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| 1 | Epidural anesthesia improves pancreatic perfusion and decreases the severity of acute pancreatitis显示文摘AIM: To study the safety of epidural anesthesia(EA),its effect on pancreatic perfusion and the outcome of patients with acute pancreatitis(AP).METHODS: From 2005 to August 2010,patients with predicted severe AP [Ranson score ≥ 2,C-reactive protein > 100 or necrosis on computed tomography(CT)] were prospectively randomized to either a group receiving EA or a control group treated by patientcontrolled intravenous analgesia. Pain management was evaluated in the two groups every eight hours using the visual analog pain scale(VAS). Parameters for clinical severity such as length of hospital stay,use of antibiotics,admission to the intensive care unit,radiological/clinical complications and the need for surgical necrosectomy including biochemical data were recorded. A CT scan using a perfusion protocol was performed on admission and at 72 h to evaluate pancreatic blood flow. A significant variation in blood flow was defined as a 20% difference in pancreatic perfusion between admission and 72 h and was measured in the head,body and tail of the pancreas.RESULTS: We enrolled 35 patients. Thirteen were randomized to the EA group and 22 to the control group. There were no differences in demographic characteristics between the two groups. The Balthazar radiological severity score on admission was higher in the EA group than in the control group(mean score 4.15 ± 2.54 vs 3.38 ± 1.75,respectively,P = 0.347) and the median Ranson scores were 3.4 and 2.7 respectively(P = NS). The median duration of EA was 5.7 d,and no complications of the epidural procedure were reported. An improvement in perfusion of the pancreas was observed in 13/30(43%) of measurements in the EA group vs 2/27(7%) in the control group(P = 0.0025). Necrosectomy was performed in 1/13 patients in the EA group vs 4/22 patients in the control group(P = 0.63). The VAS improved during the first ten days in the EA group compared to the control group(0.2 vs 2.33,P = 0.034 at 10 d). Length of stay and mortality were not statistically different between the 2 groups(26 d vs 30 d,P = 0.65,and 0% for both respectively).CONCLUSION: Our study demonstrates that EA increases arterial perfusion of the pancreas and improves the clinical outcome of patients with AP. | Samira M Sadowski Axel Andres Philippe Morel Eduardo Schiffer Jean-Louis Frossard Alexandra Platon Pierre-Alexandre Poletti Leo Bühler | 2015 | World Journal of Gastroenterology2015，21，43： | 21 |
| 2 | Effect of seasonal hypoxia on the benthic foraminiferal community of the Louisiana inner continental shelf:The 20th century record显示文摘 | Platon E Sen Gupta B K Rabalais N N | | 0，，03： | 1 |
| 3 | Percutaneous CT Scan-Guided Drainage vs. Antibiotherapy Alone for Hinchey II Diverticulitis: A Case-Control Study显示文摘 | D. Brandt M.D. P. Gervaz M.D. Y. Durmishi M.D. A. Platon M.D. Ph. Morel M.D. P. A. Poletti M.D | 2006 | Diseases of the Colon & Rectum2006，，10： | 1 |
| 4 | Investigation into iron tannage 显示文摘 | GAIDAU C PLATON F BADE A | 1997 | Journal of the Society of Leather Technologists and Chemists1997，82，： | 1 |
| 5 | Investigation into iron tanning 显示文摘 | Gaidau C Platon F Badea N | 1998 | JSLTC1998，82，4： | 1 |
| 6 | Benthic foraminiferal communities in oxygen-depleted environments of the Louisiana continental shelf显示文摘 | Platon E Gupta B K S | | 0，，01： | 1 |
| 7 | Perfusion measurement in acute pancreatitis using dynamic perfusion MDCT显示文摘 | Bize P E Platon A Beeker C D | 2006 | AJR2006，，： | 1 |
| 8 | Abdominal plain film in patients admitted with clinical suspicion of renal colic:should it be replaced by low-dose computed tomography?显示文摘 | Poletti PA Platon A Rutschmann OT | 2006 | Urology2006，67，1： | 1 |
| 9 | Perfusion measurement in a- cute pancreatitis using dynamic perfusion MDCT显示文摘 | Bize PE Platon A Poletti PA | 2006 | AJR2006，186，： | 1 |
| 10 | 显示文摘 | Sishtla C Koncar G Platon R | 1998 | Journal of Power Sources1998，71，12： | 1 |
| 11 | Perfusion measurement in acute pancreatitis using dynamic perfusion MDCT 显示文摘 | Bize PE Platon A Becker CD | 2006 | Am J Roentgenol2006，186，1： | 1 |
| 12 | Low-dose versus stand- ard-dose CT protocol in patients with clinically suspected renal colic显示文摘 | Poletti P A Platon A Rutschmann O T | 2007 | AJR2007，188，4： | 1 |
| 13 | Performance and endurance of a PEMFC operated with synthetic reformate fuel feed显示文摘 | SISHTLA C KONCAR G PLATON R | 1998 | J Power Sources1998，71，12： | 1 |
| 14 | Perfusion Measurement in Acute Pancreatitis Using Dynamic Perfusion MDCT 显示文摘 | Bize PE Platon A Becket CD | 2006 | A JR2006，186，1： | 1 |
| 15 | Tribological behaviour of DLC coatings compared to different materials used in hip joint prostheses显示文摘 | Platon F Fournier P Rouxel S | 2001 | Wear2001，250，1： | 1 |
| 16 | Performance and endurance of a PEMFC operated with synthetic reformate fuel feed显示文摘 | Sishtla C Koncar G Platon R | 1998 | Journal of Power Sources1998，71，12： | 1 |
| 17 | Fe-pillared clay as an efficient Fenton-like heterogeneous catalyst for phenol degradation显示文摘 | Platon N Siminiceanu I Nistor I D | 2011 | Rev Chim-Bucharest2011，62，6： | 1 |
| 18 | Image in clinical medicine,Pulmonary sequestration显示文摘 | Platon A Poletti PA | | 0，，20： | 1 |
| 19 | Performance and endurance of a PEMFC operated with synthetic reformate fuel feed显示文摘 | Sishtla C Koncar G Platon R | | 0，，1： | 1 |
| 20 | Perfusion measurement in acute pancreatitis using dynamic perfusion MDCT显示文摘 | Bize P E Platon A Becker C D | 2006 | AJR2006，186，1： | 1 |
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