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| 1 | High-throughput screening of mouse gene knockouts identifies established and novel skeletal phenotypes显示文摘Screening gene function in vivo is a powerful approach to discover novel drug targets. We present high-throughput screening(HTS) data for 3 762 distinct global gene knockout(KO) mouse lines with viable adult homozygous mice generated using either gene-trap or homologous recombination technologies. Bone mass was determined from DEXA scans of male and female mice at 14 weeks of age and by microCT analyses of bones from male mice at 16 weeks of age. Wild-type(WT) cagemates/littermates were examined for each gene KO. Lethality was observed in an additional 850 KO lines. Since primary HTS are susceptible to false positive findings, additional cohorts of mice from KO lines with intriguing HTS bone data were examined. Aging,ovariectomy, histomorphometry and bone strength studies were performed and possible non-skeletal phenotypes were explored. Together, these screens identified multiple genes affecting bone mass: 23 previously reported genes(Calcr, Cebpb, Crtap, Dcstamp, Dkk1, Duoxa2, Enpp1, Fgf23, Kiss1/Kiss1 r, Kl(Klotho),Lrp5, Mstn, Neo1, Npr2, Ostm1, Postn, Sfrp4, Slc30a5, Slc39a13, Sost, Sumf1, Src, Wnt10b), five novel genes extensively characterized(Cldn18, Fam20 c, Lrrk1, Sgpl1, Wnt16), five novel genes with preliminary characterization(Agpat2, Rassf5, Slc10a7, Slc26a7, Slc30a10) and three novel undisclosed genes coding for potential osteoporosis drug targets. | Robert Brommage Jeff Liu Gwenn M Hansen Laura L Kirkpatrick David G Potter Arthur T Ss Brian Zambrowicz David R Powell Peter Vogel | 2014 | Bone Research2014，2，3： | 7 |
| 2 | Medial temporal lobe atrophy on MRI scans and the diagnosis of Alzheimer disease显示文摘 | R Duara D A. Loewenstein E Potter J Appel M T. Greig R Urs Q Shen A Raj B Small W Barker E Schofield Y Wu H Potter | 2008 | Neurology2008，，24： | 2 |
| 3 | Survival after inflammatory bowel disease-associated colorectal cancer in the Colon Cancer Family Registry显示文摘AIM: To investigate the survival of individuals with colorectal cancer (CRC) with inflammatory bowel disease (IBD-associated CRC) compared to that of individuals without IBD diagnosed with CRC. METHODS: Epidemiologic, clinical, and follow-up data were obtained from the Colon Cancer Family Registry (Colon CFR). IBD-associated cases were identified from self-report of physician diagnosis. For a subset of participants, medical records were examined to confirm self-report of IBD. Cox proportional hazards regression was applied to estimate adjusted hazard ratios (aHR) and 95%CI of mortality, comparing IBD-associated to non-IBD-associated CRC, adjusted for age at CRC diagnosis, sex, Colon CFR phase, and number of prior endoscopies. Following imputation to complete CRC stage information, adjustment for CRC stage was examined. RESULTS: A total of 7202 CRC cases, including 250 cases of IBD-associated CRC, were analyzed. Over a twelve year follow-up period following CRC diagnosis, 2013 and 74 deaths occurred among non-IBD associated CRC and IBD-associated CRC patients, respectively. The difference in survival between IBD-associated and non-IBD CRC cases was not statistically significant (aHR = 1.08; 95%CI: 0.85-1.36). However, the assumption of proportional hazards necessary for valid inference from Cox regression was not met over the entire follow-up period, and we therefore limited analyses to within five years after CRC diagnosis when the assumption of proportional hazards was met. Over this period, there was evidence of worse prognosis for IBD-associated CRC (aHR = 1.36; 95%CI: 1.05-1.76). Results were similar when adjusted for CRC stage, or restricted to IBD confirmed in medical records. CONCLUSION: These results support the hypothesis that IBD-associated CRC has a worse prognosis than non-IBD-associated CRC. | Scott V Adams Dennis J Ahnen John A Baron Peter T Campbell Steven Gallinger William M Grady Loic LeMarchand Noralane M Lindor John D Potter Polly A Newcomb | 2013 | World Journal of Gastroenterology2013，19，21： | 2 |
| 4 | Freezing point depression of aqueous sodium chloride solutions 显示文摘 | Potter R W Clynne M A Brown D L | 1978 | Economic Geology1978，72，： | 1 |
| 5 | A'humanized'green fluorescent protein cDNA adapted for high level expression in mam Malian cells显示文摘 | ZOLOTHUKIN S POTTER M | 1996 | J Virol1996，70，： | 1 |
| 6 | Evalution of commercial sources of the pesticidal annonaceous acetogenins显示文摘 | Ratanyake S Rupprecht J K Potter W M | 1992 | J Econ Entomol1992，85，6： | 1 |
| 7 | A 'humanized' green fluorescent protein cDNA adapted for high-level expression in mammalian cells显示文摘 | Zolotukhin S Potter M Hauswirth W W | 1996 | J Virol1996，70，7： | 1 |
| 8 | On the Relation Among Some Definitions of Strategic Stability显示文摘 | J HLLAS M JANSEN J POTTERS and D VERMEULEN | 2002 | Mathematics of Operations Research2002，26，32： | 1 |
| 9 | Links between climate and sea levels for the past three million years 显示文摘 | Lambeck K Esat T M Potter E K | 2002 | Nature2002，419，： | 1 |
| 10 | The generation of geometrical deformations due to tool/part interaction in the manufacture of composite components显示文摘 | Potter K D Campbell M Langer C | 2005 | Composites Part A:Applied Science and Manufacturing2005，，： | 1 |
| 11 | Palladium gold removal recovery from precious metal solutions electronic scrap leachates by desulfovibrio desulfuricans 显示文摘 | Creamer N J Baxter-Plant V S Henderson J Potter M Macaskie L E | 2006 | Biotechnology Letters2006，28，18： | 1 |
| 12 | An experimental method to study the frictional processes during composites manufacturing显示文摘 | Ersoy N Potter K Wisnom M R Clegg M J | 2005 | Composites Part A: Applied Science and Manufacturing2005，36，11： | 1 |
| 13 | Phase II trial of high-dose,intermittent calcitriol(1,25 dihydroxyvitamin D3) and dexamethasone in androgen-independent prostate cancer显示文摘 | TRUMP D L POTTER D M MUINDI J | 2006 | Cancer2006，106，10： | 1 |
| 14 | Intake of Soy Protein and Soy Protein Extracts Influences Lipid Metabolismand Hepatic Gene Expression in Gerbils显示文摘 | Claudia Tovar-Palacio Susan M Potter Julie C Hafermann | 1998 | Biochemical and Molecular Roles of Nutrients1998，128，： | 1 |
| 15 | B and T lymphocyte attenuator regulates T cell activation through interaction with herpesvirus entry mediator显示文摘 | Sedy JR Gavrieli M Potter KG | 2005 | Nat Immunol2005，6，1： | 1 |
| 16 | Molecular and immunohis- tochemical staging of men with seminal vesicle invasion and nega- tive pelvic lymph nodes at radical prostatectomy 显示文摘 | Potter SR Mangold LA Shue M J | 2000 | Cancer2000，89，12： | 1 |
| 17 | Identifying nurse staffing and patient outcome relationships: A Guide for Change in Care Delivery显示文摘 | Potter P Barr N McSweeney M | 2003 | Nurs Econ2003，21，4： | 1 |
| 18 | Intake of soy protein and soy protein extracts influences lipid metabolism and hepatic gene expression in gerbils显示文摘 | Tovar-palacio C Potter S M Hafermann J C | | 0，，： | 1 |
| 19 | Cerebral small-vessel disease:what lies beyond the early year显示文摘 | Potter G M Román G | | 0，，08： | 1 |
| 20 | Topical negative pressure stimulates endothelial migration and proliferation: a suggested mechanism for improved integration of integra显示文摘 | Baldwin C Potter M Clayton E | 2009 | Ann Plast Surg2009，62，1： | 1 |
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