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| 1 | Apoptosis and its relationship with cell proliferation,p53,Waf1p21,bcl-2 and c-mycin esophageal carcinogenesis studied with a high-risk population in northern China显示文摘Apoptosisanditsrelationshipwithcelproliferation,p53,Waf1p21,bcl2andcmycinesophagealcarcinogenesisstudiedwithahighriskpopul... | WANG LiDong1, ZHOU Qi1, WEI JunPing1, YANG WanCai1, ZHAO Xin1, WANG LiXia1, ZOU Jian Xiang1, GAO ShanShan1, LI YongXin1 and YANG C.S.2Keywords esophageal neoplasms apoptosis precancerous lesions Waf1 p21 gene p53 | 1998 | World Journal of Gastroenterology1998，4，4： | 295 |
| 2 | Annual report on status of cancer in China,2010显示文摘Objective:Population-based cancer registration data in 2010 were collected,evaluated and analyzed by the National Central Cancer Registry(NCCR) of China.Cancer incident new cases and cancer deaths were estimated.Methods:There were 219 cancer registries submitted cancer incidence and death data in 2010.All data were checked and evaluated on basis of the criteria of data quality from NCCR.Total 145 registries' data were qualified and accepted for cancer statistics in 2010.Pooled data were stratified by urban/rural,area,sex,age group and cancer site.Cancer incident cases and deaths were estimated using age-specific rates and national population.The top ten common cancers in different groups,proportion and cumulative rate were also calculated.Chinese census in 2000 and Segi's population were used for age-standardized incidence/ mortality rates.Results:All 145 cancer registries(63 in urban and 82 in rural) covered a total of 158,403,248 population(92,433,739 in urban and 65,969,509 in rural areas).The estimates of new cancer incident cases and cancer deaths were 3,093,039 and 1,956,622 in 2010,respectively.The morphology verified cases(MV%) accounted for 67.11% and 2.99% of incident cases were identified through death certifications only(DCO%) with mortality to incidence ratio(M/I) of 0.61.The crude incidence rate was 235.23/100,000(268.65/100,000 in males,200.21/100,000 in females),age-standardized incidence rates by Chinese standard population(ASIRC,2000) and by world standard population(ASIRW) were 184.58/100,000 and 181.49/100,000 with the cumulative incidence rate(0-74 years old) of 21.11%.The cancer incidence and ASIRC were 256.41/100,000 and 187.53/100,000 in urban areas whereas in rural areas,they were 213.71/100,000 and 181.10/100,000,respectively.The crude cancer mortality in China was 148.81/100,000(186.37/100,000 in males and 109.42/100,000 in females),age-standardized incidence rates by Chinese standard population(ASMRC,2000) and by world standard population(ASMRW) were 113.92/100,000 and 112.86/100,000,and the cumulative incidence rate(0-74 years old) was 12.78%.The cancer mortality and ASMRC were 156.14/100,000 and 109.21/100,000 in urban areas,whereas in rural areas,they were 141.35/100,000 and 119.00/100,000 respectively.Lung cancer,gastric cancer,colorectal cancer,liver cancer,esophageal cancer,pancreas cancer,encephaloma,lymphoma,female breast cancer and cervical cancer,were the most common cancers,accounting for 75% of all cancer cases in urban and rural areas.Lung cancer,gastric cancer,liver cancer,esophageal cancer,colorectal cancer,pancreatic cancer,breast cancer,encephaloma,leukemia and lymphoma accounted for 80% of all cancer deaths.Conclusions:The coverage of cancer registration population had a rapid increase and could reflect cancer burden in each area and population.As the basis of cancer control program,cancer registry plays an irreplaceable role in cancer epidemic surveillance,evaluation of cancer control programs and making anticancer strategy.China is facing serious cancer burden and prevention and control should be enhanced. | Wanqing Chen Rongshou Zheng Siwei Zhang Ping Zhao Hongmei Zeng Xiaonong Zou Jie He | 2014 | Chinese Journal of Cancer Research2014，26，1： | 198 |
| 3 | Evidence chain-based causality identification in herb-induced liver injury: exemplification of a well-known liver-restorative herb Polygonum multiflorum显示文摘草药的药最近在美国作为导致药的肝损害(DILI ) 的第二个很普通的原因被认出了。然而,识别一些植物的 DILI 诱发性的可靠方法例如 Heshouwu (蓼 multiflorum 的弄干的根) ,留下缺乏。在这研究,有肝机能障碍和 Heshouwu DILI 的 147 个报导文学的案例的 12 307 个住院病人的一个总数被屏蔽。一个一般算法仅仅显示了那 22.5%(9/40 ) 并且(45/147 ) 分别地, 30.6% 所有住院和文学案例报告表明 Heshouwu 的 DILI 诱发性的高概率。由对比,(19/20 )95% 生药学,植物化学,和 metabolomic 有希望地调查的所有情况测试展出高度可能的诱发性,包括不正确地以前被归因的一个病人和从由 pharmacognostic 证据的 Heshouwu 诱发性被排除的一个案例。污染也是的毒素(重金属,杀虫剂,和 mycotoxins ) 从 Heshouwu DILI 诱发性排除了。为 Heshouwu DILI 诊断地址安全的这些屏蔽方法的客观性担心考虑包含芪的草药的药和饮食的补充。 | Jiabo Wang Zhijie Ma Ming Niu Yun Zhu Qingsheng Liang Yanling Zhao Jingyuan Song Zhaofang Bai Yaming Zhang Ping Zhang Na Li Yakun Meng Qi Li Lushan Qin Guangju Teng Junling Cao Baosen Li Shilin Chen Yonggang Li Zhengsheng Zou Honghao Zhou Xiaohe Xiao | 2015 | Frontiers of Medicine2015，9，4： | 47 |
| 4 | Biotransfer of heavy metals along a soil-plant-insect-chicken food chain:Field study显示文摘The accumulation and transfer of Pb,Zn,Cu,and Cd along a soil-plant-insect-chicken food chain at contaminated sites were investigated.The study site nearing the Pb/Zn mine had been contaminated by heavy metals severely.Cadmium and Pb concentrations steadily declined with increasing trophic level(p < 0.01),but concentrations of Zn and Cu slightly increased from plant to insect larva(p > 0.05).The concentrations of heavy metals were the highest in chicken muscle,with lower values in liver and blood.The bioaccumulation of Pb was observed in chicken livers.The eliminations of Pb,Zn,Cu,and Cd via insect and chicken feces avoid metal bioaccumulation in insect and chicken body.These results suggest that the accumulation of heavy metals in specific animal organ of tissues could not be neglected,although transfer of metals to chicken from plant and insect was limited. | ZHUANG Ping ZOU Huiling SHU Wensheng | 2009 | Journal of Environmental Sciences2009，21，6： | 31 |
| 5 | Lime and Phosphate Could Reduce Cadmium Uptake by Five Vegetables Commonly Grown in South China显示文摘A pot experiment was conducted in artificially Cd-contaminated (5 mg Cd kg-1) soils to investigate the feasibility of using lime (3 g kg-1) or phosphate (80 mg P kg-1) to mitigate uptake of Cd by vegetables.Five common vegetables in South China,including lettuce (Lactuca sativa L.var.ramosa Hort.),Chinese cabbage [Brassica rapa L.subsp.Chinensis (L.) var.parachinensis (L.H.Bailey) Hanect],Chinese broccoli (Brassica oleracea L.var.albiflora Kuntze),white amaranth (Amaranthus tricolor L.) and purslane (Amaranthus viridis L.),were grown in the soils and harvested after 60 d.The results showed that liming significantly reduced Cd uptake by most vegetables by 40%-50% (or a maximum of 70%),mainly due to immobilization of soil Cd.Increased availability of Ca in the soil might also contribute to the Cd uptake reduction as a result of absorption competition between Ca and Cd.Liming caused biomass reduction in white amaranth and purslane,but did not influence growth of the other vegetables.Phosphate decreased Cd uptake by vegetables by 12%-23%.Compared with lime,phosphate decreased,to a smaller extent,the bioavailability of Cd in most cases.Phosphate markedly promoted growth of vegetables.Changes in soil chemistry by adding lime or phosphate did not markedly influence nutrient uptake of vegetables except that lime increased Ca content and phosphate increased P content in shoots of the vegetables.The results suggested that a proper application of lime could be effective in reducing Cd uptake of vegetables,and phosphate could promote growth of the vegetables as well as alleviate the toxicity of Cd. | TAN Wan-Neng LI Zhi-An QIU Jing ZOU Bi LI Ning-Yu ZHUANG Ping WANG Gang | 2011 | Pedosphere2011，21，2： | 34 |
| 6 | Berberine inhibits hepatic gluconeogenesis via the LKB1-AMPK-TORC2 signaling pathway in streptozotocin-induced diabetic rats显示文摘AIM: To investigate the molecular mechanisms of berberine inhibition of hepatic gluconeogenesis in a diabetic rat model.METHODS: The 40 rats were randomly divided into five groups. One group was selected as the normal group. In the remaining groups(n = 8 each), the rats were fed on a high-fat diet for 1 mo and received intravenous injection of streptozotocin for induction of the diabetic models. Berberine(156 mg/kg per day)(berberine group) or metformin(184 mg/kg per day)(metformin group) was intragastrically administered to the diabetic rats and 5-aminoimidazole-4-carboxamide1-β-D-ribofuranoside(AICAR)(0.5 mg/kg per day)(AICAR group) was subcutaneously injected to the diabetic rats for 12 wk. The remaining eight diabetic rats served as the model group. Fasting plasma glucose and insulin levels as well as lipid profile were tested.The expressions of proteins were examined by western blotting. The nuclear translocation of CREB-regulated transcription co-activator(TORC)2 was observed by immunohistochemical staining. RESULTS: Berberine improved impaired glucose tolerance and decreased plasma hyperlipidemia. Moreover, berberine decreased fasting plasma insulin and homeostasis model assessment of insulin resistance(HOMA-IR). Berberine upregulated protein expression of liver kinase(LK)B1, AMP-activated protein kinase(AMPK) and phosphorylated AMPK(p-AMPK). The level of phophorylated TORC2(p-TORC2) protein in the cytoplasm was higher in the berberine group than in the model group, and no significant difference in total TORC2 protein level was observed. Immunohistochemical staining revealed that more TORC2 was localized in the cytoplasm of the berberine group than in the model group. Moreover, berberine treatment downregulated protein expression of the key gluconeogenic enzymes(phosphoenolpyruvate carboxykinase and glucose-6-phosphatase) in the liver tissues. CONCLUSION: Our findings revealed that berberine inhibited hepatic gluconeogenesis via the regulation of the LKB1-AMPK-TORC2 signaling pathway. | Shu-Jun Jiang Hui Dong Jing-Bin Li Li-Jun Xu Xin Zou Kai-Fu Wang Fu-Er Lu Ping Yi | 2015 | World Journal of Gastroenterology2015，21，25： | 33 |
| 7 | Cancer Incidence And Mortality in China,2006显示文摘目的将在 2006 描述癌症发生和死亡率并且在中国评估癌症负担。从 34 张癌症注册表的在 2006 的方法癌症登记数据被收集,评估并且分享了计算癌症发生和死亡率。数据分析包括了死亡到发生比率(MI ) ,词法确认百分比(MV%) 和死亡证明的比例仅仅(DCO%) 。累积发生和死亡率为癌症地点,年龄,性别和区域用粗略的数据,标准化年龄的数据,和特定的数据被计算(城市或农村) 。在 2006 的结果,有合格登记数据的 34 张注册表盖住 59,567,322 的一张全部的人口(46,558,108 在城市的区域并且 13,009,214 在农村区域) 。粗略、标准化年龄的癌症发生率分别地每 100,000 每 100,000 和 190.54 是 273.66。粗略、标准化年龄的癌症死亡率分别地每 100,000 每 100,000 和 117.67 是 175.70。在女性的肺,胃,冒号和直肠,肝,和胸的癌症是在中国的癌症的五张很普通的表格,它说明了 58.99% 所有新癌症盒子。肺癌症是癌症死亡的领先的原因,由胃癌症,肝癌症,食道的癌症和 colorectal 癌症列在后面。结论癌症仍然是在有增加的疾病负担的中国的一个重要公共健康问题。明确地,为肺癌症, colorectal 癌症和乳癌的发生率正在增加,但是那些为胃癌症和食道的癌症正在减少。然而,年龄特定的发生率仍然保持稳定,显示变老的人口是增加的癌症负担的主要来源。 | Wan-qing Chen Si-wei Zhang Xiao-nong Zou Ping Zhao | 2011 | Chinese Journal of Cancer Research2011，23，1： | 25 |
| 8 | Heavy Metal Contamination in Soil and Soybean near the Dabaoshan Mine, South China显示文摘Concentrations of Pb, Cd, Cu, Zn, Cr and Ni in soybean (Glycine max L.) grown near the Dabaoshan Mine were investigated, and their potential risk to the health of inhabitants was estimated. In the Fandong (FD) and Zhongxin (ZX) villages, which are near the Dabaoshan mineral deposit, concentrations of Pb (0.34 mg kg^(-1) for FD), Cd (0.23 mg kg^(-1) for ZX) and Cr (1.14 and 1.75 mg kg^(-1) for FD and ZX, respectively) in the seeds of soybean exceeded the tolerance limit set by Chinese standards. The estimated daily intakes (EDIs) from consumption of soybean seeds for FD inhabitants were 0.570, 0.170, 38.550, 142.400, 1.910 and 14.530 μg d^(-1) kg^(-1) boby weight for Pb, Cd, Cu, Zn, Cr and Ni, respectively. Our results indicate that soybeans grown in the vicinity of the Dabaoshan Mine accumulate some metals, and the seeds pose a potential health risk to the local inhabitants. | ZHUANG Ping LI Zhi-An ZOU Bi XIA Han-Ping WANG Gang | 2013 | Pedosphere2013，23，3： | 23 |
| 9 | A high-quality genome assembly of quinoa provides insights into the molecular basis of salt bladder-based salinity tolerance and the exceptional nutritional value显示文摘 | Changsong Zou Aojun Chen Lihong Xiao Heike M Muller Peter Ache Georg Haberer Meiling Zhang Wei Jia Ping Deng Ru Huang Daniel Lang Feng Li Dongliang Zhan Xiangyun Wu Hui Zhang Jennifer Bohm Renyi Liu Sergey Shabala Rainer Hedrich Jian-Kang Zhu Heng Zhang | 2017 | Cell Research2017，27，11： | 22 |
| 10 | Hydrogen sulfide inhibits homocysteine-induced endoplasmic reticulum stress and neuronal apoptosis in rat hippocampus via upregulation of the BDNF-TrkB pathway显示文摘 | Hai-jun WEI Jin-hua XU Man-hong LI Ji-ping TANG Wei ZOU Ping ZHANG Li WANG Chun-yan WANG Xiao-qing TANG | 2014 | Acta Pharmacologica Sinica2014，35，6： | 21 |
| 11 | Submucosal tunneling endoscopic resection: An effective and safe therapy for upper gastrointestinal submucosal tumors originating from the muscularis propria layer显示文摘AIM To evaluate the effectiveness and safety of submucosal tunneling endoscopic resection(STER) and compare its outcomes in esophageal and cardial submucosal tumors(SMTs) of the muscularis propria(MP) layer.METHODS From May 2012 to November 2017, 173 consecutive patients with upper gastrointestinal(GI) SMTs of the MP layer underwent STER. Overall, 165 patients were included, and 8 were excluded. The baseline characteristics of the patients and SMTs were recorded. The en bloc resection rate, complete resection rate,residual rate, and recurrence rate were calculated to evaluate the effectiveness of STER, and the complication rate was recorded to evaluate its safety. Effectiveness and safety outcomes were compared between esophageal and cardial SMTs.RESULTS One hundred and twelve men and 53 women with a mean age of 46.9 ± 10.8 years were included. The mean tumor size was 22.6 ± 13.6 mm. Eleven SMTs were located in the upper esophagus(6.7%), 49 in the middle esophagus(29.7%), 46 in the lower esophagus(27.9%), and 59 in the cardia(35.7%). Irregular lesions accounted for 48.5% of all lesions. STER achieved an en bloc resection rate of78.7%(128/165) for GI SMTs with an overall complication rate of 21.2%(35/165).All complications resolved without intervention or were treated conservatively without the need for surgery. The en bloc resection rates of esophageal and cardial SMTs were 81.1%(86/106) and 72.1%(42/59), respectively(P = 0.142), and the complication rates were 19.8%(21/106) and 23.7%(14/59), respectively,(P =0.555). The most common complications for esophageal SMTs were gas-related complications and fever, while mucosal injury was the most common for cardial SMTs.CONCLUSION STER is an effective and safe therapy for GI SMTs of the MP layer. Its effectiveness and safety are comparable between SMTs of the esophagus and cardia. | Chen Du Ning-Li Chai En-Qiang Ling-Hu Zhen-Juan Li Long-Song Li Jia-Le Zou Lei Jiang Zhong-Sheng Lu Jiang-Yun Meng Ping Tang | 2019 | World Journal of Gastroenterology2019，25，2： | 17 |
| 12 | Wnt and BMP signaling crosstalk in regulating dental stem cells:Implications in dental tissue engineering显示文摘Tooth is a complex hard tissue organ and consists of multiple cell types that are regulated by important signaling pathways such as Wnt and BMP signaling.Serious injuries and/or loss of tooth or periodontal tissues may significantly impact aesthetic appearance,essential oral functions and the quality of life.Regenerative dentistry holds great promise in treating oral/dental disorders.The past decade has witnessed a rapid expansion of our understanding of the biological features of dental stem cells,along with the signaling mechanisms governing stem cell self-renewal and differentiation.In this review,we first summarize the biological characteristics of seven types of dental stem cells,including dental pulp stem cells,stem cells from apical papilla,stem cells from human exfoliated deciduous teeth,dental follicle precursor cells,periodontal ligament stem cells,alveolar bone-derived mesenchymal stem cells(MSCs),and MSCs from gingiva.We then focus on how these stem cells are regulated by bone morphogenetic protein(BMP)and/or Wnt signaling by examining the interplays between these pathways.Lastly,we analyze the current status of dental tissue engineering strategies that utilize oral/dental stem cells by harnessing the interplays between BMP and Wnt pathways.We also highlight the challenges that must be addressed before the dental stem cells may reach any clinical applications.Thus,we can expect to witness significant progresses to be made in regenerative dentistry in the coming decade. | Fugui Zhang Jinlin Song Hongmei Zhang Enyi Huang Dongzhe Song Viktor Tollemar Jing Wang Jinhua Wang Maryam Mohammed Qiang Wei Jiaming Fan Junyi Liao Yulong Zou Feng Liu Xue Hu Xiangyang Qu Liqun Chen Xinyi Yu Hue H.Luu Michael J.Lee Tong-Chuan He Ping Ji | 2016 | Genes & Diseases2016，3，4： | 16 |
| 13 | Effect and mechanism of Irbesartan on occurrence of ventricular arrhythmias in rats with myocardial ischemia through connexin43(cx43)显示文摘Objective: To explore the effect and mechanism of angiotensin Ⅱ receptor blockers-Irbesartan on occurrence of ventricular arrhythmias in rats with myocardial ischemia. Methods: Rats with embryonic cardiomyocytes-H9c2 were randomly divided into control group, ischemia group, Irbesartan group and Irbesartan+ischemia group. The cell viability of rats in each group was tested using MTT. Real-time PCR was employed to detect the expression of connexin43(Cx43) mR NA and western blot to detect the expression of Cx43 and phosphorylated Cx43. SD rats were randomly divided into the sham-operation group(SO), myocardial infarction group(MI), Irbesartan group and MI+ Irbesartan group, with 10 rats in each group. HE staining was employed to observe the change in the pathomorphology of left ventricular tissue and TUNEL method to analyze the cell apoptosis in the tissue. The immunofluorescence was adopted to observe the expression and distribution of Cx43 in the left ventricular myocardium and study the change in the expression of Cx43 in the cardiac muscular tissue at mR NA and protein level. Results: The intervention of Irbesartan in the condition of ischemia indicated the significant decrease in the number of necrotic cells. The expression of Cx43 was significantly decreased under the culture of ischemia(P<0.05), but in the presence of Irbesartan, the expression of Cx43 was increased compared with the ischemia group(P<0.01). The results of WB assay showed the similar trend of change at mRNA level. There was the significant difference in the score of ventricular arerythmia between MI group and SO group(P<0.01). The incidence of ventricular tachycardia or ventricular fibrillation was significantly increased compared with the one in SO group(P<0.05). There was the significant difference in the overall score between MI+Irbesartan group and MI group(P<0.05). The expression of Cx43 in the cardiac muscular tissue in MI group was significantly decreased(P<0.01 vs SO group). But the expression of Cx43 was increased after the treatment with Irbesartan. Conclusions: Irbesartan can inhibit the injury of H9c2 cardiomyocytes and the decreased expression of Cx43 that are induced by the ischemic myocardial infarction. Irbesartan can also improve the reconstruction of Cx43 in rats with ischemic myocardium to inhibit the myocardial infarction-induced arrhythmias. | Tao Wu Dan Wu Qinghua Wu Bing Zou Xiao Huang Xiaoshu Cheng Yanqing Wu Kui Hong Ping Li | 2016 | Asian Pacific Journal of Tropical Medicine2016，9，10： | 15 |
| 14 | CYP2E1-dependent hepatotoxicity and oxidative damage after ethanol administration in human primary hepatocytes显示文摘AIM: To observe the relationship between ethanol-induced oxidative damage in human primary cultured hepatocytes and cytochrome P450 2E1 (CYP2E1) activity, in order to address if inhibition of CYP2E1 could attenuate ethanolinduced cellular damage. METHODS: The dose-dependent (25-100 mmol/L) and time-dependent (0-24 h) exposures of primary human cultured hepatocytes to ethanol were carried out. CYP2E1 activity and protein expression were detected by spectrophotometer and Western blot analysis respectively. Hepatotoxicity was investigated by determination of Iactate dehydrogenase (LDH) and aspartate transaminase (AST) level in hepatocyte culture supernatants, as well as the intracellular formation of malondialdehyde (MDA). RESULTS: A dose-and time-dependent response between ethanol exposure and CYP2E1 activity in human hepatocytes was demonstrated. Moreover, there was a time-dependent increase of CYP2E1 protein after 100 mmol/L ethanol exposure. Meanwhile, ethanol exposure of hepatocytes caused a time-dependent increase of cellular MDA level, LDH, and AST activities in supernatants. Furthermore, the inhibitor of CYP2E1, diallyl sulfide (DAS) could partly attenuate the increases of MDA, LDH, and AST in human hepatocytes. CONCLUSION: A positive relationship between ethanolinduced oxidative damage in human primary cultured hepatocytes and CYP2E1 activity was exhibited, and the inhibition of CYP2E1 could partly attenuate ethanol-induced oxidative damage. | Lie-Gang Liu Hong Yan Ping Yao Wen Zhang Li-Jun Zou Fang-Fang Song Ke Li Xiu-Fa Sun | 2005 | World Journal of Gastroenterology2005，11，29： | 12 |
| 15 | Expression and location of Smad2,4 mRNAs during and after liver fibrogenesis of rats显示文摘瞄准:在老鼠在肝调查 Smad2 和 Smad4 mRNAs 的地点改变在期间并且在纤维发生以后。方法:各称约 200 g 的八十只男 Wistar 老鼠被使用。试验性的肝的纤维变性的老鼠模型被注射与四氯化碳(CCl4 ) 建立,正常老鼠和老鼠与齐墩果油被注射并且担任了控制组。原位杂交(ISH ) 被用来在肝检测 Smad2 和 Smad4 mRNA。结果:原位杂交显示出 Smad2 和 Smad4 mRNA 在中央静脉和肝的湾穴在期间并且在纤维发生以后附近的在肝的星形细胞(HSC ) 的细胞质的表情,成纤维细胞和 myofibroblasts。Smad2 的表示, 4 mRNA 在正常和控制老鼠比那高。结论:在这个过程并且在肝的纤维变性形成, HSC,成纤维细胞和 myofibroblasts 以后是表示 Smad2 和 Smad4 的主要房间。肝的纤维变性在受伤的肝越严肃, Smad2 的水平和 Smad4 基因表示分别地是越多 higher 在期间并且在纤维发生以后。 | Yang Liu Li-Feng Wang Hai-Feng Zou Xiao-Yan Song Hua-Feng Xu Ping Lin Hai-Hong Zheng Xiao-Guang Yu | 2006 | World Journal of Gastroenterology2006，12，10： | 11 |
| 16 | Esophageal motility in patients with sliding hiatal hernia with reflux esophagitis显示文摘有滑动中断脱肠(HH ) 和倒流食道炎(RE ) 的背景病人通常受不了食道的 dysmotility。由与 HH 使用钡餐 examination.Methods RE 的学习是调查酸倒流和十二指肠的 gastroesophageal 倒流( DGER )的角色的礼品的目的,食道的 manometry ,和食道的 dysmotility 开始用倒流疾病问询表被诊断,并且被钡餐考试和内视镜检查法进一步证实。X 光线照相术的技术为 mucosa 的痉挛,苛评,和粗糙习惯于测试,也是学习倒流和清理的类型。然后,监视的食道的 manometry,食道的 24 小时的 pH,和 bilirubin 是 observed.Results 当 HH 与 RE 结合了并且根据他们的食道炎的严厉把组划分了成二, 55 个病人被诊断:组织 HH1 (等级 A 和 B ) 并且组织 HH2 (等级 C 和 D ) 。钡餐考试表明 mucosa 在所有情况中小粒或榴状。垃圾场倒流和推迟的清理比在 HH1 组(P0.05 ) 的那些在在 HH2 组的病人是更重要的。全部、仰卧、正直的酸暴露时间的百分比比在控制组(P0.01 ) 的那些在有 HH 的病人是更大的,但是 HH1 之间的差别和 HH2 组不是重要的。更低的食道的 sphictor 压力(LESP ) 比在控制组(P0.05 ) 在 HH 组是更低的。三个 DGER 参数:有比 0.14 大的吸收度的时间的百分比,胆汁倒流事件的数字,比 5 分钟长持续的胆汁倒流的数字是(28.43?? | YE Ping LI Zhao-shen XU Guo-ming ZOU Duo-wu XU Xiao-rong LU Ren-hua | 2008 | Chinese Medical Journal2008，，10： | 11 |
| 17 | Solution structure of the RNA recognition domain of METTL3-METTL14 N^6-methyladenosine methyltransferase显示文摘N^6-methyladenosine(m6A),a ubiquitous RNA modification,is installed by METTL3-METTL14 complex.The structure of the heterodimeric complex between the methyltransferase domains(MTDs)of METTL3 and METTL14 has been previously determined.However,the MTDs alone possess no enzymatic activity.Here we present the solution structure for the zinc finger domain(ZFD)of METTL3,the inclusion of which fulfills the methyltransferase activity of METTL3-METTL14.We show that the ZFD specifically binds to an RNA containing 5'-GGACU-3'consensus sequence,but does not to one without.The ZFD thus serves as the target recognition domain,a structural feature previously shown for DNA methyltransferases,and cooperates with the MTDs of METTL3-METTL14 for catalysis.However,the interaction between the ZFD and the specific RNA is extremely weak,with the binding affinity at several hundred micromolar under physiological conditions.The ZFD contains two CCCH-type zinc fingers connected by an anti-parallel P-sheet.Mutational analysis and NMR titrations have mapped the functional interface to a contiguous surface.As a division of labor,the RNA-binding interface comprises basic residues from zinc finger 1 and hydrophobic residues fromβ-sheet and zinc finger 2.Further we show that the linker between the ZFD and MTD of METTL3 is flexible but partially folded,which may permit the cooperation between the two domains during catalysis.Together,the structural characterization of METTL3 ZFD paves the way to elucidate the atomic details of the entire process of RNA m6A modification. | Jinbo Huang Xu Dong Zhou Gong Ling-Yun Qin Shuai Yang Yue-Ling Zhu Xiang Wang Delin Zhang Tingting Zou Ping Yin Chun Tang | 2019 | Protein & Cell2019，10，4： | 11 |
| 18 | Increased rate change over time of a sphincter-saving procedure for lower rectal cancer显示文摘背景:全部的中央直肠的切除(TME ) 与低直肠的癌症为更多的病人增加了括约肌保藏(SP ) 的率。这里,我们分析在更低的直肠的癌症和他们的相关因素保存率的括约肌的变化。方法:我们回顾地与更低的直肠的癌症考察了 316 个病人的医药记录,从肛门直肠的线的 1 ~ 5 厘米,从 1994 年 8 月有外科的切除术到 2005 年 11 月。12 年的跨度被划分成 2 个时期:时期我(8 月 1994-December 日 1998 ) 并且时期 II (1 月 1999-November 日 2005 ) ,基于日期(1999 年 1 月) 什么时候标准全部的中央直肠的切除(TME ) 被介绍。病人基于操作被划分成二个组:腹会阴切除术(4 月) 或 SP 外科。SP 率,漏和另外的 clinico 病理学的特征被比较在之间两次时期并且在二个不同的组之间。结果:SP 率在时期在 12 年显著地增加了,从 44.9% 我到 76.2% 在时期 II (P = 0.000 ) 。显著地影响 SP 的因素从肛门直肠的线包括了肿瘤的距离,性,时间时期,内部传播和组织分化的圆周(P <
0.05 ) 。有效差量被检测在之间两次在性,输血体积和公爵的时期是舞台(P <
0.05 ) 。漏率在时期是 2.7% 我并且 1.3% 在时期 II (P >
0.05 ) 。结论:在学习的 12 年的经期上, SP 在直肠的癌症评价 1 - 当输血体积由于 TME 的介绍减少了时,从肛门直肠的线的 5 厘米显著地增加了。然而, TME 没在操作时间和漏率上有效果。 | WU Xiao-jian WANG Jian-ping WANG Lei HE Xiao-sheng ZOU Yi-feng LIAN Lei ZHANG Long-juan LAN Ping | 2008 | Chinese Medical Journal2008，，7： | 10 |
| 19 | Efficacy and safety of itraconazole as empirical antifungal therapy in febrile neutropenic patients with hematologic malignancies: an open-lable, multicenter, observational trial in a Chinese cohort显示文摘背景侵略真菌的感染( IFI )是在有 hematological malignancy.Empirical 的 neutropenic 病人的普通、致命的复杂并发症抗真菌的治疗广泛地由于这研究的 hosts.The 目的决心和病是作为实验抗真菌的治疗评估 itraconazole 的功效和安全为的病原体的困难在实践被使用在有 hematologic malignancies.Methods 的 neutropenic 病人的坚持的发烧有 hematologic m 的 274 | CHENG Shu ZHOU Jian-feng ZOU Ping HUANG Xiao-jun JIN Jie SHEN Zhi-xiang | 2011 | Chinese Medical Journal2011，，22： | 9 |
| 20 | Constructing a Core Collection for Maize (Zea mays L.) Landrace from Wuling Mountain Region in China显示文摘Based on the genetic clustering from 42 microsatellite (SSR) markers with a combination of their geographic origin and germplasm characteristics, 124 maize landraces from Wuling Mountain region in China were used for constructing a core collection. Four evaluating parameters for maize landrace core collection, including mean difference percentage (MD), variance difference percentage (VD), coincidence rate of range (CR), and variable rate of coefficient of variation (VR), were assessed with 20 quantitative traits. It was shown that genetic relationships among landraces in Wuling Mountain region had the tendency to associate with their geographic origins. The 124 landraces were clustered into 18 subgroups when the coefficient of genetic similarity (GS) is 0.28. Eighteen landraces, each of which was from one subgroup, were applied to construct the core collection with a sampling percentage of 15%. Comparison of the initial and core collection indicated that there existed no significant differences in most quantitative traits. An average of 6.3 and 6.5 alleles were detected in the initial and core collection, respectively. Mean polymorphism information content in the core collection (0.75) was higher than that in the initial one (0.72). MD was lesser than 20% and CR was more than 80%. The results showed that the sampling strategy would be feasible for constructing the core collection that well represents the genetic diversity of the initial one. | YAO Qi-lun FAN Ping ZOU Shu-xian | 2008 | Agricultural Sciences in China2008，7，12： | 8 |
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