylation 和腐烂。如此的一个高度安排的节目看起来充分利用 pachytene piRNAs 的能力从 nontransposon intergenic 区域导出的多样化的指向的庞大的全部剧目。这些调查结果建议 pachytene piRNAs 负责为精子生产作准备,从 ES 使广阔细胞的节目失去活性。 | Lan-Tao Gou Peng Dai Jian-Hua Yang Yuanchao Xue Yun-Ping Hu Yu Zhou Jun-Yan Kang Xin Wang Hairi Li Min-Min Hua Shuang Zhao Si-Da Hu Li-Gang Wu Hui-Juan Shi Yong Li Xiang-Dong Fu Liang-Hu Qu En-Duo Wang Mo-Fang Liu | 2014 | Cell Research2014，24，6： | 39 |
| 9 | Chinese Stroke Association guidelines for clinical management of cerebrovascular disorders:executive summary and 2019 update of clinical management of stroke rehabilitation显示文摘Stroke is the third leading cause of long-term disability.Effective stroke rehabilitation should be provided to patients with a moderate or severe stroke so as to achieve functional recovery.Also,stroke rehabilitation is moving towards more intense therapy models that incorporate technologies such as robotics and computer games.Evidence-based guidelines are useful for promoting the best possible clinical practices.This guideline summarises the modes of stroke rehabilitation in China-three-stage rehabilitation network,rehabilitation of stroke dysfunction,training for activities of daily living,stroke complications and rehabilitation care.The aim of this guideline was to provide a synopsis of best clinical practices in the stroke rehabilitation of adult patients in China. | Tong Zhang Jun Zhao Xueping Li Yulong Bai Baojun Wang Yun Qu Bingjie Li Shengjie Zhao Chinese Stroke Association Stroke Council Guideline Writing Committee | 2020 | Stroke & Vascular Neurology2020，5，3： | 38 |
| 10 | Mesenchymal stem cells: a new trend for cell therapy显示文摘间充质的干细胞(MSC ) ,为房间治疗的主要干细胞,在诊所被使用约 10 年了。从动物当模特儿到临床的试用, MSC 在众多的疾病的治疗负担得起诺言,主要织物损害和有免疫力的混乱。在这评论,我们在方法上总结最近的意见,预定并且为在临床的应用的 MSC 管理的房间来源,并且提供在调停 MSC 的治疗是重要的机制的概述。尽管为房间治疗的 MSC 被显示了安全、有效,仍然有挑战,需要在诊所在他们的宽申请前被处理。 | Xin WEI Xue YANG Zhi-peng HAN Fang-fang QU Li SHAO Yu-fang SHI | 2013 | Acta Pharmacologica Sinica2013，34，6： | 32 |
| 11 | SIRT6 safeguards human mesenchymal stem cells from oxidative stress by coactivating NRF2显示文摘 | Huize Pan Di Guan Xiaomeng Liu Jingyi Li Lixia Wang Jun Wu Junzhi Zhou Weizhou Zhang Ruotong Ren Weiqi Zhang Ying Li Jiping Yang Ying Hao Tingting Yuan Guohong Yuan Hu Wang Zhenyu Ju Zhiyong Mao Jian Li Jing Qu FuchouTang Guang-Hui Liu | 2016 | Cell Research2016，26，2： | 32 |
| 12 | Influence of Atmospheric Particulate Matter on Ozone in Nanjing,China:Observational Study and Mechanistic Analysis显示文摘Particulate matter with diameters of 2.5 μm or smaller(PM_(2.5)) and ozone(O_3) are major pollutants in the urban atmosphere. PM_(2.5) can affect O_3 by altering the photolysis rate and heterogeneous reactions. However, these two processes and their relative importance remain uncertain. In this paper, with Nanjing in China as the target city, we investigate the characteristics and mechanism of interactions between particles and O_3 based on ground observations and numerical modeling.In 2008, the average concentrations of PM_(2.5) and O_3 at Caochangmen station are 64.6 ± 47.4 μg m^(-3) and 24.6 ± 22.8 ppb,respectively, while at Pukou station they are 94.1 ± 63.4 μg m^(-3) and 16.9 ± 14.9 ppb. The correlation coefficient between PM_(2.5) and O_3 is -0.46. In order to understand the reaction between PM_(2.5) and O_3, we construct a box model, in which an aerosol optical property model, ultraviolet radiation model, gas phase chemistry model, and heterogeneous chemistry model,are coupled. The model is employed to investigate the relative contribution of the aforementioned two processes, which vary under different particle concentrations, scattering capability and VOCs/NOxratios(VOCs: volatile organic compounds;NOx: nitric oxide and nitrogen dioxide). Generally, photolysis rate effect can cause a greater O_3 reduction when the particle concentrations are higher, while heterogeneous reactions dominate O_3 reduction with low-level particle concentrations.Moreover, in typical VOC-sensitive regions, O_3 can even be increased by heterogeneous reactions. In Nanjing, both processes lead to O_3 reduction, and photolysis rate effect is dominant. Our study underscores the importance of photolysis rate effect and heterogeneous reactions for O_3, and such interaction processes should be fully considered in future atmospheric chemistry modeling. | Yawei QU Tijian WANG Yanfeng CAI Shekou WANG Pulong CHEN Shu LI Mengmeng LI Cheng YUAN Jing WANG Shaocai XU | 2018 | Advances in Atmospheric Sciences2018，35，11： | 33 |
| 13 | Geological Characteristics and Ore-forming Time of the Dexing Porphyry Copper Ore Mine in Jiangxi Province显示文摘The Dexing porphyry copper ore mine is located in the Qin-Hang metallogenic belt between the Yangtze block and the Cathaysia block. It is a giant porphyry copper mine in China, including 3 ore districts: Tongchang, Fujiawu and Zhushahong. Our analyses of Re in molybdenite indicate that the ore-forming material of the copper ore deposits in Dexing should be mainly mantle-derived. Our study fills in a gap in the study of formation time of the Dexing copper mine, and further proves that the copper ore deposits in the three ore districts should be formed simultaneously, about 170 Ma, belonging to the early Yanshan period, and that the formation time of the copper ore deposits should be consistent with the formation time of granodiorite porphyry in which the copper ore deposits are hosted. Promising areas for seeking porphyry copper ore deposits is predicated to be the west or southwest of Dexing. | GUO Shuo ZHAO Yuany QU Huanchun WU Dexin XU Hong LI Chao LIU Yan ZHU Xiaoyun WANG Zengke | 2012 | Acta Geologica Sinica(English Edition)2012，86，3： | 28 |
| 14 | A metabonomic investigation on the biochemical perturbation in liver failure patients caused by hepatitis b virus显示文摘 | Yu, K Sheng, GP Sheng, JF Chen, YM Xu, W Liu, XL Cao, HC Qu, HB Cheng, YY Li, LJ | 2007 | 中国生物学文摘2007，21，11： | 25 |
| 15 | Unconjugated bilirubin alleviates experimental ulcerative colitis by regulating intestinal barrier function and immune inflammation显示文摘BACKGROUND Unconjugated bilirubin(UCB) is generally considered toxic but has gained recent prominence for its anti-inflammatory properties. However, the effects of it on the interaction between intestinal flora and organisms and how it influences immune responses remain unresolved.AIM To investigate the role of UCB in intestinal barrier function and immune inflammation in mice with dextran-sulfate-sodium-induced colitis.METHODS Acute colitis was induced by 3%(w/v) dextran sulfate sodium salt in drinking water for 6 d followed by untreated water for 2 d. Concurrently, mice with colitis were administered 0.2 mL UCB(400 μmol/L) by intra-gastric gavage for 7 d.Disease activity index(DAI) was monitored daily. Mice were sacrificed at the end of the experiment. The length of the colon and weight of the spleen were recorded. Serum level of D-lactate, intestinal digestive proteases activity, and changes to the gut flora were analyzed. In addition, colonic specimens were analyzed by histology and for expression of inflammatory markers and proteins.RESULTS Mice treated with UCB had significantly relieved severity of colitis, including lower DAI, longer colon length, and lower spleen weight(colon length: 4.92 ±0.09 cm vs 3.9 ± 0.15 cm; spleen weight: 0.33 ± 0.04 vs 0.74 ± 0.04, P < 0.001). UCB administration inactivated digestive proteases(chymotrypsin: 18.70 ± 0.69 U/g vs44.81 ± 8.60 U/g; trypsin: 1.52 ± 0.23 U/g vs 9.05 ± 1.77 U/g, P < 0.01), increased expression of tight junction(0.99 ± 0.05 vs 0.57 ± 0.03, P < 0.001), decreased serum level of D-lactate(31.76 ± 3.37 μmol/L vs 54.25 ± 1.45 μmol/L, P < 0.001), and lowered histopathological score(4 ± 0.57 vs 7 ± 0.57, P < 0.001) and activity of myeloperoxidase(46.79 ± 2.57 U/g vs 110.32 ± 19.19 U/g, P < 0.001). UCB also regulated the intestinal microbiota, inhibited expression of tumor necrosis factor(TNF) α and interleukin 1β(TNF-α: 52.61 ± 7.81 pg/mg vs 105.04 ± 11.92 pg/mg,interleukin 1β: 13.43 ± 1.68 vs 32.41 ± 4.62 pg/mg, P < 0.001), decreased expression of Toll-like receptor 4(0.61 ± 0.09 vs 1.07 ± 0.03, P < 0.001) and myeloid differentiation primary response gene 88(0.73 ± 0.08 vs 1.01 ± 0.07, P <0.05), and increased expression of TNF-receptor-associated factor 6(0.79 ± 0.02 vs0.43 ± 0.09 P < 0.05) and inhibitor of kappa B α(0.93 ± 0.07 vs 0.72 ± 0.07, P < 0.05)in the colon.CONCLUSION UCB can protect intestinal barrier function, regulate normal intestinal homeostasis, and suppress inflammation via the Toll-like receptor 4/nuclear factor-κB signaling pathway. | Jia-Dong Zheng Yan He Heng-Yuan Yu Yuan-Li Liu Yi-Xuan Ge Xue-Ting Li Xue Li Yan Wang Meng-Ru Guo Yi-Lin Qu Xiao-Fa Qin Ming-Shan Jiang Xiu-Hong Wang | 2019 | World Journal of Gastroenterology2019，25，15： | 26 |
| 16 | Epigenetic silencing of microRNA-149 in cancer-associated fibroblasts mediates prostaglandin E2/interleukin-6 signaling in the tumor microenvironment显示文摘 | Pu Li Jing-Xuan Shan Xue-Hua Chen Di Zhang Li-Ping Su Xiu-Ying Huang Bei-Qin Yu Qiao-Ming Zhi Cheng-Long Li Ya-Qing Wang Sara Tomei Qu Cai Jun Ji Jian-Fang Li Lotfi Chouchane Ying-Yan Yu Fang-Zhen Sun Zhi-Heng Xu Bing-Ya Liu Zheng-Gang Zhu | 2015 | Cell Research2015，25，5： | 24 |
| 17 | 电针和经皮穴位电刺激技术在生殖医学中的应用:专家共识(英文)显示文摘本文从传统针刺治疗不孕症的选穴依据与现代电针/经皮穴位电刺激技术的相关原理着手,从最优刺激参数选择、穴位辨证、疗程与治疗次数的确定及基本原理等方面阐述了电针/经皮穴位电刺激技术在多囊卵巢综合症、取卵镇痛、卵巢储备功能降低、胚胎移植以及男性少/弱精症等生殖领域中的具体应用。首次对电针/经皮穴位电刺激技术在生殖领域优势病种中的应用进行了系统的分析和总结,在最优刺激参数选择、穴位辨证、疗程与治疗次数的确定等方面提出了一系列专家共识,并为临床实践提供了指导意见和理论依据。 | Fan QU Rong LI Wei SUN Ge LIN Rong ZHANG Jing YANG Li TIAN Guo-gang XING Hui JIANG Fei GONG Xiao-yan LIANG Yan MENG Jia-yin LIU Li-ying ZHOU Shu-yu WANG Yan WU Yi-jing HE Jia-yu YE Song-ping HAN Ji-sheng HAN | 2017 | Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)2017，18，3： | 24 |
| 18 | Acupuncture Treatment for Post-Stroke Dysphagia: An Update Meta-Analysis of Randomized Controlled Trials显示文摘Objective: To explore the effectiveness and safety of acupuncture in patients with post-stroke dysphagia by an update meta-analysis. Methods: Potentially eligible RCTs aimed to evaluate the effects of acupuncture vs. non-acupuncture treatments, such as rehabilitation training or routine medication on the swallowing difficulty after stroke were searched from Pub Med, Cochrane Library, China National Knowledge Infrastructure, and other database from the earliest record to June 2016. Patient demographics, regimens for acupuncture, type of controls, methods of randomization, and measurements of the clinical symptoms of dysphagia were retrieved. The relative risk(RR) and 95% confidence interval(CI) of effective rate of dysphagia was calculated after intervention performed following admission. Subgroup analyses and a metaregression analysis were performed to describe the heterogeneity. Results: Twenty-nine RCTs comprising 2,190 patients were included. The included studies had a medium quality grade based on the Consolidated Standards of Reporting Trials(CONSORT) and Standards for Reporting Interventions in Clinical Trials of Acupuncture(STRICTA) checklist. Acupuncture therapy provided a higher effective rate compared with nonacupuncture treatments [RR=1.33, 95% confidence interval(CI), 1.25 to 1.43]. Subgroup and meta-regression analyses suggested that acupuncture intensity and measurement method were main sources of heterogeneity and resulted in a significant difference for pooled effect size. No severe adverse events were documented in these RCTs. Conclusions: Our meta-analysis provides a new evidence supporting the efficacy and safety of acupuncture in treatment to post-stroke dysphagia in short-term compared with rehabilitation or medication. More high-quality and large-scale research studies are needed. | LI Ling-xin DENG Kai QU Yun | 2018 | Chinese Journal of Integrative Medicine2018，24，9： | 24 |
| 19 | The progress of catalytic technologies in water purification:A review显示文摘Catalytic technologies have been paid increasing attention in refractory pollutants abatement due to its practical and potential values in water purification.As effective and effcient approaches for water purification,Fenton's reagent,ozonation,electrochemical and photocatalytic methods have been widely studied and applied in different aspects and have been reviewed by several articles.In recent years,some novel catalytic processes based on above processes have been developed for enhancing the effciency of removing the organics from water.This review emphasized on the recent development of heterogeneous catalytic ozonation,electrocatalysis in respect of novel electrodes and electro-Fenton method,photoelectrocatalysis process and photoelectron-Fenton in water purification.It was also an attempt to propose general ideas about mechanism and principle enhancing the catalytic effciency for the degradation and the mineralization of organics in water. | LI Dapeng QU Jiuhui | 2009 | Journal of Environmental Sciences2009，21，6： | 22 |
| 20 | The distribution rule and seepage effect of the fractures in the ultra-low permeability sandstone reservoir in east Gansu Province,Ordos Basin显示文摘To study the impact of the fractures on development in the ultra-low permeability sandstone reservoir of the Yangchang Formation of the Upper Triassic in the Ordos Basin,data on outcrops,cores,slices,well logging and experiments are utilized to analyze the cause of the formation of the fractures,their distribution rules and the control factors and discuss the seepage flow effect of the fractures. In the studied area developed chiefly high-angle tectonic fractures and horizontal bedding fractures,inter-granular fractures and grain boundary fractures as well. Grain boundary fractures and intragranular fractures serve as vital channels linking intragranular pores and intergranular solution pores in the reservoir matrix,thus providing a good connectivity between the pores in the ultra-low perme-ability sandstone reservoir. The formation of fractures and their distribution are influenced by such external and internal factors as the palaeo-tectonic stress field,the reservoir lithological character,the thickness of the rock layer and the anisotropy of a layer. The present-day stress field influences the preservative state of fractures and their seepage flow effect. Under the tec-tonic effect of both the Yanshan and Himalayan periods,in this region four sets of fractures are distributed,respectively assuming the NE-SW,NW-SE,nearly E-W and nearly S-N orientations,but,due to the effect of the rock anisotropy of the rock formation,in some part of it two groups of nearly orthogonal fractures are chiefly distributed. Under the effect of the present-day stress field,the fractures that assume the NE-SW direction have a good connectivity,big apertures,a high permeability and a minimum starting pressure,all of which are main advantages of the seepage fractures in this region. With the development of oilfields,the permeability of the fractures of dif-ferent directions will have a dynamic change. | ZENG LianBo1,GAO ChunYu2,QI JiaFu1,WANG YongKang2,LI Liang2 & QU XueFeng2 1 State Key Laboratory of Petroleum Resource and Prospecting,China University of Petroleum,Beijing 102249,China 2 Changqing Oilfield Branch,PetroChina,Xi’an 163517,China | 2008 | Science China Earth Sciences2008，51，S2： | 22 |
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