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| 1 | The development of a new bioartificial liver and its application in 12 acute liver failure patients显示文摘AIM: Bioartificial liver is a hope of supporting liver functions in acute liver failure patients. Using polysulfon fibers, a new bioartificial liver was developed. The aim of this study was to show whether this bioartificial liver could support liver functions or not.METHODS: Hepatocytes were procured from swine using Seglen′s methods. The bioartificial liver was constructed by polysulfon bioreactor and more than 10 10 hepatocytes. It was applied 14 times in 12 patients, who were divided into 7 cases of simultaneous HBAL and 5 cases of nonsimultaneous HBAL. Each BAL treatment lasted 6 hours. The general condition of the patients and the biochemical indexes were studied.RESULTS: After treatment with bioartificial liver, blood ammonia, prothrombin time and total bilirubin showed significant decrease. 2 days later, blood ammonia still showed improvment. within one month period, 1 case (1/7) in simultaneous group died while in non-simultaneous group 2 cases (2/5) died. The difference was significant. Mortality rate was 25 %.CONCLUSION: The constructed bioartificial liver can support liver functions in acute liver failure. The simultaneous HBAL is better than non-simultaneous HBAL. | Yi-TaoDing Yu-DongQiu ZhongChen Qing-XiangXu He-YuanZhang QingTang De-CaiYu | 2003 | World Journal of Gastroenterology2003，9，4： | 26 |
| 2 | Molecular Characterization of Viral G Gene in Emerging and Re-emerging Areas of Rabies in China, 2007 to 2011显示文摘In recent years (2007 to 2011), although the overall number of rabies cases in China has decreased, there is evidence of emerging or re-emerging cases in regions without previous rabies cases or with low incidence of rabies. To investigate the origin and the factors affecting the spread of rabies in China, specimens were collected from 2007 to 2011 from provinces with emerging and re-emerging cases and tested for the presence of the rabies virus. Positive specimens were combined with sequences from GenBank to perform comparisons of homology and functional sites, and to carry out phylogenetic analyses. Out of these regions, five provinces had 9 positive specimens from canine and cattle, and 34 canine or human specimens were obtained from previously high-incidence provinces. Complete sequences of G gene were obtained for these samples. Homology of the sequences of these 43 specimens was 87%-100% at the nucleotide level and 93.7% -100% at the amino acid level. These G gene sequences were combined with reference sequence from GenBank and used to construct a phylogenetic tree. The results showed that 43 specimens were all assigned to China clade I and clade II, with all specimens from emerging and re-emerging areas placed within clade I. Specimens isolated from Shanxi and Inner Mongolia in 2011 were distinct from previously-isolated local strains and had closer homology to strains from Hebei, Beijing and Tianjin whereas new isolates from Shanghai were tightly clustered with strains isolated in the 1990s. Finally, Shaanxi isolates were clustered with strains from adjacent Sichuan. Our results suggest that the rabies cases in emerging and re-emerging areas in China in the last 5 years are a consequence of the epidemic spreading from of neighboring provinces and regions experiencing a serious epidemic of rabies. | Shu-LinLang Xiao—YanTao Zhen-YangGuo QingTang HaoLi Cui.PingYin YingLi Guo—DongLiang | 2012 | Virologica Sinica2012，27，3： | 18 |
| 3 | Factors predicting sensory and motor recovery after the repair of upper limb peripheral nerve injuries显示文摘OBJECTIVE: To investigate the factors associated with sensory and motor recovery after the repair of upper limb peripheral nerve injuries. DATA SOURCES: The online PubMed database was searched for English articles describing outcomes after the repair of median, ulnar, radial, and digital nerve injuries in humans with a publication date between 1 January 1990 and 16 February 2011. STUDY SELECTION: The following types of article were selected:(1) clinical trials describing the repair of median, ulnar, radial, and digital nerve injuries published in English; and(2) studies that reported sufficient patient information, including age, mechanism of injury, nerve injured, injury location, defect length, repair time, repair method, and repair materials. SPSS 13.0 software was used to perform univariate and multivariate logistic regression analyses and to investigate the patient and intervention factors associated with outcomes. MAIN OUTCOME MEASURES: Sensory function was assessed using the Mackinnon-Dellon scale and motor function was assessed using the manual muscle test. Satisfactory motor recovery was defined as grade M4 or M5, and satisfactory sensory recovery was defined as grade S3+ or S4.RESULTS: Seventy-one articles were included in this study. Univariate and multivariate logistic regression analyses showed that repair time, repair materials, and nerve injured were independent predictors of outcome after the repair of nerve injuries(P < 0.05), and that the nerve injured was the main factor affecting the rate of good to excellent recovery. CONCLUSION: Predictors of outcome after the repair of peripheral nerve injuries include age, gender, repair time, repair materials, nerve injured, defect length, and duration of follow-up. | Bo He Zhaowei Zhu Qingtang Zhu Xiang Zhou Canbin Zheng Pengliang Li Shuang Zhu Xiaolin Liu Jiakai Zhu | 2014 | Neural Regeneration Research2014，9，6： | 12 |
| 4 | Multi-drug Resistance and Characteristic of Integrons in Shigella spp.Isolated from China显示文摘Objective To investigate the characteristic of integrons and the relationship between integrons and antimicrobial resistance in Shigella spp. Methods Ninety Shigella strains (83 S. flexneri and 7 S. sonnei) were isolated from the stools of patients in China. Susceptibility to 8 antimicrobials was tested for all isolated strains. PCR, RFLP and sequencing analysis of integrons were applied to all of them. Results High prevalence of multi‐drug resistance (95.6%) was identified. Of the isolates 79 (87.8%) carried integrase genes of class 1 integron (3.3%), class 2 integron (10.0%) or both (74.4%). No intI3 was detected in the tested isolates. The prevalence of intI2 was significantly higher in isolates with multi‐drug resistance to at least 3 antibiotics than that in isolates with resistance to 2 and less antibiotics (P<0.05). Gene cassettes dfrA17‐aadA5, dfrA12‐orfF‐aadA2 of class 1 integron and dfrA1‐sat1‐aadA1 of class 2 integron were identified. Conclusion The class 2 integron may play a role in the emergence of multi‐drug resistance in Shigella spp. | ZHU JingYuan DUAN GuangCai YANG HaiYan FAN QingTang XI YuanLin | 2011 | Biomedical and Environmental Sciences2011，24，1： | 11 |
| 5 | The Full-length Genome Analysis of a Street Rabies Virus Strain Isolated in Yunnan Province of China显示文摘The epidemic of rabies has rapidly increased and expanded in Yunnan province in recent years. In order to further analyze and understand the etiological reasons for the rapid expansion of rabies in Yunnan, a strain of rabies virus CYN1009D in Yunnan was isolated, and the complete genomic sequencing was carried out, and the bioimfomative analysis on genes/encoded proteins and phylogeny with reference to sequences in GenBank was performed. The complete genome of CYN1009D was 11923 nt in length and belonged to genotype I. The genes encoding different structural proteins were all conserved in their lengths, in comparison to other strains in China. The amino acid sequence was conserved at different antigen sites of NP, but the variation was detected at the secondary phosphorylation site of position 375; variations were also detected in the phosphorylation sites at positions 63-63 and 162 of PP; the sites playing important roles in virus synthesis, budding and viral morphology in MP were conserved; two glycosylation sites were detected at Asn37 and Asn319 in GP, the neutralizing antigen sites in GP were conserved; the initial amino acid of LP (ML) was different from that of most of the strains in China (MM); the variations in G-L region in the intergenic region were significant. The phylogenic tree showed that CYN1009D has a closer genetic relationship to the strains in Southeast Asia, indicating that prevention and control on rabies in borderland areas should be reinforced meanwhile efforts are made to control rabies in China. | JianZhang Hai—linZhang Xiao-yanTao HaoLi QingTang | 2012 | Virologica Sinica2012，27，3： | 11 |
| 6 | Tobacco RING E3 Ligase NtRFP1 Mediates Ubiquitination and Proteasomal Degradation of a Geminivirus-Encoded βC1显示文摘西红柿黄叶卷屈中国联系病毒的 betasatellite 编码的 C1 蛋白质作为一个致病力决定因素工作。更好理解 C1 在致病力工作的分子的基础,酵母一个烟草 cDNA 图书馆的二混血儿的屏幕作为诱饵用 C1 被执行。屏幕表明 C1 与烟草戒指手指蛋白质交往指明了 NtRFP1,它被双分子的荧光互补和 co-immunoprecipitation 试金进一步在 Nicotiana benthamiana 房间证实。NtRFP1 的表示被 C1 导致,并且在 vitro ubiquitination,试金证明 NtRFP1 是调停的功能的 E3 ubiquitin ligase C1 ubiquitination。另外, C1 被显示是在 vivo 的 ubiquitinated 并且由植物 26S proteasome 降级。在病毒的感染以后,植物 overexpressing NtRFP1 开发了稀释症状,而有 NtRFP1 的 silenced 表示的植物显示出严重症状。证据的另外的线证明 NtRFP1 通过由 26S proteasome 支持它的降级稀释导致 C1 的症状。一起拿,我们的结果建议烟草戒指 E3 ligase NtRFP1 由与 C1 交往调停稀释疾病症状它经由 ubiquitin/26S proteasome 系统的 ubiquitination 和降级。 | Qingtang Shen Tao Hu Min Bao Linge Cao Huawei Zhang Fengmin Song Qi Xie Xueping Zhou | 2016 | Molecular Plant2016，9，6： | 8 |
| 7 | Growth Characteristics and Reinforcing Behavior of In-situ NbCp in Laser Cladded Fe-based Composite Coating显示文摘Over the past decade,researchers demonstrated much interest in laser cladded metal matrix composite coatings for its good wear resistance.In this paper,in-situ NbCp reinforced Fe-based wear-resistance coatings with different designed NbC contents were produced by laser cladding.The formation mechanism of NbC particle was analyzed.The effects of NbC content on the microstructure and mechanical properties of coatings were investigated.It was revealed that α-(Fe,Cr),(Fe,Cr)_7C_3,NbC existed in all coatings.NbC particles formed by the chemical reaction of Nb and C dissolved in the molten pool.The increase of designed NbC content led to the growth of the porosity amount,and the increase of the size and the area ratio of the particle,as well as the transformation of the NbCp morphology from quadrangle to petaloid shape.Moreover,the micro-hardness and the wear resistance of the coating were improved with the increase of NbC.When NbCp content was 30 wt%,the mechanical properties decreased slightly. | Qingtang Li Yongping Lei Hanguang Fu | 2015 | Journal of Materials Science & Technology2015，31，7： | 4 |
| 8 | A simple model of radial nerve injury in the rhesus monkey to evaluate peripheral nerve repair显示文摘Current research on bone marrow stem cell transplantation and autologous or xenogenic nerve transplantation for peripheral nerve regeneration has mainly focused on the repair of peripheral nerve defects in rodents.In this study,we established a standardized experimental model of radial nerve defects in primates and evaluated the effect of repair on peripheral nerve injury.We repaired 2.5-cm lesions in the radial nerve of rhesus monkeys by transplantation of autografts,acellular allografts,or acellular allografts seeded with autologous bone marrow stem cells.Five months after surgery,regenerated nerve tissue was assessed for function,electrophysiology,and histomorphometry.Postoperative functional recovery was evaluated by the wrist-extension test.Compared with the simple autografts,the acellular allografts and allografts seeded with bone marrow stem cells facilitated remarkable recovery of the wrist-extension functions in the rhesus monkeys.This functional improvement was coupled with radial nerve distal axon growth,a higher percentage of neuron survival,increased nerve fiber density and diameter,increased myelin sheath thickness,and increased nerve conduction velocities and peak amplitudes of compound motor action potentials.Furthermore,the quality of nerve regeneration in the bone marrow stem cells-laden allografts group was comparable to that achieved with autografts.The wrist-extension test is a simple behavioral method for objective quantification of peripheral nerve regeneration. | Dong Wang Xijun Huang Guo Fu Liqiang Gu Xiaolin Liu Honggang Wang Jun Hu Jianhua Yi Xiaofeng Niu Qingtang Zhu | 2014 | Neural Regeneration Research2014，9，10： | 3 |
| 9 | Progress and Outlook on Technologies for Processing Inferior Crude Oil in China显示文摘The recent growth of the global petroleum refining industry and the main technologies and measures for China to process inferior crude oil were introduced. The main technologies and measures include the control over equipment corrosion induced by sour and acidic crude, in particular the corrosion of atmospheric and vacuum distillation units, the development of technology for processing inferior residue, and the development of desulfurization technology and sulfur recovery technology in the course of processing of petroleum products. In order to meet the needs for national economic development, China’s refining enterprises will uninterruptedly develop and prefect technologies for processing inferior crude, enhance the process and equipment management, sum up the experience for better processing of inferior crude, so as to provide high-quality oil products and petrochemical feedstocks to public with better economic return. | Yuan Qingtang | 2008 | China Petroleum Processing & Petrochemical Technology2008，10，1： | 3 |
| 10 | Design and implementation of mediaplayer based on FFmpeg显示文摘 | Cheng Yun Liu Qingtang Zhao Chengling | 2012 | Software Engineering and Knowledge Engineering2012，115，： | 1 |
| 11 | Criteria for Score of clinical neurologicaldeficit in stroke显示文摘 | CHEN QINGTANG | 1996 | Chinese Journal of Neurology1996，29，6： | 1 |
| 12 | Optical wave breaking of high-intensity femtosecond pulses in silicon optical waveguides显示文摘 | Jianwei Wu Fengguang Luo Qingtang Zhang Mingcui Cao | 2008 | Optics and Laser Technology2008，，3： | 1 |
| 13 | Orthogonal multiwavelets with optimum time-frequency resolution 显示文摘 | | 1998 | IEEE Trans on Signal Proc1998，46，： | 1 |
| 14 | Orthogonal multiwavelets with optimum time-frequency resolution显示文摘 | Qingtang Jiang | 1998 | IEEE Trans On Signal Proc1998，46，4： | 1 |
| 15 | The hepatitis B virus X protein promotes hepatocellular carcinoma metastasis by upregulation of matrix metalloproteinases显示文摘 | Di‐PengOu Yi‐MingTao Fa‐QingTang Lian‐YueYang | 2007 | Int J Cancer2007，，6： | 1 |
| 16 | A novel model of adaptation decision-taking engine in multimedia adaptation显示文摘 | Tong Mingwen Yang Zongkai Liu Qingtang | 2010 | Journal of Network and Computer Applications2010，33，1： | 1 |
| 17 | Laser cladding in-situ NbC particle reinforced Fe-based composite coatings with rare earth oxide addition 显示文摘 | Qingtang Li Yongping Lei Hanguang Fu | 2014 | Surface and Coatings Technology2014，239，1： | 1 |
| 18 | Selection of fire-resistant tree species for southwestern China 显示文摘 | Tian Xiaorui Shu Lifu He Qingtang | 2001 | Foresty Studies in China2001，3，2： | 1 |
| 19 | Optical wave breaking of high-intensivety femto- seneond pulse in silicon optieal waveguides显示文摘 | Wu Jianwei Luo Fengguang Zhang Qingtang | 2009 | Optics & Laser Technology2009，41，： | 1 |
| 20 | Development of a lateral flow colloidal gold immunoassay strip for the rapid detection of enrofloxacin residues显示文摘 | ZHAO Yinli ZHANG Gaiping LIU Qingtang et ol | 2008 | J Agric Food Chem2008，56，12： | 1 |
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