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| 1 | Enhanced microfracture techniques in cartilage knee surgery: Fact or fiction?显示文摘The limited intrinsic healing potential of human articular cartilage is a well-known problem in orthopedic surgery. Thus a variety of surgical techniques have been developed to reduce joint pain, improve joint function and delay the onset of osteoarthritis. Microfractures as a bone marrow stimulation technique present the most common applied articular cartilage repair procedure today. Unfortunately the deficiencies of fibrocartilaginous repair tissue inevitably lead to breakdown under normal joint loading and clinical results deteriorate with time. To overcome the shortcomings of microfracture, an enhanced microfracture technique was developed with an additional collagen Ⅰ/Ⅲ membrane(Autologous, Matrix-Induced Chondrogenesis, AMIC). This article reviews the pre-clinical rationale of microfractures and AMIC, presents clinical studies and shows the advantages and disadvantages of these widely usedtechniques. PubM ed and the Cochrane database were searched to identify relevant studies. We used a comprehensive search strategy with no date or language restrictions to locate studies that examined the AMIC technique and microfracture. Search keywords included cartilage, microfracture, AMIC, knee, ChondroGide. Besides this, we included our own experiences and study authors were contacted if more and non published data were needed. Both cartilage repair techniques represent an effective and safe method of treating full-thickness chondral defects of the knee in selected cases. While results after microfracture deteriorate with time, mid-term results after AMIC seem to be enduring. Randomized studies with long-term followup are needed whether the grafted area will maintain functional improvement and structural integrity over time. | Stefan Bark Tomasz Piontek Peter Behrens Sabiah Mkalaluh Deike Varoga Justus Gille | 2014 | World Journal of Orthopedics2014，5，4： | 3 |
| 2 | Managing customer relationships through E-business decision support applications显示文摘 | Rajiv Kohli Frank Piontek | 2001 | Decision Support Systems2001，32，： | 1 |
| 3 | EGFR-dependent migration of glial cells is mediated by reorganisation of N-cadherin显示文摘 | Rappl A Piontek G Schlegel J | 2008 | Cell Sci2008，121，24： | 1 |
| 4 | Formation of tight junction: determinants of homophilic interaction between classic elaudins显示文摘 | Piontek J Winkler L Wolburg H | 2008 | FASEB J2008，22，： | 1 |
| 5 | J Biol Chem显示文摘 | Piontek K Antorini M Choinowski T | 2002 | 277:376632002，277，37： | 1 |
| 6 | Acidification increases microbial polysaccharide degradation in the ocean显示文摘 | Piontek J Lunau M Handel N | | 0，，： | 1 |
| 7 | MicroRNAs in the Biology and Diagnosis of Cholangiocarcinoma显示文摘 | Klaus Piontek Florin Selaru | 2015 | Semin Liver Dis2015，，01： | 1 |
| 8 | Orbital venous drainage into the anterior cavernous sinus space:microanatomic relationships显示文摘 | Piontek E Umansky F | 1997 | Neurosurgery1997，40，3： | 1 |
| 9 | High-level secretion of hirudin by Hansenula polymorphaauthentic processing of three different preprohirudins 显示文摘 | WEYDEMANN U KKUP P PIONTEK M | 1995 | Appl Microbiol Biotechnol1995，44，： | 1 |
| 10 | Managing Customer Relationships Through E-business Decision Support Applications: a Case of Hospital-physician Collaboration显示文摘 | Frank Piontek Tim Ellington | 2001 | Decision Support Systems2001，32，： | 1 |
| 11 | Managing customer relationships through E-business decision support applications显示文摘 | Rajiv Kkhli Frank Piontek | 2001 | Decision Support Systems2001，82，12： | 1 |
| 12 | Inhibition of NGF-induced neurite outgrowth of rat pheochromocytoma cells (PC 12 ) following administration of dioxyamphetamine 显示文摘 | ZOUBAA' S KONRAD R PIONTEK G | 2010 | NeurosciLett2010，476，3： | 1 |
| 13 | Formation of tightjunction: determinants of homophilic interaction between classicclaudins 显示文摘 | Piontek J Winkler L Wolburg H | 2008 | FASEB J2008，22，1： | 1 |
| 14 | PKD1 induces p21 (waft) and regulation of the cell cycle via direct activation of the JAK-STAT signaling pathway in a process requiring PKD2显示文摘 | Bhunia AK Piontek K Boletta A | 2002 | Cell2002，109，2： | 1 |
| 15 | Arthroscopically assisted combined anterior and posterior cruciate ligament reconstruction with autologous hamstring grafts-isokinetic assessment with control group显示文摘 | Piontek T Ciemniewska-Gorzela K Szulc A | 2013 | PLoS One2013，8，82： | 1 |
| 16 | Aldehyde dehydrogenase 1 positive glioblastoma cells show brain tumor stem cell capacity显示文摘 | Rasper M Schafer A Piontek G | 2010 | Neuro Oncol2010，12，10： | 1 |
| 17 | Selective rejection of H-2-deficlent lymphoma variants suggests alternative immune de- fence strategy显示文摘 | Karre K Ljunggren HG Piontek G | 1986 | Nature1986，319，6055： | 1 |
| 18 | Rapamycin ameliorates PKD resulting from conditional inactivation of Pkd 1 显示文摘 | Shillingford JM Piontek KB Gennino GG | 2010 | J Am Soc Nephrol2010，21，3： | 1 |
| 19 | Breast cancers:MR imaging of folate-receptor expression with the folate-specific nanoparticle Pl 133显示文摘 | MEIER R HENNING T D BODDINGTON S TAVRI S ARORA S PIONTEK G RUDELIUS M COROT C DALDRUP-LINK H E | 2010 | Radiology2010，255，2： | 1 |
| 20 | Decentralized adaptive robust control and its application to an uncertain flexible beam显示文摘 | CHEN Y H PIONTEK E D | 1992 | J Guidance1992，15，3： | 1 |
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