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| 1 | Overexpression of a dominant-negative mutant of SIRT1 in mouse heart causes cardiomyocyte apoptosis and early-onset heart failure显示文摘SIRT1,a mammalian ortholog of yeast silent information regulator 2(Sir2),is an NAD+-dependent protein deacetylase that plays a critical role in the regulation of vascular function.The current study aims to investigate the functional significance of deacetylase activity of SIRT1 in heart.Here we show that the early postnatal hearts expressed the highest level of SIRT1deacetylase activity compared to adult and aged hearts.We generated transgenic mice with cardiac-specific expression of a dominant-negative form of the human SIRT1(SIRT1H363Y),which represses endogenous SIRT1 activity.The transgenic mice displayed dilated atrial and ventricular chambers,and died early in the postnatal period.Pathological,echocardiographic and molecular phenotype confirmed the presence of dilated cardiomyopathy.Terminal deoxynucleotidyl transferase-mediated dUTP nick-end-labeling analysis revealed a greater abundance of apoptotic nuclei in the hearts of transgenic mice.Furthermore,we show that cardiomyocyte apoptosis caused by suppression of SIRT1 activity is,at least in part,due to increased p53acetylation and upregulated Bax expression.These results indicate that dominant negative form of SIRT1(SIRT1H363Y)overexpression in mouse hearts causes cardiomyocyte apoptosis and early-onset heart failure,suggesting a critical role of SIRT1 in preserving normal cardiac development during the early postnatal period. | MU WenLi ZHANG QingJun TANG XiaoQiang FU WenYan ZHENG Wei LU YunBiao LI HongLiang WEI YuSheng LI Li SHE ZhiGang CHEN HouZao LIU DePei | 2014 | Science China(Life Sciences)2014，57，9： | 12 |
| 2 | Design and control of methyl acetate-methanol separation via heat-integrated pressure-swing distillation显示文摘Design and control of pressure-swing distillation(PSD) with different heat integration modes for the separation of methyl acetate/methanol azeotrope are explored using Aspen Plus and Aspen Dynamics. First, an optimum steady-state separation configuration conditions are obtained via taking the total annual cost(TAC) or total reboiler heat duty as the objective functions. The results show that about 27.68% and 25.40% saving in TAC can be achieved by the PSD with full and partial heat integration compared to PSD without heat integration. Second,temperature control tray locations are obtained according to the sensitivity criterion and singular value decomposition(SVD) analysis and the single-end control structure is effective based on the feed composition sensitivity analysis. Finally, the comparison of dynamic controllability is made among various control structures for PSD with partial and full heat integration. It is shown that both control structures of composition/temperature cascade and pressure-compensated temperature have a good dynamic response performance for PSD with heat integration facing feed flowrate and composition disturbances. However, PSD with full heat integration performs the poor controllability despite of a little bit of economy. | Zhishan Zhang Qingjun Zhang Guijie Li Meiling Liu Jun Gao | 2016 | Chinese Journal of Chemical Engineering2016，24，11： | 12 |
| 3 | Memory T cells: strategies for optimizing tumor immunotherapy显示文摘Several studies have demonstrated that memory T cells including stem cell memory (Tscm) T cells and central memory (Tcm) T cells show superior persistence and antitumor immunity compared with effector memory T (Tem) cells and effector T (Teff) cells.Furthermore,the Tcm/Teff ratio has been reported to be a predictive biomarker of immune responses against some tumors.Thus,a system-level understanding of the mechanisms underlying the differentiation of effector and memory T cells is of increasing importance for developing immunological strategies against various tumors.This review focuses on recent advances in efficacy against tumors,the origin,formation mechanisms of memory T cells,and the role of the gut microbiota in memory T cell formation.Furthermore,we summarize strategies to generate memory T cells in (ex) vivo that,might be applicable in clinical practice. | Qingjun Liu Zhongjie Sun Ligong Chen | 2020 | Protein & Cell2020，11，8： | 10 |
| 4 | Relationship between Mesozoic Magmatism and Subduction in the Da Hinggan-Yanshan Area显示文摘High-resolution tomographic images of the belt crossing the Japan Trench-Changbai Mountains-Dong Ujimqin Qi are represented in this paper, revealing the shape of a subducted slab in the western Pacific region and characteristics of the lithospheric structures under the Changbai Mountains and the Da Hinggan Mountains. Studies of the spatial distribution, subduction time and the time-lag between the subduction and magmatism, combined with petrology and isotope geochemistry of the Late Mesozoic volcano-plutonic rocks from the Da Hinggan Mountains-Yanshan Mountains have further proved the independence of magmatic activities from the subduction of the Pacific plate. The Mesozoic tectono-thermal evolutionary history and structural characteristics of the lithosphere in the Da Hinggan Mountains and North China suggest that the formation and evolution of magma have probably a close relationship with the delamination and thinning of the continental lithosphere and the underplating resulting from the consequent upwelling of the asthenosphere. On the other hand, the large-scale strike-slip fault system, resulting from sinistral shearing of the Pacific plate relative to the Asian continent in the Mesozoic, is responsible for the formation and emplacement of magma on the continental margin. It was the intense crust-mantle interaction, together with structural deformation at the shallower levels that led to the large tectono-magmatic belt in the East Asian continental margin. | SHAO Ji'an LIU Futian CHEN Hui HAN Qingjun | 2001 | Acta Geologica Sinica(English Edition)2001，75，1： | 9 |
| 5 | Myelin protein zero and its antibody in serum as biomarkers of n-hexane-induced peripheral neuropathy and neurotoxicity effects显示文摘 | Jia Xiaowei Liu Qingjun Zhang Yanshu Dai Yufei Duan Huawei Bin Ping Niu Yong Liu Jie Zhong Liuzhen Guo Jisheng Liu Xiaofeng Zheng Yuxin | 2014 | Chinese Medical Journal2014，，8： | 8 |
| 6 | A new algorithm of retrieving a petroleum substances absorption coefficient in sea water based on a remote sensing image显示文摘Establishing the remote sensing algorithm of retrieving the absorption coefficient of seawater petroleum substances is an efficient way to improve the accuracy of retrieving a seawater petroleum concentration using a remote sensing technology. A remote sensing reflectance is a basic physical parameter in water color remote sensing. Apply it to directly retrieve the absorption coefficient of seawater petroleum substances is of potential advantage. The absorption coefficient of waters containing petroleum [ACWCP, a_o(λ)], consists of the absorption coefficient of pure water [ACPW, a_w(λ)], plankton [ACP, a_(ph)(λ)], colored scraps [ACCS, a_(d,g)(λ)], and petroleum substance [ACPS, a_(oil)(λ)]. Among those, ACCS consists of the absorption coefficient of nonalgal particle [ACNP, a_d(λ)] and colored dissolved organic matter [ACCDOM, a_g(λ)]. For waters containing petroleum, the retrieved ACCS using the existing method is a combination absorption coefficient of ACNP,ACCDOM and ACPA [CAC, a_(d,g,oil)(λ)]. Therefore, the principle question is how to extract ACPS from CAC.Through the analysis of the three proportion tests conducted between the year of 2013 and 2015 and the corresponding remote sensing data, an algorithm of retrieving the absorption coefficient of petroleum substances is proposed based on remote sensing reflectance. First of all, ACPS and CAC are retrieved from the reflectance using the quasi-analytical algorithm(QAA), with some parameter modified. Secondly, given the fact that the backscatter coefficient [BC, b_(bp)(555)] of total particles at 555 nm can be obtained completely from the reflectance, the relation between BC and ACNP in petroleum contaminated water can be established. As a result, ACNP can be calculated. Then, combining the remote sensing retrieving algorithm of a_g(440), the method of achieving the spectral slope of the absorption coefficient can be established, from which ACCDOM,can be calculated. Finally, ACPS can be computed as the residual. The accuracy of ACPS based on this algorithm is 86% compared with the in situ measurements. | HUANG Miaofen XING Xufeng SONG Qingjun LIU Yang DONG Wentong | 2016 | Acta Oceanologica Sinica2016，35，11： | 7 |
| 7 | Overview of Chinese First C Band Multi-Polarization SAR Satellite GF-3显示文摘The GF-3 satellite, the first C band and multi-polarization Synthetic Aperture Radar(SAR) satellite in China, achieved breakthroughs in a number of key technologies such as multi-polarization and the design of a multiimaging mode, a multi-polarization phased array SAR antenna, and in internal calibration technology. The satellite technology adopted the principle of 'Demand Pulls, Technology Pushes', creating a series of innovation firsts, reaching or surpassing the technical specifications of an international level. | ZHANG Qingjun LIU Yadong | 2017 | Aerospace China2017，18，3： | 5 |
| 8 | Methods for assessing the grooving corrosion of high-frequency electric resistance welded pipes显示文摘Grooving corrosion is a major form of corrosion and is prone to occur when high-frequency electric resistance welded (HFW) pipes are being used.Therefore,grooving corrosion is one of the performance indexes of HFW products.Grooving corrosion usually occurs along the welding fusion line,resulting in one or more corrosion grooves.The main factors affecting grooving corrosion include the contents of alloying elements and impurities (especially sulphur) in the steel,the microstructure of the welds and the steel substrate,welding parameters and the service environment as well.In this study,the existing methods for assessing grooving corrosion were systematically reviewed,improvements and new methods were proposed and developed to overcome the shortcomings of the existing methods,such as inaccuracy and excessive research time.By comparison with the existing methods,the operational procedures and the characteristics of the new methods are introduced,and issues regarding the behavior of grooving corrosion and their assessment methods,which both need further research,are discussed in this study. | WANG Wei QI Huibin LIU Changsheng ZHOU Qingjun QIAN Yuhai SHEN Jianlan | 2010 | Baosteel Technical Research2010，4，3： | 5 |
| 9 | Investigation into the flotation response of refractory molybdenum ore to depressant mixtures:A case study显示文摘In this paper, bulk flotation followed by separation was investigated to concentrate purified molybdenite product from Jinduicheng molybdenum ores(Shanxi province, China). The bench scale tests mainly focussed on separation of molybdenite from other sulfide minerals using the new type of depressants.The effect of each single depressant, including organic depressant-modified dextrin(MD), P-Nokes reagent(PN) and sodium trithiocarbonate(ST), and their mixtures on galena, chalcopyrite and other sulfide ores, was examined in turn by changing the concentrations used in cleaner flotation tests. Closed circuit experiments were carried out under the optimal condition and satisfying recovery and grade of molybdenite concentrate could be achieved(86.294% and 53.157%, respectively). A potential reagent regime was developed, with more environmental friendly and more economical advantages due to the introduction of modified dextrin. | Yin Zhigang Sun Wei Liu Jiandong Hu Yuehua Guan Qingjun Zhang Chenhu Tang Honghu Guan Changping | 2016 | International Journal of Mining Science and Technology2016，26，6： | 4 |
| 10 | Organic Carbon Isotope Geochemistry of the Neoproterozoic Doushantuo Formation,South China显示文摘The Neoproterozoic Doushantuo Formation on the Yangtze Platform,South China,documents a sedimentary succession with different sedimentary facies from carbonate platform to slope and to deep sea basin,and hosts one of the world-class phosphorite deposits.In these strata,exquisitely preserved fossils have been discovered:the Weng’an biota.This study presents carbon isotope geochemistry which is associated paired carbonate and organic matter from the Weng’an section of a carbonate platform(shelf of the Yangtze Platform,Guizhou Province)from the Songtao section and Nanming section of a transition belt(slope of the Yangtze Platform,Guizhou Province)and from the Yanwutan section(basin area of the Yangtze Platform,Hunan Province).Environmental variations and bio-events on the Yangtze Platform during the Late Neoproterozoic and their causal relationship are discussed.Negative carbon isotope values for carbonate and organic carbon(mean δ13Corg = ?35.0‰)from the uppermost Nantuo Formation are followed by an overall increase in δ13C up-section.Carbon isotope values vary between ?9.9‰ and 3.6‰ for carbonate and between ?35.6‰ and ?21.5‰ for organic carbon,respectively.Heavier δ13Ccarb values suggest an increase in organic carbon burial,possibly related to increasing productivity(such as the Weng’an biota).The δ13C values of the sediments from the Doushantuo Formation decreased from the platform via the slope to basin,reflecting a reduced environment with minor dissolved inorganic carbon possibly due to a lower primary productivity.It is deduced that the classical upwelling process,the stratification structure and the hydrothermal eruption are principally important mechanisms to interpret the carbon isotopic compositions of the sediments from the Doushantuo Formation. | GUO Qingjun LIU Congqiang Harald STRAUSS Tatiana GOLDBERG ZHU Maoyan PI Daohui WANG Jian | 2006 | Acta Geologica Sinica(English Edition)2006，80，5： | 3 |
| 11 | A new Cu^(2+)-induced color reaction of a rhodamine derivative N-(3-carboxy)acryloyl rhodamine B hydrazide显示文摘A new rhodamine derivative,N-(3-carboxy)acryloyl rhodamine B hydrazide(CARB),has been synthesized,and its unusual spectroscopic reaction with Cu2+ has been investigated.The derivative exhibits a rapid and reversible non-fluorescent absorption upon coordination to Cu2+,which is a rather unusual phenomenon for rhodamine B derivatives.Stoichiometric measurements using the Job's method and the molar ratio method reveal that one CARB molecule combines two Cu2+ ions,and the two Cu2+ ions play different roles:one opens the spirocyclic structure and the other quenches the fluorescence of the xanthene moiety.This reaction mechanism is supported by a comparative study on the model compound N-acryloyl rhodamine B hydrazide as well as by the density functional theory calculations.Furthermore,the absorption response of CARB is highly selective for Cu2+ over other common ions,which implies that CARB may be used as a colorimetric probe for the rapid visual detection of Cu2+. | SUN ChengDong CHEN JianMing MA HuiMin LIU Yang ZHANG JingHua LIU QingJun | 2011 | Science China Chemistry2011，54，7： | 3 |
| 12 | The Effect of 2,5-hexanedione on Myelin Protein Zero Expression,and Its Mitigation Using Ginkgo Biloba Extract显示文摘Objective To investigate the role of myelin protein zero (P 0) in 2,5-hexanedione (2,5-HD)-induced peripheral nerve injury,and the protective effect of Ginkgo biloba extract (Egb761) on 2,5-HD-induced toxic peripheral neuropathy.Methods After 4 weeks of treatment with 2,5-HD at different doses (50,100,200,400 mg/kg) in rats,changes in the levels of P 0 in rat sciatic nerves was investigated,and the effect of Egb761 on 2,5-HD-induced toxic peripheral neuropathy was studied.Results The blood-nerve barrier (BNB) permeability of the sciatic nerve increased,and the expression of P 0 mRNA and P 0 protein decreased in a dose-dependent manner after treatment with 2,5-HD for 4 weeks.Pretreatment with Egb761 protected against BNB interruption,and inhibited P 0 mRNA and protein reduction during 2,5-HD treatment.Pretreatment with Egb761 significantly reduced loss of body weight (P<0.01) and mitigated gait abnormalities (2.85±0.22) induced by 400 mg/kg 2,5-HD (P<0.01).It also reduced the signs of neurotoxicity induced by 2,5-HD.Conclusion 2,5-HD inhibited the expression of P 0 in a dose-dependent manner,and this may be an important mechanism by which toxic peripheral neuropathy is induced by 2,5-HD.Egb761 has a protective effect against 2,5-HD-induced peripheral neurotoxicity in rats. | ZHAO Lei LIU QingJun CHEN Hong DUAN HuaWei BIN Ping LIU Qing NIU Yong DAI YuFei ZHENG YuXin | 2011 | Biomedical and Environmental Sciences2011，24，4： | 3 |
| 13 | Microelectrode Recording of Tissue Neural Oscillations for a Bionic Olfactory Biosensor显示文摘 | Qingjun Liu Fenni Zhang Ning Hu Hua Wang Kuen Jimmy Hsia Ping Wang | 2012 | Journal of Bionic Engineering2012，9，4： | 2 |
| 14 | Manipulation of MHC-I/TCR Interaction for Immune Therapy显示文摘Adoptive immunotherapy involving the transfer of autologous tumor or virus-reactive T lymphocytes has been demonstrated to be effective in the eradication of cancer and virally infected cells. Identification of MHC-restricted antigens and progress in generation of adaptive immune responses have provided new direction for such treatment for severe pathologies such as cancer and autoimmune diseases. Here we review the latest development about the molecular basis of MHC-I/TCR interaction, and its manipulation including enhanced MHC-I expression, modification of peptide and engineered TCR for clinical applications such as vaccine design, tumor therapy and autoimmune diseases. | Qingjun Liu Bin Gao | 2008 | Cellular & Molecular Immunology2008，5，3： | 2 |
| 15 | A Novel Electric Dual Motor Transmission for Heavy Commercial Vehicles显示文摘As a vital vehicle part,the powertrain system is undergoing a fast transition towards electrification.The new integrated electric drive system has been widely used,especially for passenger cars.In this work,a novel electric dual motor transmission is proposed for heavy commercial vehicles.The transmission scheme is firstly introduced,which can achieve 9 different operating modes including 5 single motor modes and 4 dual motor modes.Then,the mode shift map with minimum energy consumption is designed based on the motor efficiency map and the proposed energy management strategy.The driving power is appropriately distributed between the two motors in dual motor modes under the condition of minimum power consumption.In addition,a coordinated control strategy is developed for mode shift control without power interruption.The results show that the electric dual motor transmission has advantages in power consumption and power shift ability compared with the conventional single motor automated manual transmission. | Xiangyang Xu Jiajia Liang Qingjun Hao Peng Dong Shuhan Wang Wei Guo Yanfang Liu Zhonghua Lu Jiantao Geng Bin Yan | 2021 | Automotive Innovation2021，4，1： | 2 |
| 16 | The development of taste transduction and taste chip technology显示文摘The intrinsic perception process of taste is ob- viously far less known than those of vision, audition, touch and olfaction. Despite that taste cells utilize a variety of sen- sory mechanisms to translate plenty of gustatory sensations such as sour, sweet, bitter, salty and umami into cellular sig- nals, gustatory perception mechanisms are still under explo- ration due to the lack of effective methods on cellular and molecular level. Recently the development of molecular bio- logical and electrophysiological studies has promoted explo- ration of olfactory and gustatory transduction and coding mechanisms dramatically. Based on the studies of artificial olfaction, artificial taste and cell-based biosensor in our laboratory, this paper reviews the current research on taste transduction mechanism. We introduce the recent advances in cell chip that combined biology with microelectronics, discuss taste cell chip as well as its potential of prospective application in taste transduction mechanism in detail and propose the research trends of taste chip in future. | LI Yan LIU Qingjun XU Ying CAI Hua QIN Lifeng WANG Lijiang WANG Ping | 2005 | Chinese Science Bulletin2005，50，14： | 2 |
| 17 | Zinc-based metal organic framework with antibacterial and anti-inflammatory properties for promoting wound healing显示文摘The synergistic effect of antibacterial and anti-inflammatory is needed to overcome the problem of wound healing difficulties.Based on the favorable antibacterial and anti-inflammatory effect of zinc ions(Zn^(2+))and the physicochemical properties of metal organic frameworks(MOFs),we prepared nanosized zinc-based MOF:Zn-BTC with the ability to slowly release Zn^(2+).In cellular levels,Zn-BTC possessed lower toxicity to fibroblasts and enhanced capacity of cell proliferation and migration.It also had good bactericidal effect on multiple drug-resistant bacteria by reducing 41.4%MRSA and 47.2%Escherichia coli.In addition,Zn-BTC also displayed the ability of lowering the expression of antioxidant genes:superoxide dismutase 1,superoxide dismutase 2 and interleukin 6,and enhancing the expression of wound healing genes:transforming growth factors-b and type I collagen.Finally,it also demonstrated that Zn-BTC could effectively improve the skin wound healing of SD rats and had no toxicity on major organs.The favorable biocompatibility,antibacterial and anti-inflammatory properties of Zn-BTC gave a new insight of designing novel MOFs for promoting skin wound healing. | Yuting Chen Jinhong Cai Dachang Liu Shuhan Liu Doudou Lei Li Zheng Qingjun Wei Ming Gao | 2022 | Regenerative Biomaterials2022，9，1： | 2 |
| 18 | Sulfate sources constrained by sulfur and oxygen isotopic compositions in the upper reaches of the Xijiang River,China显示文摘While it is critical to accurately understand the sources and transformation of sulfate based on time-series analysis, there are limited studies on temporal variation of sulfate in rivers and on rock weathering by sulfuric acids.We conducted a monthly sampling campaign in the Beipan, Nanpan, and Hongshui Rivers over the course of one hydrological year. This study examined seasonal variations in riverine sulfate impacted by the monsoon climate in the upper reaches of the Xijiang River basin. In general, the SO_4^(2-) contents in these rivers dropped from relatively high levels to low values during the high-flow season, in response to increasing discharge. The sulfate was generally enriched in heavy isotopes during the low-flow season compared to the high-flow season. The calculated results indicate that the riverine sulfate was mainly derived from sulfide oxidation, but that evaporite dissolution could be an important source during the low-flow season, based on isotopic evidence. Mine drainage is likely an important source of sulfate to these rivers during the high-flow season due to contributions from fast surface flow, which responds to frequent heavy rain in monsoonal climate regions. Arelatively high proportion of HCO_3^- was found to be derived from rock weathering by sulfuric acid during the high-flow season when compared to that observed during the low-flow season. The results suggest that approximately one quarter of the HCO_3^- in the Hongshui River originated from carbonate weathering by sulfuric acid derived from the oxidation of sulfide. Such information on the specific dual isotopic characteristics of riverine sulfate throughout a hydrological year can provide unique evidence for understanding the temporal variability of sulfate concentrations and weathering processes in rivers. | Jing Liu Siliang Li Jun Zhong Xuetao Zhu Qingjun Guo Yunchao Lang Xiaokun Han | 2017 | Acta Geochimica2017，36，4： | 2 |
| 19 | The influence of weakly-supplemented subgroups on the structure of finite groups显示文摘 | KONG Qingjun LIU Qingfeng | 2014 | Czech MathJ2014，64，139： | 1 |
| 20 | Intrinsic physical relationships between rotor modal shapes and instantaneous vibrational energy flow transmission characteristics:Theoretical and numerical analysis and application显示文摘The modal vibration of the rotor is the main cause of excessive vibration of the aeroengine overall structure.To attenuate the vibration of the rotor under different modal shapes from the perspective of energy control,the intrinsic physical relationships between rotor modal shapes and instantaneous vibrational energy flow transmission characteristics is derived from the general equation of motion base on the structural intensity method.A dual-rotor-support-casing coupling model subjected to the rotor unbalanced forces is established by the finite element method in this paper.The transmission,conversion and balance relationships of the vibrational energy flow for the rotors in the first-order bending modal shape,the conical whirling modal shape and the translational modal shape are analyzed,respectively.The results show that the vibrational energy flow transmitted to the structure can be converted into the strain energy,the kinetic energy and the energy dissipated by the damping of the structure.The vibrational energy flow transmission characteristics of rotors with different modal shapes are quite different.Especially for the first-order bending modal shape,the vibrational energy flow and the strain energy are transmitted and converted to each other in the middle part of the rotor shaft,resulting in large deformation at this part.To attenuate this harmful vibration,the influences of grooving on the shaft on the first-order bending vibration are studied from the perspective of transmission control of vibrational energy flow.This study can provide theoretical references and guidance for the vibration attenuation of the rotors in different modal shapes from a more essential perspective. | Yingqun MA Qingjun ZHAO Wei ZHAO Binbin LIU Long HAO | 2020 | Chinese Journal of Aeronautics2020，33，12： | 1 |
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