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| 1 | Effect of hydroalcoholic extract of Hibiscus rosa sinensis Linn.leaves in experimental colitis in rats显示文摘Objective:To elucidate the ameliorative effect of liydrualcuholic extract of leaves of Hibiscus rosa sinensis(HRS) in acetic acid induced experimental colitis in male wistar rats.Methods: The animals were administered with 2 mL acetic acid(4%) via intra rectal.The animals were divided into various treatment groups(n=6).Prednisolone was used as standard drug and HRS was administered at a dose of 50,100 and 200 mg/kg p.o.The control group of animals received 1 mL of vehicle(distilled water).Ulcer area,ulcer index,spleen weight,colon weight to length ratio, macroscopic score,haemalological parameters,colonic superoxide dismutase(SOD),glutathione(GSH),myeloperoxidase(MPO),malondialdchyde(MDA),tumor necrosis factor-α(TNK- α), nitric oxide(NO) and histological changes were recorded after the treatment regimen of 11 days. Results:Intrarectal instillation of acetic acid caused enhanced ulcer area,ulcer index,spleen weight,colon weight to length ratio,colonic MPO,MDA,NO and TNF-α It caused significant decreased level of SOD and GSH.Pretreatment with HRS for 7 days exhibited significant effect in lowering of oxidative stress,colonic NO,TNF- α and elevation of SOD and GSH at a dose of 100 and 200 mg/kg in acetic acid induced colilis.Conclusions:The present investigation demonstrates HRS is of potent therapeutic value in the amelioration of expcrimenlal colilis in laboralory animals by inhibiting the proinflammatory mediator like NO and TNK-α. | Amit D Kandhare Kiran S Raygude Pinaki Ghosh Arvindkumar E Ghule Tejas P Gosavi Sachin L Badole Subhash L Bodhankar | 2012 | Asian Pacific Journal of Tropical Biomedicine2012，2，5： | 2 |
| 2 | Radionuclide remediation using a bacterial biosorbent显示文摘 | Pinaki Sar Sufia K Kazy Souza S F D' | 2004 | International Biodeterioration & Biodegradation2004，54，： | 1 |
| 3 | Xylans from scinaia hatei: structural features, sulfation and anti-HSV activity 显示文摘 | Pinaki M Carlos A P Elsa B D et a | 2010 | Int J Biol Macromol2010，46，2： | 1 |
| 4 | Suprasellar tubercular abscess presenting as panhypopituitarism:A common lesion in an un-common site with a brief review of literature显示文摘 | Pinaki D Anil B Paramjeet S | 2006 | Pituitary2006，9，1： | 1 |
| 5 | Molocular determinants of the caspase promoting activity of Smac/DIABLO and its role in the death receptor pathway显示文摘 | Srinivasa MS Pinaki D Xun JU | 2000 | J Biol Chem2000，275，36： | 1 |
| 6 | Adsorption of Cr(Ⅵ) in layered double hydroxides显示文摘 | Rajib L G Pinaki S Krishna G B Dipak K D | 1998 | Applied Clay Science1998，13，1： | 1 |
| 7 | Radionuclide remediation using a bacterial biosorbent 显示文摘 | Sar Pinaki Kazy S K D'Souza S F | 2004 | International Biodeterioration & Biodegradation2004，54，23： | 1 |
| 8 | Radionuclide remedia tion using a bacterial biosorbent 显示文摘 | Pinaki Sar Sufia K Kazy S F D' Souza | 2004 | International Biodeterioration & Biodegradation2004，54，： | 1 |
| 9 | Uranium sorption by Pseudomonas biomass immobilized in radiation polymerized polyacrylamide bio-Beads 显示文摘 | D'Souza S F Pinaki S Kazy S K | 2006 | J Environ Sci Health (Part A)2006，41，3： | 1 |
| 10 | Molocular determinants of the caspase - promoting activity of Smac/DIABLO and its role in the death receptor pathway显示文摘 | Srinivasa MS Pinaki D Xun JU | 2000 | J Biol Chem2000，275，36： | 1 |
| 11 | Microbial communities in uranium mine tailing and mine water sediment fron Jaduguda U mine, India:A culture independent analysis 显示文摘 | KUMAR D P PINAKI S | 2014 | Journal of Environmental Science & Health Part A :Toxic/hazardous Substances & Environmental Engineering2014，49，6： | 1 |
| 12 | Suprasellar tubercular abscess presenting as panhypopituitarism:A common lesion in an uncommon site with a brief review of literature显示文摘 | Pinaki D Anil B Paramjeet S | 2006 | Pituitary2006，，： | 1 |
| 13 | Uranium and thorium sequestration by a Pseudomonas sp.: Mechanism and chemical characterization显示文摘 | Sufia K. Kazy S.F. D’Souza Pinaki Sar | 2008 | Journal of Hazardous Materials2008，，1： | 1 |
| 14 | Pituitary abscess : report of four cases and review of literature 显示文摘 | Pinaki D Anil B Paramjeet S | 2006 | Pituitary2006，9，3： | 1 |
| 15 | Radionuclide remediation using a bacterial biosorbent显示文摘 | Pinaki Sar Sufia K. Kazy S.F. D’Souza | 2004 | International Biodeterioration & Biodegradation2004，，2： | 1 |
| 16 | Suprasellar tubercular abscess presenting as panhypopituitarism:A common lesion in an uncommon site with a brief review of literature显示文摘 | Pinaki D Anil B Paramjeet S | 2006 | Pituitary2006，9，3： | 1 |
| 17 | Molocular determinants of the caspase-promoting activity of Smac/DIABLO and its role in the death receptor pathway 显示文摘 | Srinivasa MS Pinaki D Xun JU | 2000 | Biol Chem2000，275，36： | 1 |
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