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| 1 | Aspirin use for primary prophylaxis: Adverse outcomes in non-variceal upper gastrointestinal bleeding显示文摘AIM: To compare outcomes of patients with nonvariceal upper gastrointestinal bleeding(NVUGIB) taking aspirin for primary prophylaxis to those not taking it.METHODS: Patients not known to have any vascular disease(coronary artery or cerebrovascular disease) who were admitted to the American University of Beirut Medical Center between 1993 and 2010 with NVUGIB were included. The frequencies of in-hospital mortality, re-bleeding, severe bleeding, need for surgery or embolization, and of a composite outcome defined as the occurrence of any of the 4 bleeding related adverse outcomes were compared between patients receiving aspirin and those on no antithrombotics. We also compared frequency of in hospital complications and length of hospital stay between the two groups.RESULTS: Of 357 eligible patients, 94 were on aspirin and 263 patients were on no antithrombotics(controlgroup). Patients in the aspirin group were older, the mean age was 58 years in controls and 67 years in the aspirin group(P < 0.001). Patients in the aspirin group had significantly more co-morbidities, including diabetes mellitus and hypertension [25(27%) vs 31(112%) and44(47%) vs 74(28%) respectively,(P = 0.001)], as well as dyslipidemia [21(22%) vs 16(6%), P < 0.0001).Smoking was more frequent in the aspirin group [34(41%) vs 60(27%), P = 0.02)]. The frequencies of endoscopic therapy and surgery were similar in both groups. Patients who were on aspirin had lower inhospital mortality rates(2.1% vs 13.7%, P = 0.002),shorter hospital stay(4.9 d vs 7 d, P = 0.01), and fewer composite outcomes(10.6% vs 24%, P = 0.01). The frequencies of in-hospital complications and re-bleeding were similar in the two groups.CONCLUSION: Patients who present with NVUGIB while receiving aspirin for primary prophylaxis had fewer adverse outcomes. Thus aspirin may have a protective effect beyond its cardiovascular benefits. | Karina M Souk Hani M Tamim Hussein A Abu Daya Don C Rockey Kassem A Barada | 2016 | World Journal of Gastrointestinal Surgery2016，8，7： | 3 |
| 2 | Animal models of ex vivo lung perfusion as a platform for transplantation research显示文摘Ex vivo lung perfusion(EVLP) is a powerful experimental model for isolated lung research. EVLP allows for the lungs to be manipulated and characterized in an external environment so that the effect of specific ventilation/perfusion variables can be studied independent of other confounding physiologic contributions. At the same time,EVLP allows for normal organ level function and real-time monitoring of pulmonary physiology and mechanics. As a result,this technique provides uniqueadvantages over in vivo and in vitro models. Small and large animal models of EVLP have been developed and each of these models has their strengths and weaknesses. In this manuscript,we provide insight into the relative strengths of each model and describe how the development of advanced EVLP protocols is leading to a novel experimental platform that can be used to answer critical questions in pulmonary physiology and transplant medicine. | Kevin Nelson Christopher Bobba Samir Ghadiali Don Hayes Jr Sylvester M Black Bryan A Whitson | 2014 | World Journal of Experimental Medicine2014，4，2： | 2 |
| 3 | Global epidemiology of hepatitis B and hepatitis C in people who inject drugs: results of systematic reviews显示文摘 | Paul K Nelson Bradley M Mathers Benjamin Cowie Holly Hagan Don Des Jarlais Danielle Horyniak Louisa Degenhardt | 2011 | The Lancet . 2011 (9791)2011，，： | 2 |
| 4 | Gender differences in cochlear response time:an explanation for gender amplitude differences in the unmasked auditory brain-stem response显示文摘 | Don M Ponton C W Eggermont J J | 1993 | J Acoust Soc Am1993，94，4： | 1 |
| 5 | Reconstruction of the andiogram using brain stem responses and high - pass noise masking显示文摘 | Don M Eggermont JJ Brackmann DE | 1979 | Ann Otol Rhinol Laryngol Suppl1979，57，： | 1 |
| 6 | Community-acquired pneumonia in chil-dren:what's old?What's new?显示文摘 | Don M Canciani M Korppi M | 2010 | Acta Paediatr2010，99，11： | 1 |
| 7 | The shearing characteristics associated with e- qual-channel angular pressing 显示文摘 | Furukawa M Iwahashi Y Horita Z Nemoto M Lang- don T | 1998 | Materials Science and Engineering1998，257，2： | 1 |
| 8 | Preparation and properties of nano-silica modified nega- tive acrylate photoresist 显示文摘 | Lee C K Don T M Lai W C Chert C C Lin D J Cheng L P | 2008 | Thin Solid Films2008，516，23： | 1 |
| 9 | The mismeasurement of risk显示文摘 | Kritzman Don Rich M | 2002 | Financial Analysts Journal2002，5，6： | 1 |
| 10 | Meshless methods for shear-deformable beams and plates 显示文摘 | Donning B M Liu W K | 1998 | Computer Methods in Applied Mechanics and Engineering1998，152，1： | 1 |
| 11 | The Elliptic Curve Digital Signarure Algorithm (ECDSA)显示文摘 | DON J ALFRED M SCOTT V | 2004 | Lecture Notes in Computer Science2004，3269，： | 1 |
| 12 | Efficacy of serum procalci- tonin in evaluating severity of community-acquired pneumonia in childhood显示文摘 | Don M Valent F Korppi M | 2007 | Scand Infect Dis2007，39，2： | 1 |
| 13 | Characterization of DegU, a response regulator in Listeria monocytogenes, involved in regulation of motility and contributes to virulence显示文摘 | Knudsen G M Olsen J E Dons L | 2004 | FEMS Microbiol Lett2004，240，2： | 1 |
| 14 | Jewel of the seabed : sea cucumbers as nu- tritional and drug candidates 显示文摘 | KIEW P L DON M M | 2012 | Int J Food Sci Nutr2012，63，5： | 1 |
| 15 | Pitfalls and complicause of the proximal femoral nail显示文摘 | Windolf J dons in the Hollander DA Hakimi M | 2005 | Lxnt enhecks Arch Surt2005，390，3： | 1 |
| 16 | Characterization of acrylic copolymers applied in negative-type photoresist via a ternary composition diagram 显示文摘 | Lee C K Don T M Lin D J Chen C C Cheng L P | 2008 | Journal of Applied Polymer Science2008，109，1： | 1 |
| 17 | Maturational delays in cortical evoked potentials in cochlear implant users显示文摘 | EGGERMONT J J PONTON C W DON M | 1997 | Acta Otolaryngol1997，117，： | 1 |
| 18 | Intrapartum fetal pulse oximetry:fetal oxygen saturation trends during labor and relation to delivery outeome显示文摘 | Dildy GA Van don Berg PP Katz M | 1994 | Am J Obstet Gynecol1994，171，3： | 1 |
| 19 | A review of indicators of climate change for use in Ireland 显示文摘 | DON'NELLY A JONES M B SWEENEY J | 2004 | International Journal of Biometeorology2004，49，1： | 1 |
| 20 | Overview of the mars laser communications demonstration project 显示文摘 | Boroson Don M Chen Chienchung Edwards Bernard | 2005 | IEEE Lasers & Electro-Optics Society Newsletter2005，19，5： | 1 |
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