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| 1 | Mitochondrial DNA from hepatocytes as a ligand for TLR9: Drivers of nonalcoholic steatohepatitis?显示文摘Nonalcoholic fatty liver disease(NAFLD) is the most common liver disease worldwide, affecting approximately one third of the Western world. It consists of a wide spectrum of liver disorders, ranging from fatty liver to nonalcoholic steatohepatitis(NASH), which consists of steatosis, ballooning injury and inflammation. Despite an alarming growth in the statistics surrounding NAFLD, there are as yet no effective therapies for its treatment. Innate immune signaling has been thought to play a significant role in initiating and augmenting hepatic inflammation, contributing to the transition from nonalcoholic fatty liver to NASH. An immune response is triggered by countless signals called damage-associated molecular patterns(DAMPs) elicited by lipid-laden and damaged hepatocytes, which are recognized by pattern recognition receptors(PRRs) on hepatic immune cells to initiate inflammatory signaling. In this editorial, in addition to summarizing innate immune signaling in NAFLD and discussing potential therapies that target innate immune pathways, we have described a recent study that demonstrated that mitochondrial DNA serves as a DAMP activating a hepatic PRR, TLR9, in mice and in the plasma of NASH patients. In addition to identifying a new ligand for TLR9 during NASH progression, the study shows that blocking TLR9 reverses NASH, paving the way for the development of future NASH therapy. | Priya Handa Akhila Vemulakonda Kris V Kowdley Misael Uribe Nahum Méndez-Sánchez | 2016 | World Journal of Gastroenterology2016，22，31： | 3 |
| 2 | Collision tumor of the kidney composed of clear cell carcinoma and collecting duct carcinoma: report of a case with unusual morphology and clinical follow-up显示文摘We report the case of a 67-year-old female who presented with a large renal mass. Gross examination of the nephrectomy specimen demonstrated a 6-cm renal mass that invaded into the renal sinus and perinephric fat. Histologic examination revealed two distinct tumor types. The first type was a conventional(clear cell) renal cell carcinoma that was of low nuclear grade and comprised the minority of the overall tumor. The second type was a high-grade collecting duct carcinoma with glandular/tubular differentiation and composed the majority of the tumor. Immunohistochemical studies demonstrated distinctive patterns of the two tumor types, thus confirming two distinct lineages. Five months postoperatively, the patient developed metastasis to the lungs and right hilar lymph node region. A fine needle aspiration of a lung nodule demonstrated a metastatic, poorly differentiated carcinoma, similar to the collecting duct carcinoma component in the kidney. Collision tumors of the kidney are rare with fewer than 10 cases reported in the literature. Our report further expands the spectrum of this rare phenomenon. | Rhonda Burch-Smith Nizar M Tannir Erika Resetkova Pheroze Tamboli Priya Rao | 2014 | Chinese Journal of Cancer2014，33，7： | 3 |
| 3 | Lewis acid metal ion-exchanged MAPO-5 molecular sieves for solvent free synthesis of coumarin derivative显示文摘 | GOPALAKRISHNAN S VISWANATHAN K R PRIYA S V MABEL J H PALANICHAMY M MURUGESAN V | 2008 | Catalysis Communications2008，10，10： | 1 |
| 4 | Evaluation of antimicrobial efficacy of herbal alternatives (Triphala and green tea polyphenols), MTAD, and 5% sodium hypochlorite against Enterococcus faecalis biofilm formed on tooth substrate: an in vitro study显示文摘 | Prabhakar J Senthilkumar M Priya MS | 2010 | J Endod2010，36，1： | 1 |
| 5 | Association of interleukin-10 gene promoter poIy- morphism in allergic patients显示文摘 | GADDAM S L PRIYA V H S BABU B M V S | 2012 | Genet Test Mol Bi- omarkers2012，16，： | 1 |
| 6 | Growth Feed Utilization and Apparent Digestibility of Common Carp Cyprinus Carpio Var Communis Using Amylase Enzyme显示文摘 | Rajan M R Priya V | 1999 | Environment and Ecology1999，17，3： | 1 |
| 7 | LbL Fabricated Poly(styrene sulfonate)/TiO2 Multilayer Thin Films for Environmental Applications显示文摘 | D Neela Priya Jayant M Modak Ashok M Raichur | 2009 | ACS Appl Mater Interfaces2009，1，11： | 1 |
| 8 | Removal of total dissolved solids with simultaneous recovery of acid and alkali using bipolar membrane electrodialysis-application to RO reject of textile effluent 显示文摘 | Priya M N Palanivelu K | 2006 | Indian Journal of Chemical Technology2006，13，3： | 1 |
| 9 | Photocatalytic degradation of nitrobenzenes withcombustion synthesized nano-TiO2 显示文摘 | Priya M H Giridhar Madras | 2006 | Journal of Photochemistry and Photobiology A : Chemisrey2006，178，： | 1 |
| 10 | Effect of hydrophobic and hydrophilic properties of solid acid catalysts on the esterification of mateic anhydride with ethanol显示文摘 | Bhagiyalakshmi M Priya S V Mabel J H | 2008 | Catalysis Communications2008，9，10： | 1 |
| 11 | FPGA imple- mentation of low power image scaling processor using bilinear interpolation显示文摘 | Priya J J Annalakshmi M Ganesan R | 2014 | Programmable Device Circuits and Systems2014，6，5： | 1 |
| 12 | Pharmacogenetic Analysis of Genes Implicated in Rodent Models of Antidepres-sant Response : Association of TREK1 and Treatment Resistance in the STARD Study显示文摘 | Roy H P Priya M Jesen F | 2008 | Neuropsychopharmacology2008，33，： | 1 |
| 13 | Kinetics of the Photodegradation of Substituted Phenols by Solution Combustion Synthesized TiO2显示文摘 | SIVALINGAM G PRIYA M H MADRAS G | 2004 | Applied Catalysis B:Environmental2004，51，1： | 1 |
| 14 | Dark solitons,breathers,and rogue wave solutions of the coupled generalized nonlinear Schrdinger equations显示文摘 | Priya N V Senthilvelan M Lakshmanan M | 2014 | Phys Rev E2014，89，06： | 1 |
| 15 | An improved DNA isola- tion method and PCR protocol for efficient detection of muhicompo- nents of begomovirus in legumes 显示文摘 | Rouhibakhsh A Priya J Periasamy M | 2008 | Journal of Virological Methods2008，147，1： | 1 |
| 16 | Kinetics of photocatalytic degradation ofphenols with multiple substituent groups 显示文摘 | Priya M H Madras G | 2006 | Journal ofPhotochemistry and Photobiology A: Chemistry2006，179，3： | 1 |
| 17 | Fault Tolerance -Genetic Algorithm for Grid Task Scheduling using Check Point 显示文摘 | Priya S B Prakash M Dhawan K K | 2007 | 676 - 6802007，，： | 1 |
| 18 | Sinapic acid prevents hypertension and cardiovascular remodeling in pharmacological model of nitric oxide inhibited rats显示文摘 | Silambarasan T Manivannan J Krishna Priya M | 2014 | PLoS One2014，9，11： | 1 |
| 19 | RAPD and ISSR marker-based comparative evaluation of genetic diversity among indian germplasms of euryale ferox: an aquatic food plant显示文摘 | Kumar H Priya P Singh N Kumar M Choudhary B K Kumar L Singh I S Kumar N | 2016 | Applied Biochemistry and Biotechnology2016，11，01： | 1 |
| 20 | Insulin inhibitors intranuclear nuclear factor K and stimulates IoB in mononuclear cells in obese subjects:evidence for an anti-inflammatory effect 显示文摘 | Paresh D Ahmad A Priya M | 2001 | J Clin Endocrinol Metab2001，86，： | 1 |
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