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| 1 | Retrograde-viewing device improves adenoma detection rate in colonoscopies for surveillance and diagnostic workup显示文摘AIM:To determine which patients might benefit most from retrograde viewing during colonoscopy through subset analysis of randomized,controlled trial data.METHODS:The Third Eye Retroscope Randomized Clinical Evaluation(TERRACE) was a randomized,controlled,multicenter trial designed to evaluate the efficacy of a retrograde-viewing auxiliary imaging device that is used during colonoscopy to provide a second video image which allows viewing of areas on the proximal aspect of haustral folds and flexures that are difficult to see with the colonoscope's forward view.We performed a post-hoc analysis of the TERRACE data to determine whether certain subsets of the patient population would gain more benefit than others from use of the device.Subjects were patients scheduled for colonoscopy for screening,surveillance or diagnostic workup,and each underwent same-day tandem examinations with standard colonoscopy(SC) and Third Eye colonoscopy(TEC),randomized to SC followed by TEC or vice versa.RESULTS:Indication for colonoscopy was screening in 176/345 subjects(51.0%),surveillance after previous polypectomy in 87(25.2%) and diagnostic workup in 82(23.8%).In 4 subjects no indication was specified.Previously reported overall results had shown a net additional adenoma detection rate(ADR) with TEC of 23.2% compared to SC.Relative risk(RR) of missing adenomas with SC vs TEC as the initial procedure was 1.92(P = 0.029).Post-hoc subset analysis shows additional ADRs for TEC compared to SC were 4.4% for screening,35.7% for surveillance,55.4% for diagnostic and 40.7% for surveillance and diagnostic combined.The RR of missing adenomas with SC vs TEC was 1.11(P = 0.815) for screening,3.15(P = 0.014) for surveillance,8.64(P = 0.039) for diagnostic and 3.34(P = 0.003) for surveillance and diagnostic combined.Although a multivariate Poisson regression suggested gender as a possibly significant factor,subset analysis showed that the difference between genders was not statistically significant.Age,bowel prep quality and withdrawal time did not significantly affect the RR of missing adenomas with SC vs TEC.Mean sizes of adenomas detected with TEC and SC were similar at 0.59 cm and 0.56 cm,respectively(P = NS).CONCLUSION:TEC allows detection of significantly more adenomas compared to SC in patients undergoing surveillance or diagnostic workup,but not in screening patients(ClinicalTrials.gov Identifier:NCT01044732). | Peter D Siersema Amit Rastogi Anke M Leufkens Paul A Akerman Kassem Azzouzi Richard I Rothstein Frank P Vleggaar Alessandro Repici Giacomo Rando Patrick I Okolo Olivier Dewit Ana Ignjatovic Elizabeth Odstrcil James East Pierre H Deprez Brian P Saunders Anthony N Kalloo Bradley Creel Vikas Singh Anne Marie Lennon Daniel C DeMarco | 2012 | World Journal of Gastroenterology2012，18，26： | 6 |
| 2 | Downsizing,delayering-but where is the commitment? The development of a diagnostic tool to help management survivors显示文摘 | THORNHILL A SAUNDERS M N K STEAD J | 1997 | Personnel Review1997，26，12： | 1 |
| 3 | Typing of Listeria monocytogenes for epidemiological studies using DNA probes显示文摘 | SAUNDERS N A RIDLEY A M TAYLOR A G | 1989 | Acta Microbiol Hung1989，，36： | 1 |
| 4 | Ownership structure, deregulation and bank risk taking 显示文摘 | Saunders A Stroek E Travlos N | 1990 | Journal of Finance1990，45，2： | 1 |
| 5 | Influence of stacking- fault energy on high temperature creep of alpha titanium alloys 显示文摘 | Guo Z Miodownik A P Saunders N | 2006 | Scripta Materialia2006，54，12： | 1 |
| 6 | Incubator noise:a method to decrease decibels 显示文摘 | Saunders A N | 1995 | Pediatric Nurs1995，21，3： | 1 |
| 7 | Ownership structure, deregulation, and bank risk taking 显示文摘 | Saunders A Strock E Travlos N G | 1990 | Journal of Finance1990，45，： | 1 |
| 8 | Metastable lattice stabilities for the elements显示文摘 | Saunders N Miodowik A P Dinsdale A T | 1988 | Calphad-Computer Coupling of Phase Diagrams and thermochemistry1988，12，： | 1 |
| 9 | Intrauterine adhesions after manual vacuum aspiration for early pregnancy failure 显示文摘 | Dalton V K Saunders N A Harris L H | 2006 | Feail Steril2006，85，6： | 1 |
| 10 | Metastable lattice stabilities for the elements显示文摘 | Saunders N Miodowik A P Dinsdale A T | 1988 | CalphadComputer Coupling of Phase Diagrams and Thermochemistry1988，12，： | 1 |
| 11 | The effects of mergers and acquisitions on small business lending显示文摘 | BERGER A N SAUNDERS A SCALISE J M Udell G F | 1998 | Journal of Financial Economics1998，50，2： | 1 |
| 12 | The Use of 16S Ribosomal RNA Analyses to Investigate the Phylogeny of the Family Legionellaceae显示文摘 | FRY N K WARWICK S SAUNDERS N A | | 0，，05： | 1 |
| 13 | The E3 ubiquitin ligase EDD regulates S-phase and G (2)/M DNA damage checkpoints显示文摘 | Munoz M A Saunders D N Henderson M J | 2007 | Cell Cycle2007，6，24： | 1 |
| 14 | Secondary lithi- um-sulfur battery显示文摘 | Yao N P Heredy L A Saunders R C | 1970 | J Electrochem Soc1970，117，： | 1 |
| 15 | Phase formation in co-depos ted metallic alloy thin films显示文摘 | Saunders N Miodownik A P | 1987 | J Mater Sci1987，22，： | 1 |
| 16 | Intrauter-ine adhesions after manual vacuum aspiration for early pregnancy failure显示文摘 | DALTON V K SAUNDERS N A HARRIS L H | 2006 | Fertil Steril2006，85，6： | 1 |
| 17 | The use of 16S ribosomal RNA analyses to investigate the phylogeny of the family Legionellaceae显示文摘 | Fry N K Warwick S Saunders N A | 1991 | J Gen Microbiol1991，137，5： | 1 |
| 18 | Continuous positive air- way pressure treatment improves pulmonary hemodynamics in pa- tients with obstructive sleep apnea显示文摘 | Sajkov D Wang T Saunders N A | 2002 | Am J Respir Crit Care Med2002，165，2： | 1 |
| 19 | The use of 16S ribosomal RNA analyses to investigate the phylogeny of the family LegioneUaceae 显示文摘 | Fry N K Warwick S Saunders N A | 1991 | Journal of General Microbiology1991，137，5： | 1 |
| 20 | Ownership struc- ture, deregulation and bank risk taking 显示文摘 | Saunders A Strock E Travlos N G | 1990 | Journal of Finance1990，45，： | 1 |
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