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| 1 | Leukemic stromal hematopoietic microenvironment negatively regulates the normal hematopoiesis in mouse model of leukemia显示文摘Background and Objective: Leukemic microenvironment has a major role in the progression of leukemia. Leukemic cells can induce reversible changes in microenvironmental components, especially the stromal function which results in improved growth conditions for maintaining the malignant leukemic cells. This study aimed to investigate the survival advantage of leukemic cells over normal hematopoietic cells in stromal microenvironment in long term. Methods: The mice were injected intraperitoneally with N-N’ ethylnitrosourea (ENU) to induce leukemia; the mice received injection of normal saline were used as control. At 180 days after ENU induction, the mice were killed and the bone marrows were cultured for 19 days. Colony-forming assays were used to analyze the formation of various cell colonies. The expression of Sca-1, CD146, VEGFR2, CD95, pStat3, pStat5, and Bcl-xL in marrow cells were detected by flow cytometry. Results: Long-term leukemic bone marrow culture showed abnormal elongated stromal fibroblasts with almost absence of normal hematopoietic cells. Adherent cell colonies were increased, but CFU-F and other hematopoietic cell colonies were significantly decreased in leukemia group (P< 0.001). Primitive progenitor-specific Sca-1 receptor expression was decreased with subsequent increased expression of CD146 and VEGFR-2 in leukemic bone marrow cells. Decreased Fas antigen expression with increased intracellular pStat3, pStat5 and Bcl-xL proteins were observed in leukemic bone marrow cells. Conclusions: Stromal microenvironment shows altered morphology and decreased maturation in leukemia. Effective progenitor cells are decreased in leukemia with increased leukemia-specific cell population. Leukemic microenvironment plays a role in promoting and maintaining the leukemic cell proliferation and survivability in long term. | Pratima Basak Sumanta Chatterjee Prosun Das Madhurima Das Jacintha Archana Pereira Ranjan Kumar Dutta Malay Chaklader Samaresh Chaudhuri Sujata Law | 2010 | Chinese Journal of Cancer2010，29，12： | 3 |
| 2 | Metal contam - ination at a wood preservation site: characterization and ex - perimental studies on remediation 显示文摘 | Prosun B Mukherjee A B Gunnar J | 2002 | Science of the Total Environment2002，290，： | 1 |
| 3 | Controls on the genesis of some high-fluoride ground waters in India 显示文摘 | Gunnar Jacks Prosun Bhattacharya | 2005 | Applied Geochemistry2005，，20： | 1 |
| 4 | Behavior of arsenic and geochemical modeling of arsenic enrichment in aqueous environments显示文摘 | Ondra Sracek Prosun Bhattacharya Gunnar Jacks | 2004 | Applied Geochemistry2004，，19： | 1 |
| 5 | Metal contamination at a wood preservation site:characterization and experiment studies on remediation显示文摘 | Prosun Bhattacharyo | 2002 | The Science of the Total Environment2002，290，： | 1 |
| 6 | Distribution of geogenic arsenic in hydrologic systems: Controls and challenges 显示文摘 | Abhijit Mukherjee Prosun Bhattacharya Kaye Savage | 2008 | Journal of Contaminant Hydrology2008，99，： | 1 |
| 7 | Human Health Effects From Chronic Arsenic Poisoning-A Review显示文摘 | Simon Kapaj Hans Peterson Karsten Liber Prosun Bhattacharya | 2006 | Journal of Environmental Science and Health Part A2006，，10： | 1 |
| 8 | Arsenic enrichment in groundwater of the alluvial aquifers in Bangladesh: an overview 显示文摘 | Matin Ahmeda K Prosun Bhattacharyab Aziz Hasana M | 2004 | Applied Geochemistry2004，19，： | 1 |
| 9 | Arsenic in the environment:Biology and Chemistry显示文摘 | Prosun Bhattacharya Alan H Welch Kenneth G Stollenwerk | | 0，，379： | 1 |
| 10 | Environmental assessment of abandoned mine tailings in Adak,Va¨sterbotten district (northern Sweden)显示文摘 | Bhattacharya A Routh J Jacks G Prosun Bhattacharya P. and M(o)rth M | | 0，，： | 1 |
| 11 | Mercury flow via coal and coal utilization by-products: A global perspective显示文摘 | Arun B. Mukherjee Ron Zevenhoven Prosun Bhattacharya Kenneth S. Sajwan Ryunosuke Kikuchi | 2007 | Resources, Conservation & Recycling2007，，4： | 1 |
| 12 | Human Health Effects From Chronic Arsenic Poisoning-A Review显示文摘 | Simon Kapaj Hans Peterson Karsten Liber Prosun Bhattacharya | 2006 | Journal of Environmental Science and Health, Part A2006，，10： | 1 |
| 13 | Metal contamination at a wood preservation site: characterization and experimental studies on remediation显示文摘 | Prosun B Mukherjee A B Gunnar J Nordqvist S | 2002 | Science of the Total Environment2002，290，123： | 1 |
| 14 | Behavior of arsenic and geochemical modeling of arsenic enrichment in aqueous environments 显示文摘 | Ondra Sracek Prosun Bhattacharya | 2004 | Applied Geochemistry2004，，19： | 1 |
| 15 | Metal contamination at a wood preservation site: Characterization and experimental studies on remediation 显示文摘 | Prosun B Mukherjee A B Gunnar J Nordqvist S | 2002 | Science of the Total Environment2002，290，： | 1 |
| 16 | Controls on the genesis of some high-fluoride groundwa- ters in India显示文摘 | Gunnar Jacks Prosun Bhattacharya Vikas Chaudhary | 2005 | Applied Geochemisry2005，20，： | 1 |
| 17 | Controls on the genesis of some high- fluoride groundwaters in India显示文摘 | Gunnar Jacks Prosun Bhattacharya Vikas Chaudhary and Singh K P | 2005 | Applied Geochemistry2005，20，2： | 1 |
| 18 | Human Health Effects From Chronic Arsenic Poisoning-A Review显示文摘 | Simon Kapaj Hans Peterson Karsten Liber Prosun Bhattacharya | 2006 | Journal of Environmental Science and Health, Part A2006，，10： | 1 |
| 19 | Controls on the genesis of some high-fluoride groundwaters in India显示文摘 | Gunnar Jacks Prosun Bhattacharya Vikas Chaudhary K.P. Singh | 2004 | Applied Geochemistry2004，，2： | 1 |
| 20 | Monkeypox virus(MPXV):A Brief account of global spread,epidemiology,virology,clinical features,pathogenesis,and therapeutic interventions显示文摘The largest monkeypox virus(MPXV)outbreak of the 21st century occurred in 2022,which caused epidemics in many countries.According to WHO,physical contact with infected persons,contaminated surfaces,or affected animals might be a source of this virus transmission.A febrile sickness including few symptoms found in MPX disease.Skin rash,lesions,fever,headache,fatigue,and muscle aches symptoms were observed commonly for this disease.Animal and in vitro,studies have shown that the antiviral medications cidofovir and brincidofovir are effective against MPXV.The first-generation vaccinia virus vaccine was developed in 1960,and it helped to protect against MPXV with its side effects.A second-generation vaccination with limitations was launched in 2000.However,the CDC advised vaccinations for risk groups in endemic countries,including positive patients and hospital employees.The JYNNEOS vaccine,administered in 2 doses,also provides protection from MPX.This article presents concisely the most recent findings regarding epidemiology,genomic transmission,signs and symptoms,pathogenesis,diagnosis,and therapeutic interventions for MPXV,which may be helpful to researchers and practitioners.WHO declared that MPX was no longer a global health emergency due to its declining case rate,and a number of countries have reported new incidences.Further research-based investigations must be carried out based on the 2022 outbreak. | Md Aminul Islam Jubayer Mumin Md Masudul Haque MdAzizul Haque Ahrar Khan Prosun Bhattacharya Md Atiqul Haque | 2023 | Infectious Medicine2023，2，4： | 0 |
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