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| 1 | Body temperature and fi brinogen are related to early neurological deterioration in acute isehe mie stroke显示文摘 | Davalos A Castillo J Pumar JM | 1997 | Cerebrovasc Dis1997，7，： | 1 |
| 2 | Areas of hyperdensity following a mechanical intraarterial thrombectomy in acute ischaemic stroke显示文摘 | Pumar JM Banguero A Masso A | 2014 | Rev Neurol2014，59，2： | 1 |
| 3 | Zooming of Terrain Imagery Using Fractal-based Interpolation 显示文摘 | Pumar M A | 1996 | Computer & Graphics1996，20，1： | 1 |
| 4 | High plasma glutamate concentrations are associated with infarct growth in acute ischemic stroke显示文摘 | M Castellanos T Sobrino S Pedraza O Moldes J M. Pumar Y Silva J Serena M García-Gil J Castillo A Dávalos | 2008 | Neurology2008，，23： | 1 |
| 5 | Relationships of apolipoprotein B(100) with the metabolic syndrome in type 2 diabetes mellitus显示文摘 | Losada F Pumar A | 2002 | Diabetes Res Clin Pract2002，57，3： | 1 |
| 6 | Early hyponatraemia after pituitary surgery: cerebral salt-wasting syndrome 显示文摘 | Guerrero R Pumar A Soto A | 2007 | Eur J Endocrinol2007，156，6： | 1 |
| 7 | Preoperative serum CA15-3 and CEA levels and clinical-biological parameters in breast tumors 显示文摘 | Ruibal A Garrido Pumar M Arias JI | 2006 | Rev Esp Med Nuel2006，25，3： | 1 |
| 8 | Areas of hyperdensity fol- lowing a mechanical intraarterial thrombectomy in acute is- chaemic stroke显示文摘 | Pumar J M Banguero A Masso A | 2014 | Rev Neurol2014，59，2： | 1 |
| 9 | High plasma glutamate concentrations are associated with infarct growth in acute ischemic stroke显示文摘 | M Castellanos T Sobrino S Pedraza O Moldes J M. Pumar Y Silva J Serena M García-Gil J Castillo A Dávalos | 2008 | Neurology2008，，23： | 1 |
| 10 | Relationship of C-peptide levels and C-peptide/bloodsugar ratio with clinical/biochemical variables associated with insulin resistance in orally-treated, well-con-trolled type 2 diabetic patients 显示文摘 | Relimpio F Losada F Pumar A | 1997 | Diabeties Res Clin Pract1997，36，3： | 1 |
| 11 | Zooming of terrain imagery using fractal-based interpolation显示文摘 | Pumar M A | 1996 | Computation and Graphics1996，20，1： | 1 |
| 12 | Relative Acculturation Extended Model (RAEM): New contributions with regard to the study of acculturation显示文摘 | Marisol Navas María C. García Juan Sánchez Antonio J. Rojas Pablo Pumares Juan S. Fernández | 2005 | International Journal of Intercultural Relations2005，，1： | 1 |
| 13 | Body temperature and fibrino-gen are related to early neurological deterioration in acute ischemie stroke 显示文摘 | Davalos A Castillo J Pumar JM | 1997 | Cerebrovasc Dis1997，7，： | 1 |
| 14 | Acculturation strategies and attitudes according to the Relative Acculturation Extended Model (RAEM): The perspectives of natives versus immigrants显示文摘 | Marisol Navas Antonio J. Rojas María García Pablo Pumares | 2006 | International Journal of Intercultural Relations2006，，1： | 1 |
| 15 | Body temperature and fibrinogen arerelated to early neurological deterioration in acute ischemic stroke显示文摘 | Davalos A Castillo J Pumar JM Noya M | 1997 | Cerebrovasc Dis1997，7，1： | 1 |
| 16 | Zooming of terrain imagery using fractal based interpolation 显示文摘 | PUMAR M A | 1996 | Computer & Graphics1996，30，1： | 1 |
| 17 | Zooming of terrain imagery using fractal-based interpolation 显示文摘 | | 1996 | Comput & Graphics1996，20，1： | 1 |
| 18 | Body temperature and fi brinogen are related to early neurological deterioration in acute ischemic stroke显示文摘 | Davalos A Castillo J Pumar JM | 1997 | Cerebrovase Dis1997，7，： | 1 |
| 19 | Early hyponatraemia after pituitary surgery: cerebral salt-wasting syndrome显示文摘 | Guerrero R Pumar A Soto A | 2007 | Eur J Endocrinol2007，156，6： | 1 |
| 20 | Evaluation of ^(177)Lu-Dotatate treatment in patients with metastatic neuroendocrine tumors and prognostic factors显示文摘BACKGROUND^177Lu peptide receptor radionuclide therapy(PRRT)is a recently approved therapy in Spain that has been demonstrated to be a well-tolerated therapy for positive somatostatin receptor advanced gastroenteropancreatic neuroendocrine tumors.AIM To determine the impact of PRRT on quality of life,radiologic and metabolic response,overall survival,prognostic factors and toxicity.METHODS Thirty-six patients treated with^177Lu-PRRT from 2016 to 2019 were included.The most frequent location of the primary tumor was the gastrointestinal tract(52.8%),pancreas(27.8%),and nongastropancreatic neuroendocrine tumor(11.1%).The liver was the most common site of metastasis(91.7%),followed by distant nodes(50.0%),bone(27.8%),peritoneum(25.0%)and lung(11.1%).Toxicity was evaluated after the administration of each dose.Treatment efficacywas evaluated by two parameters:stable disease and disease progression in response evaluation criteria in solid tumors 1.1 criterion and prognostic factors were tested.RESULTS From 36 patients,55.6%were men,with a median age of 61.1±11.8 years.Regarding previous treatments,55.6%of patients underwent surgery of the primary tumor,100%of patients were treated with long-acting somatostatin analogues,66.7%of patients were treated with everolimus,27.8%of patients were treated with tyrosine kinase inhibitor,and 27.8%of patients were treated with interferon.One patient received radioembolization,three patients received chemoembolization,six patients received chemotherapy.Hematological toxicity was registered in 14 patients(G1-G2:55.5%and G3:3.1%).Other events presented were intestinal suboclusion in 4 cases,cholestasis in 2 cases and carcinoid crisis in 1 case.The median follow-up time was 3 years.Currently,24 patients completed treatment.Nineteen are alive with stable disease,two have disease progression,eight have died,and nine are still receiving treatment.The median overall survival was 12.5 mo(95%confidence interval range:9.8–15.2),being inversely proportional to toxicity in previous treatments(P<0.02),tumor grade(P<0.01)and the presence of bone lesions(P=0.009)and directly proportional with matching lesion findings between Octreoscan and computed tomography pre-PRRT(P<0.01),,primary tumor surgery(P=0.03)and metastasis surgery(P=0.045).In a multivariate Cox regression analysis,a high Ki67 index(P=0.003),a mismatch in the lesion findings between Octreoscan and computed tomography pre-PRRT(P<0.01)and a preceding toxicity in previous treatments(P<0.05)were risk factors to overall survival.CONCLUSION Overall survival was inversely proportional to previous toxicity,tumor grade and the presence of bone metastasis and directly proportional to matching lesion findings between Octreoscan and computed tomography pre-PRRT and primary tumor and metastasis surgery. | Estephany Abou Jokh Casas Virginia Pubul Núnez Urbano Anido-Herranz María del Carmen Mallón Araujo Maria del Carmen Pombo Pasín Miguel Garrido Pumar José Manuel Cabezas Agrícola José Manuel Cameselle-Teijeiro Ashraf Hilal álvaro Ruibal Morell | 2020 | World Journal of Gastroenterology2020，26，13： | 0 |
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