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| 1 | Hepatic echinococcosis:Clinical and therapeutic aspects显示文摘Echinococcosis or hydatid disease(HD)is a zoonosis caused by the larval stages of taeniid cestodes belonging to the genus Echinococcus.Hepatic echinococcosis is a life-threatening disease,mainly differentiated into alveolar and cystic forms,associated with Echinoccus multilocularis(E.multilocularis)and Echinococcus granulosus(E.granulosus)infection,respectively.Cystic echinococcosis(CE)has a worldwide distribution,while hepatic alveolar echinococcosis(AE)is endemic in the Northern hemisphere,including North America and several Asian and European countries,like France,Germany and Austria.E.granulosus young cysts are spherical,unilocular vesicles,consisting of an internal germinal layer and an outer acellular layer.Cyst expan-sion is associated with a host immune reaction and the subsequent development of a fibrous layer,called the pericyst;old cysts typically present internal septations and daughter cysts.E.multilocularis has a tumorlike,infiltrative behavior,which is responsible for tissue destruction and finally for liver failure.The liver is the main site of HD involvement,for both alveolar and cystic hydatidosis.HD is usually asymptomatic for a long period of time,because cyst growth is commonly slow;the most frequent symptoms are fatigue and abdominal pain.Patients may also present jaundice,hepatomegaly or anaphylaxis,due to cyst leakage or rupture.HD diagnosis is usually accomplished with the combined use of ultrasonography and immunodiagnosis;furthermore,the improvement of surgical techniques,the introduction of minimally invasive treatments[such as puncture,aspiration,injection,re-aspiration(PAIR)]and more effective drugs(such as benzoimidazoles)have deeply changed life expectancy and quality of life of patients with HD.The aim of this article is to provide an up-todate review of biological,diagnostic,clinical and therapeutic aspects of hepatic echinococcosis. | Giuseppe Nunnari Marilia R Pinzone Salvatore Gruttadauria Benedetto M Celesia Giordano Madeddu Giulia Malaguarnera Piero Pavone Alessandro Cappellani Bruno Cacopardo | 2012 | World Journal of Gastroenterology2012，18，13： | 72 |
| 2 | Diagnostic and therapeutic management of hepatocellular carcinoma显示文摘Hepatocellular carcinoma(HCC) is an increasing health problem, representing the second cause of cancerrelated mortality worldwide. The major risk factorfor HCC is cirrhosis. In developing countries, viral hepatitis represent the major risk factor, whereas in developed countries, the epidemic of obesity, diabetes and nonalcoholic steatohepatitis contribute to the observed increase in HCC incidence. Cirrhotic patients are recommended to undergo HCC surveillance by abdominal ultrasounds at 6-mo intervals. The current diagnostic algorithms for HCC rely on typical radiological hallmarks in dynamic contrast-enhanced imaging, while the use of α-fetoprotein as an independent tool for HCC surveillance is not recommended by current guidelines due to its low sensitivity and specificity. Early diagnosis is crucial for curative treatments. Surgical resection, radiofrequency ablation and liver transplantation are considered the cornerstones of curative therapy, while for patients with more advanced HCC recommended options include sorafenib and trans-arterial chemoembolization. A multidisciplinary team, consisting of hepatologists, surgeons, radiologists, oncologists and pathologists, is fundamental for a correct management. In this paper, we review the diagnostic and therapeutic management of HCC, with a focus on the most recent evidences and recommendations from guidelines. | Francesco Bellissimo Marilia Rita Pinzone Bruno Cacopardo Giuseppe Nunnari | 2015 | World Journal of Gastroenterology2015，21，42： | 18 |
| 3 | Fracture resistance of reattachment coronal fragments influence of different adhesive materials and bevel preparation 显示文摘 | Demarco FF Fay RM Pinzon LM | 2004 | Dent Traumatol2004，20，： | 1 |
| 4 | Gene transfection and expression of transforming growth factor-beta1 in nonobese diabetic mouse islets protects beta-cells in syngeneic islet grafts from autoimmune destruction显示文摘 | Marcoux Y | 2002 | Cell Transplant2002，11，6： | 1 |
| 5 | An Extended AVHRR 8-kin NDVI Data Set Compatible with MODIS and SPOT Vegetation NDVI Data显示文摘 | Tucker C J Pinzon J E Brown M E | 2005 | International Journal of Remote Sensing2005，26，： | 1 |
| 6 | Protein kinase C regulates rod photoreceptor differentiation through modulation of stat3 signaling显示文摘 | Pinzon - Guzman C Shaomin Zhang S Barnstable CJ | 2010 | Adv ExP Med Biol2010，664，： | 1 |
| 7 | The clinical profile and risk factors of postmenopausal lumbar osteoporosis显示文摘 | Pinzon R | | 0，，： | 1 |
| 8 | Glycosyla-tion of human milk lactoferrin exhibits dynamic changes dur-ing early lactation enhancing its role in pathogenic bacteria-host interactions 显示文摘 | Barboza M Pinzon J Wickramasinghe S | 2012 | Molecular Cellular Proteomics2012，11，6： | 1 |
| 9 | Nonparametric satellite drift correction of NDVI times series from NOAA-AVHRR radiometers using the empirical mode decomposition 显示文摘 | Pinzon J Brown M E Tucker C J | 2003 | IEEE Transactions Geoscience and Remote Sensing2003，，： | 1 |
| 10 | Higher northern latitude normalized difference vegetation index and growing season trends from 1982 to 1999 显示文摘 | Tucker C J Slayback D A Pinzon J E | 2001 | International Journal of Biometeorology2001，45，： | 1 |
| 11 | Posterior lumbar fusion using the O-arm surgical imaging system: initial experience 显示文摘 | Castro Castro J Rodino Padin J Pinzon Millan A | 2013 | Neuroeirugia (Astur)2013，24，1： | 1 |
| 12 | Imbalance between tissue inhibitor of metalloproteinase - 4 and matrix metallaproteinases during acute myocardial correction of myoctardial ischemiareperfusion injury显示文摘 | Sohulze CJ Wang W Suare- Pinzon WL | 2003 | Circulation2003，107，19： | 1 |
| 13 | Roles of cytokines in the pathogenesis and therapy of type 1 diabetes 显示文摘 | Rabinovitch A Suarez Pinzon W L | 2007 | Cell Biochem Biophys2007，48，23： | 1 |
| 14 | Mortality and Causes of Death in Celiac Disease in a Mediterranean Area显示文摘 | Mario Cottone Anna Termini Lorenzo Oliva Antonino Magliocco Ciro Marrone Ambrogio Orlando Filippo Pinzone Roberto Di Mitri Matteo Rosselli Aroldo Rizzo Luigi Pagliaro | 1999 | Digestive Diseases and Sciences1999，，12： | 1 |
| 15 | Chemical composition of the essential oil of Psidium caudatum McVaugh显示文摘 | YANEZ X PINZON M L SOLANO F | 2002 | Molecules2002，7，9： | 1 |
| 16 | The role of Dickkopf-1 in bone development, homeostasis, and disease显示文摘 | Pinzone JJ Hall BM Thudi NK | 2009 | Blood2009，113，3： | 1 |
| 17 | Beyond peroxisome proliferator-activated receptor gamma signaling:The multi-facets of the antitumor effect of thiazolidinediones显示文摘 | Weng JR Chen CY Pinzone JJ | 2006 | Endocr Relat Cancer2006，13，2： | 1 |
| 18 | Roles of cytokines in the pathogenesis and therapy of type 1 diabe- tes 显示文摘 | RABINOVITCH A SUAREZ PINZON W L | 2012 | Cell Biochemistry and Biophysics2012，48，23： | 1 |
| 19 | An extend- ed AVHRR 8 km NDVI data set compatible with MODIS and SPOT vegetation NDVI data显示文摘 | TUCKER C J PINZON J E BROWN M E | 2005 | Int J Remote Sensing2005，26，20： | 1 |
| 20 | Adsorption of sodium dodecylbenzene sulfonate on organophilic bentonites 显示文摘 | Bodrlguez Sarmiento D C Pinzon BeUo J A | 2001 | Applied Clay Science2001，18，3： | 1 |
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