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| 1 | Tumor-expressed B7-H3 mediates the inhibition of antitumor T-cell functions in ovarian cancer insensitive to PD-1 blockade therapy显示文摘Although PD-L1/PD-1 blockade therapy has been approved to treat many types of cancers,the majority of patients with solid tumors do not respond well,but the underlying reason remains unclear.Here,we studied ovarian cancer(OvCa),a tumor type generally resistant to current immunotherapies,to investigate PD-1-independent immunosuppression.We found that PD-L1 was not highly expressed in the tumor microenvironment(TME)of human OvCa.Instead,B7-H3,another checkpoint molecule,was highly expressed by both tumor cells and tumor-infiltrating antigen-presenting cells(APCs),which correlated with T-cell exhaustion in patients.Using ID8 OvCa mouse models,we found that B7-H3 expressed on tumor cells,but not host cells,had a dominant role in suppressing antitumor immunity.Therapeutically,B7-H3 blockade,but not PD-1 blockade,prolonged the survival of ID8 tumorbearing mice.Collectively,our results demonstrate that tumor-expressed B7-H3 inhibits the function of CD8^(+)T cells and suggest that B7-H3 may be a target in patients who are not responsive to PD-L1/PD-1 inhibition,particularly OvCa patients. | Dongli Cai Jiaming Li Dingfeng Liu Shanjuan Hong Qin Qiao Qinli Sun Pingping Li Nanan Lyu Tiantian Sun Shan Xie Li Guo Ling Ni Liping Jin Chen Dong | 2020 | Cellular & Molecular Immunology2020，17，3： | 8 |
| 2 | A gauge-based analysis of daily precipitation over East Asia显示文摘 | Xie Pingping Yatagai Akiyo Chen Mingyue | 2007 | Journal of Hydromcteorology2007，8，： | 1 |
| 3 | Flexibility analysis and design of heat exchanger network for syngas-to-methanol process显示文摘The heat exchanger network(HEN)in a syngas-to-methanol process was designed and optimized based on pinch technology under stable operating conditions to balance the energy consumption and economic gain.In actual industrial processes,fluctuations in production inevitably affect the stable operation of HENs.A flexibility analysis of the HEN was carried out to minimize such disturbances using the downstream paths method.The results show that two-third of the downstream paths cannot meet flexibility requirements,indicating that the HEN does not have enough flexibility to accommodate the disturbances in actual production.A flexible HEN was then designed with the method of dividing and subsequent merging of streams,which led to 13.89%and 20.82%reductions in energy consumption and total cost,respectively.Owing to the sufficient area margin and additional alternative heat exchangers,the flexible HEN was able to resist interference and maintain production stability and safety,with the total cost increasing by just 4.08%. | Jinchang Liu Pingping Zhang Qiang Xie Dingcheng Liang Lei Bai | 2021 | International Journal of Coal Science & Technology2021，8，6： | 1 |
| 4 | Study of Bandgap Characteristics of 2D Magnetoplasma Photonic Crystal by Using M-FDTD Method显示文摘 | Yang Lixia Xie Yingtao Yu Pingping | 2011 | Microwave and Optical Technology Letters2011，53，8： | 1 |
| 5 | Analysis of global monthly precipitation using gauge observations, satellite estimates and numerical model prediction 显示文摘 | Xie Pingping Arkin P A | 1996 | Journal of Climate1996，9，4： | 1 |
| 6 | Global precipitation: a 17-year monthly analysis based on gauge observations, satellite estimates, and numerical model outputs显示文摘 | Xie Pingping Arkin P A | | Bull Amer Meteor Soe0，78，11： | 1 |
| 7 | A Note on Reviving the Goddard Satellite-Based Surface Turbulent Fluxes (GSSTF) Dataset显示文摘Accurate sea surface flux measurements are crucial for understanding the global water and energy cycles. The oceanic evaporation, which is a major component of the global oceanic fresh water flux, is useful for predicting oceanic circulation and transport. The global Goddard Satellite-based Surface Turbulent Fluxes Version-2 (GSSTF2; July 1987–December 2000) dateset that was o?cially released in 2001 has been widely used by scientific community for global energy and water cycle research, and regional and short period data analyses. We have recently been funded by NASA to resume processing the GSSTF dataset with an objective of continually producing a uniform dataset of sea surface turbulent fluxes, derived from remote sensing data. The dataset is to be reprocessed and brought up-to-date (GSSTF2b) using improved input datasets such as a recently upgraded NCEP/DOE sea surface temperature reanalysis, and an upgraded surface wind and microwave brightness temperature V6 dataset (Version 6) from the Special Sensor Microwave Imager (SSM/I) produced by Remote Sensing Systems (RSS). A second new product (GSSTF3) is further proposed with a finer temporal (12-h) and spatial (0.25°× 0.25°) resolution. GSSTF2b (July 1987–December 2008) and GSSTF3 (July 1999–December 2009) will be released for the research community to use by late 2009 and early 2011, respectively. | Chung-Lin SHIE Long S. CHIU Robert ADLER Eric NELKIN I-I LIN Pingping XIE Feng-Chin WANG R. CHOKNGAMWONG William OLSON D. Allen CHU | 2009 | Advances in Atmospheric Sciences2009，26，6： | 1 |
| 8 | Diagnostic Value of Transthoracic Echocardiography for Patent Foramen Ovale: A Meta-analysis显示文摘 | Pingping Ren Ke Li Xiaofang Lu Mingxing Xie | 2013 | Ultrasound in Medicine & Biology2013，，： | 1 |
| 9 | Phylogenetic and Expression Analyses of With-No-Lysine Kinase Genes Reveal Novel Gene Family Diversity in Fruit Trees显示文摘With-No-Lysine kinases(WNK) have been reported to be associated with plant growth regulation in Arabidopsis, soybean, and rice, but little is known of their roles in fruits. In this study, a total of 114 WNK genes were identified from 8 fruit trees species, and these WNK genes belonged to 2 classes(I and II) that respectively contain 4(A, B, C, D) and 2 groups(E, F). The WNK genes had variable exon-intron structures and were randomly distributed among most chromosomes of each genus. The expression levels of six of the 18 WNK genes in peach were almost undetectable in fruits, suggesting that they may not be associated with fruit development and ripening. Of the other 12 WNK genes, PpWNK.B1 exhibited stronger stability of expression levels than the best reference genes reported previously in fruits from two peach cultivars. These results suggested that PpWNK.B1 could be a reliable reference gene for gene expression studies of peach fruit. Moreover, qRT-PCR assays yielded evidence that when using single reference gene as internal control, mistakes were more possible, indicating that the use of three reference genes is necessary for gene expression studies. Based on the gene expression profiles validated by qRT-PCR, PpWNK.A1 is predicted to likely be involved in fruit ripening, while PpWNK.A2 and PpWNK.E3.1 are likely associated with early fruit development. The present study represented the WNK genes in fruits, and it will be a valuable resource in continuing investigation of gene regulation network during fruit development and ripening. | Suhao Cao Pingping Hao Weishen Shu Guoming Wang Zhihua Xie Chao Gu Shaoling Zhang | 2019 | Horticultural Plant Journal2019，5，2： | 1 |
| 10 | Performance of high-resolution satellite precipitation products over China显示文摘 | Shen Yan Xiong Anyuan Wang Ying Xie Pingping | 2010 | Journal of Geophysical Research Atmospheres2010，，2： | 1 |
| 11 | The global precipitation climatology project: First algorithm intercovnparison project 显示文摘 | Phillip A Arkin Pingping Xie | 1994 | Bulletin American Meteorological Society1994，75，3： | 1 |
| 12 | Study ofbandgap characteristics of 2D magnetoplasma photon-ic crystal by using M-FDTD method 显示文摘 | YANG Lixia XIE Yingtao YU Pingping | 2011 | Microwaveand Optical Technology Letters2011，53，8： | 1 |
| 13 | An assessment of the surface climate in the NCEP climate forecast system reanalysis显示文摘 | Wanqiu Wang Pingping Xie Soo-Hyun Yoo Yan Xue Arun Kumar Xingren Wu | 2011 | Climate Dynamics2011，，7： | 1 |
| 14 | A gauge-based analysis of daily precipitation over East Asia显示文摘 | XIE Pingping CHEN Mingyue YANG Song | 2007 | (7) : 607-6242007，，7： | 1 |
| 15 | Performance of high-resolution satellite precipitation products over China显示文摘 | Shen Yan Xiong Anyuan Wang Ying Xie Pingping | 2010 | Journal of Geophysical Research Atmospheres2010，，2： | 1 |
| 16 | Global land precipitation:A 50-yr monthly analysis based on gauge observations显示文摘 | Chen Mingyue Xie Pingping Janowiak J E | 2002 | J Hydrometeor2002，3，3： | 1 |
| 17 | Global precipitation: A 17-year monthly analysis based on gauge observations, satellite estimates, and numerical model outputs显示文摘 | Xie Pingping Arkin P A | 1997 | Bull Amer Meteor Soc1997，78，11： | 1 |
| 18 | A gauge-based analysis of daily precipitation over east Asia显示文摘 | Xie Pingping Yatagai A Chen Mingyue | 2007 | J Hydrometeorol2007，8，3： | 1 |
| 19 | The global precipitation climatology project : first algorithm intercomparison project 显示文摘 | Arkin P A Xie Pingping | 1994 | Bull Amer Meteor Soc1994，75，3： | 1 |
| 20 | Biased heteroplasmy within the mitogenomic sequences of Gigantometra gigas revealed by sanger and high-throughput methods显示文摘Few studies have explored the differences between Sanger and HTS methods in the results of mitogenome sequencing. We used a single individual of insect to study the differences between the sequences given by Sanger and PCR-free HTS methods. Here we provided evidence for biased results of sequencing due to different methods in the mitochondrial genes of atp6, atp8, cox1, cox2, cox3, Cytb, nad2, nad3, nad4, nad5, rrn S, rrnL, trnH, trn I, and control region at various degrees. Especially, in cox1, the differently sequenced nucleotides account for 2.6% of the complete length. Furthermore, the highest value of the intraspecific genetic distance based on K2 P accounts for 2.5% using a barcode fragment size of cox1(651 bp, Sanger), while the maximum distance of the corresponding cox1 fragment obtained by the two sequencing methods was 5.0%. We revealed that the methods of Sanger and HTS may give different sequencing results of mitochondrial genes, which may reflect the heteroplasmy of mitogenomes within an insect individual. Therefore, researchers should be very cautious in using the mixed data of a gene given by different methods of sequencing. | Xiaoya Sun Yanhui Wang Pingping Chen Hesheng Wang Lixiang Lu Zhen Ye Yanzhuo Wu Teng Li Wenjun Bu Qiang Xie | 2018 | Zoological Systematics2018，43，4： | 0 |
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