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| 1 | HPLC-MS analysis of Schisandra lignans and their metabolites in Caco-2 cell monolayer and rat everted gut sac models and in rat plasma显示文摘The absorption profiles of Schisandra chinensis were evaluated using the human Caco-2 cell monolayer and rat everted gut sac models,as well as in rat plasma.By analyzing the chromatographic and MSn characteristics of individual peak acquired by HPLC-DAD-APCI-MS^(n) determination,thirteen lignans were identified as the major in vitro absorbable components of the Schisandra extract.Most of these compounds were also detected and identified in rat plasma after an oral administration of the Schisandra extract,except for angeloyl(tigloyl)gomisin H and angeloyl(tigloyl)gomisin Q,whose structures possess an ester group at the cyclooctadiene ring.In addition,four metabolites,corresponding to the hydroxylation and demethylation products of schisandrin and the hydrolysis derivative of angeloyl(tigloyl)gomisin Q,were tentatively identified.The results demonstrate that Schisandra lignans are the major absorbable components of this crude drug,and hydroxylation,demethylation and hydrolysis are important metabolic transformations of the absorbable lignans. | Jia-ming Yang Siu-po PIP Hok-keung JYeung Chun-tao Che | 2011 | Acta Pharmaceutica Sinica B2011，1，1： | 6 |
| 2 | Exercise interventions for older adults: A systematic review of meta-analyses显示文摘Background:The evidence concerning which physical exercise characteristics are most effective for older adults is fragmented.We aimed to characterize the extent of this diversity and inconsistency and identify future directions for research by undertaking a systematic review of metaanalyses of exercise interventions in older adults.Methods:We searched the Cochrane Database of Systematic Reviews,PsycInfo,MEDLINE,Embase,CINAHL,AMED,SPORTDiscus,and Web of Science for articles that met the following criteria:(1)meta-analyses that synthesized measures of improvement(e.g.,effect sizes)on any outcome identified in studies of exercise interventions;(2)participants in the studies meta-analyzed were adults aged 65+or had a mean age of 70+;(3)meta-analyses that included studies of any type of exercise,including its duration,frequency,intensity,and mode of delivery;(4)interventions that included multiple components(e.g.,exercise and cognitive stimulation),with effect sizes that were computed separately for the exercise component;and(5)meta-analyses that were published in any year or language.The characteristics of the reviews,of the interventions,and of the parameters improved through exercise were reported through narrative synthesis.Identification of the interventions linked to the largest improvements was carried out by identifying the highest values for improvement recorded across the reviews.The study included 56 meta-analyses that were heterogeneous in relation to population,sample size,settings,outcomes,and intervention characteristics.Results:The largest effect sizes for improvement were found for resistance training,meditative movement interventions,and exercise-based active videogames.Conclusion:The review identified important gaps in research,including a lack of studies investigating the benefits of group interventions,the characteristics of professionals delivering the interventions associated with better outcomes,and the impact of motivational strategies and of significant others(e.g.,carers)on intervention delivery and outcomes. | Claudio Di Lorito Annabelle Long Adrian Byrne Rowan H.Harwood John R.F.Gladman Stefan Schneider Pip Logan Alessandro Bosco Veronika van der Wardt | 2021 | Journal of Sport and Health Science2021，10，1： | 3 |
| 3 | Expression profiling defines a recurrence signa~tre in lung squamous 显示文摘 | Jill EL Sandra J P Linda PIP | 2007 | Carcinogenesis2007，28，3： | 1 |
| 4 | New understanding of the role of cytokines in the pathogenesis of Graves' ophthnopathy显示文摘 | Ajjan RA Weetman PiP | 2004 | Endocrinol Invest2004，27，3： | 1 |
| 5 | Tell me a story-A conceptual explora- tion of storytelling in healthcare eduation 显示文摘 | Carol H Pip H | 2011 | Nurs Edu Today2011，31，4： | 1 |
| 6 | Food land Life Cycle Energy Inputs:Consequences of Di- et and Ways to Increase Efficiency 显示文摘 | Carlsson - Kanyama A Pipping Ekstrom M Shanahan H | 2003 | Ecological Econom- ics2003，44，： | 1 |
| 7 | Prevalence of cervical and Lumber disc disorders in pilots of the German armed forces显示文摘 | Pipping T Kriebel J | 2000 | Eur J Med Res2000，5，1： | 1 |
| 8 | Prevalence of cervical and Lumber disc disorders in pilots of the German armed forces 显示文摘 | Pipping T Kriebel J | 2000 | Eur J Med Res2000，5，1： | 1 |
| 9 | Aluminum pigments encapsulated by inorganic-organic hybrid coatings and their stability in alkaline aqueous media 显示文摘 | LI L J PIP H WEN X F | 2008 | Journal of Coatings Technology and Research2008，5，1： | 1 |
| 10 | Minimalism and the Art of Visual Noise显示文摘 | Pip Vice | 1994 | Architecture Design1994，64，4： | 1 |
| 11 | Food and Life Cycle Energy Inputs: Consequences of Diet and Ways to Increase Efficiency 显示文摘 | Annika Carlsson -Kanyama Marianne Pipping Ekstroem Helena Shanahan | 2003 | Ecological Economics2003，44，2003： | 1 |
| 12 | An introduction to exponential random graph ( p * ) models for social networks显示文摘 | Garry Robins Pip Pattison Yuval Kalish Dean Lusher | 2006 | Social Networks2006，，2： | 1 |
| 13 | Species richness of freshwater gastropod communities in central north America显示文摘 | PIP E | 1987 | Journal of Molluscan Studies1987，53，： | 1 |
| 14 | Independent associations of bacterial vaginosis and Chlamydia trachomatis infection with adverse pregnancy outcomer 显示文摘 | Gravett MG Nelsen PIP | 1986 | JAMA1986，256，14： | 1 |
| 15 | Morphological and immonochemical differences between keloid and hypertrophic scar显示文摘 | Ehrlich PIP Desmouliere A Diegelmann RF | 1994 | Am J Pathol1994，，： | 1 |
| 16 | Two hundred gastrointestinal stromal tumors: recurrence patterns and prognostic factors for survival显示文摘 | Dematteo PiP Lewis JJ Leung D | 2000 | Ann Surg2000，231，1： | 1 |
| 17 | The severe adversereaction to vitamin K1 injection is anaphylactoid reactionbut not anaphylaxis显示文摘 | MI Y N PIP^G N N XIAO X | 2014 | PLoS One2014，9，90： | 1 |
| 18 | Clinical management of gastrointestinal stromal tumors: before and after STI-571显示文摘 | Dematteo PiP Heinrich MC EI-Rifai WM | 2002 | Hum Pathol2002，33，5： | 1 |
| 19 | Facile preparation of super-hydrophobic and super-oleophilic silica film on stainless steel mesh via sol-gel process显示文摘 | YANG H PIP H CAI Z Q | | 0，，13： | 1 |
| 20 | Survivor identity after colorectal cancer: antecedents, prevalence and outcomes显示文摘 | Suzanne K. Chambers Peter Baade Xingqiong Meng Pip Youl Joanne Aitken Jeff Dunn | 2011 | Psycho‐Oncology2011，，： | 1 |
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