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    题名 作者 年代 出处 被引量
1Ideotype root architecture for efficient nitrogen acquisition by maize in intensive cropping systems显示文摘The use of nitrogen(N) fertilizers has contributed to the production of a food supply sufficient for both animals and humans despite some negative environmental impact.Sustaining food production by increasing N use efficiency in intensive cropping systems has become a major concern for scientists,environmental groups,and agricultural policymakers worldwide.In high-yielding maize systems the major method of N loss is nitrate leaching.In this review paper,the characteristic of nitrate movement in the soil,N uptake by maize as well as the regulation of root growth by soil N availability are discussed.We suggest that an ideotype root architecture for efficient N acquisition in maize should include(i) deeper roots with high activity that are able to uptake nitrate before it moves downward into deep soil;(ii) vigorous lateral root growth under high N input conditions so as to increase spatial N availability in the soil;and(iii) strong response of lateral root growth to localized nitrogen supply so as to utilize unevenly distributed nitrate especially under limited N conditions.MI GuoHua,CHEN FanJun,WU QiuPing,LAI NingWei,YUAN LiXing & ZHANG FuSuo* Key Laboratory of Plant Nutrition,MOA Key Laboratory of Plant-Soil Interaction,MOE College of Resources and Environmental Science,China Agricultural University,Beijing 100193,China 2010Science China(Life Sciences)2010,53,12:35
2Natural variation in Ghd7.1 plays an important role in grain yield and adaptation in rice显示文摘Wenhao Yan Haiyang Liu Xiangchun Zhou Qiuping Li Jia Zhang Li Lu Touming Liu Haijun Liu Chengjun Zhang Zhanyi Zhang Guojing Shen Wen Yao Huaxia Chen Sibin Yu Weibo Xie Yongzhong Xing 2013Cell Research2013,23,7:39
3Energy-Efficient Computation Offloading and Resource Allocation in Fog Computing for Internet of Everything显示文摘With the dawning of the Internet of Everything(IoE) era, more and more novel applications are being deployed. However, resource constrained devices cannot fulfill the resource-requirements of these applications. This paper investigates the computation offloading problem of the coexistence and synergy between fog computing and cloud computing in IoE by jointly optimizing the offloading decisions, the allocation of computation resource and transmit power. Specifically, we propose an energy-efficient computation offloading and resource allocation(ECORA) scheme to minimize the system cost. The simulation results verify the proposed scheme can effectively decrease the system cost by up to 50% compared with the existing schemes, especially for the scenario that the computation resource of fog computing is relatively small or the number of devices increases.Qiuping Li Junhui Zhao Yi Gong Qingmiao Zhang 2019China Communications2019,16,3:19
4Intestinal Microbiota in Early Life and Its Implications on Childhood Health显示文摘Trillions of microbes reside in the human body and participate in multiple physiological and pathophysiological processes that affect host health throughout the life cycle. The microbiome is hallmarked by distinctive compositional and functional features across different life periods.Accumulating evidence has shown that microbes residing in the human body may play fundamental roles in infant development and the maturation of the immune system. Gut microbes are thought to be essential for the facilitation of infantile and childhood development and immunity by assisting in breaking down food substances to liberate nutrients, protecting against pathogens, stimulating or modulating the immune system, and exerting control over the hypothalamic–pituitary–adrenal axis.This review aims to summarize the current understanding of the colonization and development of the gut microbiota in early life, highlighting the recent findings regarding the role of intestinal microbes in pediatric diseases. Furthermore, we also discuss the microbiota-mediated therapeutics that can reconfigure bacterial communities to treat dysbiosis.Lu Zhuang Haihua Chen Sheng Zhang Jiahui Zhuang Qiuping Li Zhichun Feng 2019Genomics, Proteomics & Bioinformatics2019,17,1:16
5Root growth in response to nitrogen supply in Chinese maize hybrids released between 1973 and 2009显示文摘Root growth has a fundamental role in nitrogen (N) use efficiency.Nevertheless,little is known about how modern breeding progress has affected root growth and its responses to N supply.The root and shoot growth of a core set of 11 representative Chinese maize (Zea mays L.) hybrids released between 1973 and 2009 were investigated under high N (4 mmol L?1,HN) and low N (0.04 mmol L?1,LN) levels in a solution culture system.Compared with LN,HN treatment decreased root dry weight (RDW),the root:shoot ratio (R/S),and the relative growth rate for root dry weight (RGRroot),but increased the total root length (TRL) and the total lateral root length (LRL).The total axial root length (ARL) per plant was reduced under HN,mostly in hybrids released before the 1990s.The number of seminal roots (SRN) was largely unaffected by different N levels.More recently released hybrids showed higher relative growth rates in the shoot under both HN and LN.However,the roots only showed increased RGR under HN treatment.Correspondingly,there was a positive linear relationship with the year of hybrid release for TRL,LRL and ARL under HN treatment.Together,these results suggest that while shoot growth of maize has improved,its root growth has only improved under high N conditions over the last 36 years of selective breeding in China.Improving root growth under LN conditions may be necessary to increase the N use efficiency of maize.WU QiuPing CHEN FanJun CHEN YanLing YUAN LiXing ZHANG FuSuo MI GuoHua 2011Science China(Life Sciences)2011,54,7:15
6Effects of narrow plant spacing on root distribution and physiological nitrogen use efficiency in summer maize显示文摘The objective of this study was to understand the effects of plant spacing on grain yield and root competition in summer maize(Zea mays L.). Maize cultivar Denghai 661 was planted in rectangular tanks(0.54 m × 0.27 m × 1.00 m) under 27 cm(normal) and 6 cm(narrow) plant spacing and treated with zero and 7.5 g nitrogen(N) per plant. Compared to normal plant spacing, narrow plant spacing generated less root biomass in the 0–20 cm zone under both N rates, slight reductions of dry root weight in the 20–40 cm and 40–70 cm zones at the mid-grain filling stage, and slight variation of dry root weights in the 70–100 cm zone during the whole growth period. Narrow plant spacing decreased root reductive activity in all root zones, especially at the grain-filling stage. Grain yield and above-ground biomass were 5.0% and 8.4% lower in the narrow plant spacing than with normal plant spacing, although narrow plant spacing significantly increased N harvest index and N use efficiency in both grain yield and biomass, and higher N translocation rates from vegetative organs. These results indicate that the reductive activity of maize roots in all soil layers and dry weights of shallow roots were significantly decreased under narrow plant spacing conditions, resulting in lower root biomass and yield reduction at maturity. Therefore, a moderately dense sowing is a basis for high yield in summer maize.Wenshun Jiang Kongjun Wang Qiuping Wu Shuting Dong Peng Liu Jiwang Zhang 2013The Crop Journal2013,1,1:13
7Meningeal lymphatic vessels regulate brain tumor drainage and immunity显示文摘Recent studies have shown that meningeal lymphatic vessels(MLVs),which are located both dorsally and basally beneath the skull,provide a route for draining macromolecules and trafficking immune cells from the central nervous system(CNS)into cervical lymph nodes(CLNs),and thus represent a potential therapeutic target for treating neurodegenerative and neuroinflammatory diseases.However,the roles of MLVs in brain tumor drainage and immunity remain unexplored.Here we show that dorsal MLVs undergo extensive remodeling in mice with intracranial gliomas or metastatic melanomas.RNA-seq analysis of MLV endothelial cells revealed changes in the gene sets involved in lymphatic remodeling,fluid drainage,as well as inflammatory and immunological responses.Disruption of dorsal MLVs alone impaired intratumor fluid drainage and the dissemination of brain tumor cells to deep CLNs(dCLNs).Notably,the dendritic cell(DC)trafficking from intracranial tumor tissues to dCLNs decreased in mice with defective dorsal MLVs,and increased in mice with enhanced dorsal meningeal lymphangiogenesis.Strikingly,disruption of dorsal MLVs alone,without affecting basal MLVs or nasal LVs,significantly reduced the efficacy of combined anti-PD-1/CTLA-4 checkpoint therapy in striatal tumor models.Furthermore,mice bearing tumors overexpressing VEGF-C displayed a better response to anti-PD-1/CTLA-4 combination therapy,and this was abolished by CCL21/CCR7 blockade,suggesting that VEGF-C potentiates checkpoint therapy via the CCL21/CCR7 pathway.Together,the results of our study not only demonstrate the functional aspects of MLVs as classic lymphatic vasculature,but also highlight that they are essential in generating an efficient immune response against brain tumors.Xueting Hu Qiuping Deng Lu Ma Qingqing Li Yidong Chen Yuhan Liao Fan Zhou Chen Zhang Linlin Shao Jun Feng Tubao He Weihai Ning Yan Kong Yingqing Huo Aibin He Bing Liu Jingjing Zhang Ralf Adams Yulong He Fuchou Tang Xiuwu Bian Jincai Luo 2020Cell Research2020,30,3:11
8Oxidative stress, nutritional antioxidants and beyond显示文摘Free radical-induced oxidative stress contributes to the development of metabolic syndromes(Mets), including overweight,hyperglycemia, insulin resistance and pro-inflammatory state. Most free radicals are generated from the mitochondrial electron transport chain;under physiological conditions, their levels are maintained by efficient antioxidant systems. A variety of transcription factors have been identified and characterized that control gene expression in response to oxidative stress status.Natural antioxidant compounds have been largely studied for their strong antioxidant capacities. This review discusses the recent progress in oxidative stress and mitochondrial dysfunction in Mets and highlights the anti-Mets, anti-oxidative, and antiinflammatory effect of polyphenols as potential nutritional therapy.Qiuping Guo Fengna Li Yehui Duan Chaoyue Wen Wenlong Wang Lingyu Zhang Ruilin Huang Yulong Yin 2020Science China(Life Sciences)2020,63,6:10
9Multi-component assembly of luminescent rare earth hybrid materials显示文摘This review focuses on the recent research progress in the multi-component assembly of luminescent rare earth hybrid materials, which is based on the luminescent rare earth compounds and two or more other building units, including the other photoactive species. It covers the multi-component luminescent rare earth hybrids which was assembled with different(a) organic-inorganic polymeric units,(b)nanoporous units,(c) nanoparticle composites or(d) other developing special units. Finally, future challenges and opportunities in this field are discussed. Herein it mainly focuses on the work of Yan's group in recent years.Qiuping Li Bing Yan 2019Journal of Rare Earths2019,37,2:10
10Fluorescent nanoparticles for chemical and biological sensing显示文摘Fluorescent nanoparticles (NPs), including quantum dots (QDs), dye-doped NPs, and rare earth-based NPs, etc., have been a major focus of research and development during the past decade. The impetus behind such endeavors can be attributed to their unique chemical and optical properties, such as bright fluorescence, high photostability, large Stocks shift and flexible processability. The introduction of fluorescent NPs into analytical chemistry has opened up new venues for fluorescent analysis. In this review, we focus on the developments and analytical applications of fluorescent NPs in the chemical and biological sensing of pH, ions, organic compounds, small biological molecules, nucleic acids, proteins, virus and bacteria. The review also points out the in vitro and in vivo imaging application of fluorescent NPs at the cell and body levels. Meanwhile, the ad- vantages of NPs brought field of sensing and signal transductions are also discussed.LIU JianBo, YANG XiaoHai, HE XiaoXiao, WANG KeMin, WANG Qing, GUO QiuPing, SHI Hui, HUANG Jin & HUO XiQin State Key Laboratory of Chemo/Biosensing and Chemometrics College of Chemistry and Chemical Engineering, Institute of Biology, Hunan University Key Laboratory for Bio-Nanotechnology and Molecule Engineering of Hunan Province, Changsha 410082, China 2011Science China Chemistry2011,54,8:9
11Genetic diversity,population structure,and relationships of apricot(Prunus)based on restriction site-associated DNA sequencing显示文摘Single-nucleotide polymorphisms(SNPs)are the most abundant form of genomic polymorphisms and are widely used in population genetics research.Here,high-throughput sequencing was used to examine the genome-level diversity,population structure,and relationships of apricot,which are important for germplasm conservation and molecular breeding.Restriction site-associated DNA sequencing(RAD-seq)was adopted to sequence 168 Prunus spp.accessions distributed in five ecological groups,including 74 accessions of cultivated Prunus armeniaca L.and 94 accessions of wild apricots(P.armeniaca L.and Prunus sibirica L.),which generated 417,961 high-quality SNPs.We used cluster,genetic structure,and principal component analyses to examine the genetic diversities and genetic relationships of the 168 accessions.The Dzhungar-Ili ecological group accessions showed the highest genetic diversity in terms of private allele number,observed heterozygosity,and nucleotide diversity.We speculate that the Central Asian ecological group accessions were domesticated from the Dzhungar-Ili ecological group accessions.The population structure and gene flow of the North China and European ecological group accessions suggested a genetic background of P.sibirica.We argue that the two groups should be considered hybrid swarms connected to P.sibirica by continuous and extensive gene flow.P.armeniaca originated in Northwest China(Ili Valley),subsequently spread throughout Central Asia,and eventually spread to Europe.In addition,selective sweep signatures in P.armeniaca during domestication from wild to cultivated apricots,combined with differentially expressed genes,underlie distinct fruit traits,including sugars,aromas,organic acids,and carotenoids.This study provides substantive and valuable genomic resources that will significantly advance apricot improvement and effective utilization.Wenwen Li Liqiang Liu Yanan Wang Qiuping Zhang Guoquan Fan Shikui Zhang Yatong Wang Kang Liao 2020Horticulture Research2020,7,1:9
12Optimizing water and nitrogen inputs for winter wheat cropping system on the Loess Plateau,China显示文摘Optimal use of water and fertilizers can enhance winter wheat yield and increase the efficiencies of water and fertilizer usage in dryland agricultural systems.In order to optimize water and nitrogen(N)management for winter wheat,we conducted field experiments from 2006 to 2008 at the Changwu Agro-ecological Experimental Station of the Chinese Academy of Sciences on the Loess Plateau,China.Regression models of wheat yield and evapotranspiration(ET)were established in this study to evaluate the water and fertilizer coupling effects and to determine the optimal coupling domain.The results showed that there was a positive effect of water and N fertilizer on crop yield,and optimal irrigation and N inputs can significantly increase the yield of winter wheat.In the drought year(2006–2007),the maximum yield(Ymax)of winter wheat was 9.211 t/hm2for the treatment with 324 mm irrigation and 310 kg/hm2N input,and the highest water use efficiency(WUE)of 16.335 kg/(hm2 mm)was achieved with198 mm irrigation and 274 kg/hm2N input.While in the normal year(2007–2008),the maximum winter wheat yield of 10.715 t/hm2was achieved by applying 318 mm irrigation and 291 kg/hm2N,and the highest WUE was 18.69kg/(hm2 mm)with 107 mm irrigation and 256 kg/hm2N input.Crop yield and ET response to irrigation and N inputs followed a quadratic and a line function,respectively.The optimal coupling domain was determined using the elasticity index(EI)and its expression in the water-N dimensions,and was represented by an ellipse,such that the global maximum WUE(WUEmax)and Ymax values corresponded to the left and right end points of the long axis,respectively.Considering the aim to get the greatest profit in practice,the optimal coupling domain was represented by the lower half of the ellipse,with the Ymax and WUEmax on the two end points of the long axis.Overall,we found that the total amount of irrigation for winter wheat should not exceed 324 mm.In addition,our optimal coupling domain visually reflects the optimal range of water and N inputs for the maximum winter wheat yield on the Loess Plateau,and it may also provide a useful reference for identifying appropriate water and N inputs in agricultural applications.QiuPing FU QuanJiu WANG XinLei SHEN Jun FAN 2014Journal of Arid Land2014,6,2:8
13急诊生化检验的实验室内标本周转时间影响因素分析显示文摘目的统计急诊生化标本的实验室内标本周转时间(ILTAT),分析ILTAT的影响因素,采取相应的改进措施,完善服务质量,保障患者医疗安全。方法回顾性统计首都医科大学昌平教学医院2015年6-11月急诊生化标本ILTAT。比较ILTAT≤60min和ILTAT≤120min的检验及时率。着重分析实验室各时间段的ILTAT。结果 ILTAT≤120min(ILTAT1)检验及时率98.8%(8 638/8 743),ILTAT≤60min(ILTAT2)检验及时率为83.7%(7 317/8 743)。ILTAT1不同时间段检验及时率比较,差异无统计学意义(χ~2=3.36,P>0.05)。ILTAT2不同时间段ILTAT比较差异有统计学意义(χ2=134.50,P<0.01)。其中T2(10:01-12:00)检验及时率最高(88.1%),T1(8:01-10:00)检验及时率最低(76.8%),T3(12:01-14:00)、T7(6:01-8:00)这两个时段检验及时率较低,分别为79.4%、80.2%。结论目前本实验室急诊生化ILTAT满足现行的规定要求。通过分析急诊生化ILTAT影响因素,优化工作流程,改善仪器设备及人员配置,提高信息化处理程度,可进一步缩短急诊生化ILTAT,更好地满足临床和患者的需求。孙丽 李全亭 韩旭春 张霆 张海珍 宿欣 吴媛 LI Qiuping 2017国际检验医学杂志2017,38,7:8
14G protein-coupled receptor 183 facilitates endothelial-to- hematopoietic transition via Notch1 inhibition显示文摘Panpan Zhang Qiuping He Dongbo Chen Weixiao Liu Lu Wang Chunxia Zhang Dongyuan Ma Wei Li Bing Liu Feng Liu 2015Cell Research2015,25,10:7
15Supplementation of branched-chain amino acids in protein-restricted diets modulates the expression levels of amino acid transporters and energy metabolism associated regulators in the adipose tissue of growing pigs显示文摘This experiment was conducted to investigate the effects of branched-chain amino acids(BCAA)supplemented in protein-restricted diets on the growth performance and the expression profile of amino acid transporters and energy metabolism related regulators in the white adipose tissue(WAT)of different regional depots including dorsal subcutaneous adipose(DSA) and abdominal subcutaneous adipose(ASA), A total of 24 crossbred barrows(7.40 ± 0.70 kg) were randomly divided into 4 groups and were fed the following isocaloric diets for 33 days: 1) a recommended adequate protein diet(AP, 20% CP, as a positive control); 2) a low protein diet(LP, 17% CP); 3) the LP diet supplemented with BCAA(LP + B, 17% CP) to reach the same level of the AP diet group; 4) the LP diet supplemented with 2 times the amount of BCAA(LP + 2B, 17% CP). The daily gain and daily feed intake of the LP diet group were the lowest among all the treatments(P < 0.01). The feed conversion was improved markedly in the group of LP + B compared with the LP diet group(P < 0.05). No significant difference was noted for the serum biochemical parameter concentrations of glucose, triglyceride, nonesterified fatty acid and insulin among the groups(P > 0.05). Moreover, BCAA supplementation down-regulated the expression levels of amino acid transporters including L-type amino acid transporter 1 and sodium-coupled neutral amino acid transporter 2 in DSA, but up-regulated the expression level of Ltype amino acid transporter 4 in ASA(P < 0.05), Meanwhile, the energy sensor AMP-activated protein kinase α was activated in the DSA of pigs fed LP diet and in the ASA of the pigs fed AP or LP + 2B diets(P < 0.05). The mRNA expression profile of the selected mitochondrial component and mitochondrial biogenesis associated regulators in DSA and ASA also responded differently to dietary BCAA supplementation. These results suggested that the growth performance of growing pigs fed protein restricted diets supplemented with BCAA could catch up to that of the pigs fed AP diets. The results also partly demonstrated that the regulation mechanisms of BCAA are different in the adipose tissues of different depots.Yinghui Li Hongkui Wei Fengna Li Shuai Chen Yehui Duan Qiuping Guo Yingying Liu Yulong Yin 2016Animal Nutrition2016,,1:6
16Optimal configuration for photovoltaic storage system capacity in 5G base station microgrids显示文摘Base station operators deploy a large number of distributed photovoltaics to solve the problems of high energy consumption and high electricity costs of 5G base stations.In this study,the idle space of the base station’s energy storage is used to stabilize the photovoltaic output,and a photovoltaic storage system microgrid of a 5G base station is constructed.Aiming at the capacity planning problem of photovoltaic storage systems,a two-layer optimal configuration method is proposed.The inner layer optimization considers the energy sharing among the base station microgrids,combines the communication characteristics of the 5G base station and the backup power demand of the energy storage battery,and determines an economic scheduling strategy for each photovoltaic storage system with the goal of minimizing the daily operation cost of the base station microgrid.The outer model aims to minimize the annual average comprehensive revenue of the 5G base station microgrid,while considering peak clipping and valley filling,to optimize the photovoltaic storage system capacity.The CPLEX solver and a genetic algorithm were used to solve the two-layer models.Considering the construction of the 5G base station in a certain area as an example,the results showed that the proposed model can not only reduce the cost of the 5G base station operators,but also reduce the peak load of the power grid and promote the local digestion of photovoltaic power.Xiufan Ma Ying Duan Xiangyu Meng Qiuping Zhu Zhi Wang Sijia Zhu 2021Global Energy Interconnection2021,4,5:5
17Modeling and Analysis of a Micromotor with an Electrostatically Levitated Rotor显示文摘The modeling and evaluation of a prototype rotary micromotor where the annular rotor is supported electrostatically in five degrees of freedom is presented in order to study the behavior of this levitated micromotor and further optimize the device geometry.The analytical torque model is obtained based on the principle of a planar variable-capacitance electrostatic motor while the viscous damping caused by air film between the stator and rotor is derived using laminar Couette flow model.Simulation results of the closed-loop drive motor, based on the developed dynamic model after eliminating mechanical friction torque via electrostatic suspension, are presented.The effects of the high-voltage drive, required for rotation of the rotor, on overload capacity and suspension stiffness of the electrostatic bearing system are also analytically evaluated in an effort to determine allowable drive voltage and attainable rotor speed in operation.The analytical results show that maximum speed of the micromotor is limited mainly by viscous drag torque and stiffness of the bearing system.Therefore, it is expected to operate the device in vacuum so as to increase the rotor speed significantly, especially for those electrostatically levitated micromotors to be used as an angular rate micro-gyroscope.HAN Fengtian WU Qiuping ZHANG Rong 2009Chinese Journal of Mechanical Engineering2009,22,1:5
18The diagnostic rules of peripheral lung cancer preliminary study based on data mining technique显示文摘Objective: To discuss the clinical and imaging diagnostic rules of peripheral lung cancer by data mining technique, and to explore new ideas in the diagnosis of peripheral lung cancer, and to obtain early-stage technology and knowledge support of computer-aided detecting(CAD). Methods: 58 cases of peripheral lung cancer confirmed by clinical pathology were collected. The data were imported into the database after the standardization of the clinical and CT findings attributes were identified. The data was studied comparatively based on Association Rules (AR) of the knowledge discovery process and the Rough Set (RS) reduction algorithm and Genetic Algorithm(GA) of the generic data analysis tool (ROSETTA), respectively. Results: The genetic classification algorithm of ROSETTA generates 5 000 or so diagnosis rules. The RS reduction algorithm of Johnson`s Algorithm generates 51 diagnosis rules and the AR algorithm generates 123 diagnosis rules. Three data mining methods basically consider gender, age, cough, location, lobulation sign, shape, ground-glass density attributes as the main basis for the diagnosis of peripheral lung cancer. Conclusion: These diagnosis rules for peripheral lung cancer with three data mining technology is same as clinical diagnostic rules, and these rules also can be used to build the knowledge base of expert system. This study demonstrated the potential values of data mining technology in clinical imaging diagnosis and differential diagnosis.Yongqian Qiang Youmin Guo Xue Li Qiuping Wang Hao Chen Duwu Cui 2007Journal of Nanjing Medical University2007,21,3:5
19Fine mapping of cisc(t),a gene for cold-induced seedling chlorosis,and identification of its candidate in rice显示文摘The seedlings of indica rice cultivar Dular are susceptible to chlorosis under low temperature conditions.Our previous studies indicated that low temperature-induced seedling chlorosis is controlled by a recessive gene,located between SSR markers RM257 and RM242,on the long arm of chromosome 9.We temporarily named the gene cisc(t).Using a large F2 population derived from a cross between Dular and the japonica cultivar Lemont,which displays a normal green color at low temperatures,cisc(t)was fine mapped to within a 12-kb interval.There is only one annotated gene in this interval,which encodes a pentatricopeptide repeat(PPR)protein.Sequence analysis indicated that 8 bases were deleted at the 60th base in the Dular allele,resulting in a frame-shift mutation and loss of function of the gene.This is consistent with the chlorosis mutant phenotype of Dular.In addition,previous studies have shown that many chlorosis mutants of seedlings are related to PPR proteins.Hence,we presume that the PPR gene is the candidate for cisc(t).LAN Tao WANG Bin LING QiuPing XU ChunHua TONG ZhiJun LIANG KangJing DUAN YuanLin JIN Jing WU WeiRen 2010Chinese Science Bulletin2010,55,27:5
20Protective effects of taurine against muscle damage induced by diquat in 35 days weaned piglets显示文摘Background: Oxidative stress is a key factor that influences piglets' health. Taurine plays an imperative role in keeping the biological system from damage. This study was conducted to investigate the protective effect of taurine against muscle injury due to the secondary effect of diquat toxicity.Results: Our study found that taurine effectively and dose-dependently alleviated the diquat toxicity induced rise of feed/gain, with a concurrent improvement of carcass lean percentage. The plasma content of taurine was considerably increased in a dose-dependent manner. Consequently, dietary taurine efficiently improved the activity of plasma antioxidant enzymes. Furthermore, taurine attenuated muscle damage by restoring mitochondrial micromorphology, suppressing protein degradation and reducing the percentage of apoptotic cells in the skeletal muscle. Taurine supplementation also suppressed the genes expression levels of the antioxidant-, mitochondrial biogenesis-, and muscle atrophy-related genes in the skeletal muscle of piglets with oxidative stress.Conclusions: These results showed that the dose of 0.60% taurine supplementation in the diet could attenuate skeletal muscle injury induced by diquat toxicity. It is suggested that taurine could be a potential nutritional intervention strategy to improve growth performance.Chaoyue Wen Fengna Li Qiuping Guo Lingyu Zhang Yehui Duan Wenlong Wang Jianzhong Li Shanping He Wen Chen Yulong Yin 2020Journal of Animal Science and Biotechnology2020,11,4:5
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