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| 1 | Mycophenolate mofetil for maintenance of remission in steroid-dependent autoimmune pancreatitis显示文摘Systemic corticosteroids represent the standard treatment for autoimmune pancreatitis with IgG4-associated cholangitis.For steroid-dependent disease,azathioprine has been used for maintenance of remission.Mycophenolate mofetil has been used for transplant immunosuppression and more recently for autoimmune hepatitis;however,there are no case reports to date on the use of mycophenolate mofetil in adult patients with autoimmune pancreatitis.A patient with IgG4-mediated autoimmune pancreatitis and IgG4-associated cholangitis refractory to steroids and intolerant of azathioprine was treated with mycophenolate mofetil,which inhibits de novo guanosine synthesis and blockade of both B and T lymphocyte production.Introduction of mycophenolate mofetil and uptitration to 1000 mg by mouth twice daily over a treatment period of 4 mo was associated with improvement in the patient's energy level and blood glucose control and was not associated with any adverse events.The patient was managed without a biliary stent.However,there was a return of symptoms,jaundice,increase in transaminases,and hyperbilirubinemia when the prednisone dose reached 11 mg per day.In the first report of mycophenolate mofetil use in an adult patient with IgG4-associated autoimmune pancreatitis and IgG4-associated cholangitis,the introduction of mycophenolate mofetil was safe and well-tolerated without adverse events,but it did not enable discontinuation of the steroids.Mycophenolate mofetil and other immunomodulatory therapies should continue to be studied for maintenance of remission in the large subset of patients with refractory or recurrent autoimmune pancreatitis. | Jamie B Sodikoff Steven A Keilin Sheila J Bharmal Melinda M Lewis Gottumukkala S Raju Field F Willingham | 2012 | World Journal of Gastroenterology2012，18，18： | 6 |
| 2 | Aberrant Th2 inflammation drives dysfunction of alveolar macrophages and susceptibility to bacterial pneumonia显示文摘The ubiquitin ligase,Itch,is required to prevent autoinflammatory disease in mice and humans.Itch-deficient mice develop lethal pulmonary inflammation characterized by the production of Th2 cytokines(for example,interleukin-4(IL-4));however,the contribution of Itch to immune defense against respiratory pathogens has not been determined.We found that Itch-deficient mice were highly susceptible to intranasal infection with the respiratory pathogen Klebsiella pneumoniae.Infected Itch-deficient mice exhibited increased immune cell infiltration,cytokine levels and bacterial burden in the respiratory tract compared with control mice.However,numbers of resident alveolar macrophages were reduced in the lungs from Itch-deficient mice both before and after infection.High levels of Th2 cytokines in the respiratory tract correlated with deceased alveolar macrophages,and genetic ablation of IL-4 restored alveolar macrophages and host defense to K.pneumoniae in Itch-deficient mice,suggesting that loss of alveolar macrophages occurred as a consequence of Th2 inflammation.Adoptive transfer of Itch−/−CD4+T cells into Rag−/−mice was sufficient to drive reduction in numbers of Itch-replete alveolar macrophages.Finally,we found that Stat6 signaling downstream of the IL-4 receptor directly reduced fitness of alveolar macrophages when these cells were exposed to the Itch−/−inflamed respiratory tract.These data suggest that Th2 inflammation directly impairs alveolar macrophage fitness in Itch−/−mice,and elucidate a previously unappreciated link between Th2 cells,alveolar macrophages and susceptibility to bacterial infection. | Emily K Moser Natania S Field Paula M Oliver | 2018 | Cellular & Molecular Immunology2018，15，5： | 2 |
| 3 | Enhancement effects on quality characteristics of pork derived from pigs of various commercial genetic backgrounds显示文摘 | Brewer M S Sosnicki A Field B | 2004 | Journal of Food Science2004，69，1： | 1 |
| 4 | Synthetic estrogen derivatives demonstrate the functionality of intracellular GPR30 显示文摘 | Revankar C M Mitchell H D Field A S | 2007 | ACS Chem Biol2007，2，8： | 1 |
| 5 | Primary and repeat surgical treatment for female pelvic organ prolapse and incontinence in parous women in the UK: a register linkage study显示文摘 | Abdel-Fattah M Familusi A Fielding S | 2011 | BMJ Open2011，1，00： | 1 |
| 6 | Power 4 system micro architecture显示文摘 | TENDLER J M DODSON J S FIELDS J S | 2002 | IBM Journal of Research and Development2002，46，1： | 1 |
| 7 | Protein-peptide interactions analyzed with the yeast two-hybrid system显示文摘 | Yang M Wu Z Fields S | 1995 | Nucleic Acids Res1995，23，7： | 1 |
| 8 | Analysis of the obesity gene FTO in 14, 803 type 1 diabetes cases and controls 显示文摘 | FIELD S F HOWSON J M M WALKER N M | 2007 | Diabetologia2007，50，10： | 1 |
| 9 | Review of experimental techniques for high rate deformation and shock studies显示文摘 | Field J E Walley S M Proud W G | | 0，，07： | 1 |
| 10 | The Fermentable Fiber Content of the Diet Alters the Function and Composition of Canine Gut Associated Lymphoid Tissue显示文摘 | Field C J McBurney M I Massinino S | 1999 | Vet Immunol Immunopathol1999，72，34： | 1 |
| 11 | Psychometric properties of an attitude scale measuring physician-nurse coorperation显示文摘 | Hojat M Fields S K Veloski J | 1999 | Evaluation and the Health Professions1999，22，2： | 1 |
| 12 | Deformation,Strengths and Strains to Failure of Polymer Bonded Explosives显示文摘 | Palmer S J P Field J E Huntley J M | 1993 | Proc R Soc Lond A1993，440，： | 1 |
| 13 | Recent patterns and mechanisms of carbon exchange by terrestrial ecosystems显示文摘 | Schimel D S House J I Hibbard K A Bousquet P Ciais P Peylin P Braswell B H Apps M J Baker D Bondeau A Canadell J Churkina C: Cramer W Denning A S Field CB Friedlingstein P Goodale C Heimann M Houghton RA Melillo J M Moore B 3rd Murdiyarso D Noble L Pacala S W Prentice I C Raupach M R Rayner P J Scholes R J Steffen W L Wirth C | 2001 | Nature2001，414，： | 1 |
| 14 | High speed ma- chining possibilities and need显示文摘 | KAHLE J F FIELD M HARVEY S M | 1978 | CIRP Annals1978，27，2： | 1 |
| 15 | Attitudes toward physician-nurse alliance: comparisons of rnedical and nursing students显示文摘 | Hojat M Fields S K Rattner S L | 1997 | Academic Medicine1997，72，10： | 1 |
| 16 | Bum injuries benefit from massagetherapy 显示文摘 | Field T Peck M Krugman S | 1998 | J Bum Care Rehabil1998，19，3： | 1 |
| 17 | Prevalence of gastroesophageal reflux symptoms in asthma 显示文摘 | Field S K Underwood M Brant R | 1996 | Chest1996，109，2： | 1 |
| 18 | Glutamine supplementation maintains intramuscular glutamine concentrations and normalizes lymphocyte function in infected early weaned pigs显示文摘 | Yoo S S Field C J McBumey M I | 1997 | J Nutr1997，127，： | 1 |
| 19 | Evaluation of the prognostic value of IFN-gamma release assay and tuberculin skin test in household contacts of infectious tuberculosis cases in Senegal 显示文摘 | Lienhardt C Fielding K Hane AA Niang A Ndao CT Karam F Fletcher H Mbow F Oomis JF Diadhiou R Toupane M Dieye T Mboup S | 2010 | PLoS One2010，5，10： | 1 |
| 20 | Low and high tern-peratures for the control of cowpea beetle, Callosobruchus maculatus (F) (Coleoptem: Bruchidae) in chickpeas 显示文摘 | Loganathan M Jayas D S Fields P G | 2011 | Journal of Stored Products Research2011，47，3： | 1 |
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