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| 1 | Platelet-rich plasma increases transforming growth factor-beta1 expression at graft-host interface following autologous osteochondral transplantation in a rabbit model显示文摘AIM: To explore the effect of platelet-rich plasma on protein expression patterns of transforming growth factor-beta1(TGF-β1) in cartilage following autologous osteochondral transplantation(AOT) in a rabbit knee cartilage defect model.METHODS: Twelve New Zealand white rabbits received bilateral AOT. In each rabbit, one knee was randomized to receive an autologous platelet rich plasma(PRP) injection and the contralateral knee received saline injection. Rabbits were euthanized at 3, 6 and 12 wk post-operatively. Articular cartilage sections were stained with TGF-β1 antibody. Histological regions of interest(ROI)(left, right and center of the autologous grafts interfaces) were evaluated using Meta Morph. Percentage of chondrocytes positive for TGF-β1 was then assessed.RESULTS: Percentage of chondrocytes positive for TGF-β1 was higher in PRP treated knees for selected ROIs(left; P = 0.03, center; P = 0.05) compared to control and was also higher in the PRP group at each post-operative time point(P = 6.6 × 10^(-4), 3.1 × 10^(-4) and 7.3 × 10^(-3) for 3, 6 and 12 wk, respectively). TGF-β1 expression was higher in chondrocytes of PRP-treated knees(36% ± 29% vs 15% ± 18%)(P = 1.8 × 10^(-6)) overall for each post-operative time point and ROI. CONCLUSION: Articular cartilage of rabbits treated with AOT and PRP exhibit increased TGF-β1 expression compared to those treated with AOT and saline. Our findings suggest that adjunctive PRP may increase TGF-β1 expression, which may play a role in the chondrogenic effect of PRP in vivo. | Lorraine A Boakye Keir A Ross John M Pinski Niall A Smyth Amgad M Haleem Charles P Hannon Lisa A Fortier John G Kennedy | 2015 | World Journal of Orthopedics2015，6，11： | 7 |
| 2 | Current understanding of sepsis显示文摘 | Wenzel R P Pinsky M R Ulevitch R J | 1996 | Clin Infect Dis1996，22，3： | 1 |
| 3 | A Retro- spective Analysis of Immunosuppression Compliance, Dose Reduction and Discontinuation in Kidney Transplant Recipi- ents显示文摘 | Takemoto S K Pinsky B W Schnitzler M A | 2007 | Am J Transplant2007，7，12： | 1 |
| 4 | The role of competition effect in the raindrop formation显示文摘 | Segal Y M Pinsky A K | 2007 | Atmos Res2007，83，： | 1 |
| 5 | Suppression of cytokine-mediated beta2-integrin activation on circulating neutrophils in critically ill patients显示文摘 | Rosenbloom A J Pinsky M R Napolitano C | 1999 | J Leukoc Biol1999，66，： | 1 |
| 6 | Hemodynamic monitoring in the intensive care unit 显示文摘 | Pinsky M R | 2003 | Clin Chest Med2003，24，4： | 1 |
| 7 | Recent advances in the clinical application of heart lung interactions显示文摘 | Pinsky M R | 2002 | Curr Opin Crit Care2002，8，1： | 1 |
| 8 | Transvisceral lactate fluxes during early endotoxemia 显示文摘 | Bellomo R Kellum J A Pinsky M R | 1996 | Chest1996，110，1： | 1 |
| 9 | Cultivating creativity in conservation science显示文摘 | Aslan C E Pinsky M L Ryan M E | 2014 | Conservation Biology2014，28，2： | 1 |
| 10 | Death by parenteral nutrition显示文摘 | Marik PE Pinsky M | 2003 | Intensive Care Med2003，29，： | 1 |
| 11 | Introduction to Fourier Analysis and Wavelets显示文摘 | Pinsky M A | 2002 | Boo/Cole2002，，： | 1 |
| 12 | Synthesis and characterization of neodymium oxide nanoparticles 显示文摘 | Zawadzki M Kεpinski L | 2004 | Journal of Alloys and Compounds2004，380，： | 1 |
| 13 | The inflammatory balance in human sepsis显示文摘 | Adrie C Pinsky M R | 2000 | Intensive Care Med2000，26，： | 1 |
| 14 | Finite element modeling of acousto-mechanical coupling in the cat middle ear 显示文摘 | TUCK J P PINSKY P M STEELE C R | 2008 | JAcoust Soe Am2008，124，1： | 1 |
| 15 | Functional hemodynamic monitoring显示文摘 | Pinsky M R Payen D | 2005 | Crit Care2005，9，6： | 1 |
| 16 | Let us use the pulmo- nary artery catheter correctly and only when we need it显示文摘 | PINSKY M R VINCENT J L | 2005 | Crit Care Med2005，33，： | 1 |
| 17 | Effect of tidal volume,sampling duration,and cardiac contractility on pulse pressure and stroke volume variation during positive-pressure ventilation显示文摘 | Kim H K Pinsky M R | 2008 | Crit Care Med2008，36，10： | 1 |
| 18 | A Two-region Nonequilibrium Model for Solute Transport in Solution Conduits in Karstic Aquifers显示文摘 | FIELD M S PINSKY P F | 2000 | Journal of Contaminant Hydrology2000，44，34： | 1 |
| 19 | The inflammatory balance in human sepsis显示文摘 | Adrie C Pinsky M R | 2000 | Intensive Care Med2000，26，4： | 1 |
| 20 | Effects of modulation of left ventricular contractile state and loading conditions on tissue Doppler myocardial performance index显示文摘 | Cannesson M Jacques D Pinsky MR | | 0，，： | 1 |
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