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| 1 | Palmitoylation stabilizes PD-L1 to promote breast tumor growth显示文摘Dear Editor,PD-L1 is a well-known transmembrane protein, which is highly expressed on many types of cancer cells. By binding to its receptor PD-1 on T cells, PD-L1 significantly inhibits T cells activation and activity, and thus plays a pivotal role in driving the escape of tumor cells from immune surveillance.^1. | Yi Yang Jung-Mao Hsu Linlin Sun Li-Chuan Chan Chia-Wei Li Jennifer L. Hsu Yongkun Wei Weiya Xia Junwei Hou Yufan Qiu Mien-Chie Hung | 2019 | Cell Research2019，29，1： | 14 |
| 2 | Controllable synthesis of highly crystallized mesoporous TiO2/WO3 heterojunctions for acetone gas sensing显示文摘Mesoporous semiconducting metal oxides(SMOs)heterojunctions are appealing sensors for gas detecting.However,due to the different hydrolysis and condensation mechanism of every metal precursor and the contradiction between high crystallinity and high surface area,the synthesis of mesoporous SMOs heterojunctions with highly o rdered mesostructures,highly crystallized frameworks,and high surface area remains a huge challenge.In this work,we develop a novel'acid-base pair'adjusted solvent evaporation induced self-assembly(EISA)strategy to prepare highly crystallized ordered mesoporous TiO2/WO3(OM-TiO2/WO3)heterojunctions.The WCl6 and titanium isopropoxide(TIPO)are used as the precursors,respectively,which function as the'acid-base pair',enabling the coassembly with the structure directing agent(PEO-b-PS)into highly ordered meso structures.In addition,PEO-b-PS can be converted to rigid carbon which can protect the meso structures from collapse during the crystallization process.The resultant OM-TiO2/WO3 heterojunctions possess primitive cubic mesostructures,large pore size(~21.1 nm),highly crystalline frameworks and surface area(~98 m2/g).As a sensor for acetone,the obtained OM-TiO2/WO3 show excellent re sponse/recovery perfo rmance(3 s/5 s),good linear dependence,repeatability,selectivity,and long-term stability(35 days). | Changyao Wang Yuhui Li Pengpeng Qiu Linlin Duan Wei Bi Yan Chen Dingyi Guo Yupu Liu Wei Luo Yonghui Deng | 2020 | Chinese Chemical Letters2020，31，5： | 4 |
| 3 | A titanium dioxide nanorod array as a high-affinity nano-bio interface of a microfluidic device for efficient capture of circulating tumor cells显示文摘处理临床的问题的 Nanomaterials 表演答应机会(例如传播肿瘤房间的不够的俘获;CTC ) 经由为生物房间的高表面 area-to-volume 比率和高亲密关系。然而,怎么与高特性遗体为有效 CTC 俘获在一台 microfluidic 设备作为一个 nano 简历接口使用这些 nanomaterials 挑战。在现在的工作,我们首先发现那钛二氧化物(能方便地在底层的多重类型上被准备的 TiO 2) nanorod 数组为肿瘤房间有高亲密关系。然后, TiO 2 nanorod 数组在有经由热水的反应的六角形地有图案的 Si micropillars 的 microchannel 的表面上是垂直地成年的,层次地形成 micro-nano 3D 的一种新类型结构化的 microfluidic 设备。当这 3D 的一个敏感 nano 简历接口层次地组织了 microfluidic 设备,垂直地成年的 TiO 2 nanorod 数组被使用,哪个显示出 CTC 俘获的高效率(76.7% 潩獮 ? 畯 ? 牰灯獯摥栠杩 ? 数晲牯慭据 ? 潍 ? ??? 猯'T ￣楢獯湥潳獲挠湡搠瑥捥 ?? 卐? 潣据湥牴瑡潩吗?? | Jichuan Qiu Kun Zhao Linlin Li Xin Yu Weibo Guo Shu Wang Xiaodi Zhang Caofeng Pan Zhong Lin Wang Hong Liu | 2017 | Nano Research2017，10，3： | 3 |
| 4 | Chinese consensus guidelines for therapeutic drug monitoring of polymyxin B,endorsed by the Infection and Chemotherapy Committee of the Shanghai Medical Association and the Therapeutic Drug Monitoring Committee of the Chinese Pharmacological Society显示文摘Polymyxin B,which is a last-line antibiotic for extensively drug-resistant Gram-negative bacterial infections,became available in China in Dec.2017.As dose adjustments are based solely on clinical experience of risk toxicity,treatment failure,and emergence of resistance,there is an urgent clinical need to perform therapeutic drug monitoring(TDM)to optimize the use of polymyxin B.It is thus necessary to standardize operating procedures to ensure the accuracy of TDM and provide evidence for their rational use.We report a consensus on TDM guidelines for polymyxin B,as endorsed by the Infection and Chemotherapy Committee of the Shanghai Medical Association and the Therapeutic Drug Monitoring Committee of the Chinese Pharmacological Society.The consensus panel was composed of clinicians,pharmacists,and microbiologists from different provinces in China and Australia who made recommendations regarding target concentrations,sample collection,reporting,and explanation of TDM results.The guidelines provide the first-ever consensus on conducting TDM of polymyxin B,and are intended to guide optimal clinical use. | XIAOFEN LIU CHENRONG HUANG PHILLIP JBERGEN JIAN LI JINGJING ZHANG YIJIAN CHEN YONGCHUAN CHEN BEINING GUO FUPIN HU JINFANG HU LINLIN HU XIN LI HONGQIANG QIU HUA SHAO TONGWEN SUN YU WANG PING XU JING YANG YONG YANG ZHENWEI YU BIKUI ZHANG HUAIJUN ZHU XIAOCONG ZUO YI ZHANG LIYAN MIAO JING ZHANG | 2023 | Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)2023，24，2： | 1 |
| 5 | A broadly neutralizing human monoclonal antibody against the hemagglutinin of avian influenza virus H7N9显示文摘Background:The new emerging avian influenza A H7N9 virus,causing severe human infection with a mortality rate of around 41%.This study aims to provide a novel treatment option for the prevention and control of H7N9.Methods:H7 hemagglutinin(HA)-specific B cells were isolated from peripheral blood plasma cells of the patients previously infected by H7N9 in Jiangsu Province,China.The human monoclonal antibodies(mAbs)were generated by amplification and cloning of these HA-specific B cells.First,all human mAbs were screened for binding activity by enzyme-linked immunosorbent assay.Then,those mAbs,exhibiting potent affinity to recognize H7 HAs were further evaluated by hemagglutination-inhibiting(HAI)and microneutralizationin vitro assays.Finally,the lead mAb candidate was selected and tested against the lethal challenge of the H7N9 virus using murine models.Results:The mAb 6-137 was able to recognize a panel of H7 HAs with high affinity but not HA of other subtypes,including H1N1 and H3N2.The mAb 6-137 can efficiently inhibit the HA activity in the inactivated H7N9 virus and neutralize 100 tissue culture infectious dose 50(TCID_(50))of H7N9 virus(influenza A/Nanjing/1/2013)invitro,with neutralizing activity as low as 78 ng/mL.In addition,the mAb 6-137 protected the mice against the lethal challenge of H7N9 prophylactically and therapeutically.Conclusion:The mAb 6-137 could be an effective antibody as a prophylactic or therapeutic biological treatment for the H7N9 exposure or infection. | Jingxin Li Li Zhang Linlin Bao Yuxiao Wang Lin Qiu Jialei Hu Rong Tang Huiyan Yu Jun Shan Yan Li Chuan Qin Fengcai Zhu | 2022 | Chinese Medical Journal2022，，7： | 1 |
| 6 | Tsunami hazard assessment in the South China Sea:A review of recent progress and research gaps显示文摘The South China Sea region is potentially threatened by tsunami hazards originated from multiple sources:the Manila subduction zone in the east,the Littoral Fault Zone(LFZ)in the north,numerous submarine landslides on the continental slopes and the volcanic islands in the Luzon Strait.Infrequent but potentially devastating tsunami hazard poses a great threat to the populous coastal region,fishery,oil and gas exploitation in the deep sea,etc.Here we review the recent progress in tsunami hazard assessment in the South China Sea region,focusing on two primary sources:submarine earthquakes and landslides.We sort and review the literature by the two commonly used approaches:deterministic and probabilistic tsunami hazard assessment for both source types.By simulating tsunamis generated by typical earthquakes originated from the Manila Trench,the LFZ and landslides in the continental slopes,we investigate their tsunamigenic mechanism and key tsunami characteristics in the South China Sea region.We point out the research gaps and highlight the key issues to be addressed in the future. | Linlin LI Qiang QIU Zhigang LI Peizhen ZHANG | 2022 | Science China Earth Sciences2022，65，5： | 1 |
| 7 | Design of Public Communication Spaces in Urban Highrises:A Case Study of Xuzhou Hanbang Square Residential Area显示文摘Highrise residences with high plot ratio meet housing needs of urban residents, improve living conditions of residents, but also show many unreasonable problems in the design of public communication spaces with a result of interpersonal indifference and lack of sense of identity. This paper took Xuzhou Hanbang Square for example to explore strategies of improving public communication spaces in highrises from the perspectives of entrance lobby, open-floor ground design, ecological garage, and three-level property management. On the one hand, the paper tries to improve quality of residential environment and service quality of public facilities; on the other hand, to enhance sense of neighborhood and identity of residents, and change the current interpersonal indifference. | QIU Lei CAO Linlin XU Dongsheng | 2016 | Journal of Landscape Research2016，8，1： | 1 |
| 8 | Interface behavior of chalcopyrite during flotation from cyanide tailings显示文摘The interface characteristics of cyanide tailings are different from those of the raw ore. In this study, valuable elements could not be thoroughly recovered via the flotation of cyanide tailings from Shandong, China. The interface and floatability of these tailings were investig- ated by phase analysis and flotation tests. The chalcopyrite in the cyanide tailings was fine and had a porous surface. The floatability of 68% chalcopyrite was similar to that of galena in the presence of a collector. A layer of fine galena particles compactly wrapped the chalcopyrite. The chalcopyrite recovery sharply decreased as the nonpolar oil residue in cyanide tailings was extracted using alcohol;however, this removal had no effect on the galena. The remaining chalcopyrite in the flotation tailings was covered with an oxidation layer consisting of O, Fe, S, Pb, Cu, Zn, and Si. | Xuemin Qiu Hongying Yang Guobao Chen Linlin Tong Zhenan Jin Qin Zhang | 2022 | International Journal of Minerals,Metallurgy and Materials2022，29，3： | 1 |
| 9 | The 2010 Mw 7.8 Mentawai earthquake: Very shallow source of a rare tsunami earthquake determined from tsunami field survey and near-field GPS data显示文摘 | Hill Emma M. Borrero Jose C. Huang Zhenhua Qiu Qiang Banerjee Paramesh Natawidjaja Danny H. Elosegui Pedro Fritz Hermann M. Suwargadi Bambang W. Pranantyo Ignatius Ryan Li LinLin Macpherson Kenneth A. Skanavis Vassilis Synolakis Costas E. Si | 2012 | EN2012，，6： | 1 |
| 10 | Ultra-broadband optical filter based on chirped long-period fiber grating using leaky mode coupling显示文摘An ultra-broadband optical filter was proposed and demonstrated based on leaky mode coupling in a coated chirped long-period fiber grating(CLPFG). The CLPFG was coated with a material whose refractive index(RI) was higher than that of the fiber cladding, enabling the coupling of the core mode to leaky modes, to achieve a desired coupling efficiency. Complex coupled-mode theory was used to investigate the power evolution of the core mode that resulted from the coupling. From this, the conditions in which the core mode power attenuates the most rapidly were identified. In addition, phase matching turning point(PMTP) was used in the design, to overcome the conflict between the range of grating period change and the grating length in the CLPFG. Finally, an optimized CLPFG-based filter with a length of 3.5 cm was obtained, which has a symmetrical attenuation band with an operating bandwidth over 300 nm. Within the operating bandwidth, the flatness is less than 2.5 d B and the transmittance is lower than 0.1%. | XUE Linlin Bras Samuel Malumba Timoteo QIU Weiwei WANG Zhongpeng | 2022 | Optoelectronics Letters2022，18，10： | 0 |
| 11 | Upconversion luminescence Ca-Mg-Si bioactive glasses synthesized using the containerless processing technique显示文摘In this study,a series of Er^3+/Yb^3+co-doped Ca-Mg-Si glasses were prepared via the containerless processing.Phase composition and luminescent properties of the prepared materials were investigated through XRD and spectrometry,and bioactivity,biocompatibility and cytotoxicity were evaluated.The XRD patterns indicated that akermanite(AKT)ceramic powders were completely transformed into the glassy phase(AKT-G,EYA)through the containerless processing,which exhibit upconversion luminescence,and the luminescence intensity increased with the increase of the doping amount of Er^3+ and Yb^3+.High amount of Yb^3+doping and existence of Ca^2+in glasses resulted in more intensive red-light emission.The SEM observation,combined with EDS analysis,and cell culture experiments showed that the as-prepared glasses were nontoxic,biocompatible and bioactive.All these results demonstrated that the containerless processing is a facile method for preparing homogeneous luminescent bioactive glasses.Furthermore,this luminescent Ca-Mg-Si glasses may be used as bone implant materials to study the in vivo distribution of degradation products of bone implants,which may be of great significance for the development and clinical application of new bone grafting materials. | Qin LI Min XING Lan CHANG Linlin MA Zhi CHEN Jianrong QIU Jianding YU Jiang CHANG | 2019 | Frontiers of Materials Science2019，13，4： | 0 |
| 12 | Quantitative studies on charcoalification:Physical and chemical changes of charring wood显示文摘Charcoal is commonly preserved in both natural and artificial sediments,and is intensively used in paleontological,paleoenvironmental,and archaeological studies due to the abundant bio-information it contains.The biochemical properties of charcoal are also used for paleoclimatic reconstruction;however,the reliability of this approach has been challenged due to a lack of clarity on how physicochemical properties change during the charring process,as well as the temperatures required for charcoalification.To address this lack,in this study,Qinghai spruce and Chinese pine wood samples from the northeastern Tibetan Plateau were heated at different temperatures and for different lengths of time under restricted oxygen conditions.The reflectance;carbon,nitrogen,and oxygen content;and tracheid morphology were quantified before and after heating to assess changes related to the charring process.Archaeological charcoal remains were then evaluated to determine the charcoalification temperatures by comparing with the experimental results.The minimum temperature required for wood charcoalification was∼300℃,while temperatures recorded by archaeological charcoal were concentrated at 400-500℃.During the charring experiments,the tracheid cell walls gradually homogenized,and tracheid cell wall thickness and lumen area decreased by∼20%.On average,50%mass losses were observed;the carbon and oxygen content(%wt.)approximately changed from 47%to 60%and 48%to 35%respectively,while the nitrogen content(%wt.)fluctuated around 0.2%.The reflectance increased slightly from 0%to 0.5%.We propose that the charcoalification of wood tissue refers to charring(in restricted air)and carbonization(in the almost absence of air)when the wood is exposed to a heat source,which then finally transforms into a black,inert solid.This quantitative study provided valuable data and a thorough assessment of the process of wood charcoalification,as well as accurately estimated the feasibility of using charcoal physicochemical properties in paleoclimatic research. | Gang Li Linlin Gao Fengwen Liu Menghan Qiu Guanghui Dong | 2024 | Fundamental Research2024，4，1： | 0 |
| 13 | LHD3 Encoding a J-Domain Protein Controls Heading Date in Rice显示文摘Heading date is one of the most important agronomic traits of rice,which critically affects rice ecogeographical adaptation,yield and quality.In this study,a late heading date 3(lhd3)mutant was screened from the^(60)Co-γirradiation mutant library.The lhd3 delayed heading date in rice under both short day and long day conditions.Map-based cloning combined with Mutmap strategy was adopted to isolate the causal LHD3 gene.The LHD3 gene encodes a DNA_J domain protein,which was ubiquitously expressed in various plant organs,and dominant expressed in stems and leaves.Subcellular localization analysis showed that LHD3 was localized to nucleus,indicating that LHD3 may interact with other elements to regulate the expression of flowering genes.The transcriptions of the heading activators Ehd1,Hd3a and RFT1 significantly decreased in the lhd3 mutant,suggesting that LHD3 may control the heading date through the Ehd1-Hd3a/RFT1 photoperiodic flowering pathway.The variation and haplotype analyses of the genomic region of LHD3 showed that there were 7 haplotypes in the LHD3 region from 4702 accessions.The haplotypes of LHD3 can be divided into two classes:class a and class b,and the heading dates of these two classes were significantly different.Further study showed that two single nucleotide polymorphisms(SNPs),SNP10(G2100C)in Hap II and SNP3(C861T)in Hap VII,may be the functional sites causing early and late heading in accessions.Nucleotide diversity analysis showed LHD3 had been selected in the indica population,rather than in the japonica population.Therefore,the present study sheds light on the regulation of LHD3 on heading date in rice and suggests that LHD3 is a novel promising new target for rice molecular design and breeding improvement. | LIU Qiao QIU Linlin HUA Yangguang LI Jing PANG Bo ZHAI Yufeng WANG Dekai | 2023 | Rice science2023，30，5： | 0 |
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