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| 1 | Glutamine transporters as pharmacological targets: From function to drug design显示文摘Among the different targets of administered drugs,there are membrane transporters that play also a role in drug delivery and disposition.Moreover,drug-transporter interactions are responsible for off-target effects of drugs underlying their toxicity.The improvement of the drug design process is subjected to the identification of those membrane transporters mostly relevant for drug absorption,delivery and side effect production.A peculiar group of proteins with great relevance to pharmacology is constituted by the membrane transporters responsible for managing glutamine traffic in different body districts.The interest around glutamine metabolism lies in its physio-pathological role;glutamine is considered a conditionally essential amino acid because highly proliferative cells have an increased request of glutamine that cannot be satisfied only by endogenous synthesis.Then,glutamine transporters provide cells with this special nutrient.Among the glutamine transporters,SLC1A5,SLC6A14,SLC6A19,SLC7A5,SLC7A8 and some members of SLC38 family are the best characterized,so far,in both physiological and pathological conditions.Few 3D structures have been solved by CryoEM;other structural data on these transporters have been obtained by computational analysis.Interactions with drugs have been described for several transporters of this group.For some of them,the studies are at an advanced stage,for others,the studies are still in nuce and novel biochemical findings open intriguing perspectives. | Mariafrancesca Scalise Lorena Pochini Michele Galluccio Lara Console Cesare Indiveri | 2020 | Asian Journal of Pharmaceutical Sciences2020，15，2： | 5 |
| 2 | SLC38A9 is a component of the lysosomal amino acid sensing machinery that controls mTORC1 显示文摘 | Rcbsamen M Pochini L Stasyk T | 2015 | Nature2015，519，7544： | 1 |
| 3 | Interaction of β-lac-tam antibiotics with the mitochondrial camitine/acylcamitine trans-porter显示文摘 | Pochini L Calluccio M Scumaci D | 2008 | Chem Biol Interact2008，173，： | 1 |
| 4 | Treatment of achalasia: lessons learned with Chagas’ disease显示文摘 | F. A. M.Herbella J. L. B.Aquino S.Stefani‐Nakano E. L. A.Artifon P.Sakai E.Crema N. A.Andreollo L. R.Lopes C.De Castro Pochini P. R.Corsi D.Gagliardi J. C.Del Grande | 2008 | Diseases of the Esophagus2008，，5： | 1 |
| 5 | OCTN cation transport- ers in health and disease: role as drug targets and assay develop- ment显示文摘 | Pochini L Scalise M Galluccio M | 2013 | JBiomolScreen2013，18，8： | 1 |
| 6 | Synthe- sis, ^1 HNMR,^13 CNMR spectra and eonformational prefer- ence of open chain ligands on lipophilic maerocycles 显示文摘 | BOCCHI V POCHINI F A UNGARO R | 1982 | Tetrahedron1982，38，3： | 1 |
| 7 | Histoplasmosis of the larynx显示文摘 | Pochini Sobrinho F Della Negra M Queiroz W | 2007 | Braz J Otorhinolaryngol2007，73，6： | 1 |
| 8 | Synthesis,and X-ray Crystal and Molecular Structure of Novel Macrobicyclic Ligand: Crown p-tert-butyl-calixarene显示文摘 | Alfieri C Dradi E Pochini A | 1983 | J Chem Soc Chem Commun1983，19，： | 1 |
| 9 | Membranetransporters for the special amino acid glutamine: structure/function relationships and relevance to human health显示文摘 | Pochini L Scalise M Galluccio M Indiveri C | 2014 | FrontChem2014，2，： | 1 |
| 10 | Synthesis,Complexation and Membrane Transport Studies of 1,3-Ahernate Calix arene-crown-6 Confromers:A New Class of Cesium Selective Iomopjores显示文摘 | Casnati A Pochini A Ungaro R | 1995 | J Am Chem Soc1995，117，： | 1 |
| 11 | New ionizable ligands from p. t-butylcalix [4] arene显示文摘 | R. Ungaro A. Pochini G. D. Andreetti | 1984 | Journal of Inclusion Phenomena (-)1984，，1： | 1 |
| 12 | Reconstitution into liposomes of the glutamine/ami- no acid transporter from renal cell plasma membrane: functional characterization, kinetics and activation by nucleotides 显示文摘 | OPPEDISANO F POCHINI L GALLUCCIO M | 2004 | Biochimica et Biophysica Acta (BBA) : Biomembranes2004，1667，2： | 1 |
| 13 | Transport mechanism and regulatory properties of the humanamino acid transporter ASCT2 (SLC1A5) 显示文摘 | Scalise M Pochini L Panni S Pingitore P Hedfalk K IndiveriC | 2014 | Amino Acids2014，46，11： | 1 |
| 14 | Membrane transporters for the special amino acid glu- tamine: structure/function relationships and relevance to human health 显示文摘 | POCHINI L SCALISE M GALLUCCIO M | 2014 | Frontiers in Chemistry2014，2，： | 1 |
| 15 | New upper rim pyrdine-bridged calixarenes: synthesis and complexation properties toward neutral molecules and ammoniuin ions in organic media显示文摘 | McGregor W M Pochini A | 1996 | J Org Chem1996，61，： | 1 |
| 16 | Synthesis, and X - ray crystal and molecular structure of a novel macro - bicyclic ligand : Crowned p - t - butyl - calix arene 显示文摘 | ALFIERI C DRADI E POCHINI A | 1983 | J Chem Soc - Chem Com1983，，19： | 1 |
| 17 | Calixarene-based cation receptor sand carriers显示文摘 | POCHINI A | 1991 | Top Inclusion Sci1991，21，8： | 1 |
| 18 | Synthesis Complexation,and Membrane Transport Studies of 1,3-Alternate Calixarene-crown-6 Conformers:A New Class of Cesium Selective Ionophores显示文摘 | Casnati A Pochini A Ungaro R | 1995 | J Am Chem Soc1995，11，7： | 1 |
| 19 | The glutamine/amino acid transporter (ASCT2) reconstituted in liposomes; transport mechanism,regulation by ATP and characterization of the glutamine/ glutamate antiport显示文摘 | OPPEDISANO F POCHINI L GALLUCCIO M | 2007 | Biochemistry Biophysical Ac-ta2007，1768，： | 1 |
| 20 | Inactivation of the glutamine/amino acid transporter ASCT2 by 1,2,3-dithiazoles: proteoliposomes as a tool to gain insights in the molecular mechanism of action and of antitumor activity显示文摘 | Francesca Oppedisano Marco Catto Panayiotis A. Koutentis Orazio Nicolotti Lorena Pochini Maria Koyioni Antonellina Introcaso Sophia S. Michaelidou Angelo Carotti Cesare Indiveri | 2012 | Toxicology and Applied Pharmacology2012，，1： | 1 |
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