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| 1 | Mammalian WTAP is a regulatory subunit of the RNA N6-methyladenosine methyltransferase显示文摘包含 methyltransferase 建筑群的象 3 一样的 methyltransferase (METTL3 ) 催化 N6-methyladenosine (m6A ) 形成,一个新奇 epitranscriptomic 标记;然而,这建筑群的性质仍然保持大部分未知。这里,我们报导人的 m6A methyltransferase 建筑群, Wilm 的肿瘤 1 伙伴蛋白质(WTAP ) 和象 14 一样的 methyltransferase (METTL14 ) 的二个新部件。WTAP 与 METTL3 和 METTL14 交往,并且为他们的本地化被要求进在 vivo 与处理因素的 pre-mRNA 并且为 m6A methyltransferase 的催化活动充实的原子点缀。RNA 的多数在 vivo 由 WTAP 和 METTL3 跳了代表包含一致 m6A 主题的 mRNAs。当 WTAP 不在时, METTL3 的 RNA 有约束力的能力强烈被减少,建议 WTAP 可以工作调整到 mRNA 目标的 m6A methyltransferase 建筑群的招募。而且,在有 photoactivatable-ribonucleoside-enhanced crosslinking 和 immunoprecipitation (同等片断) 的联合的 transcriptomic 分析说明那 WTAP 和 METTL3 调整涉及抄写并且 RNA 处理的基因拼接的表示和选择。在 zebrafish 胚胎的调停 Morpholino 的击倒的指向 WTAP 或 METTL3 引起了织物区别缺点并且增加了 apoptosis。这些调查结果提供 WTAP 可以在 m6A methyltransferase 建筑群作为一个规章的子单元工作并且在 RNA 的 epitranscriptomic 规定起一个关键作用的充分证据新陈代谢。 | Xiao-Li Ping Bao-Fa Sun Lu Wang Wen Xiao Xin Yang Wen-Jia Wang Samir Adhikari Yue Shi Ying Lv Yu-Sheng Chen Xu Zhao Ang Li Ying Yang Ujwal Dahal Xiao-Min Lou Xi Liu Jun Huang Wei-Ping Yuan Xiao-Fan Zhu Tao Cheng Yong-Liang Zhao Xinquan Wang Jannie M Rendtlew Danielsen Feng Liu Yun-Gui Yang | 2014 | Cell Research2014，24，2： | 244 |
| 2 | Prevalence, awareness, treatment, and control of hypertension in the non-dialysis chronic kidney disease patients显示文摘 | ZHENG Ying CAI Guang-yan CHEN Xiang-mei FU Ping CHEN Jiang-hua DING Xiao-qiang YU Xue-qing LIN Hong-li LIU Jian XIE Ru-juan WANG Li-ning NI Zhao-hui LIU Fu-you YIN Ai-ping XING Chang-ying WANG Li SHI Wei LIU Jian-she HE Ya-ni DING Guo-hua LI Wen-ge WU Guang-li MIAO Li-ning CHEN Nan SU Zhen MEI Chang-lin ZHAO Jiu-yang GU Yong BAI Yun-kai LUO Hui-min LIN Shan CHEN Meng-hua GONG Li YANG Yi-bin YANG Xiao-ping LI Ying WAN Jian-xin WANG Nian-song LI Hai-ying XI Chun-sheng HAO Li XU Yan FANG Jing-ai LIU Bi-cheng LI Rong-shan WANG Rong ZHANG Jing-hong WANG Jian-qin LOU Tan-qi SHAO Feng-min MEI Feng LIU Zhi-hong YUAN Wei-jie SUN Shi-ren ZHANG Ling ZHOU Chun-hua CHEN Qin-kai JIA Shun-lian GONG Zhi-feng GUAN Guang-ju XIA Tian ZHONG Liang-bao | 2013 | Chinese Medical Journal2013，，12： | 16 |
| 3 | Analysis of Health Service Utilization and its Influencing Factors among Patients with Pneumoconiosis in China显示文摘Pneumoconiosis,an interstitial lung disease that occurs from breathing in certain kinds of damaging dust particles,is a major occupational disease in China.Patients diagnosed with occupational pneumoconiosis can avail of free medical treatment,whereas patients without a diagnosis of occupational diseases cannot not claim free medical treatment in most provinces from the government before 2019.This study aimed to analyze the priority of medical facility selection and its influencing factors among patients with pneumoconiosis. | WANG Huan Qiang JIA Jun Lin JIANG Zhao Qiang JIN Qi LI Dong Xia LING Rui Jie LI Ying CUI Ping CHEN Gang ZHAO Hong Yu LI Yan WEN Ke LYU Xiang Pei LOU Jian Lin LI Tao | 2021 | Biomedical and Environmental Sciences2021，34，1： | 9 |
| 4 | Synthesis of the novel PARP-1 inhibitor AG- 690/11026014 and its protective effects on angiotensin II-induced mouse cardiac remodeling显示文摘我们以前 poly 作为一篇小说识别了 AG-690/11026014 (6014 )( 自动数据处理核糖) 有效地阻止了血管收缩素 II (Ang II ) 的 polymerase-1 (PARP-1 ) 禁止者导致了 cardiomyocyte 肥大。在现在的学习,我们为 6014 报导了一条新合成线路,并且在 Ang 上调查了它的保护的效果在老鼠的导致 II 的心脏的改变和心脏的机能障碍和内在的机制。我们设计了一条新合成线路在 vivo 学习为这获得 6014 的足够的数量。C57BL/6J 老鼠与 Ang II 被灌输并且与 6014 对待(10, 30, 90 mg 日吗?? | Guo-shuai FENG Cui-ge ZHU Zhuo-ming LI Pan-xia WANG Yi HUANG Min LIU Ping HE Lan-lan LOU Shao-rui CHEN Pei-qing LIU | 2017 | Acta Pharmacologica Sinica2017，38，5： | 8 |
| 5 | Tunable and scalable broadband metamaterial absorber involving VO2-based phase transition显示文摘Optical absorbers with dynamic tuning features are able to flexibly control the absorption performance, which offers a good platform for realizing optical switching, filtering, modulating, etc. Here, we propose a thermally tunable broadband absorber applying a patterned plasmonic metasurface with thermo-chromic vanadium dioxide (VO2) spacers. An actively tunable absorption bandwidth and peak resonant wavelength in the region from the near-to mid-infrared (NMIR) are simultaneously achieved with the insulating.metallic phase transition ofVO2·Moreover, the scalable unit cell,which is composed of multi-width sub-cells, provides a new freedom to further manipulate (i.e., broaden or narrow) the absorption bandwidth while maintaining a high relative absorption bandwidth and efficient absorbance at the same time. For both transverse-electric and transverse-magnetic polarizations, the proposed nanostructure exhibits a high absorption over a wide angular range up to 60°.This method holds a promising potential for versatile utilizations in optical integrated devices,NMIR photodetection, thermal emitters, smart temperature control systems,and so fbrth. | Lei Lei Fei Lou Keyu Tao Haixuan Huang Xin Cheng Ping Xu | 2019 | Photonics Research2019，7，7： | 8 |
| 6 | A PKS gene, pks-1, is involved in chaetoglobosin biosynthesis, pigmentation and sporulation in Chaetomium globosum显示文摘Chaetomium globosum is one of the most common fungi in nature. It is best known for producing chaetoglobosins; however, the molecular basis of chaetoglobosin biosynthesis is poorly understood in this fungus. In this study, we utilized RNA interference (RNAi) to characterize a polyketide synthase gene, pks-1, in C. globosum that is involved in the production of chaetoglobosin A. When pks-1 was knocked down by RNAi, the production of chaetoglobosin A dramatically decreased. Knock-down mutants also displayed a pigment-deficient phenotype. These results suggest that the two polyketides, melanin and chaetoglobosin, are likely to share common biosynthetic steps. Most importantly, we found that pks-1 also plays a critical role in sporulation. The silenced mutants of pks-1 lost the ability to produce spores. We propose that polyketides may modulate cellular development via an unidentified action. We also suggest that C. globosum pks-1 is unique because of its triple role in melanin formation, chaetoglobosin biosynthesis and sporulation. This work may shed light on chaetoglobosin biosynthesis and indicates a relationship between secondary metabolism and fungal morphogenesis. | HU Yang HAO XiaoRan LOU Jing ZHANG Ping PAN Jiao ZHU XuDong | 2012 | Science China(Life Sciences)2012，55，12： | 7 |
| 7 | Elimination of misrun and gas hole defects of investment casting TiAl alloy turbocharger based on numerical simulation and experimental study显示文摘Casting technology of thin-wall TiAl alloy turbochargers was studied by investment casting and numerical simulation.Misruns and gas holes were the main defects observed in preliminary work due to the poor fluidity of alloy,and to gas entrapment.In order to eliminate these defects,cast parameters,such as centrifugal rotation rate and mould preheating temperature,were optimized by numerical simulation,meanwhile,the structure of the shell mould was optimized to improve the filling capacity of TiAl alloy.Pouring experiments were carried out by vacuum induction melting furnace equipped with a water-cooled copper crucible based on the above optimization.The quality of the TiAl alloy casting was analyzed by fluorescent penetrant inspection and X-ray detection.The results show that a centrifugal rotation rate of 200 rpm,mould preheating temperature of 600°C,shell preparation through organic fiber addition can dramatically improve the mould filling capacity,and integrated turbochargers were finally prepared. | Jun Zhao Zhi-yong Zhang Shi-bing Liu Kun Shi Chun-ling Bao Zhao-sheng Ning Ping Yan Lei Wang Yan-chun Lou | 2020 | China Foundry2020，17，1： | 6 |
| 8 | Large numbersLarge numbers of new bacterial taxa found by Yunnan Institute of Microbiology显示文摘Extreme environments, primeval forest, sea sediments and plants in China yielded members of a new suborder, Jiangellineae, a new family Sinobacteraceae, and 23 new genera of actinomycetes and other bacteria. Three suggestions were made for further discoveries of new actinomycetes. First, natural habitats such as old growth forests, and extreme environments, should be given sampling priority; second, culturing procedures need to be constantly improved to mimic natural habitats; third, less than 98.5% similarity of 16S rRNA sequence to that of a known species could be used as an indicator of a new species. | JIANG Yi CAO YanRu ZHAO LiXing TANG ShuKun WANG Yun LI WenJun XU Ping LOU Kai MAO PeiHong XU LiHua | 2011 | Chinese Science Bulletin2011，56，8： | 5 |
| 9 | Quantitative Variation in Water-Use Efficiency across Water Regimes and Its Relationship with Circadian, Vegetative, Reproductive, and Leaf Gas-Exchange Traits显示文摘干旱限制点亮收获,导致更低的植物生长和复制。为植物干旱反应重要的一个特点是水使用效率(WUE ) 。我们调查了( 1 ) WUE ,繁殖字符,和植物的特点的联合基因体系结构怎么越过干旱和浇得好的条件变化了,( 2 )是否有不同的发展的库的特点(例如叶气体交换对复制)在他们的基因体系结构的环境敏感不同,并且( 3 )在生理节奏的时期的量的变化是否与在 Brassica rapa 的干旱反应有关。总的来说, WUE 在干旱增加了,首先有气孔的传导力,并且因此浇损失,多于碳固定衰退了。有在干旱的最高的 WUE 的遗传型处于浇得好的条件表示了最低 WUE,并且在两个处理有最大的植物、花的机关。因此,在 WUE 的大变化使一些遗传型能越过环境接近植物、繁殖的特点 optima。基因建筑学越过干旱和浇得好的条件为煤气交换、植物的特点,然而并非为花的特点不同。关联在之间生理节奏并且叶煤气交换的特点是重要的,但是没越过处理变化,显示那个生理节奏的句号不管水可获得性影响生理的功能。这些结果建议 WUE 为在 Brassica rapa 的干旱忍耐是重要的并且为在干旱的增加的 WUE 的人工的选择不导致与 WUE 被相关的另外的特点的不适应的表示。 | Christine E. Edwards Brent E. Ewers C. Robertson McClung Ping Lou Cynthia Weinig | 2012 | Molecular Plant2012，5，3： | 5 |
| 10 | 供水系统中冲刷对金属管道内壁生物膜脱落的影响作用(英文)显示文摘目的:在市政供水管网系统中,由冲刷引起的管道内壁生物膜脱落可能造成饮用水二次污染。本文旨在通过研究冲刷前后生物膜理化特性和微生物种群结构的变化,探讨不同金属管材管道和不同冲刷流速对生物膜脱落的影响,从而为管道生物安全的风险评估提供科学依据。创新点:不同菌属的细菌对水力冲刷的敏感程度不同;各菌属对水力变化的敏感程度既与菌属本身的性质有关,也与其附着生长的管材有关。方法:1.采用R2A培养基平板计数、16S rD NA检测、荧光定量聚合酶链式反应及454焦磷酸测序技术。2.通过理化指标检测与测序相结合的方式进行分析,并以丰度图和热度图的形式呈现结果。结论:1.球墨铸铁管内壁生物膜的抗水力剪切能力较强,能够抵抗低剪切冲刷,在高剪切力冲刷后才会明显脱落,而灰口铸铁管和不锈钢复合管内壁生物膜的抗水力剪切能力较弱,低剪切力冲刷工况便会导致生物膜的明显脱落。2.生物膜对冲刷的抵抗作用在其群落的属水平和纲水平上有显著变化,这与群落本身和管材特性均有关联。 | Jing-qing LIU Zhi-feng LUO Ke LIU Yi-fu ZHANG Hong-xi PENG Bao-lan HU Hong-xing REN Xiao-yan ZHOU Shang-de QIU Xiao-fang HE Ping YE Hamid BASTANI Li-ping LOU | 2017 | Journal of Zhejiang University-Science A(Applied Physics & Engineering)2017，18，4： | 5 |
| 11 | Catalytic Metalloporphyrin Protects Against Paraquat Neurotoxicity in vivo显示文摘Objective To examine the neuroprotective effects of a novel manganese porphyrin, manganese (III) meso-tetrakis (N,N′-diethylimidazolium-2-yl) porphyrin (MnTDM), in the mouse model of Parkinson’s disease (PD) induced by paraquat (PQ). Methods Male C57BL / 6 mice were subcutaneously injected with either saline or PQ at 2-day intervals for a total of 10 doses, MnTDM was subcutaneously injected with the PQ 2 h before treatment. Performance on the pole and swim test were measured 7 days after the last injection and animals were sacrificed one day later. Levels of dopamine (DA) and its metabolites in the striatum were measured by high-performance liquid chromatography with an electrochemical detector (HPLC-ECD). Thiobarbituric acid (TBA) method was used to assay the lipid peroxidation product, malondialdehyde (MDA), and the number of tyrosine hydroxylase (TH) positive neurons was estimated using immunohistochemistry. Results Pretreatment with MnTDM significantly attenuated PQ-impaired behavioral performance, depleted dopamine content in striata, increased MDA, and dopaminergic neuron loss in the substantia nigra. Conclusions Oxidative stress plays an important role in PQ-induced neurotoxicity which can be potentially prevented by manganese porphyrin. These findings also propose a possible therapeutical strategy for neurodegenerative disorders associated with oxidative stress such as PD. | PING CHEN ZHEN CHEN ANG LI XIAO-CHU LOU XIAO-KANG WU CHUN-JUN ZHAO SHI-LONG WANG LI-PING LIANG | 2008 | Biomedical and Environmental Sciences2008，21，3： | 4 |
| 12 | Basal insulin therapy strategy is superior to premixed insulin therapy in the perioperative period blood glucose management显示文摘 | Huang Qing-xian Lou Fu-chen Wang Ping Liu Qian Wang Kun Zhang Li Zhu Lei Yu Shan Xu Hua Wang Qian Zhang Ying Hou Wei-kai | 2013 | Chinese Medical Journal2013，，21： | 4 |
| 13 | Effectiveness of flesh-moistening paste in psoriasis vulgaris patients with symptom pattern of blood stasis:a randomized and parallel-controlled trial显示文摘OBJECTIVE:To evaluate the efficacy and safety of flesh-moistening paste for treating psoriasis vulgaris in patients with blood stasis pattern in terms of Traditional Chinese Medicine(TCM).METHODS:Eudipleural rashes on both the left and right side of the same patients with psoriasis vulgaris,diagnosed via TCM as blood stasis pattern,were selected as the targeted skin lesions.A randomized,double-blind,parallel-controlled,multicenter controlled trial was conducted.The targeted skin lesions were categorized into either the treatment or control group.The treatment group used the flesh-moistening paste;the control group used a placebo.Both the paste and the placebo were topically applied twice daily for eight weeks.The patients were examined biweekly to evaluate the effects.The two groups were compared in terms of the psoriasis area and severity index(PASI)of the targeted skin lesions,which is scored according to erythema,desquamation,infiltration,area,pruritus,and improvement of skin barrier function.Adverse events were recorded during the study period.SPSS 21.0 was used to analyze the data.RESULTS:Fifty-six patients were enrolled between February 2016 and October 2017.Two were complicated by cardio-cerebrovascular disease and were excluded;thus,54 outpatients were finally enrolled in the study.Four dropped out during the study period:three failed to complete their follow-up visits for unknown reasons,and one exited due to an adverse event.The final trial comprised 50 of the 56 originally selected patients,with a 92.6%completion rate.After 8 weeks of treatment,the targeted skin lesion scores differed significantly(P<0.05).The PASI scores of the targeted skin lesions differed significantly beginning at week 6(P<0.05).The treatment group presented better results than those of the control group.Only one patient had an adverse reaction associated with the treatment.Improvements in skin barrier function differed significantly(P<0.05).CONCLUSION:The flesh-moistening paste demonstrated a reliable curative effect and safety for treating psoriasis vulgaris in patients with blood stasis patterns.The topical paste improved the barrier function of the skin lesions. | Guo Xinwei Lang Na Li Guanru Li Ping Qu Jianhua Zhou Dongmei Wang Ping Cang Zhang Deng BingXu Lou Weihai Xu Jingna Lan Haibing Liu Yumin Zhang Weishu Sun Liyun | 2020 | Journal of Traditional Chinese Medicine2020，40，6： | 4 |
| 14 | In situ catalytic conversion of biomass fast pyrolysis vapors on HZSM–5显示文摘In situ catalytic conversion of biomass fast pyrolysis vapors was carried out on HZSM-5 with varying Si/Al ratios(ranging from 20 to 300) at 450 °C. The effects of Si/Al ratios of HZSM-5 zeolites on the distribution of biomass fast pyrolysis products and carbon deposits on catalysts were investigated. It was quite remarkable that after in situ catalytic conversion the amount of light phenols and hydrocarbons increased significantly while that of heavy phenols decreased a lot. Besides, the yield of cyclopentenones with relatively low oxygen content generally increased. It also indicated that as the Si/Al ratios of HZSM-5 increased, the amount of hydrocarbons and light phenols was found to drop greatly. The amount of carbon deposits was found to be around 8.5% with the exception of HZSM-5 with the Si/Al ratio of 300,which is much lower. Moreover, the carbon deposits yield dropped gradually with increasing Si/Al ratios of HZSM-5.Calcination of spent catalysts at 600 °C helped to restore the catalytic activity to a large extent despite a relatively lower efficiency of deoxygenation. Results indicated that HZSM-5 with relatively high acidity displayed great catalytic performance. | Yindi Zhang Ping Chen Hui Lou | 2016 | Journal of Energy Chemistry2016，25，3： | 3 |
| 15 | NUMB maintains bone mass by promoting degradation of PTEN and GLI1 via ubiquitination in osteoblasts显示文摘The adaptor protein NUMB is involved in asymmetric division and cell fate determination and recognized as an antagonist of Notch.Previous studies have proved that Notch activation in osteoblasts contributes to a high bone mass. In this study, however, an osteopenic phenotype was found in 9-week-old mice using osteoblastic specific Col1a1–2.3-Cre to ablate both Numb and its homologue Numbl. The trabecular bone mass decreased dramatically while the cortical bone mass was unaffected. Here, the Notch signal was not activated,while the tensin homologue deleted on human chromosome 10(PTEN), which dephosphorylates phosphatidylinositide 3-kinases, was elevated, attenuating protein kinase B(Akt). The ubiquitination assay revealed that NUMB may physiologically promote PTEN ubiquitination in the presence of neural precursor cell-expressed developmentally downregulated protein 4–1. In addition, the deficiency of Numb/Numbl also activated the Hedgehog pathway through GLI1. This process was found to improve the ratio of the receptor activator of nuclear factor-k B ligand to osteoprotegerin, which enhanced the differentiation of osteoclasts and bone resorption. In conclusion, this study provides an insight into new functons of NUMB and NUMBL on bone homeostasis. | Ling Ye Feng Lou Fanyuan Yu Demao Zhang Chenglin Wang Fanzi Wu Xin Li Yilin Ping Xiao Yang Jing Yang Dian Chen Bo Gao Dingming Huang Peng Liu | 2018 | Bone Research2018，6，4： | 3 |
| 16 | High-entropy(Ca_(0.2)Sr_(0.2)Ba_(0.2)La_(0.2)Pb_(0.2))TiO_(3) perovskite ceramics with A-site short-range disorder for thermoelectric applications显示文摘Novel high-entropy perovskite-type(Ca_(0.2)Sr_(0.2)Ba_(0.2)La_(0.2)Pb_(0.2))TiO_(3)(CSBLP)ceramics with cubic structure of Pm-3 m space group were successful prepared by solid-state reaction method.Results of XRD,SEM-EDS,HRTEM confirmed a homogeneous distribution and equimolar arrangement of multicomponent cations on the A-site.The high-entropy CSBLP ceramics showed long-range structural order and short-range chemical disorder with widely dispersed nanoscale grains varying sizes of 4-6 nm in the microstructure.Because of increased configurational entropy,the CSBLP ceramic has an enhanced Seebeck coefficient(|S|=272μV/K at 1073 K)and low thermal conductivity(k=1.75 W/m·K at 1073 K)when annealed at1300℃.This work demonstrates the possibility of effectively reducing thermal conductivity and improving the performance of thermoelectric oxides through high-entropy composition design. | Ping Zhang Zhihao Lou Mengjie Qin Jie Xu Jiatong Zhu Zongmo Shi Qian Chen Michael J.Reece Haixue Yan Feng Gao | 2022 | Journal of Materials Science & Technology2022，，2： | 3 |
| 17 | Novel sesquiterpenoids isolated from Chimonanthus praecox and their antibacterial activities显示文摘In the present study,four new sesquiterpenoids,chimonols A–D(compounds 1–4),together with four known compounds(5–8) were isolated from the Et OAc extract of Chimonanthus praecox Link.The structures of these new compounds were elucidated on the basis of spectroscopic techniques(UV,IR,MS,and 1 D and 2 D NMR),and their absolute configurations were established by comparing experimental and calculated electronic circular dichroism(ECD) spectra.Compounds 1–8 were evaluated for antimicrobial activities and the minimum inhibitory concentrations(MICs) were determined by the broth microdilution method in 96-well culture plates.Compounds 1,2,and 7 exhibited weak antibacterial effects for S.aureus(ATCC 6538),E.coli(ATCC 11775),and P.aeruginosa(ATCC 10145) with MIC values being 158–249 μg·mL^(-1).Compounds 3–7 showed activities against C.glabrata(ATCC 2001) and S.aureus(ATCC 43300) with MIC values being 128–197 μg·mL^(-1).Compounds 1–4 showed activity against S.aureus(ATCC 25923) with MIC values being 162–254 μg·mL^(-1).The present study provided a basis for future evaluation of these compounds as antibacterial agents. | LOU Hua-Yong ZHANG Yu MA Xiao-Pan JIANG Sai WANG Xiang-Pei YI Ping LIANG Guang-Yi WU Hong-Mei FENG Jing JIN Feng-Yun PAN Wei-Dong | 2018 | Chinese Journal of Natural Medicines2018，16，8： | 2 |
| 18 | Effect of Traditional Chinese Medicine plus narrow-band medium-wave ultraviolet B radiation on moderate-to-severe psoriasis vulgaris in a case series显示文摘OBJECTIVE: To investigate the efficacy and safety of Traditional Chinese Medicine (TCM) therapy combined with ultraviolet B light therapy in the treatment of moderate-to-severe psoriasis. METHODS: Patients with moderate-to-severe psoriasis (skin lesion area > 10% of the body surface area) for 2 consecutive years were treated with TCM (oral and external use of herbal medicines, acupuncture, and herbal bathing) and narrow-band medium-wave ultraviolet B light treatment for 12 weeks. The treatment effect was evaluated based on the Psoriasis Area Severity Index (PASI), the achievement of a 50% reduction in the PASI (PASI50), the achievement of a 75% reduction in the PASI (PASI75), pruritus score, Dermatology Life Quality Index, and safety. RESULTS: A total of 95 outpatients were enrolled, and 92 subjects (96.8%) completed the 12-week treatment course. At baseline, the average proportion of the body surface area covered by skin lesions was 12.4%, and the average PASI was 17.7. All patients had previously been treated with conventional medicine (89.1% of patients received ultraviolet light treatment, 50.0% received glucocorticoids, and 21.7% received acitretin). After the 12-week treatment course, 22 patients (23.9%) achieved PASI75, and 43 (46.7%) achieved PASI50. The post-treatment pruritus score and Dermatology Life Quality Index of all treated patients were significantly lower than the respective baseline values (P < 0.0001). No adverse effects were detected by the monitoring of blood, urine, stools, liver and kidney function, and echocardiography.CONCLUSION: Comprehensive therapy comprising TCM therapy combined with ultraviolet B light therapy achieved good outcomes for patients with moderate-to-severe psoriasis. | Li Tiantian Zhou Dongmei Xu Xuying Qu Jianhua Jiang Chunyan Lan Haibing Lou Weihai Chen Weiwen Jin Li Liu Rongqi Liu Zhiyong Zhang Cang Duan Lanhua Bohua Li Xu Jingna Zhou Tao Jiang Xi Cao Wei Zhang Guangzhong Liu Jianping Sun Liyun Wang Ping | 2019 | Journal of Traditional Chinese Medicine2019，39，5： | 2 |
| 19 | Key point selection in large-scale FBG temperature sensors for thermal error modeling of heavy-duty CNC machine tools显示文摘Thermal error is one of the main factors that influence the machining accuracy of computer numerical control(CNC)machine tools.It is usually reduced by thermal error compensation.Temperature field monitoring and key temperature measurement point(TMP)selection are the bases of thermal error modeling and compensation for CNC machine tools.Compared with small-and medium-sized CNC machine tools,heavy-duty CNC machine tools require the use of more temperature sensors to measure their temperature comprehensively because of their larger size and more complex heat sources.However,the presence of many TMPs counteracts the movement of CNC machine tools due to sensor cables,and too many temperature variables may adversely influence thermal error modeling.Novel temperature sensors based on fiber Bragg grating(FBG)are developed in this study.A total of 128 FBG temperature sensors that are connected in series through a thin optical fiber are mounted on a heavy-duty CNC machine tool to monitor its temperature field.Key TMPs are selected using these large-scale FBG temperature sensors by using the density-based spatial clustering of applications with noise algorithm to reduce the calculation workload and avoid problems in the coupling of TMPs for thermal error modeling.Back propagation neural network thermal error prediction models are established to verify the performance of the proposed TMP selection method.Results show that the number of TMPs is reduced from 128 to 5,and the developed model demonstrates good prediction effects and strong robustness under different working conditions of the heavy-duty CNC machine tool. | Jianmin HU Zude ZHOU Quan LIU Ping LOU Junwei YAN Ruiya LI | 2019 | Frontiers of Mechanical Engineering2019，14，4： | 2 |
| 20 | Coupled Nonlinear Schrodinger Equation: Symmetries and Exact Solutions显示文摘非线性的 Schrödinger (CNLS ) 方程为大气的严肃波浪从管理系统导出的 a coupled 的对称,对称减小,和准确解决方案在这篇论文借助于古典谎言组途径被研究。计算证明 CNLS 方程在一些 Galilee 的转变下面是不变的,放大转变,阶段移动,和时空翻译。一些平常的微分方程从 CNLS 方程被导出。包括为 CNLS 方程的信封 cnoidal 波浪,独居的波浪和三角法的功能答案的几个准确答案被使用对称也获得。 | LIU Ping LOU Sen-Yue | 2009 | Communications in Theoretical Physics2009，51，1： | 2 |
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