|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Platelet-rich plasma increases transforming growth factor-beta1 expression at graft-host interface following autologous osteochondral transplantation in a rabbit model显示文摘AIM: To explore the effect of platelet-rich plasma on protein expression patterns of transforming growth factor-beta1(TGF-β1) in cartilage following autologous osteochondral transplantation(AOT) in a rabbit knee cartilage defect model.METHODS: Twelve New Zealand white rabbits received bilateral AOT. In each rabbit, one knee was randomized to receive an autologous platelet rich plasma(PRP) injection and the contralateral knee received saline injection. Rabbits were euthanized at 3, 6 and 12 wk post-operatively. Articular cartilage sections were stained with TGF-β1 antibody. Histological regions of interest(ROI)(left, right and center of the autologous grafts interfaces) were evaluated using Meta Morph. Percentage of chondrocytes positive for TGF-β1 was then assessed.RESULTS: Percentage of chondrocytes positive for TGF-β1 was higher in PRP treated knees for selected ROIs(left; P = 0.03, center; P = 0.05) compared to control and was also higher in the PRP group at each post-operative time point(P = 6.6 × 10^(-4), 3.1 × 10^(-4) and 7.3 × 10^(-3) for 3, 6 and 12 wk, respectively). TGF-β1 expression was higher in chondrocytes of PRP-treated knees(36% ± 29% vs 15% ± 18%)(P = 1.8 × 10^(-6)) overall for each post-operative time point and ROI. CONCLUSION: Articular cartilage of rabbits treated with AOT and PRP exhibit increased TGF-β1 expression compared to those treated with AOT and saline. Our findings suggest that adjunctive PRP may increase TGF-β1 expression, which may play a role in the chondrogenic effect of PRP in vivo. | Lorraine A Boakye Keir A Ross John M Pinski Niall A Smyth Amgad M Haleem Charles P Hannon Lisa A Fortier John G Kennedy | 2015 | World Journal of Orthopedics2015，6，11： | 7 |
| 2 | Current understanding of sepsis显示文摘 | Wenzel R P Pinsky M R Ulevitch R J | 1996 | Clin Infect Dis1996，22，3： | 1 |
| 3 | Finite element modeling of acousto-mechanical coupling in the cat middle ear 显示文摘 | TUCK J P PINSKY P M STEELE C R | 2008 | JAcoust Soe Am2008，124，1： | 1 |
| 4 | A Two-region Nonequilibrium Model for Solute Transport in Solution Conduits in Karstic Aquifers显示文摘 | FIELD M S PINSKY P F | 2000 | Journal of Contaminant Hydrology2000，44，34： | 1 |
| 5 | Compression of semi-solid dendritic Sn-Pb alloys at low strain rates显示文摘 | PINSKY D A CHARREYRON P FLEMINGS M C | 1984 | Metallurgical Transactions1984，15，1： | 1 |
| 6 | Rotavirus as a cause of diarrheal morbidity and mortality in the United States显示文摘 | Ho M S Glass R I Pinsky P F | 1998 | J Infect Dis1998，158，： | 1 |
| 7 | A two region nonequilibrium model for solute transport in solution conduits in karstic aquifers显示文摘 | Field M S Pinsky P F | 2000 | Journal of Contaminant Hydrology2000，44，34： | 1 |
| 8 | Death by parenteral nutrition 显示文摘 | MARIK P E PINSKY M | 2003 | Intensive Care Med2003，29，6： | 1 |
| 9 | Relationships between dioxins in soil, air, and emissions from a municipal solid waste incinerator emitting large amount of dioxins显示文摘 | Pinsky P Gehring P | 1998 | Chemosphere1998，37，912： | 1 |
| 10 | Death by parenteral nutrition显示文摘 | Marik P E Pinsky M | 2003 | Intensive Care Med2003，29，： | 1 |
| 11 | Unexpected patterns of fisheries collapse in the world' s oceans 显示文摘 | PINSKY M L JENSEN O P RICARD D | 2011 | Proceedings of the National Academy of Sciences2011，108，20： | 1 |
| 12 | An epidemic of acute hemorrhagic conjunctivitis in American Samoa caused by coxsackievirus A24variant显示文摘 | Sawyer L A Hershow R C Pallansch M A Fishbein D B Pinsky P F Broerman S F Grimm B B Anderson L J Hall D B Schonberger L B | 1989 | Am J Epidemiol1989，130，6： | 1 |
| 13 | Combined observational and model investigations of the Z - LWC 216 relationship in strato- cumulus clouds显示文摘 | Khain A P Pinsky M Magaritz L | 2008 | J Appl Met & Clim2008，47，： | 1 |
| 14 | Computational modeling of mechanical anisotropy in the cornea and sclera显示文摘 | Pinsky P M van der Heide D Chernyak D | 2005 | Journal of Cataract & Refractive Surgery2005，31，1： | 1 |
| 15 | Fluid and volume monitoring显示文摘 | PINSKY M R BROPHY P PADILLA J | 2008 | Int J Artif Organs2008，31，2： | 1 |
| 16 | Evidence for a repressive function of the long polyglutamine tract in the human androgen receptor:possible pathogenetic relevance for the (CAG)n-expanded neuronopathies显示文摘 | Kazemi-Esfarjani P Trifiro M A Pinsky L | 1995 | Hum Mol Genet1995，4，4： | 1 |
| 17 | Death by parenteml nutrition显示文摘 | Marik P E Pinsky M | 2003 | Intensive Care Med2003，29，： | 1 |
| 18 | Effect of positive pressure on venous return in volume-loaded cardiac surgical patients 显示文摘 | van den Berg P C Jansen J R Pinsky M R | 2002 | J Appl Physiol2002，92，3： | 1 |
| 19 | A residual-based finite element method for the Helmholtz equation显示文摘 | Oberai A A Pinsky P M | 2000 | Int J Numer Meth Engng2000，49，： | 1 |
| 20 | Death by parenteral nutrition显示文摘 | Marik P E Pinsky M | 2003 | Intensive Care Med2003，29，： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员