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| 1 | 固定低剂量三联抗高血压药物与常规治疗对斯里兰卡轻度至中度高血压患者血压控制的疗效差异:一项随机临床试验显示文摘控制不良的高血压是全球领先的公共卫生问题,需要新的治疗策略。该研究评估低剂量三联抗高血压药物治疗是否能达到比常规治疗更好的血压控制。研究者纳入2016年2月至2017年5月在斯里兰卡11所城市医院诊所就诊的需要开始抗高血压治疗(未治疗的患者)或接受单药治疗的患者,进行低剂量三联降压与常规治疗比较的随机、开放性试验,随访至2017年10月。 | Web-ster R Salam A de Silva HA Selak V Stepien S Rajapakse S Amarasekara S Amarasena N Billot L de Silva AP Fernando M Guggilla R Jan S Jayawardena J Maulik PK Mendis S Munasinghe J Naik N Prabhakaran D Ranasinghe G Thom S Tisserra N Senaratne V Wijekoon S Wijeyasingam S Rodgers A Patel A 刘莉 叶鹏 | 2018 | 中华高血压杂志2018,26,12: | 7 |
| 2 | Diagnostic value of drain amylase for detecting intrathoracic leakage after esophagectomy显示文摘AIM:To investigate the value of elevated drain amylase concentrations for detecting anastomotic leakage(AL) after minimally invasive Ivor-Lewis esophagectomy(MIILE).METHODS:This was a retrospective analysis of prospectively collected data in two hospitals in the Netherlands. Consecutive patients undergoing MI-ILE were included. A Jackson-Pratt drain next to the dorsal side of the anastomosis and bilateral chest drains were placed at the end of the thoracoscopic procedure. Amylase levels in drain fluid were determined in all patients during at least the first four postoperative days. Contrast computed tomography scans and/or endoscopic imaging were performed in cases of a clinically suspected AL. Anastomotic leakage was defined as any sign of leakage of the esophago-gastric anastomosis on endoscopy,re-operation,radiographic investigations,post mortal examination or when gastro-intestinal contents were found in drain fluid. Receiver operator characteristic curves were used to determine the cut-off values. Sensitivity,specificity,positive predictive value,negative predictive value,risk ratio and overall test accuracy were calculated for elevated drain amylase concentrations.RESULTS:A t o t a l o f 8 9 p a t ie n t s w e re in c lu d e d between March 2013 and August 2014. No differences in group characteristics were observed between patients with and without AL,except for age. Patients with AL were older than were patients without AL(P = 0.01). One patient(1.1%) without AL died within 30 d after surgery due to pneumonia and acute respiratory distress syndrome. Anastomotic leakage that required any intervention occurred in 15 patients(16.9%). Patients with proven anastomotic leakage had higher drain amylase levels than patients without anastomotic leakage [median 384 IU/L(IQR 34-6263) vs median 37 IU/L(IQR 26-66),P = 0.003]. Optimal cut-off values on postoperative days 1,2,and 3 were 350 IU/L,200 IU/L and 160 IU/L,respectively. An elevated amylase level was found in 9 of the 15 patients with AL. Five of these 9 patients had early elevations of their amylase levels,with a median of 2 d(IQR 2-5) before signs and symptoms occurred.CONCLUSION:Measurement of drain amylase levels is an inexpensive and easy tool that may be used to screen for anastomotic leakage soon after MI-ILE. However,clinical validation of this marker is necessary. | Gijs HK Berkelmans Ewout A Kouwenhoven Boudewijn JJ Smeets Teus J Weijs Luis C Silva Corten Marc J van Det Grard AP Nieuwenhuijzen Misha DP Luyer | 2015 | World Journal of Gastroenterology2015,21,30: | 3 |
| 3 | The coronary circulation of the pig heart:comparison with the human heart显示文摘 | Silva AP Agusa | 2005 | Eur J Anat2005,9,2: | 1 |
| 4 | Altering the time of the second gonadotropin-releasing hormone injection and artificial insemination(AI) during Ovsynch affects pregnancies per AI in lactating dairy cows显示文摘 | Brusveen DJ Cunha AP Silva CD | 2008 | Dairy Sei2008,91,3: | 1 |
| 5 | NPY regulates catecholamine secretion from human adrenal chromaffin cells显示文摘 | Cavadas C Silva AP Mosimann F | 2001 | J Clin Endocrinol Metab2001,86,: | 1 |
| 6 | Up-regulation of neuropeptide Y levels and modulation of glutamate release through neuropeptide Y receptors in the hippo campus of kainite-induced epileptic rats 显示文摘 | Silva AP Xapelli S Pinheiro PS | 2005 | J Neurochem2005,93,1: | 1 |
| 7 | Antioxidant and inflammatoryaspects of lipoprotein-associated phospholipase A(2)(Lp-PLA(2)):a review显示文摘 | Silva IT Mello AP Damasceno NR | 2011 | Lipids Health Dis2011,10,: | 1 |
| 8 | Hydrotherapy versusconventional land-base显示文摘 | Silva LE Valim V Pessanha AP | 2008 | Physical Therapy2008,88,1: | 1 |
| 9 | Least limiting water range:A potential indicator of changes in near-surface soil physical quality afterthe conversion of Brazilian Savanna into pasture显示文摘 | LEO T P DA SILVA AP MACEDO M C M | 2006 | Soil&Tillage Re-search2006,88,: | 1 |
| 10 | NPY regulatcs catecholamine secretion from human adrenal chromaffin cells显示文摘 | Cavadas C Silva AP Mosimann F | | 0,,12: | 1 |
| 11 | Nocturnal sleep quality and circadian blood pressure variation 显示文摘 | Silva AP Moreira C Bicho M | 2000 | Rev Poa Cal''diol2000,19,10: | 1 |
| 12 | In vivo neuronal tract tracing using manganese-enhanced magnetic resonance imaging 显示文摘 | Pautler RG Silva AC Koretsky AP | 1998 | Magn Reson Med1998,40,: | 1 |
| 13 | Analysis of Ki67 and Bcl-2 protein expression in normal colorectal mucosa of women with breast cancer 显示文摘 | Sousa-Jnior EC Alencar AP da Silva BB | 2009 | EurJ Cancer2009,45,17: | 1 |
| 14 | Polarographic determination of sunscreen agents in cosmetic products in mitellar media显示文摘 | DA SILVA AP TRINDADE MAG FERREIRA VS | 2006 | Talanta2006,68,3: | 1 |
| 15 | Feature extraction via multi-resolution analysis for short-term load forecasting显示文摘 | Rocha Reis A J Alves da Silva AP | 2005 | IEEE Transactions on Power Systems2005,20,1: | 1 |
| 16 | PP1 inhibition by hbeta peptide as a potential pa- thological mechanism in hlzheimer's disease显示文摘 | Vint 6m AP Henriques AG da Cruz E Silva 0A | 2009 | Ne- urotoxicol Teratol2009,31,2: | 1 |
| 17 | A new pelvic muscle trainer for the treatment of urinary incontinence 显示文摘 | Schmidt AP Sanches PR Silva DP Jr | 2009 | Int J Gynaecol Obstet2009,105,3: | 1 |
| 18 | Optimal Design of Shell-and-Tube Heat Exchangers Using Particle Swarm Optimization 显示文摘 | Ravagnani MASS Silva AP Biscala Jr EC | 2009 | Industrial & Engineering Chemistry Research2009,48,29: | 1 |
| 19 | Validity of multislice computerized tomography for diagnosis of maxillofacial fracture using an independent workstation显示文摘 | Dos Santos DT Costa e Silva AP Wannier MW | 2004 | Oral Surg Oral Med Oral pathol Oral Radiol Endod2004,98,6: | 1 |
| 20 | Antioxidant and inflammatory aspects of lipoprotein-associated phospholipase A2(Lp-PLA2):a review显示文摘 | Silva IT Mello AP Damasceno NR | 2011 | Lipids in health Dis2011,10,1: | 1 |