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| 1 | Generalized megaviscera of lupus:Refractory intestinal pseudo-obstruction,ureterohydronephrosis and megacholedochus显示文摘Dilated dysfunction involving multiple visceral organs has been reported in patients with systemic lupus erythematosus(SLE).Chronic intestinal pseudo-obstruction(CIPO) resulting from intestinal smooth muscle damage has presented in conjunction with ureterohydronephrosis and, more rarely, biliary dilatation(megacholedochus).While the molecular pathogenesis is largely unknown, observed histo-pathologic features include widespread myositis, myocyte necrosis in the intestinal muscularis propria with subsequent atrophy and fibrosis, preserved myenteric innervations and little vasculitis.High dose immunosuppression usually results in resolution of symptoms with recovery of smooth muscle function, indicative of an autoimmune etiology.We report a patient with SLE who presented with intestinal pseudo-obstruction, ureterohydronephrosis and megacholedochus, and present images that illustrate megaviscera simultaneously involving all 3 visceral organs.Since the co-manifestation of all 3 is unusual and has been reported only once previously, wehave termed this rare clinical syndrome generalized megaviscera of lupus(GML).Although the SLE disease-activity parameters responded to aggressive immunomodulative therapy in our patient, clinical evidence of peristaltic dysfunction persisted in all involved viscera.This is a variation from the favorable outcomes reported previously in SLE patients with GML and we attribute this poor clinical outcome to disease severity and, most importantly, delayed clinical presentation.Since inflammation followed by atrophy and fibrosis are key aspects in the pathogenesis and natural history of GML, the poor response in our patient who presented late in the clinical course may be the result of ‘burnt out' inflammation with irreversible end-stage flbrosis.Thus, early recognition and timely initiation of treatment may be the key to recover visceral peristaltic function in patients with GML. | Frederick D Park Jeffrey K Lee Ganga D Madduri Pradipta Ghosh | 2009 | World Journal of Gastroenterology2009，15，28： | 20 |
| 2 | Evidence for colorectal sarcomatoid carcinoma arising from tubulovillous adenoma显示文摘Sarcomatoid carcinomas of the colorectum are rare tu- mors that display both malignant epithelial and stromal components. Clinically, they are aggressive tumors with early metastasis. Due to their infrequent occurrence, the pathogenesis is poorly understood. We report a case of a 52-year-old woman who presented with a rectal mass and intermittent hematochezia. Superficial biopsies during colonoscopy revealed a tubulovillous adenoma with high-grade dysplasia. Endoscopic ultra- sonography confirmed an invasive nature of the mass, and deeper biopsies revealed the presence of neoplasm with mixed histological components. The surgically- excised specimen demonstrated the presence of poorly differentiated spindle cells underneath the tubulovillous adenoma and an intermediate stage of invasive adeno- carcinoma. Based on the histological appearance and immunohistochemical studies, a diagnosis of sarcoma- toid carcinoma was made. Only nine cases of sarcoma- toid carcinomas of the colorectum have been reported to date. As a result, the terminology and pathogenesis of sarcomatoid carcinoma remain speculative. To the best of our knowledge, this is the first report of co- existence of sarcomatoid carcinoma and invasive ad- enocarcinoma with tubulovillous adenoma; all stages represented within the same tumor. This observation supports the 'monoclonal theory' of pathogenesis with an adenoma-sarcoma progression with or without an intermediate stage of carcinoma. | Jeffrey K Lee Pradipta Ghosh Valerie McWhorter Misty Payne Ryan Olson Mary L Krinsky Sonia Ramamoorthy John M Carethers | 2008 | World Journal of Gastroenterology2008，14，27： | 2 |
| 3 | Primary endoscopic stapedotomy using 3 mm nasal endoscope:Audiologic and clinical outcomes显示文摘Objective:To report the use of a 3 mm rigid nasal endoscope in primary endoscopic stapedotomy and clinical and audiological outcomes.Materials and methods:Thirty patients diagnosed with primary otosclerosis underwent endoscopic stapedotomy that was performed using a 3 mm nasal endoscope(Karl Storz).At 6 months follow-up,the patients were evaluated for intraoperative findings,postoperative hearing outcomes and complications.Results:Canaloplasty was performed in 2(6.66%)patients,and no curettage of the canal wall was required in 12(40%)patients.Transposition of the chorda tympani nerve was conducted in 11(36.66%)patients.The average duration of surgery was 36 min(range 31e65 min).The air-bone gap(ABG)was 35 dB(range 24e50 dB)preoperatively and 14.63 dB(range 9e20 dB)postoperatively(p?0.00).At 6 months follow-up,<20 dB ABG was achieved in 93.33%of the patients.No major intraoperative/postoperative complications were detected.Conclusion:A 3 mm rigid nasal endoscope can be effectively used in stapedotomy to obtain adequate audiological outcomes.It can be considered as a better alternative to the standard microscope or 4 mm endoscope in preserving the posterior canal wall and chorda tympani nerve while minimizing operative time without causing significant complications. | Pradeep Pradhan Chappity Preetam Pradipta kumar Parida | 2020 | Journal of Otology2020，15，4： | 2 |
| 4 | Screening and antibacterial efficacy of selected Indian medicinal plants显示文摘Objective: To evaluate the antibacterial efficacy of five Indian medicinal plants such as Acalypha indica L.(A. indica), Aerva lanata(L.) Juss. ex Schult.(A. lanata), Clerodendrum inerme(L.) Gaertn., Pergularia daemia(Forsk.) Chiov. and Solanum surattense Burm. f. against opportunistic bacterial pathogens isolated from HIV infected patients for the potential phytoconstituents in plant extracts.Methods: The opportunistic bacterial pathogens such as Escherichia coli(E. coli),Pseudomonas aeruginosa, Salmonella typhi and Serratia marcescens from Gramnegative group and Staphylococcus aureus from Gram-positive group were isolated from HIV infected patients. The antibacterial efficacy of ethanolic extracts of selected medicinal plants was carried out by disc diffusion method. The potential phytoconstituents of medicinal plant extracts were identified by gas chromatography and mass spectrometry(GC–MS) analysis.Results: Among the five medicinal plants tested, A. indica and A. lanata showed the significant antibacterial activity. A. indica showed potential activity against Staphylococcus aureus and E. coli. A. lanata significantly exhibited antibacterial activity against E. coli, Salmonella typhi and Pseudomonas aeruginosa. A total of 19 phytoconstituents were identified in the ethanolic extract of A. indica and A. lanata by GC–MS analysis respectively.Conclusions: The results of the present investigation revealed that A. indica and A. lanata, possessed significant antibacterial activity when compared with the other plant extracts tested. The presence of 3-O-methyl-D-glucose by GC–MS analysis in both A. indica and A. lanata extracts has not been reported elsewhere in the literature and the findings in this study could be the first one to report. | Suresh Mickymaray Mohammad Saleh Al Aboody Pradipta Kumar Rath Panneerselvam Annamalai Thajuddin Nooruddin | 2016 | Asian Pacific Journal of Tropical Biomedicine2016，6，3： | 2 |
| 5 | A late Neolithic expansion of Y chromosomal haplogroup O2a1-M95 from east to west显示文摘Y-Chromosomal haplogroup O2a1-M95 的起源和疏开,越过 Austro 分布式东方和南亚的亚洲说带,充分还有待于被理解。各种各样的研究也建议了一个东方印第安人或 O2a1-M95 的东南亚洲起源。我们从印度,老挝,和中国由采样 8748 人处理了古代的问题和 O2a1-M95 的疏开并且从从文学拿的另外的干涉区域把他们比作 3307 件样品。一个总数上的 haplogroup 频率和 Y-STR 数据的分析 2413 个 O2a1-M95 染色体表明老挝样品拥有了 O2a1-M95 的最高的频率(74%与> 0.5 )并且它的祖先的 haplogroups ( O2 *-P31, O *象有 14STR-median haplotype 的样品的一个更高的比例一样的-M175)( 17 取样在里面 14 张人口),深结合时间( 5.7 ± 0.3 Kya )和 consorted O2a1-M95 扩大从 STR 证实了进化。所有这些建议老挝将在学习区域之中带 O2a1-M95 的深古代。在西方的从东方的扩大时间的连续减少:在老挝,在东北印度的 5.2 ± 0.6,和在东方印度的 4.3 ± 0.2 的 5.7 ± 0.3 Kya,建议到西方的晚过时的东方从老挝系 O2a1-M95 传播了。 | GaneshPrasad Arunkumar Lan-Hai Wei Valampuri John Kavitha Adhikarla Syama Varatharajan Santhakumari Arun Surendra Sathua Raghunath Sahoo R. Balakrishnan Tomo Riba Jharna Chakravarthy Bapukan Chaudhury Premanada Panda Pradipta K. Das Prasanna K. Nayak Hui Li Ramasamy Pitchappan 无 | 2015 | Journal of Systematics and Evolution2015，53，6： | 1 |
| 6 | Presentation of the candidate rheumatoid arthritis autoantigen aggrecan by antigen-specific B cells induces enhanced CD4(+) T helper type 1 subset differentiation显示文摘 | Wilson CL Hine DW Pradipta A | 2012 | Immunology2012，135，4： | 1 |
| 7 | Content-based image retrieval using visually significant point features显示文摘 | Minakshi Banerjee Malay Kumar Kundu Pradipta Maji | | 0，，23： | 1 |
| 8 | Commissioning and Evaluation of a Fiber-Optic Sensor System for Bridge Monitoring显示文摘 | Richard H Scott Pradipta Banerji | 2013 | Sensors Journal IEEE2013，13，7： | 1 |
| 9 | An illumination tolerant class specific 2D subspace based face recognition technique using optimum correlation filter显示文摘 | Pradipta K Banerjee K | 2013 | IEEE Trans on Image Processing2013，124，12： | 1 |
| 10 | Maximum class separability for roughfuzzy c-means based brain mr image segmentation 显示文摘 | Pradipta M Sankar K P | 2008 | Transactions on Rough Sets Ⅸ2008，5390，7： | 1 |
| 11 | Link reliability in WDM optical network 显示文摘 | Chinnaayaaanda Panda Surya Narayan Patro Pradipta Kumar Das | 2012 | Indian Jour- nal of Computer Science and Engineering2012，3，1： | 1 |
| 12 | Rough set based maximum relevance-maximum significance criterion and Gene selection from microarray data显示文摘 | Pradipta Maji Sushmita Paul | 2010 | International Journal of Approximate Reasoning2010，，3： | 1 |
| 13 | Rough-fuzzy C-Medoids Algorithm and Selection of Bio-basis for Amino Acid Sequence Analysis 显示文摘 | Pradipta M Sankar K P | 2007 | IEEE Transactions on Knowledge and Data Engineering2007，19，6： | 1 |
| 14 | Design considerations for a multihop wireless network testbed 显示文摘 | Pradipta De Ashish Raniwala Srikant Sharma Tzi-cker Chiueh | 2005 | IEEE Communications (S0163-6804)2005，43，10： | 1 |
| 15 | Presentation of the candidate rheumatoid arthritis autoantigen aggrecan by antigen-specific B cells induces enhanced CD4(+) T helper type 1 subset differentiation显示文摘 | Wilson C L Hine D W Pradipta A | | 0，，04： | 1 |
| 16 | Newer antipsychotics: Brexpiprazole, cariprazine, and lumateperone: A pledge or another unkept promise?显示文摘Antipsychotic agents are used for various indications in the treatment of psychiatric disorders.Despite their proven roles in multiple conditions,the treatment-emergent side effects of antipsychotic medications,such as metabolic side effects,are often the limiting factor for their long-term and short-term uses.Moreover,antipsychotic medications are often criticized for being less effective in treating different disabling symptoms such as negative symptoms of schizophrenia.As a result,the search for safer and more efficacious antipsychotic agents is ongoing.Newer antipsychotic agents are gaining attention related to emerging efficacy and tolerability data in treating neuropsychiatric conditions.In this review,we attempt to appraise the scientific data on psychopharmacology,safety profile,and efficacy of the newer additions to the list of second-generation antipsychotics,namely brexpiprazole,cariprazine,and lumateperone.We conducted a selective review utilizing PubMed,clinicaltrials.gov,and Cochrane databases to gather appropriate publications,keeping broad inclusion criteria.There were no restrictions on the age of the study population or the year of publication.We also cross-referenced articles and references to capture all existing studies.Our review of the current literature indicates that all three antipsychotic agents appear to be promising based on their short-term studies,while long-term studies remain limited.There is also a need for a head to head comparison between the newer antipsychotics with the other antipsychotic agents to ascertain if the newer agents are any better than the others. | Rajdip Barman Pradipta Majumder Tejaswini Doifode Anita Kablinger | 2021 | World Journal of Psychiatry2021，11，12： | 1 |
| 17 | Isolation of novel bioactive regions from bovine Achilles tendon collagen having angiotensin I- converting enzyme-inhibitory properties显示文摘 | Pradipta B C Shanthi | 2012 | Process Biochem istry2012，47，12： | 1 |
| 18 | Mutual Information-Based Supervised Attribute Clustering for Microarray Sample Classification显示文摘 | Pradipta Maji | 2012 | IEEE Transactions on Knowledge and Data Engineering2012，24，1： | 1 |
| 19 | Tuned Liquid Dampers for Controlling Earthquake Response of Structures 显示文摘 | PRADIPTA B MOHAN M | 2000 | Earthquake Engineering and Structural Dynamics2000，29，5： | 1 |
| 20 | Sorption behavior of thiourea-grafted polymeric resin toward silver ion,reduction to silver nanoparticles, and their antibacterial properties显示文摘 | Kumar Pradipta Ansari Khursheed B Koli Aditya C | 2013 | Industrial & Engineering Chemistry Research2013，52，19： | 1 |
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