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| 1 | Natural Morin-Based Metal Organic Framework Nanoenzymes Modulate Articular Cavity Microenvironment to Alleviate Osteoarthritis显示文摘Osteoarthritis(OA)is always characterized as excessive reactive oxygen species(ROS)inside articular cavity.Mimicking natural metalloenzymes with metal ions as the active centers,stable metal organic framework(MOF)formed by natural polyphenols and metal ions shows great potential in alleviating inflammatory diseases.Herein,a series of novel copper-morin-based MOF(CuMHs)with different molar ratios of Cu^(2+)and MH were employed to serve as ROS scavengers for OA therapy.As a result,CuMHs exhibited enhanced dispersion in aqueous solution,improved biocompatibility,and efficient ROS-scavenging ability compared to MH.On the basis of H_(2)O_(2)-stimulated chondrocytes,intracellular ROS levels were efficiently declined and cell death was prevented after treated by Cu_(6)MH(Cu^(2+)and MH molar ratio of 6:1).Meanwhile,Cu_(6)MH also exhibited efficient antioxidant and anti-inflammation function by down-regulating the expression of IL6,MMP13,and MMP3,and up-regulating cartilage specific gene expression as well.Importantly,Cu_(6)MH could repair mitochondrial function by increasing mitochondrial membrane potential,reducing the accumulation of calcium ions,as well as promoting ATP content production.In OA joint model,intra-articular(IA)injected Cu_(6)MH suppressed the progression of OA.It endowed that Cu_(6)MH might be promising nanoenzymes for the prevention and treatment of various inflammatory diseases. | Jinhong Cai Lian-feng Liu Zainen Qin Shuhan Liu Yonglin Wang Zhengrong Chen Yi Yao Li Zheng Jinmin Zhao Ming Gao | 2023 | Research2023，，4： | 0 |
| 2 | 澳洲坚果壳活性炭载锌复合抗菌材料的制备及性能研究显示文摘以澳洲坚果壳为原料,采用氯化锌活化法制备粉末活性炭作为抗菌材料载体,通过浸渍法将Zn^(2+)负载于活性炭的表面和微孔中,得到活性炭载锌复合抗菌材料。利用碘吸附值、氮气吸脱附、扫描电子显微镜、电感耦合等离子体-发射光谱及抗菌实验对材料进行表征。结果表明:活性炭材料具有多孔结构,比表面积达644.118 m^(2)/g,平均孔径为2.289 nm,碘吸附值为1018 mg/g。以硫酸锌为锌源,炭锌接触时间7 h、炭锌浸渍比1∶25、锌溶液浓度1.0 mol/L时,制备的活性炭载锌复合抗菌材料具有较好的杀菌性能,对大肠杆菌和金黄色葡萄球菌都能达到99.9%的抗菌率。活性炭载锌复合抗菌材料与织物浸渍得到的抗菌织物也具有较好的抗菌效果,展现了良好的应用前景。本研究可为拓宽废弃生物质资源的应用范围提供参考。 | 张建珠 杨正芳 潘源江 张彬 聂艳丽 | 2024 | 西南林业大学学报(自然科学)2024，44，1： | 0 |
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