|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Platelet-rich plasma increases transforming growth factor-beta1 expression at graft-host interface following autologous osteochondral transplantation in a rabbit model显示文摘AIM: To explore the effect of platelet-rich plasma on protein expression patterns of transforming growth factor-beta1(TGF-β1) in cartilage following autologous osteochondral transplantation(AOT) in a rabbit knee cartilage defect model.METHODS: Twelve New Zealand white rabbits received bilateral AOT. In each rabbit, one knee was randomized to receive an autologous platelet rich plasma(PRP) injection and the contralateral knee received saline injection. Rabbits were euthanized at 3, 6 and 12 wk post-operatively. Articular cartilage sections were stained with TGF-β1 antibody. Histological regions of interest(ROI)(left, right and center of the autologous grafts interfaces) were evaluated using Meta Morph. Percentage of chondrocytes positive for TGF-β1 was then assessed.RESULTS: Percentage of chondrocytes positive for TGF-β1 was higher in PRP treated knees for selected ROIs(left; P = 0.03, center; P = 0.05) compared to control and was also higher in the PRP group at each post-operative time point(P = 6.6 × 10^(-4), 3.1 × 10^(-4) and 7.3 × 10^(-3) for 3, 6 and 12 wk, respectively). TGF-β1 expression was higher in chondrocytes of PRP-treated knees(36% ± 29% vs 15% ± 18%)(P = 1.8 × 10^(-6)) overall for each post-operative time point and ROI. CONCLUSION: Articular cartilage of rabbits treated with AOT and PRP exhibit increased TGF-β1 expression compared to those treated with AOT and saline. Our findings suggest that adjunctive PRP may increase TGF-β1 expression, which may play a role in the chondrogenic effect of PRP in vivo. | Lorraine A Boakye Keir A Ross John M Pinski Niall A Smyth Amgad M Haleem Charles P Hannon Lisa A Fortier John G Kennedy | 2015 | World Journal of Orthopedics2015，6，11： | 7 |
| 2 | Epidemiology of severe sepsis in the United States: Analysis of incidence, outcome, and associated costs of care显示文摘 | Derek C. Angus Walter T. Linde-Zwirble Jeffrey Lidicker Gilles Clermont Joseph Carcillo Michael R. Pinsky | 2001 | Critical Care Medicine2001，，7： | 5 |
| 3 | Ongoing colorectal cancer risk despite surveillance colonoscopy: the Polyp Prevention Trial Continued Follow-up Study显示文摘 | Keith Leung Paul Pinsky Adeyinka O. Laiyemo Elaine Lanza Arthur Schatzkin Robert E. Schoen | 2010 | Gastrointestinal Endoscopy2010，，1： | 2 |
| 4 | A multiplex, real-time PCR assay for rapid identification of Mycobacterium tuberculosis complex members to the species level显示文摘 | Pinsky B A Banaei N | 2008 | J Clin Microbiol2008，46，7： | 1 |
| 5 | Ventricular assist by cardial cyclespecific increases in intrathoracic pressure显示文摘 | Pinsky P R Martin D | 1997 | Chest1997，91，5： | 1 |
| 6 | Current understanding of sepsis显示文摘 | Wenzel R P Pinsky M R Ulevitch R J | 1996 | Clin Infect Dis1996，22，3： | 1 |
| 7 | Grading the severity of congestive heart failure in infants显示文摘 | Ross RD Bollinger RO Pinsky WW | 1992 | Pediatr Cardiol1992，13，： | 1 |
| 8 | Evaluation of a patient with splenosis by varions imaging modalities显示文摘 | Chung SY Ryo Y Pinsky S | 1996 | J Natl Med Assoc1996，78，： | 1 |
| 9 | Genetics of individualizing patient care显示文摘 | Pinsky MR | | 0，，： | 1 |
| 10 | Assessing contamination and compliance in the prostate component of the prostate,lung,colorectal,and ovarian (PLCO) Cancer Screening Trial显示文摘 | PINSKY PF BLACKA A KRAMER BS | | 0，，4： | 1 |
| 11 | A Retro- spective Analysis of Immunosuppression Compliance, Dose Reduction and Discontinuation in Kidney Transplant Recipi- ents显示文摘 | Takemoto S K Pinsky B W Schnitzler M A | 2007 | Am J Transplant2007，7，12： | 1 |
| 12 | Estimating left ventricular filling pressure during positive end-expiratory preure in human显示文摘 | Pinsky MR Vincent JL De' Smet JM | 1991 | Am Rev Respir Dis1991，143，1： | 1 |
| 13 | Recipient iNOS but not eNOS deficiency reduces luminal narrowing in tracheal allografts 显示文摘 | Minamoto K Pinsky DJ | 2002 | J Exp Med2002，196，10： | 1 |
| 14 | The epidemiology of Heart failure:the Framingham study显示文摘 | Ho KKL Pinsky JL Kannel WB | 1993 | J Am Coll Cardiol1993，22，： | 1 |
| 15 | The epidemiology of heart failure:the Framingham study显示文摘 | Ho KKL Pinsky JL Kannel WB | 1993 | J Am Coll Cardiol1993，22，： | 1 |
| 16 | Fluid and vol- ume monitoring显示文摘 | Pinsky MR Brophy P Padilla J | 2008 | Int J Artif Organs2008，31，： | 1 |
| 17 | Accuracy of three-Dimensional measurements using cone-beam CT显示文摘 | Pinsky HM Dyda S Pinsky RW | 2006 | Dento maxillofac Radio2006，35，6： | 1 |
| 18 | 首次证实结核分枝杆菌发生了对异烟肼的复敏显示文摘背景:结核分枝杆菌耐药株在全世界范围内呈现播散的趋势,对全球的公共卫生造成了严重威胁。然而,关于耐药突变在菌群中是否永久存在,或者说在没有药物压力下耐药突变是否会发生逆转,目前还没有定论。目的:为证实在1位耐多药结核(TB)病人身上发生了异烟肼(INH)复敏的情况,并研究与之相关的细菌生存能力的降低。设计:应用基因型分析和表型分析研究来自1位肺结核病人的耐异烟肼分离株发生异烟肼复敏的情况。应用全敏感株重新构建了与复敏发生前katG突变一致的细菌模型(H_(37) Rv katG::katGW300G),并测试了此菌株对INH的敏感性和对氧化压力的反应。结果:基因分型和药物敏感性试验显示在不应用INH治疗的情况下,同一基因型的结核分枝杆菌菌株发生了从INH耐药向INH敏感的转变。对这种现象的基因型基础也进行了分析,发现katG的第300位密码子发生了改变,从GGG(甘氨酸,G)回复到野生型密码子TGG(色氨酸,W)。菌株H_(37)Rv katG::katG W300G对INH耐药,但是也同时显示出对氧化压力的反应性差。结论:此次研究证实,在没有INH药物压力的情况下,一些INH耐药突变株会转变成药物敏感的表型。此次发现对于研究异烟肼耐药的菌株和临床使用INH的时限可能有广泛的意义。 | E. T. Richardson S-Y. G. Lin B. A. Pinsky E. Desmond N.Banaei 黄海荣(译) 刘宇红(审校) | 2009 | 国际结核病与肺部疾病杂志2009，4，4： | 1 |
| 19 | Estimating cardiac filling pressure in mechanically ventilated patients with hyperinflation 显示文摘 | Teboul JL Pinsky MR Mereat A | 2000 | Crit Care Med2000，28，2： | 1 |
| 20 | Estimating cardiac filling pressure in mechanically ventilated patients with hyperinflation显示文摘 | Teboul JL Pinsky MR Mercat A | 2000 | Crit Care Med2000，28，1： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员