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| 1 | Single-operator cholangioscopy for biliary complications in liver transplant recipients显示文摘AIM To evaluate cholangioscopy in addition to endoscopic retrograde cholangiopancreatography(ERCP) for management of biliary complications after liver transplantation(LT).METHODS Twenty-six LT recipients with duct-to-duct biliary reconstruction who underwent ERCP for suspected biliary complications between April and December2016 at the university hospital of Muenster were consecutively enrolled in this observational study. After evaluating bile ducts using fluoroscopy, cholangioscopy using a modern digital single-operator cholangioscopy s y s t e m(S py G la s s D S ?) wa s pe r fo r me d dur ing the same procedure with patients under conscious sedation. All patients received peri-interventional antibiotic prophylaxis and bile was collected during the intervention for microbial analysis and for antibiotic susceptibility testing.RESULTS Thirty-three biliary complications were found in a total of 22 patients, whereas four patients showed normal bile ducts. Anastomotic strictures were evident in 14(53.8%) patients, non-anastomotic strictures in seven(26.9%), biliary cast in three(11.5%), and stones in six(23.1%). A benefit of cholangioscopy was seen in 12(46.2%) patients. In four of them, cholangioscopy was crucial for selective guidewire placement prior to planned intervention. In six patients, biliary cast and/or stones failed to be diagnosed by ERCP and were only detectable through cholangioscopy. In one case, a bile duct ulcer due to fungal infection was diagnosed by cholangioscopy. In another case, signs of bile duct inflammation caused by acute cholangitis were evident. One patient developed post-interventional cholangitis. No further procedure-related complications occurred. Thirty-seven isolates were found in bile. Sixteen of these were gram-positive(43.2%), 12(32.4%) were gram-negative bacteria, and Candida species accounted for 24.3% of all isolated microorganisms. Interestingly, only 48.6% of specimens were sensitive to prophylactic antibiotics.CONCLUSION Single-operator cholangioscopy can provide important diagnostic information, helping endoscopists to plan and perform interventional procedures in LT-related biliary complications. | Anna Hüsing-Kabar Hauke Sebastian Heinzow Hartmut Hans-Jürgen Schmidt Carina Stenger Hans Ulrich Gerth Michele Pohlen Gerold Tholking Christian Wilms Iyad Kabar | 2017 | World Journal of Gastroenterology2017，23，22： | 4 |
| 2 | Improvement of biodistribution with PEGylated liposomes containing docetaxel with degradable starch microspheres for hepatic arterial infusion in the treatment of liver metastases:a study in CC-531 liver tumor-bearing WAG RIJ rats显示文摘 | Pohlen U Buhr HJ Berger G | | 0，，01： | 1 |
| 3 | Efficacy and toxicity of a rituximab and metliotrexate based regimen (GMALL B-ALL/NHL 2002 protocol)in Bukritt,s and primary mediastinal large B-cell lymplioma显示文摘 | Pohlen M Gertli HU Liersch R | | 0，，12： | 1 |
| 4 | Supply Chain Metrics 显示文摘 | Lambert Douglas M Terrance L Pohlen | 2001 | The International Journal of Logistics Management2001，12，1： | 1 |
| 5 | Temporary unilateral microembolization of the lung-a new approach to regional chemotherapy for pulmonary metastases 显示文摘 | Schneider P Foitzik T Pohlen U | 2002 | J Surg Res2002，107，： | 1 |
| 6 | Increased carboplatin concentration in liver tumors through temporary flow retardation with starch microspheres (spherex) and gelatin powder (Gelfoam):an experimental study in liver tumor-bearing rabbits显示文摘 | Pohlen U Berger G Binnenhei M | 2000 | Journal of Surgical Research2000，92，： | 1 |
| 7 | Impact of haemoglobin concentration and chronic kidney disease in patients with coronary heart disease undergoing percutaneous coronary interventions 显示文摘 | Husemann W Fobker M Pohlen M | 2007 | Nephrol Dial Transplant2007，22，9： | 1 |
| 8 | Implementing activity -based costing ( ABC ) in logistics 显示文摘 | Pohlen T L LaLonde B J | 1994 | Journal of Business Logistics1994，15，2： | 1 |
| 9 | Temporary unilateral microembolization of the lung-a new approach to regional chemotherapy for pulmonary metastases 显示文摘 | Schneider P Foitzik T Pohlen U | 2002 | J Surg Res2002，107，： | 1 |
| 10 | Improvement in 5 fluorouracil (5-FU) and 5-fluoro 2-deoxyuridine (FdUrd) concen tration by 5 fluorouracil polyethylene-Glycol liposomes in abdominal stop-flow:treatment of VX2 liver tumor-bearing rabbits 显示文摘 | Pohlen U Rieger H Binnenhei M | 2005 | J Chemother2005，17，4： | 1 |
| 11 | Chemoembolization of lung metastases-pharmacokinetic behaviour of carboplatin in a rat model显示文摘 | Pohlen U Rieger H Meyer BT | 2007 | Anticancer Res2007，27，： | 1 |
| 12 | Reverse logistics in plastics recycling显示文摘 | POHLEN T L FARRIS T | 1992 | International Journal of Physical Distribution&Logistics Man-agement1992，22，7： | 1 |
| 13 | From Black to White- Problem Solving for Heavy Load Applications显示文摘 | Josef Pohlen Graham Gow AB Axel | 2000 | NLGI Spokesman2000，64，2： | 1 |
| 14 | Efficacy and toxicity of a rituximab? and methotrexate based regimen (GMALL B-ALL/NHL 2002 protocol) in Burkitt's and primary mediastinal large B-cell lymphoma显示文摘 | Pohlen M Gerth HU Liersch R | | 0，，12： | 1 |
| 15 | Reverse logistics in plastics recycling 显示文摘 | Pohlen T L Farris M T | 1992 | International Journal of Physical Distribution and Logistics1992，22，7： | 1 |
| 16 | Buyer opportunism in business-to-business exchange显示文摘 | Timothy G. Hawkins Terrance L. Pohlen Victor R. Prybutok | 2013 | Industrial Marketing Management2013，，： | 1 |
| 17 | Increased Carboplatin Concentration in Liver Tumors through Temporary Flow Retardation with Starch Microspheres(Spherex)and Gelatin Powder(Gelfoam):An Experimental Study in Liver Tumor-Beating Rabbits显示文摘 | U Pohlen G Berger M Binnenhei | 2000 | Journal of Surgical Research2000，92，： | 1 |
| 18 | Implementing activity-based costing(ABC)in logistics显示文摘 | POHLEN T L LA LONDE B J | 1994 | Journal of Business Logistics1994，15，2： | 1 |
| 19 | Implementing activitybased costing (ABC) in logistics 显示文摘 | Pohlen T L LaLonde B J | 1994 | Journal of Business Logistics1994，，2： | 1 |
| 20 | Simultaneous determination of resveratrol and its active metabolites in serum and tissue by high-performance liquid chromatography显示文摘 | Jung M Berger G Pohlen U | 2000 | J Chromatography B2000，702，12： | 1 |
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