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| 1 | Proton nuclear magnetic resonance-based metabonomic models for non-invasive diagnosis of liver fibrosis in chronic hepatitis C:Optimizing the classification of intermediate fibrosis显示文摘AIM To develop metabonomic models(MMs), using 1 H nuclear magnetic resonance(NMR) spectra of serum, to predict significant liver fibrosis(SF: Metavir ≥ F2), advanced liver fibrosis(AF: METAVIR ≥ F3) and cirrhosis(C: METAVIR = F4 or clinical cirrhosis) in chronic hepatitis C(CHC) patients. Additionally, to compare the accuracy of the MMs with the aspartate aminotransferase to platelet ratio index(APRI) and fibrosis index based on four factors(FIB-4). METHODS Sixty-nine patients who had undergone biopsy in the previous 12 mo or had clinical cirrhosis were included. The presence of any other liver disease was a criterion for exclusion. The MMs, constructed using partial least squares discriminant analysis and linear discriminant analysis formalisms, were tested by cross-validation, considering SF, AF and C. RESULTS Results showed that forty-two patients(61%) presented SF, 28(40%) AF and 18(26%) C. The MMs showed sensitivity and specificity of 97.6% and 92.6% to predict SF; 96.4% and 95.1% to predict AF; and 100% and 98.0% to predict C. Besides that, the MMs correctly classified all 27(39.7%) and 25(38.8%) patients with intermediate values of APRI and FIB-4, respectively. CONCLUSION The metabonomic strategy performed excellently in predicting significant and advanced liver fibrosis in CHC patients, including those in the gray zone of APRI and FIB-4, which may contribute to reducing the need for these patients to undergo liver biopsy. | Andrea Dória Batista Carlos Jonnatan Pimentel Barros Tássia Brena Barroso Carneiro Costa Michele Maria Goncalves de Godoy Ronaldo Dionísio Silva Joelma Carvalho Santos Mariana Montenegro de Melo Lira Norma ThoméJucá Edmundo Pessoa de Almeida Lopes Ricardo Oliveira Silva | 2018 | World Journal of Hepatology2018，10，1： | 2 |
| 2 | Naproxen-induced liver injury显示文摘BACKGROUND: Nonsteroidal anti-inflammatory drugs (NSAIDs) have been reported to induce liver injury. Patterns of the injury usually range from mild elevations of liver enzymes to sometimes severe fulminant hepatic failure. Likewise, naproxen is a propionic acid derivative NSAID that was introduced in 1980 and has been available as an over-the- counter medication since 1994, but has rarely been reported to cause liver injury. METHODS: We treated a 30-year-old woman with jaundice and intractable pruritus that developed shortly after taking naproxen. We reviewed the medical history and liver histopathology of the patient as well as all previously published case reports of naproxen-associated liver toxicity in the English language literature. RESULTS: The liver biochemical profile of the patient revealed a mixed cholestasis and hepatitis pattern. Consecutive liver biopsies demonstrated focal lobular inflammation, hepatocyte drop-out, and a progressive loss of the small interlobular bile ducts (ductopenia). The biopsy performed two years after onset of the disease showed partial recovery of a small number of bile ducts; however, 10 years passed before the biochemical profile returned to near normal. CONCLUSIONS: Naproxen-associated liver toxicity remains a rare entity, but should be considered in any patient presenting with cholestasis shortly after its use. Liver injury is most commonly seen in a mixed pattern characterized by cholestasis and hepatitis. The resulting liver damage may take years to resolve. | Sharif Ali Jason D Pimentel | 2011 | Hepatobiliary & Pancreatic Diseases International2011，10，5： | 2 |
| 3 | The association between the neutrophil-to-lymphocyte ratio and mortality in critical illness:an observational cohort study显示文摘 | SALCICCIOLI J D MARSHALL D C PIMENTEL M A | 2015 | Crit Care2015，19，： | 1 |
| 4 | Economic and Environmental Benefits of Biodiversity 显示文摘 | PIMENTEL D WILSON C MCCULLUM C | 1997 | Bioscience1997，47，11： | 1 |
| 5 | Environmental and economic costs of nonindigenous species in the United States显示文摘 | Pimentel D Lach L Zuniga R | 2000 | BioScience2000，50，1： | 1 |
| 6 | Environment and economic effects of reducing pesticide use in agriculture显示文摘 | Pimentel D McLaughlin L Zeep A | 1993 | Agriculture Ecosystems and Environment1993，46，： | 1 |
| 7 | Environmental and e- conomic cost s of soil erosion and conservation benefits显示文摘 | Pimentel D Harvey C Resosudarmo P | 1995 | Science1995，267，： | 1 |
| 8 | Adiponectin protects against myocardial ischemiareperfusion injury through AMPK-and COX-2-dependent mechanisms显示文摘 | SHIBATA R SATO K PIMENTEL D R | 2005 | Nat Med2005，11，： | 1 |
| 9 | A new adjacent bis-tetrahydrofuran annonaceous acetogenin from the seeds of Uvafia chamae 显示文摘 | Fall D Pimentel L Champy Petal | 2006 | Planta Med2006，72，10： | 1 |
| 10 | Environmental and economic costs of soil erosion and conservation benefits显示文摘 | PIMENTEL D | 1995 | Science1995，267，： | 1 |
| 11 | Human amyloidogenic chains directly impair cardiomyocyte function through an increase in cellular oxidant stress显示文摘 | Brenner DA Jain M Pimentel D R | 2004 | Circ Res2004，94，： | 1 |
| 12 | Economic and Environmental Benefits of Biodiversity 显示文摘 | PIMENTEL D WILSON C MCCULLUM C | 1997 | Bioscience1997，47，11： | 1 |
| 13 | Environmental and economic costs of the application of pes- ticide primarily in the United States显示文摘 | Pimentel D | 2005 | Environmental Development and Sustainability2005，7，2： | 1 |
| 14 | Phosphine resistance, respiration rate and witness consequences in stored-product insects显示文摘 | PIMENTEL M A G FARONI L R D A TOTOLA M R | 2007 | Pest Manage- ment Science2007，63，9： | 1 |
| 15 | Feasibility of large scale biofuel production显示文摘 | ULGIATI S PIMENTEL D | 1997 | Bioscience1997，147，： | 1 |
| 16 | Predictive monitoring of mobile patients by combining clinical observations with data from wearable sensor显示文摘 | CLIFTON L CLIFTON D A PIMENTEL M A | 2014 | IEEE Journal of Biomedical and Health Informatics2014，18，3： | 1 |
| 17 | Environmental and economic costs of non-indigenous species in the Unites States显示文摘 | Pimentel D Lach L Zuniga R | 2000 | Bioscience2000，50，： | 1 |
| 18 | Association of IL23R and ERAP1 genes with ankylosing spondylitis in a Portuguese population 显示文摘 | Pimentel - Santos FM Ligeiro D Matos M | 2009 | Clin Exp Rheumatol2009，27，： | 1 |
| 19 | E- cology of increasing diseases: population growth and environ- mental degradation 显示文摘 | PIMENTEL D COOPERSTEIN S RANDELL H | 2007 | Hum Ecol2007，35，6： | 1 |
| 20 | Environmental and economic effects of reducing pesticide use in agriculture显示文摘 | Pimentel D McLaughlin L Zepp A | 1993 | Ag- ric Ecosyst Environ1993，46，1： | 1 |
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