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| 1 | Platelet-rich plasma increases transforming growth factor-beta1 expression at graft-host interface following autologous osteochondral transplantation in a rabbit model显示文摘AIM: To explore the effect of platelet-rich plasma on protein expression patterns of transforming growth factor-beta1(TGF-β1) in cartilage following autologous osteochondral transplantation(AOT) in a rabbit knee cartilage defect model.METHODS: Twelve New Zealand white rabbits received bilateral AOT. In each rabbit, one knee was randomized to receive an autologous platelet rich plasma(PRP) injection and the contralateral knee received saline injection. Rabbits were euthanized at 3, 6 and 12 wk post-operatively. Articular cartilage sections were stained with TGF-β1 antibody. Histological regions of interest(ROI)(left, right and center of the autologous grafts interfaces) were evaluated using Meta Morph. Percentage of chondrocytes positive for TGF-β1 was then assessed.RESULTS: Percentage of chondrocytes positive for TGF-β1 was higher in PRP treated knees for selected ROIs(left; P = 0.03, center; P = 0.05) compared to control and was also higher in the PRP group at each post-operative time point(P = 6.6 × 10^(-4), 3.1 × 10^(-4) and 7.3 × 10^(-3) for 3, 6 and 12 wk, respectively). TGF-β1 expression was higher in chondrocytes of PRP-treated knees(36% ± 29% vs 15% ± 18%)(P = 1.8 × 10^(-6)) overall for each post-operative time point and ROI. CONCLUSION: Articular cartilage of rabbits treated with AOT and PRP exhibit increased TGF-β1 expression compared to those treated with AOT and saline. Our findings suggest that adjunctive PRP may increase TGF-β1 expression, which may play a role in the chondrogenic effect of PRP in vivo. | Lorraine A Boakye Keir A Ross John M Pinski Niall A Smyth Amgad M Haleem Charles P Hannon Lisa A Fortier John G Kennedy | 2015 | World Journal of Orthopedics2015，6，11： | 7 |
| 2 | Ventricular assist by cardial cyclespecific increases in intrathoracic pressure显示文摘 | Pinsky P R Martin D | 1997 | Chest1997，91，5： | 1 |
| 3 | Current understanding of sepsis显示文摘 | Wenzel R P Pinsky M R Ulevitch R J | 1996 | Clin Infect Dis1996，22，3： | 1 |
| 4 | Fluid and vol- ume monitoring显示文摘 | Pinsky MR Brophy P Padilla J | 2008 | Int J Artif Organs2008，31，： | 1 |
| 5 | Ventricular assist by cardial eyelespecific increases in intrathoracic pressure显示文摘 | Pinsky P R Martin D | 1997 | Chest1997，91，5： | 1 |
| 6 | Finite element modeling of acousto-mechanical coupling in the cat middle ear 显示文摘 | TUCK J P PINSKY P M STEELE C R | 2008 | JAcoust Soe Am2008，124，1： | 1 |
| 7 | Ventricular assist by cardial cyclespecific increases in intra - t horadc pressure显示文摘 | PINSKY P R MARTIN D | 1997 | Chest1997，91，5： | 1 |
| 8 | A Two-region Nonequilibrium Model for Solute Transport in Solution Conduits in Karstic Aquifers显示文摘 | FIELD M S PINSKY P F | 2000 | Journal of Contaminant Hydrology2000，44，34： | 1 |
| 9 | Growth hormone-releasing hormone antagonist MZ-4-71 inhibits in vivo proliferation of Caki-I renal adenoearcinoma 显示文摘 | Jungwirth A Schally A V Pinski J Groot K Armatis P Halmos G | 1997 | Proc Natl Acad Sci USA1997，94，： | 1 |
| 10 | Compression of semi-solid dendritic Sn-Pb alloys at low strain rates显示文摘 | PINSKY D A CHARREYRON P FLEMINGS M C | 1984 | Metallurgical Transactions1984，15，1： | 1 |
| 11 | Rotavirus as a cause of diarrheal morbidity and mortality in the United States显示文摘 | Ho M S Glass R I Pinsky P F | 1998 | J Infect Dis1998，158，： | 1 |
| 12 | Relationship of demographic and clinical factors to free and total prostate-specific antigen显示文摘 | Gelmann E P Chia D Pinsky P F | 2001 | Urology2001，58，4： | 1 |
| 13 | A two region nonequilibrium model for solute transport in solution conduits in karstic aquifers显示文摘 | Field M S Pinsky P F | 2000 | Journal of Contaminant Hydrology2000，44，34： | 1 |
| 14 | Growth hormone-releasing hormone antagonist MZ- 4-71 inhibits in vivo proliferation of Caki- Ⅰ renal adenocarcinoma显示文摘 | Jungwirth A Sehally A V Pinski J Groot K Armatis P Halmos G | 1997 | Proc Natl Acad Sci USA1997，94，： | 1 |
| 15 | Information processing in single neurons显示文摘 | Pinsky P Rinzel J | 1994 | Comput Neurosci1994，，1： | 1 |
| 16 | Predictors of advanced proximal neoplasia in persons with abnormal screening flexible sigmoidoscopy 显示文摘 | Pinsky P F Schoen R E Weissfeld J L | 2003 | Clin Gastroenterol Hepatol2003，1，2： | 1 |
| 17 | Ventrieular assist by eardial cyelespeeifie in intrsthoracic pressure显示文摘 | Pinsky P R Martin D | 2006 | Chest2006，114，： | 1 |
| 18 | Death by parenteral nutrition 显示文摘 | MARIK P E PINSKY M | 2003 | Intensive Care Med2003，29，6： | 1 |
| 19 | Growth hormone-releasing hormone antagonist MZ-4 71 inhibits in vivo proliferation of caki- Ⅰ renal adeno carainoma显示文摘 | Jungwirth A Sehally A V Pinski J Groot K Armatis P Hal mos G | 1997 | Proc Natl Acad Sci USA1997，94，： | 1 |
| 20 | Relationships between dioxins in soil, air, and emissions from a municipal solid waste incinerator emitting large amount of dioxins显示文摘 | Pinsky P Gehring P | 1998 | Chemosphere1998，37，912： | 1 |
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