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| 1 | ICC density predicts bacterial overgrowth in a rat model of post-infectious IBS显示文摘AIM:To investigate the interstitial cells of Cajal(ICC) number using a new rat model.METHODS:Sprague-Dawley rats were assigned to two groups.The first group received gavage with Campylobacter jejuni(C.jejuni) 81-176.The second group was gavaged with placebo.Three months after clearance of Campylobacter from the stool,precise segments of duodenum,jejunum,and ileum were ligated in self-contained loops of bowel that were preserved in anaerobic bags.Deep muscular plexus ICC(DMP-ICC) were quantified by two blinded readers assessing the tissue in a random,coded order.The number of ICC per villus was compared among controls,Campylobacter recovered rats without small intestinal bacterial overgrowth(SIBO),and Campylobacter recovered rats with SIBO.RESULTS:Three months after recovery,27% of rats gavaged with C.jejuni had SIBO.The rats with SIBO had a lower number of DMP-ICC than controls in the jejunum and ileum.Additionally there appeared to be a density threshold of 0.12 DMP-ICC/villus that was associated with SIBO.If ileal density of DMP-ICC was < 0.12 ICC/villus,54% of rats had SIBO compared to 9% among ileal sections with > 0.12(P<0.05).If the density of ICC was < 0.12 DMP-ICC/villus in more than one location of the bowel,88% of these had SIBO compared to 6% in those who did not(P<0.001).CONCLUSION:In this post-infectious rat model,the development of SIBO appears to be associated with a reduction in DMP-ICC.Further study of this rat model might help understand the pathophysiology of postinfectious irritable bowel syndrome. | Sam-Ryong Jee Walter Morales Kimberly Low Christopher Chang Amy Zhu Venkata Pokkunuri Soumya Chatterjee Edy Soffer Jeffrey L Conklin Mark Pimentel | 2010 | World Journal of Gastroenterology2010，16，29： | 3 |
| 2 | Environmental and economic costs of nonindigenous species in the United States显示文摘 | Pimentel D Lach L Zuniga R | 2000 | BioScience2000，50，1： | 1 |
| 3 | Environment and economic effects of reducing pesticide use in agriculture显示文摘 | Pimentel D McLaughlin L Zeep A | 1993 | Agriculture Ecosystems and Environment1993，46，： | 1 |
| 4 | Bio-transformation of betulinic and betulonic acids by fungi 显示文摘 | Denise Z Bastos L Pimentel I C | 2007 | phytochemistry2007，68，： | 1 |
| 5 | A new adjacent bis-tetrahydrofuran annonaceous acetogenin from the seeds of Uvafia chamae 显示文摘 | Fall D Pimentel L Champy Petal | 2006 | Planta Med2006，72，10： | 1 |
| 6 | Downregulation of transient receptor potential melastatin 8by protein kinase C mediated dephosphorylation显示文摘 | Premkumar L S Raisinghani M Pingle S C Long C Pimentel F | 2005 | J Neurosci2005，25，11： | 1 |
| 7 | Dry-fer- mented chicken sausage produced with inulin and corn oil: physicochemieal, microbiological, and textural characteristics and acceptability during storage 显示文摘 | Menegas L Z Pimentel T C Garcia S | 2013 | Meat Science2013，93，3： | 1 |
| 8 | Phosphine resistance, respiration rate and witness consequences in stored-product insects显示文摘 | PIMENTEL M A G FARONI L R D A TOTOLA M R | 2007 | Pest Manage- ment Science2007，63，9： | 1 |
| 9 | The influence of weathering conditions on the properties of poly( vinyl chloride) for outdoor applications:An analytical study using surface analysis techniques 显示文摘 | L E Pimentel Real A M Ferraria A M Botelho do Rego | 2007 | Polymer Testing2007，26，： | 1 |
| 10 | Predictive monitoring of mobile patients by combining clinical observations with data from wearable sensor显示文摘 | CLIFTON L CLIFTON D A PIMENTEL M A | 2014 | IEEE Journal of Biomedical and Health Informatics2014，18，3： | 1 |
| 11 | Environmental and economic costs of non-indigenous species in the Unites States显示文摘 | Pimentel D Lach L Zuniga R | 2000 | Bioscience2000，50，： | 1 |
| 12 | Environmental and economic effects of reducing pesticide use in agriculture显示文摘 | Pimentel D McLaughlin L Zepp A | 1993 | Ag- ric Ecosyst Environ1993，46，1： | 1 |
| 13 | Environmental and economic costs of non-indigenous species in the United States显示文摘 | Pimentel D Lach L Zuniga R and Morrison D | 2000 | BioScience2000，50，： | 1 |
| 14 | Role of angiotensin Ⅱ in the expression and regulation of transforming growth factor-beta in obstructive nephropathy显示文摘 | Pimentel J L Jr Sundell C L Wang S | 1995 | Kidney Int1995，48，4： | 1 |
| 15 | Gaussian processes for personalized e-health monitoring with wearable sensors 显示文摘 | Clifton L Clifton DA Pimentel M | 2013 | IEEE Trans Biomed Eng2013，60，1： | 1 |
| 16 | Thyroid disease in the emergency depart- ment: a clinical and laboratory review 显示文摘 | Pimentel L Hansen KN | 2005 | J Emerg Med2005，28，2： | 1 |
| 17 | Oxidative stress in Alzheimer's and Parkinson's diseases:insights from the Yeast Saccharomyces cerevisiae显示文摘 | PIMENTEL C BATISTA-NASCIMENTO L RODRIGUES-POUSADA C | | 0，，： | 1 |
| 18 | Food production and the energy crisis显示文摘 | Pimentel D Hurd L E Bellotti A C | | 0，，： | 1 |
| 19 | Environmental and economic costs of soil erosion and conservation benefits 显示文摘 | PIMENTEL D HARVEY C RESOSUDARMO P SINCLAIR K KURZ D MCNAIR M CRIST S SHPRITZ L FITTON L SAFFOURI R BLAIR R A | 1995 | Science1995，267，： | 1 |
| 20 | A new adjacent bis-tetrahydrofuran annonaceous acetogenin from the seeds of Uvaria chamae 显示文摘 | Fall D Pimentel L Champy P | 2006 | Planta Med2006，72，10： | 1 |
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