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| 1 | Insights into tertiary lymphoid structures in the solid tumor microenvironment: anti-tumor mechanism, functional regulation, and immunotherapeutic strategies显示文摘Tertiary lymphoid structures(TLSs)are ectopic immune cell aggregations that develop in peripheral tissues in response to a wide range of chronic inflammatory conditions,including infection,autoimmune disease,and cancer.In the tumor microenvironment(TME),the structures of TLSs,including B-cell-and T-cell-enriched areas indicate that the TLSs might be the local site during the initiation and maintenance of humoral and cellular immune responses against cancers.Numerous studies have evaluated the expression of TLSs in different cancer patients and their association with prognoses of cancer patients.It was shown that welldeveloped TLSs characterized by mature B cells synthesized tumor specific antibodies,which were considered as specific markers for a good prognosis.However,there are still some immunosuppressive factors existing in the TLSs that may affect anti-tumor responses.These factors include dysfunctional B cells,regulatory T cells,and T follicular regulatory cells.The complexity and heterogeneity of the TLS composition may affect the function and activity of TLSs;it is therefore essential to fully understand the function and influencing factors in TLSs.It has been reported that checkpoint inhibitors and vaccines are currently being developed to reprogram the TME by establishing mature TLSs to improve cancer immunotherapies.In this review,we focused on recent advances in TLSs in human solid tumors,including structural characteristics and classes,antitumor mechanisms,immunosuppressive factors,and TLSbased therapeutic approaches. | Hua Zhao Hao Wang Qiuru Zhou Xiubao Ren | 2021 | Cancer Biology & Medicine2021，18，4： | 2 |
| 2 | Comparison of Mastoscopic and Conventional Axillary Lymph Node Dissection in Breast Cancer: Long-term Results From a Randomized, Multicenter Trial显示文摘 | Chengyu Luo Wenbin Guo Jie Yang Qiuru Sun Wei Wei Suhua Wu Shubing Fang Qingliang Zeng Zhensheng Zhao Fanjie Meng Xuandong Huang Xianlan Zhang Ruihua Li Xiufeng Ma Chaoying Luo Yun Yang | 2012 | Mayo Clinic Proceedings2012，，12： | 1 |
| 3 | The impact of quality of work life on job embeddedness and affective commitment and their co‐effect on turnover intention of nurses显示文摘 | XiaoWen Zhao Tao Sun QiuRu Cao Ce Li XiaoJian Duan LiHua Fan Yan Liu | 2012 | Journal of Clinical Nursing2012，，5： | 1 |
| 4 | Cucurbitacin E suppresses cytokine expression in human Jurkat T cells through down-regulating the NF-κB signaling显示文摘Cucurbitacin E (CucE ) ,从 Cucurbitaceae 植物孤立的 triterpenoid,被显示了在 vitro 并且在 vivo 拥有 anti-inammatory 或抑制免疫力的活动,然而,内在的机制不完全地被理解。现在的学习的目的是作为一个细胞的模型在人的 Jurkat T 房间在 cytokine 表示和内在的机制上探索它的效果。结果证明 CucE 显著地禁止了 interleukin-2 的生产,肿瘤坏死因素 -- ,并且干扰素 -- 在加 ionomycin (离子) 与 phorbol 12,13-dibutyrate (PDB ) 对待的房间的文化媒介。而且, mRNA 在激活的 Jurkat T 房间这些 cytokines 铺平,建议为 cytokine 表示的批评发信号小径上的潜在的调节效果,包括原子 factor-B (NF-B ) 或激活 mitogen 的蛋白质 kinases (MAPK ) 是也在 CucE 处理之上减少了。在它表明小径的 NF-B 上的效果的支持, CucE 减少了 B (IB ) 和在 PDB + 刺激离子的房间的 NF-B/p65 的禁止者的 phosphorylation 层次。进一步支持这, NF-B/p65 的原子 translocation 显著地面对 CucE 响应 PDB 正离子刺激被压制。然而, p38MAPK, c6 月 N 终端 kinase (JNK ) ,和 Erk1/2 的 phosphorylation 没被 CucE 处理在一些时间点减少或稍微增加了。一起,这些数据建议 CucE 可以由 attenuating 展出抑制免疫力的效果批评 cytokine 表示通过下面调整发信号的 NF-B 小径。 | Lixian Wang Chenguang Li Qiuru Li Xiaoyu Zhang Hao Pan Lihui Xu Zijian Shi Dongyun Ouyang Xianhui He | 2015 | Acta Biochimica et Biophysica Sinica2015，47，6： | 1 |
| 5 | Multi-Scale Image Segmentation Model for Fine-Grained Recognition of Zanthoxylum Rust显示文摘Zanthoxylum bungeanum Maxim,generally called prickly ash,is widely grown in China.Zanthoxylum rust is the main disease affecting the growth and quality of Zanthoxylum.Traditional method for recognizing the degree of infection of Zanthoxylum rust mainly rely on manual experience.Due to the complex colors and shapes of rust areas,the accuracy of manual recognition is low and difficult to be quantified.In recent years,the application of artificial intelligence technology in the agricultural field has gradually increased.In this paper,based on the DeepLabV2 model,we proposed a Zanthoxylum rust image segmentation model based on the FASPP module and enhanced features of rust areas.This paper constructed a fine-grained Zanthoxylum rust image dataset.In this dataset,the Zanthoxylum rust image was segmented and labeled according to leaves,spore piles,and brown lesions.The experimental results showed that the Zanthoxylum rust image segmentation method proposed in this paper was effective.The segmentation accuracy rates of leaves,spore piles and brown lesions reached 99.66%,85.16%and 82.47%respectively.MPA reached 91.80%,and MIoU reached 84.99%.At the same time,the proposed image segmentation model also had good efficiency,which can process 22 images per minute.This article provides an intelligent method for efficiently and accurately recognizing the degree of infection of Zanthoxylum rust. | Fan Yang Jie Xu Haoliang Wei Meng Ye Mingzhu Xu Qiuru Fu Lingfei Ren Zhengwen Huang | 2022 | Computers, Materials & Continua2022，，5： | 0 |
| 6 | Upgrading to urban water system 3.0 through sponge city construction显示文摘 | Nanqi Ren Qian Wang Qiuru Wang Hong Huang Xiuheng Wang | 2017 | Frontiers of Environmental Science & Engineering2017，11，4： | 0 |
| 7 | A case study of aggregation behaviors of titanium dioxide nanoparticles in the presence of dodecylbenzene sulfonate in natural water显示文摘The present work aims to ascertain the mechanisms of surfactant(dodecylbenzene sulfonate; DBS) effects on the aggregation behaviors of TiO2 nanoparticles(TiO2-NPs) in natural water samples. Aggregation experiments were conducted at a TiO2-NPs concentration of 10 mg/L in deionized water and in natural water samples via dynamic light scattering and Zeta potential determination. Average attachment efficiency was calculated to compare the aggregation behaviors of nanoparticles in the two aqueous media. Results showed that the effects of DBS on aggregation could be interpreted by both Derjaguin–Landau–Verwey–Overbeek(DLVO) and non-DLVO mechanisms. In natural water samples,aggregation did not occur rapidly and was able to develop slowly under all conditions, and the roles of DBS were obvious at high DBS concentration owing to the impacts of inherent components of natural water samples, such as colloids and natural organic compounds.Future aggregation studies should concentrate on multi-factor, multi-colloidal and dynamic aspects under similar environmental conditions. | Xin Du Xiuheng Wang Shijie You Qiuru Wang Xiaobo Gong | 2015 | Journal of Environmental Sciences2015，27，10： | 0 |
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