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| 1 | Reduced striatal volumes in Parkinson’s disease:a magnetic resonance imaging study显示文摘Background:The presence and extent of structural changes in the brain as a consequence of Parkinson’s disease(PD)is still poorly understood.Methods:High-resolution 3-tesla T1-weighted structural magnetic resonance images in sixty-five PD and 27 age-matched healthy control participants were examined.Putamen,caudate,and intracranial volumes were manually traced in the axial plane of 3D reconstructed images.Striatal nuclei volumes were normalized to intracranial volume for statistical comparison.Disease status was assessed using the Unified Parkinson’s Disease Rating Scale and Hoehn and Yahr scale.Cognitive status was assessed using global status tests and detailed neuropsychological testing.Results:Both caudate and putamen volumes were smaller in PD brains compared to controls after adjusting for age and gender.Caudate volumes were reduced by 11%(p=0.001)and putamen volumes by 8.1%(p=0.025).PD striatal volumes were not found to be significantly correlated with cognitive or motor decline.Conclusion:Small,but significant reductions in the volume of both the caudate and putamen occur in PD brains.These reductions are independent of the effects of age and gender,however the relation of these reductions to the functional loss of dopamine,which is characteristic of PD,remains unclear. | Toni L Pitcher Tracy R Melzer Michael R MacAskill Charlotte F Graham Leslie Livingston Ross J Keenan Richard Watts John C Dalrymple-Alford Tim J Anderson | 2012 | Translational Neurodegeneration2012，1，1： | 2 |
| 2 | Structure,antifer-romgnetism and superconductivity of the layered iron arsenide NaFeAs显示文摘 | Parker D R Pitcher M J Clarke S J | 2009 | Chem Commun2009，28，16： | 1 |
| 3 | Mycoplasma host specificity: fact or fiction? 显示文摘 | Pitcher D G Nicholas R A | 2005 | Vet J2005，170，： | 1 |
| 4 | Structure and superconductivity of LiFeAs显示文摘 | Pitcher M J Parker D R Adamson P | 2008 | Chem Commun2008，45，11： | 1 |
| 5 | Short-term variability during an anchor station study in the southern Benguela upwelling system:phytoplankton dynamics显示文摘 | PITCHER G C WALKER D R MITCHELL-INNES B A | 1991 | Progress in Oceanography1991，28，12： | 1 |
| 6 | DREAM is a critical transcriptional repressor for pain modulation显示文摘 | CHENG H Y PITCHER G M LAVIOLETTE S R | | 0，，01： | 1 |
| 7 | Stimulation of cutaneous low threshold mechanoreceptors in mice after intracolon- ic capsaicin increases spinal c - fos labeling in an NKCC1 - de- pendent fashion 显示文摘 | PITCHER M H NIETO F R CERVERO F | 2013 | The journal of pain2013，14，1： | 1 |
| 8 | Brown tides and maricul- ture in Saldanha Bay, South Africa 显示文摘 | Probyn T Pitcher G Pienaar R | 2001 | Marine pollution bulle- tin2001，42，5： | 1 |
| 9 | Carbon taxes and India显示文摘 | Fisher-Vanden K A Shukla P R Edmonds J A Kim S H Pitcher H M | 1997 | Energy Economics1997，19，3： | 1 |
| 10 | DREAM is a critical transcriptional repressor for pain modulation 显示文摘 | Cheng H Y Pitcher G M Laviolette S R | 2002 | Cell2002，108，1： | 1 |
| 11 | Investigation into the effect of closed-system suctioning on the frequency of pediatric ventilator-associated pneumonia in a developing country显示文摘 | Morrow BM Mowzer R Pitcher R | 2012 | Pediatr Crit Care Med2012，13，1： | 1 |
| 12 | Investigation into the effect of closed-system suctioning on the frequency of pediatric venti- lator-associated pneumonia in a developing country显示文摘 | Morrow BM Mowzer R Pitcher R | 2012 | Pediatr Crit Care Med2012，13，： | 1 |
| 13 | G protein-coupled receptor kinases显示文摘 | Pitcher J A Freedman N J Lefkowitz R J | 1998 | Annu Rev Biochem1998，67，： | 1 |
| 14 | The effect of dietary calcium content and oral vitamin D3 supplementation on mineral homeostasis in a subterranean mole-rat Cryptomys damarensis显示文摘 | Pitcher T PettiforJM Buffenstein R | 1994 | Bone Miner1994，27，2： | 1 |
| 15 | Brown tides and mariculture in Saldanha Bay, South Africa显示文摘 | PROBYN T PITCHER G PIENAAR R | 2001 | Marine Pollution Bulletin2001，42，5： | 1 |
| 16 | Vitamin D metabolism in the Damara mole-rat is altered by exposure to sunlight yet mineral metabolism is unaffected显示文摘 | Pitcher T Sergeev IN Buffenstein R | 1994 | J Endocrinol1994，143，2： | 1 |
| 17 | Rapid extraction of bacterial genomic DNA with guanidium thiocyanate 显示文摘 | Pitcher D G Saunders N A Owen R J | 1989 | Lett Appl Microbiol1989，8，： | 1 |
| 18 | Short-term variability during an anchor station study in the southern Benguela upwelling system: Phytoplankton dynamics 显示文摘 | Pitcher G C Walker D R Mitchell-Innes B A | 1991 | Progress in Oceanograph1991，28，： | 1 |
| 19 | G protein-coupled receptor kinases显示文摘 | Pitcher J A Freedman N J Lefkowitz R J | 1998 | Annu Rev Biochem1998，67，1： | 1 |
| 20 | Brown tides and maricuhure in Saldanha Bay,South Africa显示文摘 | PROBYN T PITCHER G PIENAAR R | 2001 | Marine Pollution Bulletin2001，42，5： | 1 |
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