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| 1 | Effect of sintering temperature in argon atmosphere on microstructure and properties of 3D printed alumina ceramic cores显示文摘Alumina ceramics with different sintering temperatures in argon atmosphere were obtained using stereolithography-based 3D printing.The effects of sintering temperature on microstructure and physical and mechanical properties were investigated.The results show that the average particle size,shrinkage,bulk density,crystallite size,flexural strength,Vickers hardness,and nanoindentation hardness increased with the increase in sintering temperature,whereas the open porosity decreased with increasing sintering temperature.No change was observed in phase composition,chemical bond,atomic ratio,and surface roughness.For the sintered samples,the shrinkage in Z direction is much greater than that in X or Y direction.The optimum sintering temperature in argon atmosphere is 1350℃with a shrinkage of 3.0%,3.2%,and 5.5%in X,Y,and Z directions,respectively,flexural strength of 26.7 MPa,Vickers hardness of 198.5 HV,nanoindentation hardness of 33.1 GPa,bulk density of 2.5 g/cm^3,and open porosity of 33.8%.The optimum sintering temperature was 70℃higher than that sintering in air atmosphere when achieved the similar properties. | He LI Yongsheng LIU Yansong LIU Qingfeng ZENG Kehui HU Zhigang LU Jingjing LIANG | 2020 | Journal of Advanced Ceramics2020，9，2： | 13 |
| 2 | Hierarchical Ni-Co-S@Ni-W-O core-shell nanosheet arrays on nickel foam for high-performance asymmetric supercapacitors显示文摘镍钴硫化物(Ni-Co-S ) 由于他们的优秀传导性和高电气化学的电容在电子设备为申请吸引了广泛的注意。为了便于 Ni-Co-S,优秀的率能力和这些的周期的稳定性的大规模实际申请,混合物必须充分被利用。因此,镍泡沫上的层次 Ni-Co-S@Ni-W-O (Ni-Co-S-W ) 核心 / 壳混血儿 nanosheet 数组经由一个灵巧的三步的热水的方法此处被设计并且综合,由在氩空气下面在一个管状的炉子退火列在后面。混合结构直接作为一个自立的电极被装配,它展出了 1,988 F | Weidong He Zhifu Liang Keyu ji Qingfeng Sun Tianyou Zhai Xijin Xu | 2018 | Nano Research2018，11，3： | 7 |
| 3 | Massive cranium from Harbin in northeastern China establishes a new Middle Pleistocene human lineage显示文摘It has recently become clear that several human lineages coexisted with Homo sapiens during the late Middle and Late Pleistocene.Here,we report an archaic human fossil that throws new light on debates concerning the diversification of the Homo genus and the origin of H.sapiens.The fossil was recovered in Harbin city in northeastern China,with a minimum uranium-series age of 146 ka.This cranium is one of the best preserved Middle Pleistocene human fossils.Its massive size,with a large cranial capacity(1,420 mL)falling in the range of modern humans,is combined with a mosaic of primitive and derived characters.It differs from all the other named Homo species by presenting a combination of features,such as long and low cranial vault,a wide and low face,large and almost square orbits,gently curved but massively developed supraorbital torus,flat and low cheekbones with a shallow canine fossa,and a shallow palate with thick alveolar bone supporting very large molars.The excellent preservation of the Harbin cranium advances our understanding of several less-complete late Middle Pleistocene fossils from China,which have been interpreted as local evolutionary intermediates between the earlier species Homo erectus and later H.sapiens.Phylogenetic analyses based on parsimony criteria and Bayesian tip-dating suggest that the Harbin cranium and some other Middle Pleistocene human fossils from China,such as those from Dali and Xiahe,form a third East Asian lineage,which is a part of the sister group of the H.sapiens lineage.Our analyses of such morphologically distinctive archaic human lineages from Asia,Europe,and Africa suggest that the diversification of the Homo genus may have had a much deeper timescale than previously presumed.Sympatric isolation of small populations combined with stochastic long-distance dispersals is the best fitting biogeographical model for interpreting the evolution of the Homo genus. | Xijun Ni Qiang Ji Wensheng Wu Qingfeng Shao Yannan Ji Chi Zhang Lei Liang Junyi Ge Zhen Guo Jinhua Li Qiang Li Rainer Grun Chris Stringer | 2021 | The Innovation2021，2，3： | 6 |
| 4 | Molecular characteristics of the omp A gene of serotype B Chlamydia trachomatis in Qinghai Tibetan primary school students显示文摘To study the molecular characteristics of Chlamydia trachomatis, the major outer membrane protein gene(omp A) of C. trachomatis from primary school students with trachoma residing in the Qinghai Tibetan area was sequenced and compared with the same serotype in Gen Bank. In Jianshetang Primary School and Galeng Central Primary School in the Galeng Tibetan Township of Qinghai Haidong Sala Autonomous County, scraped samples were collected from the upper tarsal conjunctiva and lower conjunctival sac of both eyes of 45 students with trachoma, stored at 4°C, and transported to Beijing Tongren Hospital by air within 24 h. The samples were screened for C. trachomatis by real-time PCR. The omp A gene from the C. trachomatis-positive samples was amplified by nested PCR. The serotype was confirmed by National Center for Biotechnology Information(NCBI) BLAST search and homology analysis. The entire omp A gene sequence was compared with the corresponding gene sequences of serotype B strains available in Gen Bank. Of the 45 students aged 6–13 years with trachoma, 26 C. trachomatis-positive students were identified by the initial real-time PCR screening(average age,(9.09±1.63) years; sex ratio, 1.0), accounting for 57.78%(26/45). The cycle threshold values for real-time PCR were 16.79–37.77. Half(13/26) of C. trachomatis-positive students had a bacterial copy number of >105. The compliance rate of the omp A gene sequences with the C. trachomatis serotype B strains in Gen Bank was up to 99%. Two novel genetic mutations were found when the omp A gene was compared with those of the 11 serotype B strains in Gen Bank. The two non-synonymous mutations were located at(i) position 271 in the second constant domain, an adenine(A) to guanine(G) substitution(ACT?GCT), changing the amino acid at position 91 from threonine to alanine(Thr?Ala) in all 26 strains; and(ii) position 887 in the fourth variable domain, a cytosine(C) to thymine(T) substitution(GCA?GTA), changing the amino acid at residue 296 from alanine to valine(Ala?Val) in four of the 26 strains. Six mutations were identified relative to ATCC VR-573. The strains could be divided into two gene clusters according to the mutation at nucleotide position 887: CQZ-1(China Qinghai Tibetan-1) and CQZ-2(China Qinghai Tibetan-2). We thus detected two novel serotype B mutant strains of C. trachomatis among study subjects with trachoma. | Xue Li Shaoya Zhang Qingfeng Liang Mei Wang Ailian Hu Xiuyuan Li Benshan Yang Mingxin Zhang Ningli Wang Xinxin Lu | 2016 | Science China(Life Sciences)2016，59，6： | 6 |
| 5 | The chimeric genes in the hybrid lineage of Carassius auratus cuvieri(♀)×Carassius auratus red var.(♂)显示文摘Hybridization can combine the genomes of different strains or species, which leads to changes of genotype and phenotype in the hybrids. In this study, we aimed to investigate the genetic variations of hybrids(WR-F1 and WR-F2) derived from the intraspecific hybridization of white crucian carp(Carassius auratus cuvieri, WCC, ♀) and red crucian carp(Carassius auratus red var., RCC, ♂). Here, we compared the orthologous genes in the liver transcriptomes of hybrids with those of WCC and RCC, and classified the orthologous genes into eight gene patterns within three categories(chimera, mutant, and biparental origin genes).The results revealed 19.04%, 4.17% chimeric genes and 6.90%, 5.05% mutations of orthologous genes in WR-F1 and WR-F2 respectively. Seventeen of twenty-three characterized genes(77%) were confirmed to be the chimeras at the genomic DNA level.The GO classification discovered that some chimeric and mutant genes were related to metabolic process, immune system and developmental process in WR-F1. Our results provide the new evidence that hybridization can combine the parental genomes,leading to changes in the genotype of the resultant hybrids. This is the first report on the formation of chimeric genes from fish intraspecific hybridization, which is potentially interesting from the context of both evolution and the genetic breeding of fish. | Qingfeng Liu Yanhua Qi Qiuli Liang Xiujuan Xu Fangzhou Hu Jing Wang Jun Xiao Shi Wang Wuhui Li Min Tao Qinbo Qin Rurong Zhao Zhanzhou Yao Shaojun Liu | 2018 | Science China(Life Sciences)2018，61，9： | 6 |
| 6 | Targeted disruption of tyrosinase causes melanin reduction in Carassius auratus cuvieri and its hybrid progeny显示文摘The white crucian carp(Carassius auratus cuvieri,WCC) not only is one of the most economically important fish in Asia,characterized by strong reproductive ability and rapid growth rates,but also represents a good germplasm to produce hybrid progenies with heterosis.Gene knockout technique provides a safe and acceptant way for fish breeding.Achieving gene knockout in WCC and its hybrid progeny will be of great importance for both genetic studies and hybridization breeding.Tyrosinase(TYR) is a key enzyme in melanin synthesis.Depletion of tyr in zebrafish and mice results in mosaic pigmentation or total albinism.Here,we successfully used CRISPR-Cas9 to target tyr in WCC and its hybrid progeny(WR) derived from the cross of WCC(♀) and red crucian carp(Carassius auratus red var.,RCC,♂).The level of TYR protein was significantly reduced in mutant WCC.Both the mutant WCC and the mutant WR showed different degrees of melanin reduction compared with the wild-type sibling control fish,resulting from different mutation efficiency ranging from 60% to 90%.In addition,the transcriptional expression profiles of a series of pivotal pigment synthesis genes,i.e.tyrp1,mitfa,mitfb,dct and sox10,were down-regulated in tyr-CRISPR WCC,which ultimately caused a reduction in melanin synthesis.These results demonstrated that tyr plays a key role in melanin synthesis in WCC and WR,and CRISPR-Cas9 is an effective tool for modifying the genome of economical fish.Furthermore,the tyr-CRISPR models could be valuable in understanding fundamental mechanisms of pigment formation in non-model fish. | Qingfeng Liu Yanhua Qi Qiuli Liang Jia Song Junmei Liu Wuhui Li Yuqin Shu Min Tao Chun Zhang Qinbo Qin Jing Wang Shaojun Liu | 2019 | Science China(Life Sciences)2019，62，9： | 4 |
| 7 | Fargeted elimination of mutant mitochondria DNA in MELAS-iPSCs by mitoTALENs显示文摘 | Yi Yang Han Wu Xiangjin Kang Yanhui Liang Ting Lan Tianjie Li Tao Tan Jiangyun Peng Quanjun Zhang Geng An Yali Liu Qian Yu Zhenglai Ma Ying Lian Boon Seng Soh Qingfeng Chen Ping Liu Yaoyong Chen Xiaofang Sun Rong Li Xiumei Zhen Yang Yu Xiaoping Li Yong Fan | 2018 | Protein & Cell2018，9，3： | 4 |
| 8 | Characteristics of pathogenic microorganisms found in 99 cases of conjunctivitis from the Qinghai Tibetan area显示文摘Dear Editor,Morbidity associated with conjunctivitis is higher in developing countries,particularly among children,because of the poorer standards of living(Azari and Barney,2013;Yetman and Coody,1997).Presently,little is known regarding the microorganisms that cause conjunctivitis in the remote area of Chinese Tibet.In particular,it is difficult to monitor and control the occurrence of conjunctivitis in children from this area.Conjunctivitis has two forms:acute and chronic. | Benshan Yang Xiuyuan Li Qingfeng Liang Shaoya Zhang Shijing Deng | 2016 | Science China(Life Sciences)2016，59，6： | 4 |
| 9 | Study of infectious conjunctivitis among children in rural areas of Qinghai province显示文摘Infectious conjunctivitis is no longer a common eye disease in cities and developed areas, but in remote mountainous regions of China where living conditions are relatively under-developed, the occurrence of infectious conjunctivitis remains a public health issue. Here, we evaluate the ratio of infectious conjunctivitis among primary school students in the rural areas of Xunhua, Huangyuan, and Huzhu Counties in the Qinghai province of China, and report the microorganisms involved in causing infection. Of the 765 eligible primary school students, 694 participated to this study(a response rateof 90.7%), 381 boys and 313 girls, with a mean age of 7.52 years(range 7–9 years). A clinical diagnosis of infectious conjunctivitis was returned for 238 of the 694 children examined. The ratio of infectious conjunctivitis in Xunhua County(46.64%) was higher compared to that in Huangyuan(26.67%; P=0.03) and Huzhu Counties(23.61%; P=0.02). The leading cause of conjunctivitis was bacterial, followed by chlamydial and viral. Our results show that there is a high ratio of infectious conjunctivitis among rural primary school students in Qinghai province. | Qingfeng Liang Xinxin Lu Mei Wang Lei Tian Antoine Labbé Ailian Hu | 2016 | Science China(Life Sciences)2016，59，6： | 3 |
| 10 | Contents Variation Analysis ofγ-Amino Butyric Acid in Semen sojae praeparatum Fermentation Using Online Pre-Column Derivatization-HPLC显示文摘This paper reported the contents variation analysis ofγ-amino butyric acid(GABA)in Semen sojae praeparatum(SSP)which is a famous traditional Chinese medicine.High performance liquid chromatography(HPLC)was used and GABA was derivatized by online pre-column derivatization with o-phthalaldehyde(OPA).To validate this method,the precision,stability,repeatability and recovery were discussed.In the concentration range from 0.0125 to 0.400 mg/m L,the calibration curve for GABA was linear and the regression equation was obtained with correlation coefficient(R2)of 0.9999.Relatively high levels of GABA exist in SSP and the content changes of GABA at different time points during the fermenting process were detected.At the'yellow cladding'stage,GABA level was very low or even undetectable;the'secondary fermentation'stage witnessed a rapid increase of GABA content to 1.39-5.52 mg/g,which remained stable after 18 days of'secondary fermentation'.This study demonstrated that GABA was generated at the'secondary fermentation'stage,revealing the significance and rationality of the'secondary fermentation'stage in the fermenting process of SSP.On the other hand,it suggested the downside of taking soy isoflavones as the only measurement in existing quality assessment and optimization approach for the fermenting process of SSP. | WENG Meizhi HE Jing REN Jiaxiu LIANG Yonghong CHEN Qingfeng SU Mingsheng WANG Liyuan XIE Xiaomei | 2021 | Wuhan University Journal of Natural Sciences2021，26，1： | 2 |
| 11 | Mechanism study of trans-lamina cribrosa pressure difference correlated to optic neuropathy in individuals with glaucoma显示文摘Glaucoma is the second leading cause of blindness after cataract worldwide.However,among irreversible blinding eye diseases,glaucoma is the primary cause(Liang et al.,2011).To date,most studies have indicated that glaucoma is not only an ocular disease,but also an optic nerve disease.In particular,primary open-angle glaucoma(POAG)is characterized by insidious onset,painless visual impairment,and complicated pathological mechanism,and patients with such condition require long-term follow-up.However,the underlying cause of POAG remains unclear,and there are several theories about its exact etiology.Some mechanisms have presented underlying optic nerve damage,which include the mechanical theory,vascular theory,and the in・volvement of other factors. | Qingfeng Liang Leying Wang Xuyang Liu | 2020 | Science China(Life Sciences)2020，63，1： | 2 |
| 12 | Development of a roll-bonded UNS N08825 alloy clad pipeline steel in Baosteel显示文摘In this study,a roll-bonded UNS N088225 alloy clad pipeline steel was investigated and developed in Baosteel. Based on the requirements of a number of potential projects,we performed a series of strict evaluations including mechanical and corrosion tests. The results show the mechanical properties and corrosion resistance of this clad steel to be excellent and to meet the requirements of all the design parameters. | LIANG Xiaojun MA Tianjun FU Yanhong JIAO Sihai DING Jianhua YUAN Xiangqian WANG Baosen ZHANG Qingfeng | 2017 | Baosteel Technical Research2017，11，1： | 1 |
| 13 | Numeri-cal modeling for non-steady thermal stress analysis of slag layer in a membrane wall entrained-flow gasifier显示文摘 | LIN Weining LIANG Qingfeng YU Guangsuo | 2011 | Fu-el2011，90，7： | 1 |
| 14 | Understanding production potentials and yield gaps in intensive maize production in China显示文摘 | Qingfeng Meng Peng Hou Liang Wu Xinping Chen Zhenling Cui Fusuo Zhang | 2012 | Field Crops Research2012，，： | 1 |
| 15 | Science with the 2.5-meter Wide Field Survey Telescope(WFST)显示文摘The Wide Field Survey Telescope(WFST) is a dedicated photometric surveying facility being built jointly by University of Science and Technology of China(USTC) and the Purple Mountain Observatory(PMO). It is equipped with a 2.5-meter diameter primary mirror, an active optics system, and a mosaic CCD camera with 0.73 gigapixels on the primary focal plane for highquality image capture over a 6.5-square-degree field of view. The installation of WFST near the summit of Saishiteng mountain in the Lenghu region is scheduled in summer of 2023, and the operation is planned to start three months later. WFST will scan the northern sky in four optical bands(u, g, r and i) at cadences from hourly/daily in the deep high-cadence survey(DHS) program, to semi-weekly in the wide field survey(WFS) program. During a photometric night, a nominal 30 s exposure in the WFS program will reach a depth of 22.27, 23.32, 22.84, and 22.31(AB magnitudes) in these four bands, respectively, allowing for the detection of a tremendous amount of transients in the low-z universe and a systematic investigation of the variability of Galactic and extragalactic objects. In the DHS program, intranight 90 s exposures as deep as 23(u) and 24 mag(g), in combination with target of opportunity follow-ups, will provide a unique opportunity to explore energetic transients in demand for high sensitivities, including the electromagnetic counterparts of gravitational wave events, supernovae within a few hours of their explosions,tidal disruption events and fast, luminous optical transients even beyond redshift of unity. In addition, the final 6-year co-added images, anticipated to reach g■25.8 mag in WFS or 1.5 mags deeper in DHS, will be of fundamental importance to general Galactic and extragalactic science. The highly uniform legacy surveys of WFST will serve as an indispensable complement to those of the Vera C. Rubin Observatory's Legacy Survey of Space and Time(LSST) that monitors the southern sky. | Tinggui Wang Guilin Liu Zhenyi Cai Jinjun Geng Min Fang Haoning He Ji-an Jiang Ning Jiang Xu Kong Bin Li Ye Li Wentao Luo Zhizheng Pan Xuefeng Wu Ji Yang Jiming Yu Xianzhong Zheng Qingfeng Zhu Yi-Fu Cai Yuanyuan Chen Zhiwei Chen Zigao Dai Lulu Fan Yizhong Fan Wenjuan Fang Zhicheng He Lei Hu Maokai Hu Zhiping Jin Zhibo Jiang Guoliang Li Fan Li Xuzhi Li Runduo Liang Zheyu Lin Qingzhong Liu Wenhao Liu Zhengyan Liu Wei Liu Yao Liu Zheng Lou Han Qu Zhenfeng Sheng Jianchun Shi Yiping Shu Zhenbo Su Tianrui Sun Hongchi Wang Huiyuan Wang Jian Wang Junxian Wang Daming Wei Junjie Wei Yongquan Xue Jingzhi Yan Chao Yang Ye Yuan Yefei Yuan Hongxin Zhang Miaomiao Zhang Haibin Zhao Wen Zhao | 2023 | Science China(Physics,Mechanics & Astronomy)2023，66，10： | 1 |
| 16 | Charge disproportionation induced exchange bias in La_(0.5)Ca_(0.5)FeO_(3-δ)显示文摘We observed an exchange bias effect in La0.5Ca0.5FeO3 perovskite compound.The exchange bias is associated with the charge disproportionation transition from Fe4+ions to Fe3+and Fe5+ions below 175 K.The competition between the ferromagnetic interaction of Fe3+and Fe5+ions and the antiferromagnetic one of Fe3+and Fe3+ions results in a unidirectional anisotropy in the cluster-glass system.An antiferromagnetically interfacial exchange coupling constant Ji1.95 meV at the cluster-glass region was yielded by fitting the cooling field-dependence of the exchange bias field. | LIANG YaQiong ZHANG XiangQun JIN JinLing ZHAN QingFeng CHENG ZhaoHua | 2013 | Science China(Physics,Mechanics & Astronomy)2013，56，11： | 1 |
| 17 | Estimating the Spatial Variation of Electricity Consumption Anomalies and the Influencing Factors显示文摘Effective detection of abnormal electricity users and analysis of the spatial distribution and influencing factors of abnormal electricity consumption in urban areas have positive effects on the quality of electricity consumption by customers,safe operation of power grids,and sustainable development of cities.However,current abnormal electricity consumption detection models do not consider the time dependence of time-series data and rely on a large number of training samples,and no study has analyzed the spatial distribution and influencing factors of abnormal electricity consumption in urban areas.In this study,we use the Seasonal-Trend decomposition procedure based on Loess(STL)based time series decomposition and outlier detection to detect abnormal electricity consumption in the central city of Pingxiang,and analyze the relationship between spatial variation and urban functions through Geodetector.The results show that the degree of abnormal electricity consumption in urban areas is related to geographic location and has spatial heterogeneity,and the abnormal electricity users are mainly located in areas with highly mixed residential,commercial and entertainment functions in the city.The results obtained from this study can provide a reference basis and a theoretical foundation for the detection of abnormal electricity consumption by users and the arming of electricity theft devices in the power grid. | Yuyun LIANG Yao YAO Xiaoqin YAN Qingfeng GUAN | 2022 | Journal of Geodesy and Geoinformation Science2022，5，2： | 1 |
| 18 | Ice-volume and insolation influences on hydroclimate changes in central eastern China during the antepenultimate glacial period显示文摘The rainfall changes in East Asian summer monsoon(EASM)regions on the orbital timescale remain controversial due to the lack of reliable rainfall records.Here,we present new multiproxy records(δ^(18)O,δ^(13)C,Sr/Ca and Mg/Ca)of a230Thdated stalagmite from Hulu Cave in central eastern China.Multiproxy records reconstruct a regional hydroclimate history from 340 to 261 kyr BP(thousand years before present),approximately covering the antepenultimate glacial period.Theδ^(18)O record is dominated by the precessional cycles,suggesting that EASM responds to changes in Northern Hemisphere summer insolation(NHSI)on the orbital timescale.Significant correlations amongst theδ^(13)C,Sr/Ca and Mg/Ca suggest that a common factor,i.e.,the local hydrological cycle,controlled their variability,and their leading principal component can be used as a proxy linked to regional rainfall.This composite record bears a good similarity to those from the Chinese Loess Plateau,showing a gradually decreasing rainfall during the antepenultimate glacial period,consistent with changes in global ice volume.Superimposed on the long-term trend,three relative wetter intervals were responding to the higher NHSI periods,suggesting that EASM rainfall variability was induced by integrated effects of global ice volume and NHSI.The increased ice sheets and lower NHSI resulted in an increased meridional temperature gradient and southward shift of the westerlies,which shortened the duration of Meiyu and midsummer rainfall.The differences between the rainfall record and the stalagmiteδ^(18)O record indicate that the latter represents the overall EASM intensity linked to monsoon circulation,but does not directly reflect the rainfall changes at the cave sites. | Quan WANG Shayue YUAN Yijia LIANG Kan ZHAO Qingfeng SHAO Zhenqiu ZHANG Junji ZHU Xinggong KONG Yongjin WANG Jianghu LAN Hai CHENG Chengwei XIA Yi LI | 2023 | Science China Earth Sciences2023，66，1： | 0 |
| 19 | Modification Mechanism and Uniaxial Fatigue Performances of A356.2 Alloy Treated by Al-Sr-La Composite Refinement-Modification Agent显示文摘Modification mechanism and uniaxial fatigue properties of A356.2 alloy treated by Al-6Sr-7La and traditional Al-5Ti-1B/Al-10Sr(hereinafter refers to traditional treated alloy) were investigated by constant stress amplitude method. Microstructure, dislocation and Si twinning of the alloys were studied by thermal analysis, scanning electron microscopy(SEM) and transmission electron microscopy(TEM). The results showed that Al-6Sr-7La possesses better refining and modification effect than Al-5Ti-1B/Al-10Sr. Meanwhile, fatigue properties of the alloy treated by Al-6Sr-7La are higher than traditional treated alloy, and this is mainly owing to that Al-6Sr-7La treated alloy has more twins in eutectic Si and lower twin spacing. In addition, higher density of nanophases formed on twin faces and La-rich clusters appear at multiple twin intersections. Stacking faults and entrapped nanophases appeared on growing Si twin faces. Impurity induced twinning(IIT) mechanism and twin plane re-entrant edge(TPRE) mechanism are valid for eutectic Si which are important for mechanical optimization of A356.2 alloy. | Liang Chang Qingfeng Zhao Xingchuan Xia Yuming Ding Binxu Guo Jian Ding Ying Tang Zan Zhang Chong Li Xiaomian Sun Junjie Guo Kaihong Song Yongchang Liu | 2022 | Acta Metallurgica Sinica(English Letters)2022，35，6： | 0 |
| 20 | Anti-miR-200b promotes wound healing by regulating fibroblast functions in a novel mouse model显示文摘MicroRNA-200b(miR-200b)down-regulation has been found in wound-healing tissues.Fibroblasts are the predom inant cells that orchestrate the production of collagen in w ound healing.However,it is still unclear w hether miR-200b can affect the wound healing by regulating the fibroblasts function.The current rodent wound-healing models are not ideal due to their marked difference in structure compared w ith the human skin.In this study,we dem onstrated that the m urine plantar skin had sim ilar anatomical features to the human skin.Using this model,the gain/loss of-function studies showed that miR-200b caused a significantly delayed w ound healing in vivo.Furthermore,using cell proliferation,m igration and collagen synthesis assays,we found that miR-200b attenuated cell proliferation,m igration and collagen synthesis of fibroblasts,which are critical aspects of w ound healing.miR-200b also decreased the expression of Zeb1.Collectively,we established a new m urine plantar skin model for the investigation of wound healing,and based on it we found that miR-200b affected the wound healing by regulating the biological function of fibroblasts,which provided a new insight for wound healing. | Renpeng Zhou Chen Wang Yimin Liang Xiangqi Li Qingfeng Li | 2019 | Acta Biochimica et Biophysica Sinica2019，51，10： | 0 |
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